Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYAMP5)

Drug Name
EHT-1864 Drug Info
Synonyms EHT-0101; EHT-0206; EHT-101; EHT-206; Rac1 inhibitor (Alzheimer's disease/cancer),Exonhit
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Terminated [1]
Cross-matching ID
PubChem CID
9938202
CAS Number
CAS 754240-09-0
TTD Drug ID
DMYAMP5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [4]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [5]
Gefitinib DM15F0X Colon adenocarcinoma Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [7]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [8]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [9]
Quercetin DM3NC4M Obesity 5B81 Approved [10]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [11]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [7]
Estrone DM5T6US Acne vulgaris ED80 Approved [12]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [13]
Methotrexate DM2TEOL Anterior urethra cancer Approved [14]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [15]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [16]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [17]
Paclitaxel DMLB81S Breast carcinoma Approved [18]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [19]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [21]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [22]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [24]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [26]
Selenium DM25CGV N. A. N. A. Approved [27]
Etretinate DM2CZFA Keratosis ED56 Approved [28]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [29]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [30]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
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Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [33]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [34]
Gefitinib DM15F0X Colon adenocarcinoma Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [42]
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Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [44]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [45]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [29]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Fluoxetine DM3PD2C Bipolar depression Approved [48]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [53]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [34]
Gefitinib DM15F0X Colon adenocarcinoma Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [55]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [59]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [62]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [17]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [63]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [64]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [66]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [67]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [68]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Methotrexate DM2TEOL Anterior urethra cancer Approved [14]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [74]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [75]
Testosterone DM7HUNW Hot flushes GA30 Approved [76]
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Drug(s) Affected By Cyclin-A1 (CCNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [80]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [78]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [82]
Folic Acid DMEMBJC Colorectal carcinoma Approved [83]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [84]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [85]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [55]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [86]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [87]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [88]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Testosterone DM7HUNW Hot flushes GA30 Approved [89]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [92]
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Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [93]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [95]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [94]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [96]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [97]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [98]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [99]
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Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [102]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [104]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [105]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ras-related C3 botulinum toxin substrate 1 (RAC1) TT2M9CG RAC1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [2]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [2]
Cyclin-A1 (CCNA1) OTX4HD45 CCNA1_HUMAN Gene/Protein Processing [2]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Gene/Protein Processing [3]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Gene/Protein Processing [2]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Gene/Protein Processing [2]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Gene/Protein Processing [2]
kinase isozyme 1, mitochondrial (PDK1) OTMABK9Z PDK1_HUMAN Gene/Protein Processing [2]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Gene/Protein Processing [2]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Post-Translational Modifications [2]

References

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52 eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
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54 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
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59 Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
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62 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
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