Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5D9YK)

• Drug Name: CHOLINE Drug Info
• Synonyms: choline; Choline ion; Bilineurine; Choline cation; Cholinum; 2-Hydroxy-N,N,N-trimethylethanaminium; 62-49-7; (2-Hydroxyethyl)trimethylammonium; trimethylethanolamine; N-trimethylethanolamine; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; CCRIS 5847; UNII-N91BDP6H0X; AI3-24208; BRN 1736748; N,N,N-trimethylethanol-ammonium; CHEBI:15354; (beta-hydroxyethyl)trimethylammonium; EINECS 200-535-1; CHEMBL920; N91BDP6H0X; 2-hydroxyethyl(trimethyl)ammonium

Indication

Disease Entry	ICD 11	Status	REF
Insomnia	7A00-7A0Z	Approved	[1]
Leukemia		Approved	[1]
Discovery agent	N.A.	Investigative	[2]

• Cross-matching ID:
  PubChem CID: 305
  ChEBI ID: CHEBI:15354
  CAS Number: CAS 62-49-7
  TTD Drug ID: DM5D9YK
  VARIDT Drug ID: DR00121
  INTEDE Drug ID: DR0315

Molecule-Related Drug Atlas

Drug(s) Targeting Neuronal acetylcholine receptor alpha-2 (CHRNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rocuronium	DMY9BMK	Muscle spasm	MB47.3	Approved	[18]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[18]
Cisatracurium	DMUZPJ5	Muscle spasm	MB47.3	Approved	[18]
Vecuronium	DMP0UK2	Spasm	MB47.3	Approved	[18]
Levallorphan	DMCOLUP	Narcotic depression	6A7Z	Approved	[19]
Mivacurium	DM473VD	Anaesthesia	9A78.6	Approved	[18]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[19]
Pipecuronium	DM5F84A	Spasm	MB47.3	Approved	[19]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[20]
[125I]epibatidine	DMZWQH3	Discovery agent	N.A.	Investigative	[21]

Drug(s) Transported By Organic cation transporter 2 (SLC22A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[23]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[24]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[25]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[26]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[27]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[28]
Metformin	DM89QE1	Colorectal carcinoma		Approved	[29]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[27]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[30]

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[9]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[34]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[35]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[36]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[37]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[27]

Drug(s) Transported By Choline transporter-like protein 4 (SLC44A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[38]
Vitamin B1	DMZ1WXJ	Vitamin B1 deficiency	5B5A	Approved	[39]

Drug(s) Transported By Na(+)/Cl(-) betaine/GABA transporter (SLC6A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[40]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[7]
L-Proline	DMKSTWR	Malnutrition	5B50-5B71	Approved	[7]
Betaine	DMGRZW2	Cystitis	GC00	Approved	[41]

Drug(s) Metabolized By Choline dehydrogenase (CHDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Choline salicylate	DM8P137	Inflammation	1A00-CA43.1	Approved	[14]

Drug(s) Metabolized By Choline O-acetyltransferase (CHAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Choline salicylate	DM8P137	Inflammation	1A00-CA43.1	Approved	[11]

Drug(s) Metabolized By Choline/ethanolaminephosphotransferase 1 (CEPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Choline salicylate	DM8P137	Inflammation	1A00-CA43.1	Approved	[12]

Drug(s) Affected By Choline dehydrogenase, mitochondrial (CHDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[49]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]

Drug(s) Affected By Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[52]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[53]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[54]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[55]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[56]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[57]
Ethopropazine	DM0N3L7	Parkinson disease	8A00.0	Approved	[53]
Dimenhydrinate	DM264B3	Meniere disease	AB31.0	Approved	[58]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[59]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[58]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[60]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[61]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[62]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[65]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[66]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[69]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Selenium	DM25CGV	N. A.	N. A.	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[78]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[88]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By Retinal dehydrogenase 2 (ALDH1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[94]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[94]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[94]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[94]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[94]

Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By Cystatin-C (CST3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[109]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[110]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[112]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[114]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[115]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[118]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[122]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[130]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[131]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[132]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]

Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Selenium	DM25CGV	N. A.	N. A.	Approved	[100]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[135]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[147]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]

Drug(s) Affected By Matrix Gla protein (MGP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[134]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[156]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[157]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[158]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[83]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[160]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[161]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[164]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[165]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]

Drug(s) Affected By Interleukin-2 receptor subunit beta (IL2RB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[170]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[173]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[174]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[175]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[179]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[180]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[184]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[185]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[185]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[190]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[185]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[56]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[191]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[193]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[195]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]

Drug(s) Affected By Probable global transcription activator SNF2L1 (SMARCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[197]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[198]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[199]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[201]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[206]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[207]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[208]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[205]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[209]

Drug(s) Affected By CX3C chemokine receptor 1 (CX3CR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[212]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[213]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[206]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[214]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[175]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[215]

