General Information of DTT (ID: TTANPDJ)

DTT Name Carbonic anhydrase II (CA-II) DTT Info
Gene Name CA2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
9 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzthiazide DMQWZ0H High blood pressure BA00 Approved [1]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [2]
Cyclothiazide DMJ4AWC Congestive heart failure BD10 Approved [3]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [4]
Dorzolamide DMA17D0 Ocular hypertension 9C61.01 Approved [5]
Ethinamate DMK57GB Insomnia 7A00-7A0Z Approved [6]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [4]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [7]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [8]
------------------------------------------------------------------------------------
⏷ Show the Full List of 9 Approved Drug(s)
10 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
CG-100649 DMIKMA9 Arthritis FA20 Phase 3 [9]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [10]
GUAIACOL DMN4E7T N. A. N. A. Phase 3 [11]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [12]
SULTHIAME DM07653 N. A. N. A. Phase 3 [4]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [10]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [13]
STX-140 DMJK5CT Osteoporosis FB83.0 Phase 2 [14]
BUTYLATEDHYDROXYTOLUENE DMJ56MS N. A. N. A. Phase 1 [11]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [15]
------------------------------------------------------------------------------------
⏷ Show the Full List of 10 Clinical Trial Drug(s)
1 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [12]
------------------------------------------------------------------------------------
259 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(2,2-dimethyl-1,3-dioxolan-4-yl)methyl sulfamate DM2ATRC Discovery agent N.A. Investigative [16]
(2-bromophenyl)difluoromethanesulfonamide DMFX9H8 Discovery agent N.A. Investigative [17]
(4-bromophenyl)difluoromethanesulfonamide DMOCYZJ Discovery agent N.A. Investigative [17]
1,2,4-Triazole DM73F5A Discovery agent N.A. Investigative [18]
1,4-Dihydro-1-methyl-4-oxo-3-pyridinesulfonamide DMNHGVD Discovery agent N.A. Investigative [19]
1,4-phenylene disulfamate DMEDBO2 Discovery agent N.A. Investigative [20]
1-(3,4-dichlorophenyl)-3-hydroxyurea DMVOJ7K Discovery agent N.A. Investigative [21]
1-acetamido-5-sulfonamidoindane DM92ZCU Discovery agent N.A. Investigative [22]
1-Benzyl-1,4-dihydro-4-oxo-3-pyridinesulfonamide DMUXSH5 Discovery agent N.A. Investigative [19]
1-cyclohexylamido-5-sulfonamidoindane DMFPQME Discovery agent N.A. Investigative [22]
1-pentafluorophenylamido-5-sulfonamidoindane DM9PNTQ Discovery agent N.A. Investigative [22]
1-pentenyl-4-(aminosulfonyl)benzoate DMNUAB9 Discovery agent N.A. Investigative [23]
1-valproylamido-5-sulfonamidoindane DM9ZRU2 Discovery agent N.A. Investigative [22]
2,2,2-Trifluoro-N-(4-sulfamoyl-phenyl)-acetamide DMG4ITB Discovery agent N.A. Investigative [24]
2,2-Dimethyl-N-(4-sulfamoyl-phenyl)-propionamide DMATB8H Discovery agent N.A. Investigative [24]
2,3-dihydro-1H-indene-5-sulfonamide DM46MKY Discovery agent N.A. Investigative [4]
2,4-dichloro-5-sulfamoylbenzoic acid DM4EY5S Discovery agent N.A. Investigative [25]
2,4-Disulfamyltrifluoromethylaniline DM2AW0Z Discovery agent N.A. Investigative [26]
2,6-di-t-butylphenol DMY8LDT Discovery agent N.A. Investigative [11]
2,6-di-tert-butyl-4-methoxyphenol DMFO1H2 Discovery agent N.A. Investigative [11]
