Details of Disease

General Information of Disease (ID: DISRBCMD)

• Disease Name: Dental caries
• Synonyms: dental caries extending into pulp; dental caries pit and fissure; dental caries of smooth surface
• Disease Class: DA08: Dental disease
• Definition: The decay of a tooth, in which it becomes softened, discolored, and/or porous.
• Disease Hierarchy:
  DISYQYMA: Tooth hard tissue disease
  DISRBCMD: Dental caries
• ICD Code:
  ICD-11: ICD-11: DA08.0
  ICD-9: ICD-9: 521
  Expand ICD-11: 'DA08.0
  Expand ICD-10: 'K02; 'K02.0; 'K02.1; 'K02.2; 'K02.3; 'K02.4; 'K02.5; 'K02.8; 'K02.9
  Expand ICD-9: 521
• Disease Identifiers:
  MONDO ID: MONDO_0005276
  MESH ID: D003731
  UMLS CUI: C0011334
  MedGen ID: 8288
  HPO ID: HP:0000670
  SNOMED CT ID: 80967001

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
STAMP	DM4O4IH	Phase 3	NA	[1]
C16G2	DM6BBQK	Phase 2	Peptide	[2]
CaroRx	DMW0YXQ	Phase 2	NA	[3]
Streptococcus mutans vaccine	DMRZ6SV	Phase 1	NA	[4]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Sharon-2000	DMP5DML	Investigative	NA	[5]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 29 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ABCG2	TTIMJ02	Limited	Genetic Variation	[6]
CA2	TTANPDJ	Limited	Biomarker	[7]
CACNA1E	TTYRP0M	Limited	Biomarker	[8]
DYRK3	TTV4EX0	Limited	Biomarker	[9]
GSS	TTVEWR4	Limited	Biomarker	[10]
INHBA	TTVB30D	Limited	Biomarker	[11]
KRT6A	TT2FX8W	Limited	Genetic Variation	[12]
MTM1	TTY2TCU	Limited	Genetic Variation	[13]
RUNX2	TTD6SZ8	Limited	Genetic Variation	[14]
SRGN	TTCHB06	Limited	Biomarker	[15]
AAK1	TT0Z32T	Strong	Genetic Variation	[16]
ALK	TTPMQSO	Strong	Genetic Variation	[16]
CA12	TTSYM0R	Strong	Genetic Variation	[16]
CA6	TTCFSPE	Strong	Genetic Variation	[17]
ESRRB	TTKF0XS	Strong	Biomarker	[18]
KCNJ3	TTGM19J	Strong	Genetic Variation	[16]
KLK4	TT4319X	Strong	Biomarker	[19]
MBL2	TTMQDZ5	Strong	Genetic Variation	[20]
MMP13	TTHY57M	Strong	Biomarker	[21]
NEDD9	TT1UREA	Strong	Genetic Variation	[22]
NPEPPS	TT371QC	Strong	Genetic Variation	[16]
OPA1	TTTU49Q	Strong	Genetic Variation	[16]
P2RY2	TTOZHQC	Strong	Genetic Variation	[16]
PROM1	TTXMZ81	Strong	Genetic Variation	[23]
RHCG	TTN5MZ3	Strong	Genetic Variation	[16]
RPS6KA2	TT0ZW9O	Strong	Genetic Variation	[24]
SQSTM1	TTOT2RY	Strong	Biomarker	[25]
TMEM219	TTY078U	Strong	Genetic Variation	[16]
VDR	TTK59TV	Strong	Genetic Variation	[26]

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC25A20	DTQOUM4	Limited	Biomarker	[7]
SLC25A32	DTM8E7H	Strong	Biomarker	[27]
SLC2A2	DTUJPOL	Strong	Genetic Variation	[28]

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
ADHFE1	DE8RJ3F	Limited	Biomarker	[29]
LPO	DEHX1DZ	Strong	Biomarker	[30]

