Details of the Drug Combination

General Information of Drug Combination (ID: DCIWFQL)

Drug Combination Name
Hydroquinone Tranexamic Acid
Indication
Disease Entry Status REF
Melasma Phase 3 [1]
Component Drugs Hydroquinone   DM6AVR4 Tranexamic Acid   DMFI8A7
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Hydroquinone
Disease Entry ICD 11 Status REF
Melasma ED60.1 Approved [2]
Hydroquinone Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) TT38RM1 ITA2B_HUMAN; ITB3_HUMAN Antagonist [14]
Tyrosinase (TYR) TTULVH8 TYRO_HUMAN Inhibitor [15]
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Hydroquinone Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [16]
Fumarate reductase flavoprotein (frdA) DEQUXZ5 FRDA_WOLSU Metabolism [17]
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Hydroquinone Interacts with 630 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Affects Expression [6]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [6]
Tumor necrosis factor ligand superfamily member 12 (TNFSF12) OT6FQ02V TNF12_HUMAN Decreases Expression [6]
ATP-dependent DNA helicase Q4 (RECQL4) OT59LSW7 RECQ4_HUMAN Increases Expression [6]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [6]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Affects Expression [6]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Increases Expression [6]
Aldehyde dehydrogenase, mitochondrial (ALDH2) OTKJ9I3N ALDH2_HUMAN Increases Expression [6]
Microsomal glutathione S-transferase 1 (MGST1) OTGN1KVZ MGST1_HUMAN Increases Expression [6]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [6]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Expression [6]
DnaJ homolog subfamily A member 1 (DNAJA1) OT38BZQQ DNJA1_HUMAN Increases Expression [6]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [6]
Death-associated protein 1 (DAP) OT5YLL7E DAP1_HUMAN Decreases Expression [6]
Matrix metalloproteinase-15 (MMP15) OT1XF517 MMP15_HUMAN Affects Expression [6]
Heat shock-related 70 kDa protein 2 (HSPA2) OTSDET7B HSP72_HUMAN Increases Expression [6]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Decreases Expression [6]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Decreases Expression [6]
Peroxiredoxin-1 (PRDX1) OTZ3BEC4 PRDX1_HUMAN Increases Expression [6]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Decreases Expression [6]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Increases Expression [6]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) OTVZ7I3A TNR25_HUMAN Decreases Expression [6]
TNF receptor-associated factor 4 (TRAF4) OTJLRVMC TRAF4_HUMAN Decreases Expression [6]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Decreases Expression [18]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [18]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Increases Expression [19]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Increases Expression [19]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Increases Expression [19]
Eotaxin (CCL11) OT3BIFPK CCL11_HUMAN Increases Expression [19]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Increases Expression [20]
Glutathione synthetase (GSS) OTVSBEIW GSHB_HUMAN Increases Expression [21]
Protein phosphatase 1D (PPM1D) OT8NLZ9D PPM1D_HUMAN Increases Expression [22]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Increases Expression [22]
G1/S-specific cyclin-E2 (CCNE2) OTBBUKQQ CCNE2_HUMAN Increases Expression [22]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [22]
Histone H2A type 1 (H2AC11) OTN9P0BO H2A1_HUMAN Decreases Expression [22]
Histone H1.4 (H1-4) OTQ450A3 H14_HUMAN Decreases Expression [22]
Histone H1.5 (H1-5) OTAN7RD9 H15_HUMAN Decreases Expression [22]
Histone H1.3 (H1-3) OTT7VPRB H13_HUMAN Decreases Expression [22]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [22]
High mobility group protein B2 (HMGB2) OTGEGAOK HMGB2_HUMAN Decreases Expression [22]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [22]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [22]
Cyclin-F (CCNF) OTJFVU43 CCNF_HUMAN Decreases Expression [22]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [22]
Sestrin-2 (SESN2) OT889IXY SESN2_HUMAN Increases Expression [22]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [22]
Histone H3.1 (H3C1) OTGBGOZW H31_HUMAN Decreases Expression [22]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [22]
ETS-related transcription factor Elf-3 (ELF3) OTUTLEQO ELF3_HUMAN Increases Expression [22]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [22]
Histone H2A type 2-C (H2AC20) OTEIVLM1 H2A2C_HUMAN Decreases Expression [22]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [22]
Histone H2A type 2-A (H2AC18) OTCE5JC7 H2A2A_HUMAN Decreases Expression [22]
Proline/serine-rich coiled-coil protein 1 (PSRC1) OT7MDJMN PSRC1_HUMAN Decreases Expression [22]
Protein aurora borealis (BORA) OTV2ZPKP BORA_HUMAN Decreases Expression [22]
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP) OTZ4BG4B PARPT_HUMAN Increases Expression [22]
Histone H2A type 2-B (H2AC21) OTH7W2NJ H2A2B_HUMAN Decreases Expression [22]
Tripartite motif-containing protein 59 (TRIM59) OT14I72L TRI59_HUMAN Decreases Expression [22]
Holliday junction recognition protein (HJURP) OTWMV16B HJURP_HUMAN Decreases Expression [22]
Kinesin-like protein KIF18A (KIF18A) OTSMBJ24 KI18A_HUMAN Decreases Expression [22]
Apoptosis-enhancing nuclease (AEN) OTUL3PSA AEN_HUMAN Increases Expression [22]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [22]
Histone H2A type 1-H (H2AC12) OTLXVB97 H2A1H_HUMAN Decreases Expression [22]
Centriolar and ciliogenesis-associated protein HYLS1 (HYLS1) OT3SW5UC HYLS1_HUMAN Decreases Expression [22]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [22]
Histone H2A type 1-J (H2AC14) OT5Y4MMC H2A1J_HUMAN Decreases Expression [22]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [22]
Protein FAM83D (FAM83D) OTQWZ1UO FA83D_HUMAN Decreases Expression [22]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [22]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) OTOSRDJT TR10D_HUMAN Decreases Expression [22]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [22]
Sestrin-1 (SESN1) OTSFDZWL SESN1_HUMAN Increases Expression [22]
Transcription regulator protein BACH1 (BACH1) OTY8004K BACH1_HUMAN Affects Localization [23]
Cytochrome P450 2E1 (CYP2E1) OTHQ17JG CP2E1_HUMAN Increases Expression [24]
Death-associated protein-like 1 (DAPL1) OTQZZSZY DAPL1_HUMAN Decreases Expression [7]
Killer cell lectin-like receptor subfamily G member 2 (KLRG2) OTBLEXSC KLRG2_HUMAN Decreases Expression [7]
Rho GTPase-activating protein 42 (ARHGAP42) OTIDSJMK RHG42_HUMAN Decreases Expression [7]
Leucine-rich repeat and IQ domain-containing protein 3 (LRRIQ3) OTOIU3OH LRIQ3_HUMAN Decreases Expression [7]
