Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0762O)

• Drug Name: Fenfluramine Drug Info
• Synonyms: Acino; Adifax; Adipomin; Fenfluramina; Fenfluraminum; Isomeride; Obedrex; Pesos; Ponderex; Rotondin; Dexfenfluramina [Spanish]; Dexfenfluraminum [Latin]; Fenfluramina [DCIT]; Fenfluramine hydrochloride; Levofenfluramine [INN]; Ponderax PA; S 768; D-Fenfluramine; Dexfenfluramine [INN:BAN]; Fenfluramine (INN); Fenfluramine [INN:BAN]; Fenfluraminum [INN-Latin]; Ponderax (TN); Fenfluramine, (+-)-Isomer; N-Ethyl-alpha-methyl-3-trifluoromethylphenethylamine; D-N-Ethyl-alpha-methyl-m-trifluoromethylphenethylamine; N-Ethyl-alpha-methyl-3-(trifluoromethyl)benzeneethanamine; N-Ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine; N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine; Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-(9CI); Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, (S)-(9CI);Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, (+-)-(9CI); (+)-Fenfluramine; (+-)-Fenfluramine; (+/-)-Fenfluramine hydrochloride; (S)-Fenfluramine; 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane; 1-(meta-Trifluoromethyl-phenyl)-2 ethylaminopropane; 2-Ethylamino-1-(3-trifluoromethylphenyl)propane; 3-(Trifluoromethyl)-N-ethyl-alpha-methylphenethylamine

Indication

Disease Entry	ICD 11	Status	REF
Dravet syndrome	8A61.11	Phase 3	[1]
LennoxGastaut syndrome	8A62.1	Phase 3	[1]
Obesity	5B81	Withdrawn from market	[2]

• Cross-matching ID:
  PubChem CID: 3337
  ChEBI ID: CHEBI:5000
  CAS Number: CAS 458-24-2
  TTD Drug ID: DM0762O
  VARIDT Drug ID: DR00583

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT receptor (5HTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[8]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[9]
Ramosetron	DMH7GN8	Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[8]
Pizotyline	DMV74ZH	Headache	8A80-8A84	Approved	[9]
Tandospirone	DMPHWU6	Anxiety disorder	6B00-6B0Z	Approved	[8]
Nafronyl	DMVMQ1L	Cerebrovascular ischaemia	8B1Z	Approved	[9]
ITI-007	DMUQ1DO	Depression	6A70-6A7Z	Phase 3	[10]
MIN-117	DMSLIW6	Major depressive disorder	6A70.3	Phase 2	[10]
Lu-AA34893	DM2ZUXK	Anxiety disorder	6B00-6B0Z	Phase 2	[11]
SEP--4199	DMA12HB	Bipolar disorder	6A60	Phase 2	[12]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 12B (PPP1R12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[14]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[15]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[18]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[19]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[20]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[22]

Drug(s) Affected By Protein cordon-bleu (COBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[23]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[30]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[32]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[36]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[37]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[38]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[39]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[40]

Drug(s) Affected By Submaxillary gland androgen-regulated protein 3B (SMR3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Integrin alpha-2 (ITGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]

Drug(s) Affected By 5-hydroxytryptamine receptor 2A (HTR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[51]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[52]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[53]
Haloperidol	DM96SE0	Delirium		Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[59]

Drug(s) Affected By 5-hydroxytryptamine receptor 2C (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[60]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[60]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[60]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]

Drug(s) Affected By DNA ligase 4 (LIG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Bortezomib	DMNO38U	Leukemia		Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[69]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Galactocerebrosidase (GALC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[74]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[23]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]

Drug(s) Affected By Interferon regulatory factor 8 (IRF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
MK-2206	DMT1OZ6	Rectal adenocarcinoma	2B92	Phase 2	[82]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[84]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[85]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[77]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[85]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[86]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[89]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[49]

Drug(s) Affected By Mucin-like protein 3 (MUCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[71]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Krueppel-like factor 17 (KLF17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[93]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[94]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]

Drug(s) Affected By MORN repeat-containing protein 5 (MORN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[96]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[96]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Coiled-coil domain-containing protein 62 (CCDC62)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[99]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[96]

Drug(s) Affected By Monocarboxylate transporter 14 (SLC16A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[23]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[100]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[101]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[79]

Drug(s) Affected By Olfactory receptor 2W3 (OR2W3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[103]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[104]

Drug(s) Affected By Protein GAPT (GAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[30]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[106]

Drug(s) Affected By Follistatin-related protein 5 (FSTL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Stress-associated endoplasmic reticulum protein 2 (SERP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[18]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[23]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[111]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[112]

Drug(s) Affected By N-acetylaspartate synthetase (NAT8L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[114]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[115]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[23]

Drug(s) Affected By Cytoplasmic dynein 2 heavy chain 1 (DYNC2H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[117]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[112]

Drug(s) Affected By Dedicator of cytokinesis protein 8 (DOCK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[100]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Nitazoxanide	DMOWLVG	Clostridioides difficile infection	1A04	Approved	[120]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[99]

Drug(s) Affected By Myozenin-3 (MYOZ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[121]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[18]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[23]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[76]

Drug(s) Affected By Tumor protein D55 (TPD52L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Uncharacterized protein C12orf42 (C12ORF42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Guanidino acid hydrolase, mitochondrial (AGMAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[16]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[23]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[75]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[125]

Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[49]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[126]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]

Drug(s) Affected By Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (OXCT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[117]

Drug(s) Affected By Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[23]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[18]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[129]

Drug(s) Affected By Dickkopf-like protein 1 (DKKL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[130]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[117]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[103]

Drug(s) Affected By 5-hydroxytryptamine receptor 2B (HTR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[132]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[133]
Bortezomib	DMNO38U	Leukemia		Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[134]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Bone morphogenetic protein receptor type-2 (BMPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[139]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[96]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT receptor (5HTR)	TT85JO3	NOUNIPROTAC	Antagonist	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Protein Interaction/Cellular Processes	[4]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Drug Response	[5]
5-hydroxytryptamine receptor 2C (HTR2C)	OT6H8DE0	5HT2C_HUMAN	Protein Interaction/Cellular Processes	[4]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Gene/Protein Processing	[6]
Angiopoietin-related protein 4 (ANGPTL4)	OTQL5SPX	ANGL4_HUMAN	Gene/Protein Processing	[6]
Bone morphogenetic protein receptor type-2 (BMPR2)	OTM9W547	BMPR2_HUMAN	Drug Response	[7]
Coiled-coil domain-containing protein 62 (CCDC62)	OTTIAOBP	CCD62_HUMAN	Gene/Protein Processing	[6]
Cytoplasmic dynein 2 heavy chain 1 (DYNC2H1)	OTLC8K6B	DYHC2_HUMAN	Gene/Protein Processing	[6]
Dedicator of cytokinesis protein 8 (DOCK8)	OTNQLL21	DOCK8_HUMAN	Gene/Protein Processing	[6]
Dickkopf-like protein 1 (DKKL1)	OTWS7DED	DKKL1_HUMAN	Gene/Protein Processing	[6]

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