Details of Disease

General Information of Disease (ID: DIS58KQX)

Disease Name	Seasonal allergic rhinitis
Synonyms	hay fever; seasonal allergic rhinitis
Disease Class	CA08: Vasomotor/allergic rhinitis
Definition	Allergic rhinitis caused by outdoor allergens.
Disease Hierarchy	DIS3U9HN: Allergic rhinitis DIS58KQX: Seasonal allergic rhinitis
ICD Code	ICD-11 ICD-11: CA08.01 ICD-10 ICD-10: J30.2 Expand ICD-11 'CA08.01 Expand ICD-10 'J30.2 Expand ICD-9 472.0,477
Disease Identifiers	MONDO ID MONDO_0005324 MESH ID D006255 UMLS CUI C0018621 MedGen ID 42335 HPO ID HP:0012395 SNOMED CT ID 21719001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 29 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Acrivastine	DMTIGA0	Approved	Small molecular drug	[1]
Azatadine	DMZ80SB	Approved	Small molecular drug	[2]
Azelastine	DMXTMBJ	Approved	Small molecular drug	[3]
Bromodiphenhydramine	DMNDJT5	Approved	Small molecular drug	[4]
Brompheniramine	DMFOVSD	Approved	Small molecular drug	[5]
Carbinoxamine	DMCT31R	Approved	Small molecular drug	[6]
Cetirizine	DMOMP9U	Approved	Small molecular drug	[7]
Ciclesonide	DM2NA4K	Approved	Small molecular drug	[8]
Cyclizine	DM9G7BS	Approved	Small molecular drug	[9]
Desloratadine	DM56YN7	Approved	Small molecular drug	[10]
Dexbrompheniramine	DMKVWGE	Approved	Small molecular drug	[11]
Dexchlorpheniramine Maleate	DMA8DPN	Approved	Small molecular drug	[12]
Diphenhydramine	DMKQTBA	Approved	Small molecular drug	[13]
Doxylamine	DMKOXFE	Approved	Small molecular drug	[14]
Ephedrine	DMMV0KW	Approved	Small molecular drug	[15]
Fexofenadine	DM17ONX	Approved	Small molecular drug	[16]
Grass pollen extract sublingual vaccine	DMST6NR	Approved	NA	[17]
Levocetirizine	DMQYLGP	Approved	Small molecular drug	[18]
Loratadine	DMF3AN7	Approved	Small molecular drug	[19]
Mepyramine	DMB4SFH	Approved	Small molecular drug	[20]
Methylprednisolone	DM4BDON	Approved	Small molecular drug	[21]
Olopatadine	DMKMWQG	Approved	Small molecular drug	[22]
Pheniramine	DMCH7RU	Approved	Small molecular drug	[23]
Phenylephrine	DMZHUO5	Approved	Small molecular drug	[24]
Promethazine	DM6I5GR	Approved	Small molecular drug	[25]
Pseudoephedrine	DMIVJ0D	Approved	Small molecular drug	[15]
Triamcinolone	DM98IXF	Approved	Small molecular drug	[26]
Triprolidine	DM7SWIA	Approved	Small molecular drug	[15]
Chlorphenamine	DM6C4YJ	Phase 4	NA	[27]
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⏷ Show the Full List of 29 Drug(s)

This Disease is Treated as An Indication in 7 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Injectable MPL allergy vaccine	DM7WJK8	Phase 3	NA	[28]
Levomequitazine	DMAYC76	Phase 3	Small molecular drug	[29]
Grass pollen allergy vaccine	DM1OG4W	Phase 2/3	NA	[30]
Chlorcyclizine	DM3L52Q	Phase 1	Small molecular drug	[31]
JNJ-38224342	DMAUQ8U	Phase 1	NA	[32]
Ragweed allergy immunotherapy vaccine	DM4C6Y1	Phase 1	NA	[33]
Ragweed mix vaccine	DM67SCK	Phase 1	NA	[28]
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⏷ Show the Full List of 7 Drug(s)