Cysteine-rich tail protein 1 (CYSRT1) OTJ8MXU4 CRTP1_HUMAN Increases Expression [7]
Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L) OT7QO47I RBG10_HUMAN Decreases Expression [7]
Thymidine kinase 2, mitochondrial (TK2) OTS1V4XB KITM_HUMAN Decreases Expression [7]
Unconventional myosin-If (MYO1F) OTOAV4AR MYO1F_HUMAN Decreases Expression [7]
Eukaryotic elongation factor 2 kinase (EEF2K) OT40Z0OV EF2K_HUMAN Decreases Expression [7]
Interferon-related developmental regulator 1 (IFRD1) OT4SQMLQ IFRD1_HUMAN Increases Expression [7]
Butyrophilin subfamily 3 member A3 (BTN3A3) OTKMSJRA BT3A3_HUMAN Decreases Expression [7]
Golgi SNAP receptor complex member 2 (GOSR2) OTYHIYN2 GOSR2_HUMAN Decreases Expression [7]
Putative transcription factor Ovo-like 1 (OVOL1) OTFJ62UI OVOL1_HUMAN Increases Expression [7]
Tumor necrosis factor ligand superfamily member 11 (TNFSF11) OTJEPKEQ TNF11_HUMAN Decreases Expression [7]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) OTPGHZB9 IFIT3_HUMAN Decreases Expression [7]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [7]
Inositol polyphosphate 4-phosphatase type II (INPP4B) OTLROA7G INP4B_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase Midline-1 (MID1) OTWN1PGU TRI18_HUMAN Decreases Expression [7]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Decreases Expression [7]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [7]
Toll-like receptor 3 (TLR3) OT8QPYXZ TLR3_HUMAN Decreases Expression [7]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [7]
Lysine-specific demethylase 6A (KDM6A) OTZM3MJJ KDM6A_HUMAN Decreases Expression [7]
Mitotic checkpoint protein BUB3 (BUB3) OTU91HAU BUB3_HUMAN Decreases Expression [7]
Calcineurin B homologous protein 2 (CHP2) OT4UMKUR CHP2_HUMAN Decreases Expression [7]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Decreases Expression [7]
Serine protease inhibitor Kazal-type 4 (SPINK4) OTHTCW94 ISK4_HUMAN Decreases Expression [7]
Calcium-transporting ATPase type 2C member 2 (ATP2C2) OTGIHTYQ AT2C2_HUMAN Increases Expression [7]
Arachidonate 12-lipoxygenase, 12R-type (ALOX12B) OTQ0BYK6 LX12B_HUMAN Increases Expression [7]
Jerky protein homolog (JRK) OTO8E77P JERKY_HUMAN Decreases Expression [7]
PR domain zinc finger protein 1 (PRDM1) OTQLSVBS PRDM1_HUMAN Increases Expression [7]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [7]
Krueppel-like factor 7 (KLF7) OTS3YVA0 KLF7_HUMAN Increases Expression [7]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Decreases Expression [7]
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1) OT1U2GWG DDAH1_HUMAN Decreases Expression [7]
Extracellular matrix protein 2 (ECM2) OTNGYVMR ECM2_HUMAN Increases Expression [7]
Protein transport protein Sec24D (SEC24D) OTXR3KC9 SC24D_HUMAN Increases Expression [7]
Protein FAM13A (FAM13A) OTZ6GN0Q FA13A_HUMAN Decreases Expression [7]
Olfactory receptor 2C1 (OR2C1) OTNILX0M OR2C1_HUMAN Decreases Expression [7]
Interleukin-33 (IL33) OTT5YWK3 IL33_HUMAN Decreases Expression [7]
Caveolae-associated protein 2 (CAVIN2) OTFHHDRU CAVN2_HUMAN Decreases Expression [7]
Chloride intracellular channel protein 3 (CLIC3) OT5KUZ3A CLIC3_HUMAN Increases Expression [7]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) OT9QIHEQ RECK_HUMAN Decreases Expression [7]
Cholesterol 25-hydroxylase (CH25H) OT9S2BSW CH25H_HUMAN Increases Expression [7]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [7]
Serine protease inhibitor Kazal-type 1 (SPINK1) OTSUVAL2 ISK1_HUMAN Increases Expression [7]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [7]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [7]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Decreases Expression [7]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [7]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Increases Expression [7]
Arginase-1 (ARG1) OTHZITAM ARGI1_HUMAN Increases Expression [7]
Ubiquitin-like protein ISG15 (ISG15) OT53QQ7N ISG15_HUMAN Decreases Expression [7]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Decreases Expression [7]
Neuroendocrine protein 7B2 (SCG5) OTXSJMT1 7B2_HUMAN Increases Expression [7]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Decreases Expression [7]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Increases Expression [7]
Carbonic anhydrase 3 (CA3) OT9ILP2U CAH3_HUMAN Decreases Expression [7]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [7]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [7]
Inhibin beta A chain (INHBA) OTSP64PQ INHBA_HUMAN Increases Expression [7]
Keratin, type I cytoskeletal 19 (KRT19) OTDGDQ75 K1C19_HUMAN Decreases Expression [7]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [7]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Decreases Expression [7]
Calcitonin gene-related peptide 2 (CALCB) OTNVY7WY CALCB_HUMAN Increases Expression [7]
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (DBT) OT4KZ5R9 ODB2_HUMAN Decreases Expression [7]
Glycogen phosphorylase, brain form (PYGB) OT2ZTJT0 PYGB_HUMAN Increases Expression [7]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Increases Expression [7]
C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) OTMKHVWC C1TC_HUMAN Decreases Expression [7]
Neurofilament heavy polypeptide (NEFH) OTMSCW5I NFH_HUMAN Decreases Expression [7]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Increases Expression [7]
Protein L-Myc (MYCL) OT1MFQ5U MYCL_HUMAN Decreases Expression [7]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Decreases Expression [7]
Keratin, type I cytoskeletal 13 (KRT13) OTTYSKGX K1C13_HUMAN Decreases Expression [7]
Sodium/glucose cotransporter 1 (SLC5A1) OT0T78JI SC5A1_HUMAN Increases Expression [7]
Nidogen-1 (NID1) OTKLBLS6 NID1_HUMAN Decreases Expression [7]
Glutamine synthetase (GLUL) OTYGTCGF GLNA_HUMAN Decreases Expression [7]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Increases Expression [7]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Decreases Expression [7]
Aspartate aminotransferase, cytoplasmic (GOT1) OTZLM5UB AATC_HUMAN Increases Expression [7]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Decreases Expression [7]
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12) OTFL5KR5 LOX12_HUMAN Increases Expression [7]
Glutathione peroxidase 2 (GPX2) OTXI2NTI GPX2_HUMAN Increases Expression [7]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [7]
Neutrophil cytosol factor 2 (NCF2) OTAUW7L2 NCF2_HUMAN Increases Expression [7]
Elafin (PI3) OT47MTC3 ELAF_HUMAN Increases Expression [7]
Ras-related protein Rab-3B (RAB3B) OTZA4SXL RAB3B_HUMAN Increases Expression [7]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Decreases Expression [7]
Endothelin-2 (EDN2) OTQ7RCPI EDN2_HUMAN Decreases Expression [7]
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (FUT3) OTXQ6P8R FUT3_HUMAN Increases Expression [7]
