General Information of DME (ID: DEIBDNY)

DME Name Cytochrome P450 3A5 (CYP3A5) DME Info
Gene Name CYP3A5

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
178 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [1]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [2]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [3]
Alfentanil DMVO0UB Anaesthesia 9A78.6 Approved [4]
Alprazolam DMC7XDN Anxiety Approved [5]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [6]
Amprenavir DMLMXE0 Human immunodeficiency virus infection 1C62 Approved [7]
Anastrozole DMNP60F Breast cancer 2C60-2C65 Approved [8]
Apixaban DM89JLN Thrombosis DB61-GB90 Approved [9]
Argatroban DMFI46A Thrombosis DB61-GB90 Approved [10]
Aripiprazole DM3NUMH Bipolar I disorder Approved [11]
Armodafinil DMGB035 Malignant glioma 2A00.0 Approved [12]
Artemether DM48QOT Malaria 1F40-1F45 Approved [13]
Atazanavir DMSYRBX Human immunodeficiency virus infection 1C62 Approved [14]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [15]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [16]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [17]
Aztreonam DMDNJHG Bacterial infection 1A00-1C4Z Approved [18]
Bimatoprost DMX0E5B Alopecia ED70 Approved [19]
BOCEPREVIR DMBSHMF Hepatitis C virus infection 1E51.1 Approved [20]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [21]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [22]
Cabazitaxel DMPAZHC Breast cancer 2C60-2C65 Approved [23]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [25]
Cenobamate DM8KLU9 Complex partial seizure 8A68.0 Approved [26]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [11]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [27]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [11]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [29]
Cisapride DMY7PED Gastroesophageal reflux disease DA22.Z Approved [30]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [11]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [31]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [32]
Cobicistat DM6L4H2 Human immunodeficiency virus infection 1C62 Approved [33]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [34]
Cortisone Acetate DMG8K57 Acne vulgaris ED80 Approved [35]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [36]
Daclatasvir DMSFK9V Hepatitis C virus infection 1E51.1 Approved [37]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [11]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [38]
Delavirdine DM3NF5G Human immunodeficiency virus infection 1C62 Approved [11]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [39]
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [40]
Diazepam DM08E9O Alcohol withdrawal Approved [41]
Diltiazem DMAI7ZV Angina pectoris BA40 Approved [42]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [43]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [11]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [11]
Doxapram DMCYANK Respiratory disease CB40 Approved [44]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [45]
Dronedarone DMA8FS5 Angina pectoris BA40 Approved [46]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [47]
E-2007 DMJDYNQ Diabetic neuropathy 8C0Z Approved [48]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [49]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [38]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [50]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [11]
Estradiol Acetate DM07U2A Hormone replacement therapy 8E01 Approved [11]
Estradiol Cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [11]
Estradiol Valerate DM8MC6O Hormone replacement therapy 8E01 Approved [11]
Estrone DM5T6US Acne vulgaris ED80 Approved [51]
Ethosuximide DMDZ9LT Epilepsy 8A60-8A68 Approved [52]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [53]
Felodipine DMOSW35 Hypertension BA00-BA04 Approved [11]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [54]
Fexinidazole DMOYE70 African trypanosomiasis 1F51 Approved [55]
Finasteride DMWV3TZ Baldness, male pattern Approved [11]
Fluoxetine DM3PD2C Bipolar depression Approved [56]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [57]
Fluticasone DMGCSVF Allergic rhinitis CA08.0 Approved [58]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [59]
Gefitinib DM15F0X Colon adenocarcinoma Approved [60]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [61]
