General Information of Drug (ID: DMHZJCG)

Drug Name
Pentamidine Drug Info
Synonyms
Lomidine; Nebupent; PENTAM; PNT; Pentacarinat; Pentamide; Pentamidin; Pentamidina; Pentamidinum; Pneumopent; PENTAMIDINE ISETHIONATE; Pentamidina [DCIT]; Pentamidine isetionate; Pentamidine mesylate; MB 800; Pentam 300; Lomidine (TN); MB-800; Nebupent (as isethionate); Pentacarinat (as isethionate); Pentam 300 (as isethionate); Pentamidine (INN); Pentamidinum [INN-Latin]; RP-2512; Nebupent (*Isethionate); Pentacarinat (*Isethionate); Pentam 300 (*Isethionate); Pentamidine Isethionate 2-Hydroxy-Ethanesulfonic Acid;Pentamidine [INN:BAN:DCF]; RP 2512 (*Isethionate); P,p'-(Pentamethylenedioxy)bis[benzamidine]; P,p'-(Pentamethylenedioxy)dibenzamidine; P,p'-(Pentamethylene-dioxy)bis-benzamidine; Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-(9CI); 1,3-BIS(4-AMIDINOPHENOXY)PENTANE; 4, 4'-Diamidinodiphenoxypentane; 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide; 4,4'-(Pentamethylenedioxy)dibenzamide; 4,4'-(Pentamethylenedioxy)dibenzamidine; 4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane; 4,4'-Diamidinodiphenoxypentane; 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide; 4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
Indication
Disease Entry ICD 11 Status REF
African trypanosomiasis 1F51 Approved [1]
Fungal infection 1F29-1F2F Approved [2]
Pneumocystis pneumonia CA40.20 Approved [1]
Human immunodeficiency virus infection 1C62 Withdrawn from market [3]
Therapeutic Class
Antifungal Agents
Cross-matching ID
PubChem CID
4735
ChEBI ID
CHEMBL55
CAS Number
CAS 100-33-4
TTD Drug ID
DMHZJCG
VARIDT Drug ID
DR00085
INTEDE Drug ID
DR1252