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) OTMZN747 PUR6_HUMAN Decreases Expression [7]
Fibroblast growth factor receptor 3 (FGFR3) OTSAXDIL FGFR3_HUMAN Decreases Expression [7]
Calretinin (CALB2) OTSNMCG9 CALB2_HUMAN Increases Expression [7]
Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5) OTZNYEKF GTR5_HUMAN Decreases Expression [7]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Expression [7]
Proteinase-activated receptor 1 (F2R) OT4WVWBO PAR1_HUMAN Decreases Expression [7]
Zinc-alpha-2-glycoprotein (AZGP1) OTPD9TDR ZA2G_HUMAN Increases Expression [7]
Protein S100-P (S100P) OTJCXNJG S100P_HUMAN Increases Expression [7]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Increases Expression [7]
Calmodulin-like protein 3 (CALML3) OTM8DNQU CALL3_HUMAN Decreases Expression [7]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [7]
Transketolase (TKT) OTT5KPUB TKT_HUMAN Increases Expression [7]
2'-5'-oligoadenylate synthase 2 (OAS2) OT64CCTM OAS2_HUMAN Decreases Expression [7]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Increases Expression [7]
Protein S100-A7 (S100A7) OTJFVJRF S10A7_HUMAN Increases Expression [7]
Glycerol kinase (GK) OTK2YRA0 GLPK_HUMAN Increases Expression [7]
Guanylate-binding protein 2 (GBP2) OTVU4G07 GBP2_HUMAN Decreases Expression [7]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Increases Expression [7]
Ribonuclease 4 (RNASE4) OTA5SZLC RNAS4_HUMAN Decreases Expression [7]
Trypsin-3 (PRSS3) OTN3S5YB TRY3_HUMAN Increases Expression [7]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [7]
Cystathionine beta-synthase (CBS) OT46FSKD CBS_HUMAN Increases Expression [7]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Decreases Expression [7]
Transcription factor SOX-11 (SOX11) OT4LG7LA SOX11_HUMAN Decreases Expression [7]
Glutaredoxin-1 (GLRX) OT0QHTAR GLRX1_HUMAN Increases Expression [7]
ADP-ribosylation factor-like protein 3 (ARL3) OT3OGOMX ARL3_HUMAN Decreases Expression [7]
GMP reductase 1 (GMPR) OTERWHYM GMPR1_HUMAN Decreases Expression [7]
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Increases Expression [7]
Pre-B-cell leukemia transcription factor 1 (PBX1) OTORABGO PBX1_HUMAN Decreases Expression [7]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Increases Expression [7]
Signal transducer and activator of transcription 1-alpha/beta (STAT1) OTLMBUZ6 STAT1_HUMAN Decreases Expression [7]
ETS translocation variant 4 (ETV4) OT8C98UZ ETV4_HUMAN Increases Expression [7]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Decreases Expression [7]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Increases Expression [7]
Microtubule-associated protein 1B (MAP1B) OTVXW089 MAP1B_HUMAN Increases Expression [7]
DNA-binding protein inhibitor ID-4 (ID4) OTPMJ39I ID4_HUMAN Increases Expression [7]
DNA-binding protein RFX5 (RFX5) OT73KJ5P RFX5_HUMAN Decreases Expression [7]
Transcription factor SOX-2 (SOX2) OTFAWCAU SOX2_HUMAN Decreases Expression [7]
Lanosterol synthase (LSS) OT9W2SFH LSS_HUMAN Decreases Expression [7]
Heat shock 70 kDa protein 13 (HSPA13) OTYXMC4G HSP13_HUMAN Increases Expression [7]
Selenoprotein P (SELENOP) OT02B8IR SEPP1_HUMAN Decreases Expression [7]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Decreases Expression [7]
Serpin B9 (SERPINB9) OTJ811IF SPB9_HUMAN Increases Expression [7]
Sodium/myo-inositol cotransporter (SLC5A3) OT6FY2KA SC5A3_HUMAN Decreases Expression [7]
Growth arrest-specific protein 1 (GAS1) OTKJXG52 GAS1_HUMAN Decreases Expression [7]
ADP-ribosylhydrolase ARH1 (ADPRH) OTLJ5511 ADPRH_HUMAN Increases Expression [7]
GTP-binding protein RAD (RRAD) OTW2O4GD RAD_HUMAN Increases Expression [7]
SH3 domain-binding glutamic acid-rich protein (SH3BGR) OT13LJ1A SH3BG_HUMAN Increases Expression [7]
Claudin-8 (CLDN8) OT7IIWXG CLD8_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase SIK1 (SIK1) OT6FCHME SIK1_HUMAN Decreases Expression [7]
Caspase recruitment domain-containing protein 18 (CARD18) OTBMLB80 CAR18_HUMAN Increases Expression [7]
Sestrin-3 (SESN3) OTJRY1Y5 SESN3_HUMAN Decreases Expression [7]
cAMP-dependent protein kinase inhibitor alpha (PKIA) OT8M5GVO IPKA_HUMAN Decreases Expression [7]
SH3 domain-binding protein 2 (SH3BP2) OT90JNBS 3BP2_HUMAN Increases Expression [7]
Cyclin-A1 (CCNA1) OTX4HD45 CCNA1_HUMAN Increases Expression [7]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Increases Expression [7]
Neutrophil gelatinase-associated lipocalin (LCN2) OTSB42BR NGAL_HUMAN Increases Expression [7]
DNA-binding protein SATB1 (SATB1) OTT7SUVW SATB1_HUMAN Decreases Expression [7]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Decreases Expression [7]
Guanylate cyclase soluble subunit beta-1 (GUCY1B1) OTSHPHVB GCYB1_HUMAN Increases Expression [7]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Decreases Expression [7]
Transforming growth factor beta receptor type 3 (TGFBR3) OTQOOUC4 TGBR3_HUMAN Decreases Expression [7]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2) OTRZH80H TNAP2_HUMAN Increases Expression [7]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Expression [7]
2-5A-dependent ribonuclease (RNASEL) OTP6UQUP RN5A_HUMAN Decreases Expression [7]
Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1) OTQBDO45 GFPT1_HUMAN Increases Expression [7]
Early growth response protein 3 (EGR3) OTGPJIRA EGR3_HUMAN Increases Expression [7]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Decreases Expression [7]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Decreases Expression [7]
Bone marrow stromal antigen 2 (BST2) OTU4LCJV BST2_HUMAN Decreases Expression [7]
BMP and activin membrane-bound inhibitor homolog (BAMBI) OTCEJ8W5 BAMBI_HUMAN Increases Expression [7]
Growth factor receptor-bound protein 10 (GRB10) OTCKXGRC GRB10_HUMAN Increases Expression [7]
Interferon-induced protein with tetratricopeptide repeats 5 (IFIT5) OTYTSO77 IFIT5_HUMAN Decreases Expression [7]
Gamma-sarcoglycan (SGCG) OTOLWHIQ SGCG_HUMAN Increases Expression [7]
Phospholipase D1 (PLD1) OTMVUKW6 PLD1_HUMAN Decreases Expression [7]
Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2) OTK5T6HZ NFAC2_HUMAN Increases Expression [7]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [7]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Increases Expression [7]
Septin-6 (SEPTIN6) OTIV9RTK SEPT6_HUMAN Decreases Expression [7]
Frizzled-2 (FZD2) OT952ML1 FZD2_HUMAN Decreases Expression [7]
Raftlin (RFTN1) OT8875JE RFTN1_HUMAN Increases Expression [7]
Calcium-activated chloride channel regulator 4 (CLCA4) OTCRR1M9 CLCA4_HUMAN Decreases Expression [7]
Ribosomal protein S6 kinase alpha-2 (RPS6KA2) OTIOYUSU KS6A2_HUMAN Increases Expression [7]
Corneodesmosin (CDSN) OTQW4HV6 CDSN_HUMAN Increases Expression [7]
Ras-related protein Rab-30 (RAB30) OTW49G8B RAB30_HUMAN Decreases Expression [7]
Cystatin-M (CST6) OTZVHJTF CYTM_HUMAN Increases Expression [7]