Granisetron DMIUW25 Malignant glioma 2A00.0 Approved [62]
Halofantrine DMOMK1V Malaria 1F40-1F45 Approved [63]
Haloperidol DM96SE0 Delirium Approved [64]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [3]
Hydroxyprogesterone DMIKQH5 Solid tumour/cancer 2A00-2F9Z Approved [65]
Hydroxyzine DMF8Y74 Allergic rhinitis CA08.0 Approved [66]
Ibrutinib DMHZCPO Mantle cell lymphoma 2A85.5 Approved [67]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [68]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [69]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [70]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [71]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [72]
Istradefylline DM20VSK Parkinson disease 8A00.0 Approved [73]
Ivacaftor DMZC1HS Cystic fibrosis CA25 Approved [74]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [38]
Lercanidipine DMPWSEM Hypertension BA00-BA04 Approved [11]
Levomethadyl acetate hydrochloride DM429AE N. A. N. A. Approved [11]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [11]
Lonafarnib DMGM2Z6 Hutchinson-Gilford progeria syndrome LD2B Approved [75]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [76]
Lorlatinib DMICDLV Non-small-cell lung cancer 2C25.Y Approved [77]
Losartan DM72JXH Diabetic kidney disease GB61.Z Approved [40]
Lumefantrine DM29GAD Malaria 1F40-1F45 Approved []
Mephenytoin DM5UGDK Epilepsy 8A60-8A68 Approved [78]
Metronidazole DMTIVEN Abscess Approved [79]
Midazolam DMXOELT Agitation 6A70.3 Approved [80]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [81]
MK-1439 DM215WE Human immunodeficiency virus infection 1C62 Approved [82]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [83]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [11]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [84]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [85]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [80]
Nimodipine DMQ0RKZ Cerebral vasospasm BA85.Z Approved [86]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [11]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [11]
Norethindrone acetate DMDGCQP N. A. N. A. Approved [87]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [88]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [89]
Ondansetron DMOTQ1I Chemotherapy-induced nausea MD90 Approved [90]
Ornidazole DM6QHDJ Amoebiasis 1A36 Approved [91]
Oxazepam DMXNZM4 Alcohol withdrawal delirium Approved [92]
Oxybutynin hydrochloride DMF2KLU Urinary incontinence MF50.2 Approved [93]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [94]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [95]
Phenelzine DMHIDUE Depression 6A70-6A7Z Approved [96]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [97]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [98]
Pimozide DMW83TP Schizophrenia 6A20 Approved [11]
Ponatinib DMYGJQO Acute lymphoblastic leukaemia 2A85 Approved [99]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [100]
Praziquantel DMOU1PK Flatworm infection 1F70-1F86 Approved [101]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [102]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [103]
Propranolol DM79NTF Angina pectoris BA40 Approved [104]
Quetiapine DM1N62C Anorexia nervosa cachexia 6B80 Approved [105]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [11]
Risperidone DMN6DXL Bipolar I disorder Approved [94]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [11]
Rivaroxaban DMQMBZ1 Deep vein thrombosis BD71 Approved [106]
Romidepsin DMT5GNL Cutaneous T-cell lymphoma 2B01 Approved [107]
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [11]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [84]
Saxagliptin DMGXENV Type-2 diabetes 5A11 Approved [108]
Sildenafil citrate DMSWJ5X N. A. N. A. Approved [109]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [110]
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [11]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [11]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [111]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [11]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [112]
Tadalafil DMJZHT1 Benign prostatic hyperplasia GA90 Approved [113]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [114]
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [115]
Telithromycin DMZ4P3A Bacterial infection 1A00-1C4Z Approved [116]