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lactoferrin DMA7QTC Solid tumour/cancer 2A00-2F9Z Approved [4]
APC-2059 DM8IB6K Inflammatory bowel disease DD72 Discontinued in Phase 2 [14]
APC-366 DM02DNQ Asthma CA23 Discontinued in Phase 2 [4]
BABIM DM8AGOE Asthma CA23 Terminated [4]
BAY-17-1998 DM7LZFQ Asthma CA23 Terminated [15]
BAY-44-3428 DM40ORU Asthma CA23 Terminated [16]
Grassystatin a DM1PWX2 Discovery agent N.A. Investigative [17]
BMS-262084 DMETNA3 Discovery agent N.A. Investigative [18]
AMG-126737 DM9H7AZ Discovery agent N.A. Investigative [19]
MOL 6131 DMSF8UC Discovery agent N.A. Investigative [19]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [20]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [26]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [27]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [28]
Propranolol DM79NTF Angina pectoris BA40 Approved [29]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [31]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [32]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [33]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [31]
Verapamil DMA7PEW Angina pectoris BA40 Approved [38]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [39]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [40]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [41]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [42]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [43]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [44]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [45]
Verapamil DMA7PEW Angina pectoris BA40 Approved [46]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [47]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [48]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [49]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [50]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [38]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [51]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [52]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [53]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [54]
Propranolol DM79NTF Angina pectoris BA40 Approved [55]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [56]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [57]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [58]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [59]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [60]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [61]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [62]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [63]
Verapamil DMA7PEW Angina pectoris BA40 Approved [64]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [59]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [39]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [65]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [65]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [66]
Verapamil DMA7PEW Angina pectoris BA40 Approved [67]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [68]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [69]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [65]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [70]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [71]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [72]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [73]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [74]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [75]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [66]
Verapamil DMA7PEW Angina pectoris BA40 Approved [76]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [77]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [78]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [79]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [71]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [80]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [81]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [82]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [83]
Capsaicin DMGMF6V Back pain ME84.Z Approved [84]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [85]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [10]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [81]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [86]
Clobazam - Lundbeck DMW1OQ0 Anxiety disorder 6B00-6B0Z Approved [87]
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Drug(s) Affected By Nuclear protein 1 (NUPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [88]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [8]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [89]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [90]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Fluoxetine DM3PD2C Bipolar depression Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [92]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [89]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [8]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [90]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [8]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [94]
Fluoxetine DM3PD2C Bipolar depression Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [95]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [95]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [8]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [96]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [97]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [8]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [90]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [98]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Fluoxetine DM3PD2C Bipolar depression Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
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Drug(s) Affected By Inhibin beta E chain (INHBE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [8]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [90]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Fluoxetine DM3PD2C Bipolar depression Approved [8]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [100]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [89]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [8]
Panobinostat DM58WKG Chronic graft versus host disease Approved [101]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [102]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [8]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [103]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [105]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [89]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [106]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Fluoxetine DM3PD2C Bipolar depression Approved [8]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [8]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [8]
Fluoxetine DM3PD2C Bipolar depression Approved [8]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [89]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [8]
Haloperidol DM96SE0 Delirium Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [107]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [108]
Clozapine DMFC71L Schizophrenia 6A20 Approved [8]
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Drug(s) Affected By Protein DEPP1 (DEPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [8]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [89]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [109]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Fluoxetine DM3PD2C Bipolar depression Approved [8]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [110]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [89]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [89]
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Drug(s) Affected By Nibrin (NBN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [112]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [113]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [114]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [108]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [115]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [116]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [117]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [118]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [119]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [12]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [12]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [120]
Allopurinol DMLPAOB Gout FA25 Approved [121]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [122]
Selenium DM25CGV N. A. N. A. Approved [123]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [12]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [124]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [112]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Methotrexate DM2TEOL Anterior urethra cancer Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [128]
Leflunomide DMR8ONJ Arthritis FA20 Approved [129]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [130]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [108]
Clozapine DMFC71L Schizophrenia 6A20 Approved [131]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [132]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [133]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [134]
Selenium DM25CGV N. A. N. A. Approved [123]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [135]
Etretinate DM2CZFA Keratosis ED56 Approved [136]
Methotrexate DM2TEOL Anterior urethra cancer Approved [137]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [138]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [139]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [140]
Quercetin DM3NC4M Obesity 5B81 Approved [141]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [142]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [107]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [143]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [115]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [116]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [117]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [118]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [144]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [146]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [147]
Etretinate DM2CZFA Keratosis ED56 Approved [148]
Quercetin DM3NC4M Obesity 5B81 Approved [149]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [110]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [150]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [151]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [156]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [157]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [158]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [156]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [154]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [159]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [160]
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Drug(s) Affected By Bile acid receptor (NR1H4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [161]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [162]
Quercetin DM3NC4M Obesity 5B81 Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [163]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [164]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [161]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [162]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [9]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [107]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tryptase alpha/beta-1 (Tryptase) TTM1TDX TRYB1_HUMAN Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [6]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [6]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [7]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [6]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [6]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Gene/Protein Processing [8]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Gene/Protein Processing [9]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [10]
Double-strand break repair protein MRE11 (MRE11) OTGU8TZM MRE11_HUMAN Gene/Protein Processing [11]
Fibronectin type III domain-containing protein 4 (FNDC4) OTOQK0WK FNDC4_HUMAN Gene/Protein Processing [8]
Histone acetyltransferase KAT5 (KAT5) OTL7257A KAT5_HUMAN Gene/Protein Processing [11]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Protein Interaction/Cellular Processes [11]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Gene/Protein Processing [12]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Gene/Protein Processing [8]
Interferon gamma receptor 1 (IFNGR1) OTCTQBWW INGR1_HUMAN Gene/Protein Processing [13]

References

1 Pentamidine FDA Label
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3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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