Cysteine and glycine-rich protein 2 (CSRP2) OT4SW0HI CSRP2_HUMAN Decreases Expression [7]
Lymphocyte antigen 6E (LY6E) OTMG16BZ LY6E_HUMAN Decreases Expression [7]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [7]
Glutaminyl-peptide cyclotransferase (QPCT) OT0TSHP4 QPCT_HUMAN Increases Expression [7]
Carbonic anhydrase 9 (CA9) OTNA51XT CAH9_HUMAN Decreases Expression [7]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2) OTJ8LX4N PCKGM_HUMAN Increases Expression [7]
Dual specificity protein phosphatase 6 (DUSP6) OT4H6RKW DUS6_HUMAN Increases Expression [7]
Keratin, type I cytoskeletal 24 (KRT24) OTR7MT1E K1C24_HUMAN Decreases Expression [7]
Hereditary hemochromatosis protein (HFE) OTDD93KB HFE_HUMAN Decreases Expression [7]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2) OTCH86VF AL1L2_HUMAN Increases Expression [7]
Galectin-related protein (LGALSL) OTC983KJ LEGL_HUMAN Increases Expression [7]
Ankyrin repeat and death domain-containing protein 1A (ANKDD1A) OTPNBHZS AKD1A_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase SBK1 (SBK1) OTCO4NEI SBK1_HUMAN Decreases Expression [7]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Decreases Expression [7]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [7]
Interferon-induced protein 44-like (IFI44L) OTXKORJP IF44L_HUMAN Decreases Expression [7]
Retroviral-like aspartic protease 1 (ASPRV1) OT8WVIBW APRV1_HUMAN Increases Expression [7]
Sigma intracellular receptor 2 (TMEM97) OTH76ZWK SGMR2_HUMAN Decreases Expression [7]
UMP-CMP kinase 2, mitochondrial (CMPK2) OTOG90R0 CMPK2_HUMAN Decreases Expression [7]
RRP12-like protein (RRP12) OTQQAEH4 RRP12_HUMAN Decreases Expression [7]
Signal-regulatory protein beta-2 (SIRPB2) OTC033T8 SIRB2_HUMAN Decreases Expression [7]
Calcium homeostasis modulator protein 6 (CALHM6) OTLX9B4Y CAHM6_HUMAN Decreases Expression [7]
Exosome complex component MTR3 (EXOSC6) OTAC10N6 EXOS6_HUMAN Increases Expression [7]
Synaptonemal complex protein 2-like (SYCP2L) OT926TNQ SYC2L_HUMAN Decreases Expression [7]
Proline-rich protein 9 (PRR9) OT4ZHG7T PRR9_HUMAN Increases Expression [7]
Protein furry homolog (FRY) OT74IAG2 FRY_HUMAN Increases Expression [7]
NEDD4-binding protein 2-like 1 (N4BP2L1) OTEGV3GO N42L1_HUMAN Decreases Expression [7]
Transcription initiation factor TFIID subunit 3 (TAF3) OTVMULE9 TAF3_HUMAN Decreases Expression [7]
LEM domain-containing protein 1 (LEMD1) OTII3FTO LEMD1_HUMAN Decreases Expression [7]
Scavenger receptor class A member 3 (SCARA3) OT46I38Y SCAR3_HUMAN Decreases Expression [7]
Multiple C2 and transmembrane domain-containing protein 2 (MCTP2) OTFMZ8I2 MCTP2_HUMAN Decreases Expression [7]
Multiple C2 and transmembrane domain-containing protein 1 (MCTP1) OTSFI0HS MCTP1_HUMAN Increases Expression [7]
Elongator complex protein 2 (ELP2) OTBXG37N ELP2_HUMAN Decreases Expression [7]
Centriole, cilia and spindle-associated protein (CCSAP) OTE72F4O CCSAP_HUMAN Decreases Expression [7]
Pyrin and HIN domain-containing protein 1 (PYHIN1) OT30GD05 IFIX_HUMAN Decreases Expression [7]
Keratin, type II cytoskeletal 80 (KRT80) OTAU54U3 K2C80_HUMAN Increases Expression [7]
Teneurin-4 (TENM4) OT91K3FC TEN4_HUMAN Decreases Expression [7]
Proactivator polypeptide-like 1 (PSAPL1) OTSLOX04 SAPL1_HUMAN Increases Expression [7]
Protein FAM117B (FAM117B) OT11P91V F117B_HUMAN Decreases Expression [7]
NIPA-like protein 3 (NIPAL3) OTI858LL NPAL3_HUMAN Decreases Expression [7]
Glutamate-rich protein 5 (ERICH5) OTQEY1SQ ERIC5_HUMAN Decreases Expression [7]
Surfactant-associated protein 2 (SFTA2) OTVRIUIV SFTA2_HUMAN Increases Expression [7]
Golgi-associated kinase 1B (GASK1B) OT2HPHEI GAK1B_HUMAN Decreases Expression [7]
Protein GPR15LG (GPR15LG) OTNZ0VVM GP15L_HUMAN Decreases Expression [7]
Ly6/PLAUR domain-containing protein 5 (LYPD5) OTGP7UKA LYPD5_HUMAN Increases Expression [7]
Serine protease inhibitor Kazal-type 6 (SPINK6) OTYKZANJ ISK6_HUMAN Decreases Expression [7]
Myelin protein zero-like protein 3 (MPZL3) OTC4LRBU MPZL3_HUMAN Increases Expression [7]
Teashirt homolog 1 (TSHZ1) OTYQ9ECW TSH1_HUMAN Decreases Expression [7]
Tumor protein p63-regulated gene 1 protein (TPRG1) OTS48DQM TPRG1_HUMAN Increases Expression [7]
Rho GTPase-activating protein 27 (ARHGAP27) OT8BSRPC RHG27_HUMAN Increases Expression [7]
Lysophospholipid acyltransferase 2 (MBOAT2) OTZI3BXD MBOA2_HUMAN Increases Expression [7]
Small integral membrane protein 5 (SMIM5) OTIN1T0L SMIM5_HUMAN Increases Expression [7]
Lysophospholipase D GDPD3 (GDPD3) OTOHM9QM GDPD3_HUMAN Increases Expression [7]
Lysosomal cholesterol signaling protein (GPR155) OT2ZCDS7 LYCHS_HUMAN Decreases Expression [7]
Transmembrane channel-like protein 6 (TMC6) OTKH50J4 TMC6_HUMAN Decreases Expression [7]
MOB kinase activator 3B (MOB3B) OTZJQG1D MOB3B_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3) OT89V4N5 MARH3_HUMAN Increases Expression [7]
Kelch repeat and BTB domain-containing protein 6 (KBTBD6) OTFQ12ZJ KBTB6_HUMAN Decreases Expression [7]
Transmembrane protein 200A (TMEM200A) OTVJZIOR T200A_HUMAN Increases Expression [7]
Cilium assembly protein DZIP1 (DZIP1) OTBVPO66 DZIP1_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase SIAH1 (SIAH1) OT29A838 SIAH1_HUMAN Increases Expression [7]
Serpin A12 (SERPINA12) OTS1E6IP SPA12_HUMAN Increases Expression [7]
DCN1-like protein 3 (DCUN1D3) OTG20VWE DCNL3_HUMAN Increases Expression [7]
Cadherin-like protein 26 (CDH26) OTFW5YN6 CAD26_HUMAN Decreases Expression [7]
Protein mono-ADP-ribosyltransferase PARP9 (PARP9) OT7K4494 PARP9_HUMAN Decreases Expression [7]
Probable ATP-dependent RNA helicase DDX60 (DDX60) OTVPHA0C DDX60_HUMAN Decreases Expression [7]
Threonine synthase-like 1 (THNSL1) OTQNFH3E THNS1_HUMAN Decreases Expression [7]
EP300-interacting inhibitor of differentiation 3 (EID3) OTAND0C7 EID3_HUMAN Decreases Expression [7]
Keratin, type II cytoskeletal 78 (KRT78) OT706ZLF K2C78_HUMAN Increases Expression [7]
Serine/threonine-protein kinase 40 (STK40) OT4R325X STK40_HUMAN Increases Expression [7]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Increases Expression [7]
Angiogenic factor with G patch and FHA domains 1 (AGGF1) OTA7U2T8 AGGF1_HUMAN Decreases Expression [7]
ELMO domain-containing protein 1 (ELMOD1) OT0WRVJC ELMD1_HUMAN Increases Expression [7]
Secreted frizzled-related protein 1 (SFRP1) OT0U9G41 SFRP1_HUMAN Decreases Expression [7]
Actin filament-associated protein 1 (AFAP1) OTR473H8 AFAP1_HUMAN Decreases Expression [7]
Transcription elongation factor A N-terminal and central domain-containing protein (TCEANC) OTERP9MX TEANC_HUMAN Decreases Expression [7]
Prostaglandin reductase 2 (PTGR2) OTYPYOUM PTGR2_HUMAN Decreases Expression [7]
Fibrous sheath-interacting protein 1 (FSIP1) OTYLL6GM FSIP1_HUMAN Increases Expression [7]
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) OTLUM9L7 PK3C3_HUMAN Decreases Expression [7]