2,6-Difluorobenzenesulfonamide DMGEYAK Discovery agent N.A. Investigative [27]
2-(4-chlorobenzyloxyamino)-N-hydroxyacetamide DM1JKWL Discovery agent N.A. Investigative [28]
2-(4-chlorobenzyloxyamino)-N-hydroxyhexanamide DMFGQ7K Discovery agent N.A. Investigative [28]
2-(4-chlorobenzyloxyamino)-N-hydroxypropanamide DMRADWB Discovery agent N.A. Investigative [28]
2-(4-hydroxybenzylideneamino)ethanesulfonamide DMCPN7V Discovery agent N.A. Investigative [29]
2-(4-tert-butylbenzylideneamino)ethanesulfonamide DMIOW3D Discovery agent N.A. Investigative [29]
2-(benzylideneamino)ethanesulfonamide DM3VJLZ Discovery agent N.A. Investigative [29]
2-(benzyloxyamino)-N-hydroxyhexanamide DMOUKTH Discovery agent N.A. Investigative [28]
2-(N''-Acetyl-hydrazino)-benzenesulfonamide DMHYKR8 Discovery agent N.A. Investigative [30]
2-acetamido-5-sulfonamidoindane DMPKBVR Discovery agent N.A. Investigative [22]
2-Acetylamino-indan-5-sulfonic acid hydrate DMEQKIU Discovery agent N.A. Investigative [31]
2-Amino-benzenesulfonamide DMEMANH Discovery agent N.A. Investigative [26]
2-Amino-indan-5-sulfonic acid DMCUSH1 Discovery agent N.A. Investigative [31]
2-butylamido-5-sulfonamidoindane DML9MCU Discovery agent N.A. Investigative [22]
2-cyclohexylamido-5-sulfonamidoindane DMFBD3K Discovery agent N.A. Investigative [22]
2-ethylamido-5-sulfonamidoindane DMDY3JQ Discovery agent N.A. Investigative [22]
2-Hydrazinocarbonyl-benzenesulfonamide DMG78U2 Discovery agent N.A. Investigative [30]
2-hydrazinylbenzenesulfonamide DMCNXZM Discovery agent N.A. Investigative [5]
2-Hydroxycinnamic acid DM86HTZ Discovery agent N.A. Investigative [10]
2-Mercapto-N-(4-sulfamoyl-phenyl)-benzamide DMXEUDM Discovery agent N.A. Investigative [4]
2-methoxyestradiol-17-O-sulfamate DMIBKNZ Discovery agent N.A. Investigative [14]
2-methoxyestrrone-3-O-sulfamate DMD6L7C Discovery agent N.A. Investigative [14]
2-Morpholin-4-yl-N-(4-sulfamoyl-phenyl)-acetamide DMDTRZ2 Discovery agent N.A. Investigative [32]
2-nonylamido-5-sulfonamidoindane DMOGWIK Discovery agent N.A. Investigative [22]
2-oxo-2H-thiochromene-3-carboxylic acid DMZTCOM Discovery agent N.A. Investigative [33]
2-pentafluorophenylamido-5-sulfonamidoindane DMZ9NCA Discovery agent N.A. Investigative [22]
2-propylamido-5-sulfonamidoindane DMG0I25 Discovery agent N.A. Investigative [22]
2-Sulfamoyl-benzoic acid methyl ester DMAO7DS Discovery agent N.A. Investigative [30]
2-Sulfhydryl-Ethanol DMJBO3D Discovery agent N.A. Investigative [18]
2-valproylamido-5-sulfonamidoindane DM8XSE3 Discovery agent N.A. Investigative [22]
3,5-Difluorobenzenesulfonamide DMET46F Discovery agent N.A. Investigative [18]
3-((4-aminophenyl)diazenyl)benzenesulfonamide DM37X04 Discovery agent N.A. Investigative [34]
3-((4-hydroxyphenyl)diazenyl)benzenesulfonamide DMAPZQW Discovery agent N.A. Investigative [34]
3-(3-Phenyl-ureido)-benzenesulfonamide DM314ZE Discovery agent N.A. Investigative [24]
3-(4'-Hydroxyphenyl)diazenylbenzenesulfonamide DM18MOH Discovery agent N.A. Investigative [34]
3-(4-sulfamoylphenyl)propanoic acid DMBDW8P Discovery agent N.A. Investigative [4]
3-Amino-benzenesulfonamide DME0TNA Discovery agent N.A. Investigative [35]
3-bromophenyl-difluoromethanesulfonamide DMXZW3R Discovery agent N.A. Investigative [17]
3-Chloro-4-hydrazino-benzenesulfonamide DMSB5IQ Discovery agent N.A. Investigative [30]
3-Fluoro-4-hydrazino-benzenesulfonamide DMLG69R Discovery agent N.A. Investigative [30]