Temsirolimus DMS104F Renal cell carcinoma 2C90 Approved [11]
Tenapanor DMCOZJY Irritable bowel syndrome DD91.0 Approved [117]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [118]
Testosterone cypionate DMC1TEV N. A. N. A. Approved [80]
Testosterone enanthate DMB6871 N. A. N. A. Approved [80]
Testosterone undecanoate DMZO10Y Hypogonadism 5A61.0 Approved [80]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [119]
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [11]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Triamcinolone diacetate DM7LRKD N. A. N. A. Approved [121]
Triazolam DMETYK5 Insomnia 7A00-7A0Z Approved [80]
Udenafil DM1IQRP Erectile dysfunction HA01.1 Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Vardenafil DMTBGW8 Cystic fibrosis CA25 Approved [109]
Verapamil DMA7PEW Angina pectoris BA40 Approved [123]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [45]
Vincristine DMINOX3 Acute lymphoblastic leukaemia 2A85 Approved [124]
Vindesine DMVR628 Acute lymphoblastic leukaemia 2A85 Approved [125]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [126]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [127]
Zaleplon DMGFWSM Insomnia 7A00-7A0Z Approved [11]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [128]
Zonisamide DM0DTF7 Alcohol dependence 6C40.2 Approved [129]
ZOTEPINE DMF3VXA Anxiety disorder 6B00-6B0Z Approved [130]
Icotinib hydrochloride DM5GFIK Non-small-cell lung cancer 2C25.Y Registered [131]
Benidipine DMWNP6B N. A. N. A. Phase 4 [132]
Chlorphenamine DM6C4YJ Allergic rhinitis CA08.0 Phase 4 [11]
RUPATADINE DMBPN7T N. A. N. A. Phase 4 [133]
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⏷ Show the Full List of 178 Approved Drug(s)
21 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
AL3818 DM3WP0N Alveolar soft part sarcoma 2A60-2C35 Phase 3 [134]
Azimilide DMUIBV8 Atrial fibrillation BC81.3 Phase 3 [135]
Cethromycin DMIGX84 Bacterial infection 1A00-1C4Z Phase 3 [136]
GLYCYRRHIZIN DM8M2N3 Influenza virus infection 1E30-1E32 Phase 3 [137]
Linopirdine DM0ZOGX Cognitive impairment 6D71 Phase 3 [138]
Nabiximols DMHKJ5I Cancer related pain MG30 Phase 3 [24]
Semagacestat DML83IW Parkinson disease 8A00.0 Phase 3 [139]
TAK-875 DMIM5AP Type-2 diabetes 5A11 Phase 3 [140]
Vicriviroc DMMTW9K Human immunodeficiency virus infection 1C62 Phase 3 [85]
VX-661 DMJBXO3 Cystic fibrosis CA25 Phase 3 [141]
AZD2014 DMOEARH Solid tumour/cancer 2A00-2F9Z Phase 2 [142]
BMS 650032 DMQI43G Hepatitis C virus infection 1E51.1 Phase 2 [143]
Dexloxiglumide DM52HUD Pancreatic malfunction DC30-DC3Z Phase 2 [144]
EMIVIRINE DMQH1NV Human immunodeficiency virus infection 1C62 Phase 2 [145]
Famitinib DMSFWT7 Solid tumour/cancer 2A00-2F9Z Phase 2 [146]
Trastuzumab emtansine DMU1LXS HER2-positive breast cancer 2C60-2C65 Phase 2 [147]
Dapivirine DMJPSIL Human immunodeficiency virus infection 1C62 Phase 1/2 [148]
H3B-6545 DMIFCY2 Breast cancer 2C60-2C65 Phase 1/2 [149]
H3B-6527 DMAYTRK Hepatocellular carcinoma 2C12.02 Phase 1 [150]
ITX-5061 DM702MU Human immunodeficiency virus-1 infection 1C62 Phase 1 [151]
Tetrandrine DMAOJBX Sarcoma 2A60-2C35 Phase 1 [152]
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⏷ Show the Full List of 21 Clinical Trial Drug(s)
5 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Astemizole DM2HN6Q Allergic rhinitis CA08.0 Withdrawn from market [11]
Terfenadine DM4KLPT Allergy 4A80-4A85 Withdrawn from market [11]
Octopamine DMLQVTJ Thrombosis DB61-GB90 Discontinued in Phase 2a [54]
Ezlopitant DMTUPZ2 Irritable bowel syndrome DD91.0 Discontinued in Phase 2 [153]
FCP-3P1 DMTQLIJ Arteriosclerosis BD40 Discontinued in Phase 2 [154]
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1 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Oxycodone hydrochloride DMCA7LN Chronic pain MG30 Application submitted [155]
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3 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin salnacedin DM0PHEW Discovery agent N.A. Investigative [50]
Mepacrine DMU8L7C Discovery agent N.A. Investigative [156]
PARAOXON DMN4ZKC Discovery agent N.A. Investigative [157]
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Molecule Interaction Atlas

References

1 FDA label of Acalabrutinib. The 2020 official website of the U.S. Food and Drug Administration.
2 Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation. Drug Metab Dispos. 2007 Oct;35(10):1754-8.