Short-chain dehydrogenase/reductase family 9C member 7 (SDR9C7) OTQY8SJ3 DR9C7_HUMAN Increases Expression [7]
V-type proton ATPase subunit C 2 (ATP6V1C2) OTSM7ML1 VATC2_HUMAN Increases Expression [7]
Retinoic acid-induced protein 3 (GPRC5A) OTPOCWR7 RAI3_HUMAN Decreases Expression [7]
BPI fold-containing family C protein (BPIFC) OTBMBD7I BPIFC_HUMAN Increases Expression [7]
Delta and Notch-like epidermal growth factor-related receptor (DNER) OT2GH2E5 DNER_HUMAN Decreases Expression [7]
Syntaxin-binding protein 6 (STXBP6) OTUEKTIP STXB6_HUMAN Decreases Expression [7]
Protein phosphatase PTC7 homolog (PPTC7) OTBKUQPI PPTC7_HUMAN Decreases Expression [7]
Fin bud initiation factor homolog (FIBIN) OTTP8DRJ FIBIN_HUMAN Increases Expression [7]
Polyamine-modulated factor 1-binding protein 1 (PMFBP1) OTA551F7 PMFBP_HUMAN Increases Expression [7]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Decreases Expression [7]
Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12) OT0EDNV9 GTR12_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase DTX3L (DTX3L) OTCCO2QZ DTX3L_HUMAN Decreases Expression [7]
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1) OTBML9D9 CGAT1_HUMAN Increases Expression [7]
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) OT83O8WI ES8L1_HUMAN Increases Expression [7]
SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1) OT0HYZIU S3TC1_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2) OT2IVOK4 SH3R2_HUMAN Decreases Expression [7]
Dual specificity protein phosphatase 19 (DUSP19) OT0RRSG9 DUS19_HUMAN Decreases Expression [7]
Sec1 family domain-containing protein 2 (SCFD2) OTYM55ET SCFD2_HUMAN Decreases Expression [7]
Cell migration-inducing and hyaluronan-binding protein (CEMIP) OTK80FYN CEMIP_HUMAN Increases Expression [7]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [7]
Kelch repeat and BTB domain-containing protein 7 (KBTBD7) OT1NIRLK KBTB7_HUMAN Decreases Expression [7]
Glycosylated lysosomal membrane protein (GLMP) OT2NSDT2 GLMP_HUMAN Decreases Expression [7]
Interleukin-1 family member 10 (IL1F10) OTJAASGC IL1FA_HUMAN Increases Expression [7]
Protein N-lysine methyltransferase METTL21A (METTL21A) OTXJTNXY MT21A_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase MYLIP (MYLIP) OTL0PFGV MYLIP_HUMAN Decreases Expression [7]
Cysteine/serine-rich nuclear protein 3 (CSRNP3) OTOANEHZ CSRN3_HUMAN Decreases Expression [7]
C-type lectin domain family 2 member B (CLEC2B) OT0W0M0L CLC2B_HUMAN Decreases Expression [7]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Decreases Expression [7]
Kallikrein-6 (KLK6) OTIEA234 KLK6_HUMAN Increases Expression [7]
Rho guanine nucleotide exchange factor 2 (ARHGEF2) OTBQTFRT ARHG2_HUMAN Increases Expression [7]
Thymic stromal lymphopoietin (TSLP) OT52AOIG TSLP_HUMAN Increases Expression [7]
Transmembrane protein 106A (TMEM106A) OTHTBYDN T106A_HUMAN Decreases Expression [7]
Ras-related protein Rab-7b (RAB7B) OT60A0E9 RAB7B_HUMAN Decreases Expression [7]
Transmembrane protein 125 (TMEM125) OTWF8MC1 TM125_HUMAN Increases Expression [7]
Transmembrane protein 45B (TMEM45B) OTVQCO8N TM45B_HUMAN Increases Expression [7]
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) OTIUA60B SH3K1_HUMAN Increases Expression [7]
Coiled-coil domain-containing protein 127 (CCDC127) OTHO04TE CC127_HUMAN Decreases Expression [7]
RalBP1-associated Eps domain-containing protein 1 (REPS1) OTX4ERRK REPS1_HUMAN Decreases Expression [7]
U8 snoRNA-decapping enzyme (NUDT16) OTWSL9JQ NUD16_HUMAN Decreases Expression [7]
Rho guanine nucleotide exchange factor 26 (ARHGEF26) OTX0U8PX ARHGQ_HUMAN Decreases Expression [7]
Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1) OTWE5G4T P3IP1_HUMAN Decreases Expression [7]
Fumarylacetoacetate hydrolase domain-containing protein 2A (FAHD2A) OTHQP0L5 FAH2A_HUMAN Decreases Expression [7]
Uncharacterized protein C16orf74 (C16ORF74) OTLLVHH0 CP074_HUMAN Increases Expression [7]
Transmembrane protein 19 (TMEM19) OTKWMDYH TMM19_HUMAN Decreases Expression [7]
Androgen-dependent TFPI-regulating protein (ADTRP) OTFI2BQX ADTRP_HUMAN Increases Expression [7]
Peptidoglycan recognition protein 4 (PGLYRP4) OTI115BR PGRP4_HUMAN Increases Expression [7]
KICSTOR subunit 2 (KICS2) OTA3Z5LE KICS2_HUMAN Decreases Expression [7]
Cilia- and flagella-associated protein 44 (CFAP44) OT1273MD CFA44_HUMAN Decreases Expression [7]
Tetratricopeptide repeat protein 14 (TTC14) OTMTYOPF TTC14_HUMAN Decreases Expression [7]
Retinol dehydrogenase 12 (RDH12) OTELFRRJ RDH12_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) OT1B19RU NED4L_HUMAN Decreases Expression [7]
DEP domain-containing protein 7 (DEPDC7) OT62C942 DEPD7_HUMAN Decreases Expression [7]
Alpha-protein kinase 1 (ALPK1) OTBW6SGD ALPK1_HUMAN Increases Expression [7]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [7]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Increases Expression [7]
MAP7 domain-containing protein 2 (MAP7D2) OTN85925 MA7D2_HUMAN Decreases Expression [7]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Increases Expression [7]
P2X purinoceptor 4 (P2RX4) OTEGBTE1 P2RX4_HUMAN Increases Expression [7]
Pituitary homeobox 2 (PITX2) OTWMXAOY PITX2_HUMAN Decreases Expression [7]
ATP-sensitive inward rectifier potassium channel 15 (KCNJ15) OTZT6EQB KCJ15_HUMAN Decreases Expression [7]
BAG family molecular chaperone regulator 1 (BAG1) OTRQNIA4 BAG1_HUMAN Decreases Expression [7]
Plakophilin-2 (PKP2) OTJOVF68 PKP2_HUMAN Increases Expression [7]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [7]
Dehydrogenase/reductase SDR family member 6 (BDH2) OTDD7G8S DHRS6_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase TRIM62 (TRIM62) OT15YO6N TRI62_HUMAN Increases Expression [7]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5) OTH91ETM SIA7E_HUMAN Decreases Expression [7]
Serine/threonine-protein kinase RIO2 (RIOK2) OTQODJ7F RIOK2_HUMAN Decreases Expression [7]
Cell division cycle-associated protein 7 (CDCA7) OT12HDZY CDCA7_HUMAN Decreases Expression [7]
GTP-binding protein 2 (GTPBP2) OTOJ1KUA GTPB2_HUMAN Increases Expression [7]
Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) OTIMWEK5 LGR4_HUMAN Decreases Expression [7]
Cornifelin (CNFN) OTSTJPBF CNFN_HUMAN Increases Expression [7]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Decreases Expression [7]
Hydroperoxide isomerase ALOXE3 (ALOXE3) OT76J52A LOXE3_HUMAN Increases Expression [7]
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) OTOOXC7B HOIL1_HUMAN Increases Expression [7]
Interferon-induced helicase C domain-containing protein 1 (IFIH1) OTZA2AHA IFIH1_HUMAN Decreases Expression [7]
Protein Niban 1 (NIBAN1) OTYOLI12 NIBA1_HUMAN Increases Expression [7]
Normal mucosa of esophagus-specific gene 1 protein (C15ORF48) OT85J32K NMES1_HUMAN Increases Expression [7]