3-hydroxy-2-methoxybenzaldehyde DMI785L Discovery agent N.A. Investigative [11]
3-mercapto-N-(4-sulfamoyl-phenyl)-propionamide DMQ09J8 Discovery agent N.A. Investigative [36]
3-Mercuri-4-Aminobenzenesulfonamide DMX3ANZ Discovery agent N.A. Investigative [18]
3-Nitro-benzenesulfonamide DMAY4OZ Discovery agent N.A. Investigative [37]
3-phenyl-5-sulfamoyl-1H-indole-2-carboxamide DM43CIK Discovery agent N.A. Investigative [38]
3-phenylprop-1-enylboronic acid DMIJN9E Discovery agent N.A. Investigative [39]
4,4'-thiodipyridine-3-sulfonamide DM0K5JM Discovery agent N.A. Investigative [40]
4,6-Dinitro salicylic acid DMIJ4VZ Discovery agent N.A. Investigative [41]
4-((4-hydroxyphenyl)diazenyl)benzenesulfonamide DM5EP3V Discovery agent N.A. Investigative [34]
4-((benzylideneamino)methyl)benzenesulfonamide DM6R43J Discovery agent N.A. Investigative [29]
4-(2-AMINOETHYL)BENZENESULFONAMIDE DMEK6WX Discovery agent N.A. Investigative [4]
4-(2-aminopyrimidin-4-ylamino)benzenesulfonamide DMWG706 Discovery agent N.A. Investigative [26]
4-(2-Hydroxy-ethyl)-benzenesulfonamide DM1C5U6 Discovery agent N.A. Investigative [42]
4-(2-Methyl-8-quinolinoxy)-3-pyridinesulfonamide DME6DHX Discovery agent N.A. Investigative [40]
4-(2-Phenylacetamido)-3-bromobenzenesulfonamide DMZ62L3 Discovery agent N.A. Investigative [43]
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide DM9GOTA Discovery agent N.A. Investigative [43]
4-(2-Phenylacetamido)-3-fluorobenzenesulfonamide DMCOD4N Discovery agent N.A. Investigative [43]
4-(2-Phenylacetamido)benzenesulfonamide DMFYR6H Discovery agent N.A. Investigative [43]
4-(2-Phenylacetamidoethyl)benzenesulfonamide DM1JL03 Discovery agent N.A. Investigative [43]
4-(2-Phenylacetamidomethyl)benzenesulfonamide DMDYHXE Discovery agent N.A. Investigative [43]
4-(2-Propynylthio)pyridine-3-sulfonamide DMT9RAC Discovery agent N.A. Investigative [40]
4-(2-Pyridin-2-ylacetamido)benzenesulfonamide DM9LKMP Discovery agent N.A. Investigative [43]
4-(2-Pyridin-4-ylacetamido)benzenesulfonamide DMD6AYQ Discovery agent N.A. Investigative [43]
4-(4-Cyanophenoxy)-3-pyridinesulfonamide DMNEAJH Discovery agent N.A. Investigative [40]
4-(4-Fluorophenoxy)-3-pyridinesulfonamide DMRJLAP Discovery agent N.A. Investigative [40]
4-(4-hydroxy-benzylideneamino)-benzenesulfonamide DMNY0I5 Discovery agent N.A. Investigative [29]
4-(4-hydroxybenzylideneamino)benzoic acid DML357W Discovery agent N.A. Investigative [29]
4-(4-tert-butylbenzylideneamino)benzoic acid DMFLH2G Discovery agent N.A. Investigative [29]
4-(5-Methyl-2-pirazolino)-3-pyridinesulfonamide DMKT20Q Discovery agent N.A. Investigative [40]
4-(Allylamino)-3-pyridinesulfonamide DM6MQCI Discovery agent N.A. Investigative [40]
4-(benzylideneamino)benzenesulfonamide DM03BQD Discovery agent N.A. Investigative [29]
4-(benzylideneamino)benzoic acid DMJM2H1 Discovery agent N.A. Investigative [29]
4-(Carbamolymethylthio)pyridine-3-sulfonamide DM12R4M Discovery agent N.A. Investigative [40]
4-(Cyanomethylthio)pyridine-3-sulfonamide DMZP20H Discovery agent N.A. Investigative [40]
4-(Hydroxymercury)Benzoic Acid DMWJN73 Discovery agent N.A. Investigative [18]
4-(hydroxymethyl)benzenesulfonamide DMR6VWL Discovery agent N.A. Investigative [26]
4-(Methylhydrazino)-3-pyridinesulfonamide DM4BPL1 Discovery agent N.A. Investigative [40]
4-(N-Methyl-hydrazino)-benzenesulfonamide DMADWTI Discovery agent N.A. Investigative [44]
4-(N-Oxide-2-pyridylthio)pyridine-3-sulfonamide DMYCV8E Discovery agent N.A. Investigative [40]