3 CYP3A5 genotype is associated with elevated blood pressure. Pharmacogenet Genomics. 2005 Oct;15(10):737-41.
4 Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam. Clin Pharmacol Ther. 2007 Oct;82(4):410-26.
5 Identification and phenotype characterization of two CYP3A haplotypes causing different enzymatic capacity in fetal livers. Clin Pharmacol Ther. 2005 Apr;77(4):259-70.
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18 Aztreonam decreases hepatic microsomal cytochrome P450 in cynomolgus monkeys. Pharmacology. 1994 Mar;48(3):137-42.
19 Product monograph: LUMIGAN RC (Bimatoprost).
20 Direct-acting antiviral agents for hepatitis C virus infection. Annu Rev Pharmacol Toxicol. 2013;53:427-49.
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38 Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.
39 Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells. J Pharmacol Exp Ther. 2003 Feb;304(2):745-52.
40 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
41 Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism. Drug Metab Dispos. 1999 Jan;27(1):102-9.
42 Significant impacts of CYP3A4*1G and CYP3A5*3 genetic polymorphisms on the pharmacokinetics of diltiazem and its main metabolites in Chinese adult kidney transplant patients. J Clin Pharm Ther. 2016 Jun;41(3):341-7.
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44 Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea. Eur J Pediatr. 2015 Apr;174(4):509-18.
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46 Inactivation of human cytochrome P450 3A4 and 3A5 by dronedarone and N-desbutyl dronedarone. Mol Pharmacol. 2016 Jan;89(1):1-13.
47 Product monograph: Avodart (dutasteride capsules).
48 FDA label of Perampanel. The 2020 official website of the U.S. Food and Drug Administration.
49 The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
50 Differential regulation of CYP3A4 and CYP3A5 and its implication in drug discovery. Curr Drug Metab. 2017;18(12):1095-1105.
51 16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5. Carcinogenesis. 1998 May;19(5):867-72.
52 Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes. Xenobiotica. 2003 Mar;33(3):265-76.
53 Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug Metab Dispos. 2004 Sep;32(9):993-1000.
54 Pharmacogenomics as molecular autopsy for forensic toxicology: genotyping cytochrome P450 3A4*1B and 3A5*3 for 25 fentanyl cases. J Anal Toxicol. 2005 Oct;29(7):590-8.
55 Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923.
56 (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91.
57 Identification of a novel glutathione conjugate of flutamide in incubations with human liver microsomes. Drug Metab Dispos. 2007 Jul;35(7):1081-8.
58 Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35.
59 Lipid-lowering response to statins is affected by CYP3A5 polymorphism. Pharmacogenetics. 2004 Aug;14(8):523-5.
60 Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7.
61 Identification of CYP3A7 for glyburide metabolism in human fetal livers. Biochem Pharmacol. 2014 Dec 15;92(4):690-700.
62 Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron. Br J Clin Pharmacol. 1994 Dec;38(6):557-66.
63 Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5. J Pharm Pharmacol. 1999 Apr;51(4):419-26.
64 Assessment of the contributions of CYP3A4 and CYP3A5 in the metabolism of the antipsychotic agent haloperidol to its potentially neurotoxic pyridinium metabolite and effect of antidepressants on the bioactivation pathway. Drug Metab Dispos. 2003 Mar;31(3):243-9.
65 Prevention of preterm delivery with 17-hydroxyprogesterone caproate: pharmacologic considerations. Semin Perinatol. 2014 Dec;38(8):516-22.
66 Product characteristics of HYDROXYZINE (Hydroxyzine Hydrochloride Capsules).
67 Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.
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