Protein sprouty homolog 4 (SPRY4) OT2VK9N0 SPY4_HUMAN Increases Expression [7]
Keratin, type I cytoskeletal 23 (KRT23) OTQW6UAG K1C23_HUMAN Increases Expression [7]
Leucine-rich repeat-containing protein 27 (LRRC27) OTKO4Y6G LRC27_HUMAN Decreases Expression [7]
B-cell lymphoma/leukemia 11B (BCL11B) OT8KKCVJ BC11B_HUMAN Decreases Expression [7]
Very long chain fatty acid elongase 4 (ELOVL4) OT2M9W26 ELOV4_HUMAN Increases Expression [7]
Paternally-expressed gene 3 protein (PEG3) OTHQW98S PEG3_HUMAN Decreases Expression [7]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) OTVSFHTL CRLD2_HUMAN Increases Expression [7]
Coiled-coil domain-containing protein 8 (CCDC8) OTO295IH CCDC8_HUMAN Decreases Expression [7]
B-cell lymphoma/leukemia 11A (BCL11A) OTI6ZBP6 BC11A_HUMAN Decreases Expression [7]
Ribonuclease 7 (RNASE7) OTIXO0Z4 RNAS7_HUMAN Increases Expression [7]
Kelch-like protein 31 (KLHL31) OTXZVWDL KLH31_HUMAN Decreases Expression [7]
CXADR-like membrane protein (CLMP) OTU7C3GQ CLMP_HUMAN Increases Expression [7]
Thiol S-methyltransferase TMT1A (TMT1A) OT4IAAZP TMT1A_HUMAN Decreases Expression [7]
DNA-directed RNA polymerase I subunit RPA2 (POLR1B) OTKREU8M RPA2_HUMAN Decreases Expression [7]
Sp110 nuclear body protein (SP110) OTFW6WH7 SP110_HUMAN Decreases Expression [7]
Centrosomal protein 15 (CEP15) OT52961J CEP15_HUMAN Decreases Expression [7]
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A) OT9X261C PDE11_HUMAN Decreases Expression [7]
Palmdelphin (PALMD) OTRLOZ4Y PALMD_HUMAN Decreases Expression [7]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) OT5V52LN TNR12_HUMAN Increases Expression [7]
Lactosylceramide 4-alpha-galactosyltransferase (A4GALT) OTPX3UGY A4GAT_HUMAN Decreases Expression [7]
Arf-GAP with dual PH domain-containing protein 2 (ADAP2) OTGQ8UH7 ADAP2_HUMAN Increases Expression [7]
Exosome complex component RRP40 (EXOSC3) OTNCF906 EXOS3_HUMAN Decreases Expression [7]
PI-PLC X domain-containing protein 1 (PLCXD1) OTU7KCQL PLCX1_HUMAN Increases Expression [7]
Muscleblind-like protein 3 (MBNL3) OT2T2YOK MBNL3_HUMAN Decreases Expression [7]
S-acyl fatty acid synthase thioesterase, medium chain (OLAH) OTZVRM40 SAST_HUMAN Increases Expression [7]
Syntabulin (SYBU) OT3FQV7N SYBU_HUMAN Increases Expression [7]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Decreases Expression [7]
Interleukin-36 gamma (IL36G) OT19IAAS IL36G_HUMAN Increases Expression [7]
Grainyhead-like protein 1 homolog (GRHL1) OTZ4MNEW GRHL1_HUMAN Increases Expression [7]
Protein Daple (CCDC88C) OTIU02BS DAPLE_HUMAN Decreases Expression [7]
Ammonium transporter Rh type C (RHCG) OT1MTYUH RHCG_HUMAN Increases Expression [7]
Interleukin-36 receptor antagonist protein (IL36RN) OT5CO95A I36RA_HUMAN Increases Expression [7]
Regulator of G-protein signaling 17 (RGS17) OT5RVUDS RGS17_HUMAN Increases Expression [7]
Cysteine-rich C-terminal protein 1 (CRCT1) OTPYME8V CRCT1_HUMAN Increases Expression [7]
E3 ISG15--protein ligase HERC5 (HERC5) OTZ5PR39 HERC5_HUMAN Decreases Expression [7]
TRAF2 and NCK-interacting protein kinase (TNIK) OTDZBJ4K TNIK_HUMAN Increases Expression [7]
Histone deacetylase 9 (HDAC9) OTO8O0LF HDAC9_HUMAN Increases Expression [7]
ETS-related transcription factor Elf-5 (ELF5) OTLRU8YF ELF5_HUMAN Increases Expression [7]
Phospholipase A and acyltransferase 4 (PLAAT4) OTI66SAJ PLAT4_HUMAN Decreases Expression [7]
Microtubule-associated tumor suppressor 1 (MTUS1) OTBPALMU MTUS1_HUMAN Decreases Expression [7]
NACHT and WD repeat domain-containing protein 2 (NWD2) OTN47UBK NWD2_HUMAN Increases Expression [7]
Polyadenylate-binding protein-interacting protein 2B (PAIP2B) OT7MUY3B PAI2B_HUMAN Decreases Expression [7]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Increases Expression [7]
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (DAPP1) OTZTE1PG DAPP1_HUMAN Increases Expression [7]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [7]
Band 4.1-like protein 3 (EPB41L3) OTS6CHG2 E41L3_HUMAN Increases Expression [7]
Guanine deaminase (GDA) OTW394V5 GUAD_HUMAN Increases Expression [7]
Plasmolipin (PLLP) OTFGCB9U PLLP_HUMAN Decreases Expression [7]
Sorting nexin-24 (SNX24) OTMA5FLK SNX24_HUMAN Increases Expression [7]
Carbohydrate sulfotransferase 2 (CHST2) OTV11IZF CHST2_HUMAN Increases Expression [7]
Krueppel-like factor 2 (KLF2) OTIP1UFX KLF2_HUMAN Increases Expression [7]
Endothelial lipase (LIPG) OTHEE942 LIPG_HUMAN Increases Expression [7]
Lymphocyte antigen 96 (LY96) OTN4HXA2 LY96_HUMAN Increases Expression [7]
E3 ubiquitin-protein ligase NEURL1B (NEURL1B) OT3BZWO8 NEU1B_HUMAN Increases Expression [25]
Galectin-9 (LGALS9) OT7MF91K LEG9_HUMAN Increases Expression [25]
Late cornified envelope protein 2B (LCE2B) OTA53PGQ LCE2B_HUMAN Increases Expression [26]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [27]
Core histone macro-H2A.1 (MACROH2A1) OTV2DQDD H2AY_HUMAN Decreases Expression [28]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Increases Expression [29]
Transient receptor potential cation channel subfamily A member 1 (TRPA1) OTRDIR5M TRPA1_HUMAN Increases Activity [30]
Leukocyte cell-derived chemotaxin 1 (CNMD) OTHND8EL CNMD_HUMAN Increases Expression [31]
Ubiquitin-like protein ATG12 (ATG12) OTJRO09Y ATG12_HUMAN Increases Expression [32]
Dickkopf-related protein 1 (DKK1) OTRDLUSP DKK1_HUMAN Affects Expression [11]
6-phosphogluconolactonase (PGLS) OTO6C0IQ 6PGL_HUMAN Affects Expression [33]
Ubiquitin-like modifier-activating enzyme ATG7 (ATG7) OTVT4YA1 ATG7_HUMAN Increases Expression [34]
Cytochrome c oxidase subunit 1 (COX1) OTG3O9BN COX1_HUMAN Increases Expression [35]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [36]
GTPase NRas (NRAS) OTVQ1DG3 RASN_HUMAN Decreases Expression [37]
GTPase HRas (HRAS) OTWQN0DP RASH_HUMAN Affects Expression [37]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Increases Expression [38]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [34]
Immunoglobulin J chain (JCHAIN) OTR8M5TX IGJ_HUMAN Decreases Expression [25]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Increases Expression [39]
Collagen alpha-1(IV) chain (COL4A1) OTL6D1YE CO4A1_HUMAN Decreases Expression [39]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Affects Expression [33]
Glycophorin-A (GYPA) OTABU4YV GLPA_HUMAN Decreases Expression [40]
Protein AMBP (AMBP) OTLU8GU8 AMBP_HUMAN Increases Expression [25]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Decreases Expression [40]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Increases Expression [36]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Decreases Secretion [41]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [36]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Decreases Expression [37]