4-(Quinolinoxy)-3-pyridinesulfonamide DMPNXFA Discovery agent N.A. Investigative [40]
4-Amino-3-bromo-benzenesulfonamide DMVUCZK Discovery agent N.A. Investigative [26]
4-Amino-3-chloro-benzenesulfonamide DMERTQ4 Discovery agent N.A. Investigative [26]
4-Amino-3-fluoro-benzenesulfonamide DMIQ3VR Discovery agent N.A. Investigative [42]
4-Amino-3-iodo-benzenesulfonamide DMCOYHR Discovery agent N.A. Investigative [26]
4-amino-6-chlorobenzene-1,3-disulfonamide DMIWGZS Discovery agent N.A. Investigative [42]
4-amino-N-(4-sulfamoylbenzyl)benzenesulfonamide DMJZNX6 Discovery agent N.A. Investigative [26]
4-azidobenzenesulfonamide DM7EQ06 Discovery agent N.A. Investigative [45]
4-Benzenesulfonylamino-benzenesulfonamide DMC7HKA Discovery agent N.A. Investigative [24]
4-Benzythiopyridine-3-sulfonamide DMI1EFY Discovery agent N.A. Investigative [40]
4-bromophenylboronic acid DM2YN37 Discovery agent N.A. Investigative [39]
4-butylphenylboronic acid DMD9FZW Discovery agent N.A. Investigative [39]
4-Chloro-N-(5-sulfamoyl-indan-2-yl)-benzamide DM2UYCS Discovery agent N.A. Investigative [31]
4-CYANOPHENOL DMN12EX Discovery agent N.A. Investigative [7]
4-Ethoxy-3-pyridinesulfonamide DM8WAOR Discovery agent N.A. Investigative [40]
4-ethynyl benzene sulfonamide DMIF1D6 Discovery agent N.A. Investigative [46]
4-Flourobenzenesulfonamide DMNDS19 Discovery agent N.A. Investigative [18]
4-fluoro-N-(4-sulfamoylbenzyl)benzenesulfonamide DMGBKN7 Discovery agent N.A. Investigative [20]
4-Hydrazino-3-pyridinesulfonamide DMSZMQU Discovery agent N.A. Investigative [40]
4-Hydrazino-benzenesulfonamide DM49B18 Discovery agent N.A. Investigative [47]
4-Hydrazinocarbonyl-benzenesulfonamide DM8PBEJ Discovery agent N.A. Investigative [30]
4-isothiocyanatobenzenesulfonamide DMBK67H Discovery agent N.A. Investigative [48]
4-Methanesulfonylamino-benzenesulfonamide DMPH4C8 Discovery agent N.A. Investigative [24]
4-Methoxy-3-pyridinesulfonamide DMJIX7H Discovery agent N.A. Investigative [40]
4-methoxyphenylboronic acid DMP5YFQ Discovery agent N.A. Investigative [39]
4-methoxyphenylsulfamide DMVW8KN Discovery agent N.A. Investigative [16]
4-Methylamino-benzenesulfonamide DM5XMI9 Discovery agent N.A. Investigative [44]
4-Methylimidazole DM45N6U Discovery agent N.A. Investigative [27]
4-methylphenyl-difluoromethanesulfonamide DMR5NLM Discovery agent N.A. Investigative [17]
4-Methylthiopyridine-3-sulfonamide DMEB5XP Discovery agent N.A. Investigative [40]
4-Nitro-benzenesulfonamide DMZY8UW Discovery agent N.A. Investigative [37]
4-nitrophenyl phosphate DMBX4UJ Discovery agent N.A. Investigative [49]
4-nitrophenyl-difluoromethanesulfonamide DM9ETMD Discovery agent N.A. Investigative [17]
4-nitrophenylsulfamide DM47IFL Discovery agent N.A. Investigative [16]
4-phenoxyphenylboronic acid DMMWYI9 Discovery agent N.A. Investigative [39]
4-Sulfonamide-[1-(4-Aminobutane)]Benzamide DM61CJK Discovery agent N.A. Investigative [18]
4-Thiocyanato-benzenesulfonamide DMUGMVI Discovery agent N.A. Investigative [37]
4-[2-(2-Thienyl)acetamidoethyl]benzenesulfonamide DMH3UPO Discovery agent N.A. Investigative [43]
4-[2-(2-Thienyl)acetamido]benzenesulfonamide DMYESXB Discovery agent N.A. Investigative [43]
4-[2-(3-Phenyl-ureido)-ethyl]-benzenesulfonamide DMGXM9C Discovery agent N.A. Investigative [24]
5-Amino-[1,3,4]thiadiazole-2-thiol DMGA47N Discovery agent N.A. Investigative [50]
5-Chlorosalicylic Acid DMH397E Discovery agent N.A. Investigative [41]