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Phenylpropanolamine	DMTFK3O	Withdrawn from market	Small molecular drug	[34]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Pollen allergen immunotherapy	DMYWHGT	Investigative	NA	[35]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 19 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IKZF3	TTCZVFZ	Limited	Genetic Variation	[36]
IL1RL1	TT4GZA4	Limited	Genetic Variation	[36]
TLR1	TTW14D0	Limited	Genetic Variation	[36]
ADAM33	TTQICM2	Strong	Genetic Variation	[37]
CCL11	TTCF05Y	Strong	Altered Expression	[38]
CSF2RB	TTPYS82	Strong	Genetic Variation	[39]
CYSLTR1	TTGKOY9	Strong	Biomarker	[40]
CYSLTR2	TT0PZR5	Strong	Biomarker	[40]
ENPP3	TTD4TKP	Strong	Altered Expression	[41]
EPX	TTCIO0M	Strong	Genetic Variation	[42]
HDC	TTV9GOF	Strong	Altered Expression	[43]
HRH1	TTTIBOJ	Strong	Altered Expression	[43]
IL2	TTF89GD	Strong	Genetic Variation	[44]
IL4R	TTDWHC3	Strong	Genetic Variation	[45]
IL5	TTPREZD	Strong	Genetic Variation	[46]
LRRC32	TT0FAYT	Strong	Genetic Variation	[36]
PTGDR2	TTQDMX5	Strong	Biomarker	[47]
SMAD3	TTHQZV7	Strong	Genetic Variation	[36]
SMAD6	TTON5JB	Strong	Altered Expression	[48]
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⏷ Show the Full List of 19 DTT(s)

This Disease Is Related to 17 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CLEC16A	OTLGV5SV	Limited	Genetic Variation	[36]
GSDMA	OT912R2E	Limited	Genetic Variation	[36]
IL18R1	OT83XMPQ	Limited	Genetic Variation	[36]
CPEB4	OTW1SCZW	Strong	Biomarker	[49]
CST1	OTE4I83Q	Strong	Biomarker	[50]
DEXI	OT60W9CN	Strong	Genetic Variation	[36]
GLCCI1	OTU0R1CU	Strong	Biomarker	[51]
GPR162	OTK4LT3K	Strong	Biomarker	[52]
GYPB	OTESHUIX	Strong	Biomarker	[52]
GYPE	OTBHAG6A	Strong	Biomarker	[52]
IFTAP	OTZXGVJ9	Strong	Genetic Variation	[53]
IL17RB	OT0KDNSF	Strong	Altered Expression	[54]
MZF1	OTMVZCPW	Strong	Genetic Variation	[55]
SDAD1	OTP4468N	Strong	Biomarker	[56]
SRL	OT7IEBWZ	Strong	Biomarker	[57]
TES	OTL8PP6V	Strong	Biomarker	[58]
TNS1	OTZ8S1PL	Strong	Genetic Variation	[36]
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⏷ Show the Full List of 17 DOT(s)