Integrin beta-2 (ITGB2) OTEKPEPR ITB2_HUMAN Decreases Expression [42]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [9]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Secretion [43]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Phosphorylation [10]
Integrin beta-1 (ITGB1) OT6G1IAR ITB1_HUMAN Decreases Expression [42]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [44]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [26]
Involucrin (IVL) OT4VPNGY INVO_HUMAN Increases Expression [26]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Decreases Activity [45]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [46]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Decreases Expression [47]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Secretion [43]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Decreases Expression [36]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Increases Expression [38]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [9]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Activity [48]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Secretion [43]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Increases Expression [49]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) OTNIZPEA ATF2_HUMAN Increases Phosphorylation [10]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [46]
Erythroid transcription factor (GATA1) OTX1R7O1 GATA1_HUMAN Decreases Expression [40]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [50]
Cyclic AMP-responsive element-binding protein 1 (CREB1) OT1MDLA1 CREB1_HUMAN Increases Phosphorylation [10]
Transcription factor PU.1 (SPI1) OTVCA1D0 SPI1_HUMAN Increases Phosphorylation [51]
Interleukin-1 receptor antagonist protein (IL1RN) OT308CBE IL1RA_HUMAN Increases Secretion [41]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Decreases Expression [32]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [52]
Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1) OTODG57A FUT1_HUMAN Decreases Expression [25]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [53]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) OTDS2EAR TNR1B_HUMAN Increases Expression [52]
Filaggrin (FLG) OTE9QDV6 FILA_HUMAN Increases Expression [26]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Increases Expression [11]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Secretion [41]
Loricrin (LORICRIN) OTFRPVEO LORI_HUMAN Increases Expression [26]
Endothelial transcription factor GATA-2 (GATA2) OTBP2QQ2 GATA2_HUMAN Decreases Expression [40]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Increases Expression [44]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [54]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Affects Phosphorylation [53]
DNA cytosine-5)-methyltransferase 1 (DNMT1) OTM2DGTK DNMT1_HUMAN Decreases Expression [36]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [10]
Aryl hydrocarbon receptor nuclear translocator (ARNT) OTMSIEZY ARNT_HUMAN Increases Expression [55]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [10]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Increases Cleavage [29]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [32]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [56]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Expression [27]
Small proline-rich protein 2B (SPRR2B) OTQ9WPKY SPR2B_HUMAN Increases Expression [26]
Transaldolase (TALDO1) OTDKV2S2 TALDO_HUMAN Affects Expression [57]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Increases Expression [58]
Thrombopoietin receptor (MPL) OTZEN192 TPOR_HUMAN Decreases Methylation [36]
Interleukin-15 (IL15) OTQSYWQS IL15_HUMAN Decreases Secretion [41]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Increases Expression [59]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Decreases Phosphorylation [32]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Expression [44]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [60]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [54]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Expression [11]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Increases Expression [56]
Glutamate--cysteine ligase regulatory subunit (GCLM) OT6CP234 GSH0_HUMAN Increases Expression [61]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Cleavage [9]
Interleukin-1 receptor-associated kinase 1 (IRAK1) OT133G8J IRAK1_HUMAN Decreases Expression [53]
Rho GDP-dissociation inhibitor 1 (ARHGDIA) OTEXWJDO GDIR1_HUMAN Affects Expression [33]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Decreases Activity [11]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Cleavage [10]
Gasdermin-D (GSDMD) OTH39BKI GSDMD_HUMAN Increases Expression [29]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Decreases Expression [25]
Growth factor receptor-bound protein 2 (GRB2) OTOP7LTE GRB2_HUMAN Affects Expression [57]
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) OT83PT85 PP2AA_HUMAN Increases Expression [10]
Hemoglobin subunit beta (HBB) OT514IKQ HBB_HUMAN Decreases Methylation [62]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Decreases Expression [11]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) OTTM6KRB ADA17_HUMAN Increases Expression [60]
Protein S100-A12 (S100A12) OTF9IIXW S10AC_HUMAN Increases Expression [26]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Increases Expression [55]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Decreases Expression [53]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [25]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [44]
Melanocyte-stimulating hormone receptor (MC1R) OTB95LIK MSHR_HUMAN Decreases Expression [35]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Phosphorylation [29]
Tumor necrosis factor receptor superfamily member 9 (TNFRSF9) OTNOM26L TNR9_HUMAN Increases Expression [63]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Decreases Expression [38]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [10]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Increases Expression [64]
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (ST3GAL3) OTOORKUE SIAT6_HUMAN Decreases Expression [54]
TAR DNA-binding protein 43 (TARDBP) OTVOSFWW TADBP_HUMAN Affects Expression [57]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Decreases Expression [65]
Histone deacetylase 1 (HDAC1) OTQDNOXZ HDAC1_HUMAN Increases Expression [66]
Runt-related transcription factor 2 (RUNX2) OT97RQQM RUNX2_HUMAN Increases Expression [11]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Increases Secretion [29]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Decreases Expression [29]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Increases Expression [65]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [54]
LIM and SH3 domain protein 1 (LASP1) OT2QIDCL LASP1_HUMAN Affects Expression [57]