5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one DM5RI4H Discovery agent N.A. Investigative [51]
6-(aminomethyl)-2H-chromen-2-one DMJU9TG Discovery agent N.A. Investigative [33]
6-(hydroxymethyl)-2H-chromen-2-one DM5TOX2 Discovery agent N.A. Investigative [33]
6-Amino-benzothiazole-2-sulfonic acid amide DMWPELS Discovery agent N.A. Investigative [52]
6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE DMPSOIF Discovery agent N.A. Investigative [4]
6-Hydroxy-benzothiazole-2-sulfonic acid amide DM2B4S5 Discovery agent N.A. Investigative [47]
6-hydroxybenzo[d][1,3]oxathiol-2-one DMDRSNH Discovery agent N.A. Investigative [53]
6-methoxy-2-oxo-2H-chromene-3-carboxylic acid DM7WH82 Discovery agent N.A. Investigative [33]
6-methyl-2-oxo-2H-chromene-3-carboxylic acid DMZ6HQL Discovery agent N.A. Investigative [33]
6-Nitro-benzothiazole-2-sulfonic acid amide DMYP7UG Discovery agent N.A. Investigative [37]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [18]
ACETYLSULFANILAMIDE DMG8P24 Discovery agent N.A. Investigative [24]
AL4623 DMHG54F Discovery agent N.A. Investigative [18]
AL5300 DM1QJIV Discovery agent N.A. Investigative [18]
AL5424 DMSD2U1 Discovery agent N.A. Investigative [18]
AL5927 DM624WO Discovery agent N.A. Investigative [18]
AL6528 DM1JIVR Discovery agent N.A. Investigative [18]
Al7089a DMTXPJI Discovery agent N.A. Investigative [18]
AL7099A DMRI08C Discovery agent N.A. Investigative [27]
AL7182 DMG2D4S Discovery agent N.A. Investigative [18]
Allyl 4-(aminosulfonyl)benzoate DMYNKLR Discovery agent N.A. Investigative [23]
Aminobenzolamide derivative DMWYS0Z Discovery agent N.A. Investigative [54]
Azide DM5XZYB Discovery agent N.A. Investigative [15]
BENZOLAMIDE DME5QPX Discovery agent N.A. Investigative [26]
Benzothiazole-2-sulfonic acid amide DMROP5Q Discovery agent N.A. Investigative [55]
Beta-naphthylboronic acid DMZ8Y67 Discovery agent N.A. Investigative [39]
Biphenyl-4-ylboronic acid DMIHMP5 Discovery agent N.A. Investigative [39]
Carzenide DMVD481 Discovery agent N.A. Investigative [23]
CATECHIN DMY38SB Discovery agent N.A. Investigative [10]
CATECHOL DML0YEK Discovery agent N.A. Investigative [12]
CL-5343 DM9AFZ3 Solid tumour/cancer 2A00-2F9Z Investigative [56]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [57]
Dansylamide DMQ4L1I Discovery agent N.A. Investigative [18]
Decane-1,10-diyl disulfamate DM1ESVR Discovery agent N.A. Investigative [58]
Decyl sulfamate DMIERWO Discovery agent N.A. Investigative [58]
Di(2,6-di-t-butylphenol) DMO6Z02 Discovery agent N.A. Investigative [11]
Di(2,6-diisopropylphenol) DMG21PZ Discovery agent N.A. Investigative [11]
Di(2,6-dimethylphenol) DMZ3EML Discovery agent N.A. Investigative [11]
ELLAGIC ACID DMX8BS5 Discovery agent N.A. Investigative [12]
EMATE DMFQX1U Discovery agent N.A. Investigative [59]
ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE DMKJGLO Discovery agent N.A. Investigative [4]
Formic Acid DMNFZC6 Discovery agent N.A. Investigative [18]
GALLICACID DM6Y3A0 Discovery agent N.A. Investigative [12]
HYDROSULFIDE DMO32HN Discovery agent N.A. Investigative [15]
IODIDE DM3FZ6P Discovery agent N.A. Investigative [15]
Mercuribenzoic Acid DMT56ER Discovery agent N.A. Investigative [18]
Methyl 4-(4-hydroxybenzylideneamino)benzoate DMUROGX Discovery agent N.A. Investigative [29]
Methyl 4-(4-tert-butylbenzylideneamino)benzoate DMSBCL6 Discovery agent N.A. Investigative [29]