Drug(s) Affected By Regulator of G-protein signaling 19 (RGS19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[206]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[209]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[215]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[216]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[217]

Drug(s) Affected By Granzyme K (GZMK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[218]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[219]

Drug(s) Affected By Myomesin-2 (MYOM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[221]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[222]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[216]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[223]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[224]

Drug(s) Affected By Hepatocyte nuclear factor 3-alpha (FOXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[225]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[228]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Melanoma antigen preferentially expressed in tumors (PRAME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[230]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[232]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[237]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[238]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]

Drug(s) Affected By 1,4-alpha-glucan-branching enzyme (GBE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[240]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[240]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[241]

Drug(s) Affected By 28 kDa heat- and acid-stable phosphoprotein (PDAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[242]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[243]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[244]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[206]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[217]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[245]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[247]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[248]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[250]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[251]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[252]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[251]

Drug(s) Affected By Protein tyrosine phosphatase receptor type C-associated protein (PTPRCAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[170]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[174]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[209]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Borealin (CDCA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[255]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[256]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[257]

Drug(s) Affected By Collectin-12 (COLEC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[259]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[259]

Drug(s) Affected By Scavenger receptor cysteine-rich type 1 protein M130 (CD163)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[250]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[260]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[261]

Drug(s) Affected By Secreted frizzled-related protein 1 (SFRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[265]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[266]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[267]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[268]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF1 (MARCHF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[270]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]

Drug(s) Affected By Dedicator of cytokinesis protein 2 (DOCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[271]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[174]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[46]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Protein MAL2 (MAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[197]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[274]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]

Drug(s) Affected By Rho GTPase-activating protein 9 (ARHGAP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[276]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[277]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[277]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[46]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[203]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[216]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[278]

Drug(s) Affected By Aminopeptidase RNPEPL1 (RNPEPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[279]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]

Drug(s) Affected By Killer cell lectin-like receptor subfamily F member 1 (KLRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[280]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[177]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Fructose	DM43AN2	Vomiting	MD90	Approved	[282]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[283]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[285]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[286]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[286]

Drug(s) Affected By Y+L amino acid transporter 1 (SLC7A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[287]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[288]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]

Drug(s) Affected By Phosphatidylethanolamine N-methyltransferase (PEMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[149]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[268]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[290]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[291]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[206]

Drug(s) Affected By C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[48]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[277]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[277]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Neuronal acetylcholine receptor alpha-2 (CHRNA2)	TTF4E0J	ACHA2_HUMAN	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Choline transporter-like protein 5 (SLC44A5)	DTU8NCX	CTL5_HUMAN	Substrate	[4]
Choline transporter-like protein 2 (SLC44A2)	DTSF91X	CTL2_HUMAN	Substrate	[5]
Choline transporter-like protein 4 (SLC44A4)	DT8KXR9	CTL4_HUMAN	Substrate	[6]
Na(+)/Cl(-) betaine/GABA transporter (SLC6A12)	DTBPTJF	S6A12_HUMAN	Substrate	[7]
Choline transporter-like protein 1 (SLC44A1)	DT3I2SU	CTL1_HUMAN	Substrate	[8]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[9]
Organic cation transporter 2 (SLC22A2)	DT9IDPW	S22A2_HUMAN	Substrate	[10]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Choline O-acetyltransferase (CHAT)	DE5NGOW	CLAT_HUMAN	Substrate	[11]
Choline/ethanolaminephosphotransferase 1 (CEPT1)	DEL87ZT	CEPT1_HUMAN	Substrate	[12]
Choline kinase alpha (CHKA)	DEMRAYN	CHKA_HUMAN	Substrate	[13]
Choline dehydrogenase (CHDH)	DEAHED0	CHDH_HUMAN	Substrate	[14]
Choline/ethanolamine kinase (CHKB)	DEHWR6V	CHKB_HUMAN	Substrate	[13]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1,4-alpha-glucan-branching enzyme (GBE1)	OTK2N05B	GLGB_HUMAN	Gene/Protein Processing	[15]
28 kDa heat- and acid-stable phosphoprotein (PDAP1)	OTJSWMOD	HAP28_HUMAN	Gene/Protein Processing	[15]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[15]
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[16]
Aminopeptidase RNPEPL1 (RNPEPL1)	OT58DCKC	RNPL1_HUMAN	Gene/Protein Processing	[15]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Gene/Protein Processing	[15]
C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)	OTMKHVWC	C1TC_HUMAN	Drug Response	[15]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[17]
Choline dehydrogenase, mitochondrial (CHDH)	OTO2DPGL	CHDH_HUMAN	Drug Response	[15]
Cholinesterase (BCHE)	OTOH3WQ9	CHLE_HUMAN	Gene/Protein Processing	[16]

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