2'-5'-oligoadenylate synthase-like protein (OASL) OTZ05YRP OASL_HUMAN Increases Expression [25]
ELAV-like protein 1 (ELAVL1) OTY55PLY ELAV1_HUMAN Decreases Expression [34]
Histone-lysine N-methyltransferase EZH2 (EZH2) OTIEHTKW EZH2_HUMAN Decreases Expression [12]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Decreases Expression [67]
Laminin subunit alpha-4 (LAMA4) OTHI7TA0 LAMA4_HUMAN Increases Expression [39]
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Increases Phosphorylation [34]
Filaggrin-2 (FLG2) OTIIKCFS FILA2_HUMAN Increases Expression [26]
Transcription factor E4F1 (E4F1) OTL5ESAC E4F1_HUMAN Increases Expression [68]
Thiol S-methyltransferase TMT1B (TMT1B) OTP0QOAL TMT1B_HUMAN Decreases Expression [25]
Repetin (RPTN) OTOAA25U RPTN_HUMAN Increases Expression [26]
Maestro heat-like repeat family member 5 (MROH5) OT7U3SXU MROH5_HUMAN Decreases Expression [25]
Protein S100-A7A (S100A7A) OTNM8DCP S1A7A_HUMAN Decreases Expression [26]
Beta/gamma crystallin domain-containing protein 2 (CRYBG2) OTTPFG2M CRBG2_HUMAN Increases Expression [25]
Leucine-rich repeat-containing protein 71 (LRRC71) OT0YAW9S LRC71_HUMAN Increases Expression [25]
SID1 transmembrane family member 2 (SIDT2) OTU2L002 SIDT2_HUMAN Increases Expression [34]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Decreases Expression [25]
Histone deacetylase 2 (HDAC2) OTUYVFKN HDAC2_HUMAN Increases Expression [66]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) OTAYZMOY SIR1_HUMAN Affects Expression [38]
Histone-lysine N-methyltransferase EHMT2 (EHMT2) OTC4DWB6 EHMT2_HUMAN Decreases Expression [12]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Increases Expression [29]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Decreases Expression [25]
Late cornified envelope protein 3D (LCE3D) OTNAIJSE LCE3D_HUMAN Increases Expression [26]
Small proline-rich protein 2G (SPRR2G) OT35ZKLI SPR2G_HUMAN Increases Expression [26]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Lipidation [32]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Increases Expression [65]
NADPH oxidase 4 (NOX4) OTTYQ097 NOX4_HUMAN Increases Expression [34]
Nuclear receptor-binding protein 2 (NRBP2) OTJSTU62 NRBP2_HUMAN Increases Expression [25]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) OTMEF544 SIR3_HUMAN Decreases Expression [34]
Protein AATF (AATF) OT1QOKLD AATF_HUMAN Increases Adp-Ribosylation [47]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Expression [29]
Methyl-CpG-binding domain protein 2 (MBD2) OTUQPP0R MBD2_HUMAN Decreases Expression [36]
DNA (DNMT3B) OTZ0JCNP DNM3B_HUMAN Decreases Expression [36]
Small proline-rich protein 3 (SPRR3) OTN9QJKG SPRR3_HUMAN Increases Expression [26]
Tight junction protein ZO-2 (TJP2) OTQUY6BV ZO2_HUMAN Decreases Expression [69]
DnaJ homolog subfamily B member 4 (DNAJB4) OTUD01BK DNJB4_HUMAN Increases Expression [61]
Lymphoid enhancer-binding factor 1 (LEF1) OTWS5I5H LEF1_HUMAN Decreases Expression [27]
Apoptosis-associated speck-like protein containing a CARD (PYCARD) OT67RON3 ASC_HUMAN Increases Expression [29]
Sialidase-3 (NEU3) OTQ5PQOW NEUR3_HUMAN Increases Expression [54]
Proliferation-associated protein 2G4 (PA2G4) OT7IG7HT PA2G4_HUMAN Affects Expression [33]
TNF receptor-associated factor 6 (TRAF6) OTA5GO5K TRAF6_HUMAN Decreases Expression [53]
DNA (DNMT3A) OTEJP0GH DNM3A_HUMAN Decreases Expression [36]
Catalase (CAT) OTHEBX9R CATA_HUMAN Decreases Response To Substance [70]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Affects Response To Substance [71]
DNA polymerase eta (POLH) OTN07WXU POLH_HUMAN Affects Response To Substance [50]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Increases Chemical Synthesis [72]
Glutathione S-transferase theta-1 (GSTT1) OTRFMWBK GSTT1_HUMAN Affects Response To Substance [71]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Affects Response To Substance [73]
------------------------------------------------------------------------------------
⏷ Show the Full List of 630 DOT(s)
Indication(s) of Tranexamic Acid
Disease Entry ICD 11 Status REF
Excessive bleeding GA30.02 Approved [3]
Menorrhagia GA20.50 Approved [4]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [5]
Endometriosis GA10 Investigative [4]
Tranexamic Acid Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Plasminogen (PLG) TTP86E2 PLMN_HUMAN Inhibitor [74]
------------------------------------------------------------------------------------

References

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2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6573).
4 Tranexamic acid FDA Label
5 Tranexamic Acid (TXA) and Corona Virus 2019 (COVID19) in Inpatients (TCInpatient)
6 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
7 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
8 Human retinal pigment epithelial cell proliferation by the combined stimulation of hydroquinone and advanced glycation end-products via up-regulation of VEGF gene. Biochem Biophys Rep. 2015 May 29;2:123-131. doi: 10.1016/j.bbrep.2015.05.005. eCollection 2015 Jul.
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22 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
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24 Benzene-induced mouse hematotoxicity is regulated by a protein phosphatase 2A complex that stimulates transcription of cytochrome P4502E1. J Biol Chem. 2019 Feb 15;294(7):2486-2499.
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34 Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF- expression in hydroquinone-treated leukemia cells. Cell Biol Toxicol. 2023 Oct;39(5):2207-2225. doi: 10.1007/s10565-022-09705-5. Epub 2022 Mar 18.
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36 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
37 Poly(ADP-ribosyl)ation enhances H-RAS protein stability and causes abnormal cell cycle progression in human TK6 lymphoblastoid cells treated with hydroquinone. Chem Biol Interact. 2015 Aug 5;238:1-8. doi: 10.1016/j.cbi.2015.05.019. Epub 2015 Jun 3.
38 Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS. Toxicol Lett. 2016 Sep 30;259:133-142. doi: 10.1016/j.toxlet.2016.08.006. Epub 2016 Aug 8.
39 MMP-14 and TIMP-2 overexpression protects against hydroquinone-induced oxidant injury in RPE: implications for extracellular matrix turnover. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5662-70. doi: 10.1167/iovs.07-0392.
40 Phenolic metabolites of benzene inhibited the erythroid differentiation of K562 cells. Toxicol Lett. 2011 Jun 24;203(3):190-9. doi: 10.1016/j.toxlet.2011.03.012. Epub 2011 Mar 23.
41 Altered cytokine profiles of human retinal pigment epithelium: oxidant injury and replicative senescence. Mol Vis. 2013;19:718-28. Epub 2013 Mar 21.
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