References

1	Acrivastine FDA Label
2	Azatadine FDA Label
3	Azelastine FDA Label
4	Bromodiphenhydramine FDA Label
5	Brompheniramine FDA Label
6	Carbinoxamine FDA Label
7	Cetirizine FDA Label
8	Ciclesonide FDA Label
9	Cyclizine FDA Label
10	Desloratadine FDA Label
11	Dexbrompheniramine FDA Label
12	Dexchlorpheniramine maleate FDA Label
13	Diphenhydramine FDA Label
14	Doxylamine FDA Label
15	Ephedrine FDA Label
16	Fexofenadine FDA Label
17	Clinical pipeline report, company report or official report of Stallergenes.
18	Levocetirizine FDA Label
19	Loratadine FDA Label
20	Antiallergic anti-inflammatory effects of H1-antihistamines in humans. Clin Allergy Immunol. 2002;17:101-39.
21	Methylprednisolone FDA Label
22	Olopatadine FDA Label
23	Pheniramine FDA Label
24	Isoproterenol FDA Label
25	Promethazine FDA Label
26	Triamcinolone FDA Label
27	Efficacy and central nervous system impairment of newer-generation prescription antihistamines in seasonal allergic rhinitis. South Med J. 2006 Jun;99(6):593-9.
28	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
29	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034359)
30	Clinical pipeline report, company report or official report of ALK Abello.
31	Chlorcyclizine hydrochloride poisoning in an infant. Br Med J. 1954 Mar 20;1(4863):687-8.
32	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031502)
33	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033111)
34	Phenylpropanolamine FDA Label
35	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
36	Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.J Allergy Clin Immunol. 2014 Jun;133(6):1564-71. doi: 10.1016/j.jaci.2013.10.030. Epub 2013 Dec 31.
37	Association study on ADAM33 polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.PLoS One. 2014 Apr 21;9(4):e95033. doi: 10.1371/journal.pone.0095033. eCollection 2014.
38	Inhibitory action of levocetirizine on the production of eosinophil chemoattractants RANTES and eotaxin in vitro and in vivo.In Vivo. 2014 Jul-Aug;28(4):657-66.
39	Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster.Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):199-207. doi: 10.1158/1055-9965.EPI-10-0779. Epub 2010 Nov 11.
40	Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis.Clin Exp Allergy. 2003 Oct;33(10):1380-8. doi: 10.1046/j.1365-2222.2003.01786.x.
41	Allergen-specific basophil reactivity exhibits daily variations in seasonal allergic rhinitis.Allergy. 2015 Mar;70(3):319-22. doi: 10.1111/all.12552. Epub 2014 Dec 22.
42	Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with Japanese cedar pollinosis.Int Arch Allergy Immunol. 2004 Sep;135(1):40-3. doi: 10.1159/000080222. Epub 2004 Aug 13.
43	Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats.J Pharmacol Sci. 2016 Apr;130(4):212-8. doi: 10.1016/j.jphs.2016.02.002. Epub 2016 Feb 11.
44	A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.J Allergy Clin Immunol. 2011 Nov;128(5):996-1005. doi: 10.1016/j.jaci.2011.08.030.
45	The differences in the involvements of loci of promoter region and Ile50Val in interleukin-4 receptor chain gene between atopic dermatitis and Japanese cedar pollinosis.Allergol Int. 2012 Mar;61(1):57-63. doi: 10.2332/allergolint.10-OA-0302. Epub 2011 Sep 25.
46	Evidence for local eosinophil differentiation within allergic nasal mucosa: inhibition with soluble IL-5 receptor.J Immunol. 2000 Feb 1;164(3):1538-45. doi: 10.4049/jimmunol.164.3.1538.
47	Efficacy and safety of setipiprant in seasonal allergic rhinitis: results from Phase 2 and Phase 3 randomized, double-blind, placebo- and active-referenced studies.Allergy Asthma Clin Immunol. 2017 Apr 4;13:18. doi: 10.1186/s13223-017-0183-z. eCollection 2017.
48	Transforming growth factor-beta gene expression studies in nasal mucosal biopsies in naturally occurring allergic rhinitis.Ann R Coll Surg Engl. 2007 Sep;89(6):563-73. doi: 10.1308/003588407X202164.
49	Bioinformatics-Based Approaches Predict That MIR-17-5P Functions in the Pathogenesis of Seasonal Allergic Rhinitis Through Regulating ABCA1 and CD69.Am J Rhinol Allergy. 2019 May;33(3):269-276. doi: 10.1177/1945892418823388. Epub 2019 Jan 8.
50	Epithelial proteome profiling suggests the essential role of interferon-inducible proteins in patients with allergic rhinitis.J Allergy Clin Immunol. 2017 Nov;140(5):1288-1298. doi: 10.1016/j.jaci.2017.05.040. Epub 2017 Jun 19.
51	Glucocorticoid-Induced Transcription Factor 1 (GLCCI1) Variant Impacts the Short-Term Response to Intranasal Corticosteroids in Chinese Han Patients with Seasonal Allergic Rhinitis.Med Sci Monit. 2018 Jul 7;24:4691-4697. doi: 10.12659/MSM.908814.
52	Erythrocyte antigens as immunogenetic markers of respiratory atopic diseases in Georgians.J Investig Allergol Clin Immunol. 1995 Jan-Feb;5(1):35-9.
53	Effects of a Cloth Panel Containing a Specific Ore Powder on Patients with Japanese Cedar Pollen Allergy During the Pollen Dispersal Season.J Clin Med. 2019 Dec 6;8(12):2164. doi: 10.3390/jcm8122164.
54	Upregulation of IL17RB during natural allergen exposure in patients with seasonal allergic rhinitis.Allergol Int. 2011 Mar;60(1):87-92. doi: 10.2332/allergolint.10-OA-0230. Epub 2011 Jan 25.
55	Twin concordance for a binary trait: III. A bivariate analysis of hay fever and asthma.Genet Epidemiol. 1990;7(4):277-89. doi: 10.1002/gepi.1370070406.
56	Association of a haplotype block spanning SDAD1 gene and CXC chemokine genes with allergic rhinitis.J Allergy Clin Immunol. 2005 Mar;115(3):548-54. doi: 10.1016/j.jaci.2004.11.034.
57	Role of IL-35 in sublingual allergen immunotherapy.J Allergy Clin Immunol. 2019 Mar;143(3):1131-1142.e4. doi: 10.1016/j.jaci.2018.06.041. Epub 2018 Jul 25.
58	Humanization of a mouse anti-human IgE antibody: a potential therapeutic for IgE-mediated allergies.Protein Eng. 1993 Nov;6(8):971-80. doi: 10.1093/protein/6.8.971.