General Information of Drug (ID: DMNFUZR)

Drug Name
Enalapril Drug Info
Synonyms
Vasotec; Enalapril (INN); Enalapril (TN); N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl-L-proline; N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline; (2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Congestive heart failure BD10 Approved [1]
Hypertension BA00-BA04 Approved [2]
Malignant essential hypertension BA00 Approved [1]
Therapeutic Class
Antihypertensive Agents
Cross-matching ID
PubChem CID
5388962
ChEBI ID
CHEBI:4784
CAS Number
CAS 75847-73-3
TTD Drug ID
DMNFUZR
VARIDT Drug ID
DR00010
INTEDE Drug ID
DR0573
ACDINA Drug ID
D00229

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [20]
Captopril DM458UM Chronic heart failure BD1Z Approved [21]
Benazepril DMH1M9B Hypertension BA00-BA04 Approved [22]
Moexipril DM26E4B Hypertension BA00-BA04 Approved [23]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [24]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [25]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [26]
Fosinopril DM9NJ52 Chronic heart failure BD1Z Approved [27]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [28]
Enalaprilat DMFYAM1 Congestive heart failure BD10 Approved [29]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Folic Acid DMEMBJC Colorectal carcinoma Approved [32]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [33]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [34]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [35]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [36]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [37]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [38]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [39]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [41]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [42]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [43]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [42]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [44]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [45]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [46]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [47]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [44]
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Drug(s) Transported By Peptide transporter 1 (SLC15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [48]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [49]
Ampicillin DMHWE7P Acute epiglottitis Approved [50]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [51]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [52]
Ceftriaxone DMCEW64 Acute gonococcal cervicitis Approved [53]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [49]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [51]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [51]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [51]
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Drug(s) Transported By Peptide transporter 2 (SLC15A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [48]
Ampicillin DMHWE7P Acute epiglottitis Approved [54]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [55]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [56]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [54]
Valaciclovir DMHKS94 Genital herpes 1A94 Approved [57]
Cefaclor DMJXDGC Bacterial infection 1A00-1C4Z Approved [48]
Aminolevulinic acid hci DMS4BLQ Acne vulgaris ED80 Approved [58]
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [59]
Cefixime DMY60I8 Acute gonococcal cervicitis Approved [54]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [61]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [62]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [63]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [64]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [65]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [66]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [67]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [68]
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [69]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [70]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [42]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [71]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [72]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [42]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [73]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [45]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [47]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [74]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [47]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [75]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [76]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [77]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [78]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [79]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [80]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [81]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [82]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [76]
Verapamil DMA7PEW Angina pectoris BA40 Approved [83]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [94]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [95]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [96]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [97]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [98]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [98]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [99]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [100]
Capsaicin DMGMF6V Back pain ME84.Z Approved [101]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [102]
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Drug(s) Metabolized By Carboxylesterase 1 (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [84]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [85]
Salbutamol DMN9CWF Acute asthma CA23 Approved [86]
Methylphenidate DM7SJD6 Attention deficit hyperactivity disorder 6A05.Z Approved [87]
PSI-7977 DMLSUWZ HCV 1-6 infection 1E51 Approved [88]
Rufinamide DMWE60C Epilepsy 8A60-8A68 Approved [89]
Dexmethylphenidate DMUQE2A Attention deficit hyperactivity disorder 6A05.Z Approved [90]
MK-4827 DMLYGH4 Ovarian cancer 2C73 Phase 3 [91]
Dabigatran etexilate DMRDZ4X Venous thromboembolism BD72 Phase 3 [92]
Pradaxa DM2ZYX9 Stroke 8B20 Phase 3 [93]
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Drug(s) Metabolized By Dipeptidase (pepV)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spirapril DM5XLTY Hypertension BA00-BA04 Approved [11]
Enalaprilat DMFYAM1 Congestive heart failure BD10 Approved [11]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [103]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [104]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [105]
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [107]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [108]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [108]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [109]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [110]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [111]
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Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [112]
Epinephrine DM3KJBC Acute asthma CA23 Approved [113]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [116]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [117]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [118]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [119]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [121]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [122]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [123]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [124]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [125]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [126]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [127]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [128]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [129]
Epinephrine DM3KJBC Acute asthma CA23 Approved [130]
Chlorthalidone DM4DMBT Edema MG29 Approved [131]
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Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [132]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [133]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [134]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [125]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [135]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [136]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [137]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Natriuretic peptides A (NPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [139]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [140]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [143]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [137]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [144]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [146]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [147]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Erythropoietin (EPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [121]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [151]
Fenoterol DMIP3ZV Asthma CA23 Approved [152]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [153]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [154]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [155]
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Drug(s) Affected By Angiogenin (ANG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [114]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [156]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [157]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [158]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [146]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [159]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [155]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [160]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [161]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [162]
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Drug(s) Affected By Tissue factor (F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [163]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [165]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [166]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [167]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Fructose DM43AN2 Vomiting MD90 Approved [169]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [170]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [164]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [116]
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Drug(s) Affected By Somatotropin (GH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [171]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [172]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [173]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [174]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [146]
Sodium oxybate DMBOV5P Narcolepsy 7A20 Approved [175]
Ethanol DMDRQZU Chronic pain MG30 Approved [171]
Connexyn DMF29Q5 Attention deficit hyperactivity disorder 6A05.Z Approved [176]
Gamma Hydroxybutyric Acid DMGBKVD Narcolepsy 7A20 Approved [177]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [178]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [179]
Quercetin DM3NC4M Obesity 5B81 Approved [180]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [181]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [182]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [184]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [185]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [186]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [187]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [15]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [188]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [189]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [146]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [155]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [190]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [191]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [192]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [193]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [194]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [195]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [196]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [197]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [198]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [199]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [202]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [203]
Methotrexate DM2TEOL Anterior urethra cancer Approved [195]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin-converting enzyme (ACE) TTL69WB ACE_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Peptide transporter 2 (SLC15A2) DT8QKNP S15A2_HUMAN Substrate [4]
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [5]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [6]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [7]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [8]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [9]
Carboxylesterase 1 (CES1) DEB30C5 EST1_HUMAN Substrate [10]
Dipeptidase (pepV) DEQMBHW Q84BU9_LACLH Substrate [11]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiogenin (ANG) OT3ECS6P ANGI_HUMAN Gene/Protein Processing [12]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Gene/Protein Processing [13]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Regulation of Drug Effects [14]
B2 bradykinin receptor (BDKRB2) OTOA9D3W BKRB2_HUMAN Drug Response [15]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Gene/Protein Processing [16]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Drug Response [15]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Gene/Protein Processing [13]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Drug Response [17]
Natriuretic peptides A (NPPA) OTMQNTNX ANF_HUMAN Gene/Protein Processing [18]
Renin (REN) OT52GZR2 RENI_HUMAN Gene/Protein Processing [19]

