Details of Disease

General Information of Disease (ID: DISLGEL6)

Disease Name	Liver failure
Synonyms	hepatic failure
Disease Class	DB90-DB9Z: Liver disease
Definition	A liver disease characterized by the liver losing or has lost all of its function.
Disease Hierarchy	DIS2OMMF: Liver disease DISLGEL6: Liver failure
ICD Code	ICD-11 ICD-11: DB99.7 Expand ICD-11 'DB99.7 Expand ICD-10 'K72; 'K72.1; 'K72.9
Disease Identifiers	MONDO ID MONDO_0100192 MESH ID D017093 UMLS CUI C0085605 MedGen ID 88444 HPO ID HP:0001399 SNOMED CT ID 59927004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ALF-5755	DMUA0XC	Phase 2	NA	[1]
HepaStem	DM8QGPE	Phase 2	NA	[2]
Stromal stem cell therapy	DMK2TWX	Phase 1	NA	[3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 19 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
OTC	TT5KIO9	Limited	Biomarker	[4]
SERPINA1	TTA7UJC	Limited	Biomarker	[5]
ABCB11	TTUXCAF	Strong	Genetic Variation	[6]
ARG1	TT7ZQEV	Strong	Biomarker	[7]
ATP7B	TTOPO51	Strong	Genetic Variation	[8]
CPS1	TT42M75	Strong	Biomarker	[9]
EIF2AK3	TT79U1M	Strong	Genetic Variation	[10]
EPX	TTCIO0M	Strong	Biomarker	[11]
F2	TT6L509	Strong	Biomarker	[12]
FECH	TTQ6VF4	Strong	Biomarker	[11]
GLUL	TTURQ2G	Strong	Biomarker	[13]
IL18	TTRICUF	Strong	Altered Expression	[14]
LIPA	TTS8T1M	Strong	Altered Expression	[15]
PNPLA3	TTEUAEH	Strong	Genetic Variation	[16]
PRDX4	TTPBL9I	Strong	Biomarker	[17]
PTP4A1	TTA8GFO	Strong	Biomarker	[18]
SLC6A12	TTQBMPI	Strong	Altered Expression	[19]
USP8	TT1J07C	Strong	Genetic Variation	[20]
AHCY	TTE2KUJ	Definitive	Genetic Variation	[21]
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⏷ Show the Full List of 19 DTT(s)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC27A5	DT0TQS3	Strong	Biomarker	[4]
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This Disease Is Related to 6 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
AKR1D1	DEVON3M	Strong	Genetic Variation	[22]
GSTZ1	DEQPEMB	Strong	Genetic Variation	[23]
MARS1	DE0K52I	Strong	Biomarker	[24]
CYP7B1	DE36TMY	Definitive	Altered Expression	[25]
GPT	DER5HFI	Definitive	Biomarker	[26]
WARS1	DEPVE0M	Definitive	Biomarker	[27]
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⏷ Show the Full List of 6 DME(s)

This Disease Is Related to 41 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
NUP210	OT3BLQ9M	Limited	Biomarker	[28]
POLG2	OTDBMZJB	Limited	Genetic Variation	[29]
TRMU	OTJ1KXM7	Limited	Genetic Variation	[30]
DGUOK	OT78HUZB	moderate	Biomarker	[31]
HLA-DRB4	OTNXIHQU	moderate	Genetic Variation	[32]
ORM1	OTZKSBRE	moderate	Therapeutic	[33]
TFAM	OTXXV5V7	moderate	Genetic Variation	[34]
ACADM	OTA4P0FC	Strong	Biomarker	[35]
ASL	OTI2NGQR	Strong	Biomarker	[9]
ASS1	OT4ZMG0Q	Strong	Biomarker	[9]
ATP8B1	OTALGS63	Strong	Genetic Variation	[36]
BTBD8	OT3A3RD7	Strong	Biomarker	[37]
CCL4	OT6B8P25	Strong	Biomarker	[38]
CCL4L2	OTDBSXOU	Strong	Biomarker	[39]
CHN1	OTM196M3	Strong	Genetic Variation	[40]
DLAT	OT9LBJVN	Strong	Biomarker	[41]
EVL	OTZ8ZDNY	Strong	Biomarker	[42]
FAH	OTGZA1YR	Strong	Genetic Variation	[43]
FBL	OTRODIE5	Strong	Genetic Variation	[44]
GFER	OTVK43OK	Strong	Biomarker	[45]
GFM1	OTUN4V3N	Strong	Genetic Variation	[46]
GPLD1	OTUUQOVY	Strong	Biomarker	[47]
HSPA1L	OTC2V1K6	Strong	Genetic Variation	[48]
LECT2	OTSFZ9JD	Strong	Altered Expression	[49]
MLN	OTBZ5SE5	Strong	Altered Expression	[50]
MPV17	OT579DMU	Strong	Genetic Variation	[51]
NBAS	OTW9IBRI	Strong	Genetic Variation	[52]
NPC2	OTE9UEJC	Strong	Genetic Variation	[53]
OPRPN	OT6K1ZD6	Strong	Biomarker	[18]
PARP9	OT7K4494	Strong	Biomarker	[4]
PLRG1	OTIVZ5LL	Strong	Biomarker	[18]
POLG	OTDUCT04	Strong	Genetic Variation	[54]
RPS10	OTE3VSAH	Strong	Biomarker	[55]
RPS6	OTT4D1LN	Strong	Biomarker	[55]
RPS9	OTPV69Q0	Strong	Biomarker	[55]
SCO1	OTC45UGB	Strong	Genetic Variation	[56]
SLA2	OTNVE666	Strong	Biomarker	[24]
TALDO1	OTDKV2S2	Strong	Biomarker	[57]
TANK	OTZSGFIK	Strong	Genetic Variation	[58]
TK2	OTS1V4XB	Strong	Genetic Variation	[59]
TNFAIP8	OT1G9297	Strong	Altered Expression	[60]
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⏷ Show the Full List of 41 DOT(s)

References

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34	Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion. Mol Genet Metab. 2016 Sep;119(1-2):91-9. doi: 10.1016/j.ymgme.2016.07.001. Epub 2016 Jul 4.
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