Methyl Mercury Ion DM6YEW4 Discovery agent N.A. Investigative [18]
MMI270 DM38N2K Discovery agent N.A. Investigative [28]
N-(1-benzofuran-3-ylmethyl)sulfamide DM3WBZP Discovery agent N.A. Investigative [60]
N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE DMUZL3J Discovery agent N.A. Investigative [4]
N-(2,6-Diflouro-Benzyl)-4-Sulfamoyl-Benzamide DM9ATQ6 Discovery agent N.A. Investigative [18]
N-(2-Flouro-Benzyl)-4-Sulfamoyl-Benzamide DM3CZVW Discovery agent N.A. Investigative [18]
N-(2-Thienylmethyl)-2,5-Thiophenedisulfonamide DME9HNO Discovery agent N.A. Investigative [18]
N-(4-cyanophenyl)sulfamide DMW8S2D Discovery agent N.A. Investigative [61]
N-(4-Sulfamoyl-phenyl)-benzamide DMZDACT Discovery agent N.A. Investigative [24]
N-(4-Sulfamoyl-phenyl)-butyramide DM3FW9Q Discovery agent N.A. Investigative [24]
N-(4-Sulfamoyl-phenyl)-isobutyramide DMJCXYQ Discovery agent N.A. Investigative [24]
N-(4-Sulfamoyl-phenyl)-propionamide DM7MHQD Discovery agent N.A. Investigative [24]
N-(4-sulfamoylphenylethyl)-4-sulfamoylbenzamide DM7QX03 Discovery agent N.A. Investigative [62]
N-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfamide DMNQDLC Discovery agent N.A. Investigative [63]
N-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-acetamide DMSQEXP Discovery agent N.A. Investigative [50]
N-(5-phenyl-1,3,4-thiadiazol-2-yl)sulfamide DMA21WB Discovery agent N.A. Investigative [63]
N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)sulfamide DM5E7OC Discovery agent N.A. Investigative [63]
N-(pentafluorophenyl)sulfamide DME45J8 Discovery agent N.A. Investigative [61]
N-(phosphonacetyl)-L-aspartate DMGHQJ8 Discovery agent N.A. Investigative [64]
N-1,3,4-thiadiazol-2-ylsulfamide DMJ10WH Discovery agent N.A. Investigative [63]
N-Benzyl-4-Sulfamoyl-Benzamide DMCIJU0 Discovery agent N.A. Investigative [18]
N-hydroxysulfamide DMTDBMU Discovery agent N.A. Investigative [65]
N-hydroxysulfonamides DMJBC03 Discovery agent N.A. Investigative [66]
N-propynyl amidebenzenesulphonide DMWTPJH Discovery agent N.A. Investigative [67]
N-[(4-bromo-1-benzothien-3-yl)methyl]sulfamide DMLTYPS Discovery agent N.A. Investigative [60]
N-[(5-chloro-1-benzothien-3-yl)methyl]sulfamide DMYJHRV Discovery agent N.A. Investigative [60]
N-[2-(1h-Indol-5-Yl)-Butyl]-4-Sulfamoyl-Benzamide DMM7T13 Discovery agent N.A. Investigative [18]
N-[4-(trifluoromethyl)phenyl]sulfamide DMMX65T Discovery agent N.A. Investigative [61]
N-[5-(ethylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMSI4PE Discovery agent N.A. Investigative [63]
N-[5-(methylthio)-1,3,4-thiadiazol-2-yl]sulfamide DMXLJGR Discovery agent N.A. Investigative [63]
N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE DMX4QKU Discovery agent N.A. Investigative [4]
NITRATE DMVFB93 Discovery agent N.A. Investigative [15]
NSC-654077 DMW3QAK Discovery agent N.A. Investigative [68]
Octane-1,8-diyl disulfamate DMBQMGH Discovery agent N.A. Investigative [58]
Octyl sulfamate DM40ZCA Discovery agent N.A. Investigative [58]
P-Coumaric Acid DMGJSVD Discovery agent N.A. Investigative [12]
P-toluenesulfonamide DMPEKTO Discovery agent N.A. Investigative [26]
P-tolylboronic acid DM8MZF4 Discovery agent N.A. Investigative [39]
PARAOXON DMN4ZKC Discovery agent N.A. Investigative [49]
Pentane-1,5-diamine DMVPZG9 Discovery agent N.A. Investigative [69]
Pentanoic acid (4-sulfamoyl-phenyl)-amide DMAZ07T Discovery agent N.A. Investigative [24]
Phenethylboronic acid DMPDVG2 Discovery agent N.A. Investigative [39]