References

1 Enalapril FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6322).
3 Determination of bezafibrate, methotrexate, cyclophosphamide, orlistat and enalapril in waste and surface waters using on-line solid-phase extracti... J Environ Monit. 2009 Apr;11(4):830-8.
4 Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes. Alcohol Clin Exp Res. 2008 May;32(5):777-84.
5 The intestinal H+/peptide symporter PEPT1: structure-affinity relationships. Eur J Pharm Sci. 2004 Jan;21(1):53-60.
6 Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers. J Pharmacol Exp Ther. 2006 Jul;318(1):395-402.
7 Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab Dispos. 2000 Jul;28(7):801-6.
8 The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein. Hepatology. 1998 Nov;28(5):1341-6.
9 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
10 Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models. Biopharm Drug Dispos. 2015 Sep;36(6):385-397.
11 Characterization and kinetic analysis of enzyme-substrate recognition by three recombinant lactococcal PepVs. Arch Biochem Biophys. 2006 Oct 15;454(2):137-45.
12 Effects of enalapril maleate on blood pressure, renin-angiotensin-aldosterone system, and peripheral sympathetic activity in essential hypertension. Clin Ther. 1987;9(4):390-9.
13 Worsening of anemia by angiotensin converting enzyme inhibitors and its prevention by antiestrogenic steroid in chronic hemodialysis patients. J Cardiovasc Pharmacol. 1989;13 Suppl 3:S27-30. doi: 10.1097/00005344-198900133-00007.
14 Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter. Pharm Res. 2007 Dec;24(12):2281-96.
15 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
16 Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An initro study. Chem Biol Interact. 2017 Mar 1;265:24-35.
17 Effect of enalapril and losartan on cytokines in patients with stable angina pectoris awaiting coronary artery bypass grafting and their interaction with polymorphisms in the interleukin-6 gene. Am J Cardiol. 2004 Sep 1;94(5):564-9. doi: 10.1016/j.amjcard.2004.05.017.
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