Phenoxyarsonous acid DMZJO5V Discovery agent N.A. Investigative [15]
Phenyl Boronic acid DMFZH49 Discovery agent N.A. Investigative [15]
Phenyl-phosphonic acid DMYMNBL Discovery agent N.A. Investigative [64]
PHENYLDIFLUOROMETHANESULFONAMIDE DME75VC Discovery agent N.A. Investigative [17]
PHENYLMETHANESULFONAMIDE DMGLDFI Discovery agent N.A. Investigative [17]
PHENYLSULFAMATE DMRLFJV Discovery agent N.A. Investigative [16]
PHENYLSULFAMIDE DMRTHW1 Discovery agent N.A. Investigative [16]
PRONTOCIL DMIUV25 Discovery agent N.A. Investigative [34]
Prop-2-ynyl 4-sulfamoylbenzoate DM8O41M Discovery agent N.A. Investigative [67]
Quinoline-8-sulfonamide DMTPFLU Discovery agent N.A. Investigative [20]
RESORCINOL DMM37C0 Discovery agent N.A. Investigative [7]
SACCHARIN DMRA736 Discovery agent N.A. Investigative [42]
Sodium 2,3,5,6-tetrafluorobenzoate DMSRM49 Discovery agent N.A. Investigative [70]
SODIUM PERFLUOROHEXANESULFONAMIDE DMESHV2 Discovery agent N.A. Investigative [71]
Sodium trithiocarbonate DM6WYGC Discovery agent N.A. Investigative [72]
SULFAMATE DMF1589 Discovery agent N.A. Investigative [15]
Sulfamic acid 12-sulfamoyloxy-dodecyl ester DM9XNSK Discovery agent N.A. Investigative [73]
Sulfamic acid 16-sulfamoyloxy-hexadecyl ester DM7VBSY Discovery agent N.A. Investigative [73]
Sulfamic acid 3-sulfamoyloxy-phenyl ester DMA0MEV Discovery agent N.A. Investigative [73]
Sulfamic acid 4-sulfamoyloxy-butyl ester DMQZGNJ Discovery agent N.A. Investigative [73]
Sulfamic acid 4-sulfamoyloxymethyl-benzyl ester DMFJR0S Discovery agent N.A. Investigative [73]
Sulfamic acid 6-sulfamoyloxy-hexyl ester DMT3U2D Discovery agent N.A. Investigative [73]
Sulfamic acid 7-sulfamoyloxy-heptyl ester DMVWEN3 Discovery agent N.A. Investigative [73]
Sulfamic acid benzo[1,3]dioxol-2-ylmethyl ester DMFVQYI Discovery agent N.A. Investigative [74]
Sulfamic acid chroman-2-ylmethyl ester DMN0Q71 Discovery agent N.A. Investigative [74]
Syringic Acid DM802V7 Discovery agent N.A. Investigative [12]
Thioureido sulfonamide DM8WYEM Discovery agent N.A. Investigative [75]
Trecadrine DMDX0VI Discovery agent N.A. Investigative [76]
------------------------------------------------------------------------------------
⏷ Show the Full List of 259 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Nature of the inhibition of carbonic anhydrase by acetazolamide and benzthiazide. J Pharmacol Exp Ther. 1961 Mar;131:271-4.
2 Localization of diuretic effects along the loop of Henle: an in vivo microperfusion study in rats. Clin Sci (Lond). 2000 Apr;98(4):481-8.
3 Selective effect of thiazides on the human osteoblast-like cell line MG-63. Kidney Int. 1996 Nov;50(5):1476-82.
4 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
5 Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. Bioorg Med Chem. 2009 Jul 15;17(14):5054-8.
6 Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem. 1992 Dec 15;267(35):25044-50.
7 Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8.
8 Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases. J Med Chem. 2010 Apr 8;53(7):2913-26.
9 Understanding the Dual Inhibition of COX-2 and Carbonic Anhydrase-II by Celecoxib and CG100649 Using Density Functional Theory Calculations and other Molecular Modelling Approaches. Protein Pept Lett. 2015;22(10):903-12.
10 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.
11 Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. Bioorg Med Chem. 2009 Apr 15;17(8):3207-11.
12 Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids. Bioorg Med Chem. 2010 Mar 15;18(6):2159-2164.
13 Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-r... Bioorg Med Chem Lett. 2008 Aug 1;18(15):4282-6.
14 Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. J Med Chem. 2008 Mar 13;51(5):1295-308.
15 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5435-9.
16 Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. J Med Chem. 2006 Jun 15;49(12):3496-500.
17 Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5192-6.
18 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
19 Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the... Eur J Med Chem. 2010 Sep;45(9):3656-61.
20 Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors. Bioorg Med Chem. 2009 Jan 15;17(2):553-7.
21 N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4316-20.
22 Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J Med Chem. 2006 May 4;49(9):2743-9.
23 Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5429-33.
24 Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.
25 Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex. Bioorg Med Chem. 2010 Jan 15;18(2):930-8.
26 Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, ... Bioorg Med Chem Lett. 2009 Dec 1;19(23):6649-54.
27 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
28 Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with su... Bioorg Med Chem. 2007 Mar 15;15(6):2298-311.
29 Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6014-7.
30 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamide... J Med Chem. 2005 Mar 24;48(6):2121-5.
31 Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5781-6.
32 Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic... Bioorg Med Chem Lett. 2005 Jan 17;15(2):367-72.
33 Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins. J Med Chem. 2010 Jan 14;53(1):335-44.
34 Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesul... Bioorg Med Chem Lett. 2009 Sep 1;19(17):4929-32.
35 Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1149-54.
36 Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX. J Med Chem. 2006 Sep 7;49(18):5544-51.
37 Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5703-7.
38 Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273. J Med Chem. 2009 Jul 9;52(13):4063-7.
39 Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids. Bioorg Med Chem Lett. 2009 May 15;19(10):2642-5.
40 Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associa... Eur J Med Chem. 2010 Jun;45(6):2396-404.
41 In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II. Bioorg Med Chem. 2008 Oct 15;16(20):9101-5.
42 Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5498-503.
43 Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9.
44 Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.
45 Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4624-7.
46 Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. J Med Chem. 2008 Mar 27;51(6):1945-53.
47 Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem. 2009 Feb 12;52(3):646-54.
48 Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library. J Med Chem. 2004 Oct 7;47(21):5224-9.
49 Paraoxon, 4-nitrophenyl phosphate and acetate are substrates of - but not of -, - and -carbonic anhydrases. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6208-12.
50 Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-th... Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52.
51 A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. Bioorg Med Chem. 2010 Jun 15;18(12):4468-74.
52 Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides co... J Med Chem. 1999 Jul 15;42(14):2641-50.
53 Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors Bioorg Med Chem Lett. 2008 Jul 15;18(14):3938-41.
54 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides d... Bioorg Med Chem Lett. 2004 Dec 6;14(23):5775-80.
55 Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides. Bioorg Med Chem Lett. 2005 Feb 15;15(4):971-6.
56 Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide. Eur J Med Chem. 2010 Nov;45(11):4769-73.
57 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and X... Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8.
58 Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-bi... J Med Chem. 2009 Oct 8;52(19):5990-8.
59 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity. J Med Chem. 2006 Dec 28;49(26):7683-96.
60 Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into huma... J Med Chem. 2009 Dec 10;52(23):7528-36.
61 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxy... Bioorg Med Chem Lett. 2005 May 2;15(9):2353-8.
62 Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity. Bioorg Med Chem. 2010 Jul 15;18(14):5081-9.
63 Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes ... Bioorg Med Chem Lett. 2008 Dec 15;18(24):6332-5.
64 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1683-6.
65 Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5.
66 Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IV with N-hydroxysulfonamides--a novel class of intraocular pressure lowering agents. J Enzyme Inhib. 1998 Jul;13(4):267-84.
67 A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing". J Med Chem. 2006 Nov 2;49(22):6539-48.
68 Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J Med Chem. 2008 Jun 12;51(11):3051-6.
69 Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22.
70 Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with ali... Bioorg Med Chem. 2009 Apr 1;17(7):2654-7.
71 Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase. Eur J Med Chem. 2010 Mar;45(3):1225-9.
72 Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1855-7.
73 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates. Bioorg Med Chem Lett. 2005 Feb 1;15(3):579-84.
74 Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. J Med Chem. 2005 Mar 24;48(6):1941-7.
75 Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowe... Bioorg Med Chem Lett. 2005 Sep 1;15(17):3821-7.
76 Sulfenamido-sulfonamides as inhibitors of carbonic anhydrase isozymes I, II and IV. J Enzyme Inhib. 1997 Aug;12(3):175-90.