This Disease Is Related to 71 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACTN2	OT9FOLD7	Limited	Biomarker	[31]
AMBN	OTWASIMQ	Limited	Biomarker	[32]
BCORL1	OTPTFQN5	Limited	Biomarker	[11]
BPIFA1	OTQFD2J5	Limited	Genetic Variation	[33]
BTF3	OT5ZZFJL	Limited	Altered Expression	[34]
C5AR2	OTP1Q82J	Limited	Biomarker	[35]
CALML3	OTM8DNQU	Limited	Biomarker	[36]
CCL28	OTY6XNQ7	Limited	Biomarker	[37]
CD5L	OTPY4WQR	Limited	Biomarker	[38]
CELF4	OT4FS4F5	Limited	Biomarker	[39]
COTL1	OT6YCNLF	Limited	Biomarker	[36]
CREBZF	OTO3TOEU	Limited	Biomarker	[40]
CSRP3	OTECBJMV	Limited	Biomarker	[36]
CTNND1	OTUMPSHR	Limited	Biomarker	[7]
DCD	OTV5PBGJ	Limited	Biomarker	[41]
DEFB103B	OT8RWY64	Limited	Biomarker	[42]
DMP1	OTBWBWW7	Limited	Biomarker	[43]
EFS	OT06O7XL	Limited	Biomarker	[44]
GALK2	OTHR35JF	Limited	Biomarker	[39]
GNAT3	OTS96V19	Limited	Genetic Variation	[45]
IK	OTWSSXX0	Limited	Biomarker	[9]
KPNA4	OTP0EX18	Limited	Genetic Variation	[33]
KRT6B	OTBXJYHY	Limited	Genetic Variation	[12]
KRT6C	OT9RXMPK	Limited	Genetic Variation	[12]
LYZL2	OTMOASTL	Limited	Biomarker	[46]
MPPED2	OT7XLMJ6	Limited	Biomarker	[31]
MUC19	OTM06UGV	Limited	Biomarker	[47]
NOCT	OTVSYP2D	Limited	Biomarker	[48]
PDZK1IP1	OTWA6M5K	Limited	Genetic Variation	[49]
PIF1	OTUHKKVP	Limited	Biomarker	[41]
PIGA	OT51UWUR	Limited	Genetic Variation	[50]
PLEKHO1	OTMVUQ9W	Limited	Altered Expression	[51]
PPRC1	OT6GB3WR	Limited	Biomarker	[52]
SERPINF2	OTZGAF8B	Limited	Biomarker	[53]
SMIM10L2B	OT04IG2N	Limited	Biomarker	[54]
SRSF10	OTY6IJ11	Limited	Genetic Variation	[28]
TAS1R3	OTOVM44D	Limited	Genetic Variation	[55]
TFIP11	OT7NVSWU	Limited	Genetic Variation	[56]
TMTC3	OTMTTDYG	Limited	Biomarker	[40]
ADAMTS3	OT2U6VF5	Strong	Genetic Variation	[24]
ADCY3	OTGOQM6B	Strong	Genetic Variation	[16]
ALLC	OTZE4XV7	Strong	Genetic Variation	[22]
AQP5	OT77GBY8	Strong	Altered Expression	[57]
ATXN7L1	OT5EZO0M	Strong	Genetic Variation	[23]
C4BPA	OTHNH6Y8	Strong	Biomarker	[41]
CDC14A	OTL10OY6	Strong	Genetic Variation	[58]
CDH9	OTV9N5XK	Strong	Genetic Variation	[16]
CDKN3	OTBE3H07	Strong	Genetic Variation	[24]
CYLD	OT37FKH0	Strong	Biomarker	[27]
DEFB1	OT5SV0E4	Strong	Genetic Variation	[59]
DSPP	OT1TYNDN	Strong	Biomarker	[60]
FAM118A	OT6EM97E	Strong	Genetic Variation	[16]
HOXB3	OT9UC5PE	Strong	Genetic Variation	[16]
ITPKB	OTSVVPAV	Strong	Genetic Variation	[16]
KRT75	OT28B9E6	Strong	Genetic Variation	[61]
LRWD1	OTHRVJQC	Strong	Biomarker	[25]
MAMSTR	OT4J6Z7G	Strong	Genetic Variation	[16]
MMP20	OT16S5S3	Strong	Biomarker	[62]
MTMR3	OTBIT23O	Strong	Genetic Variation	[16]
MUC5B	OTPW6K5C	Strong	Altered Expression	[63]
NEO1	OTGJ1997	Strong	Genetic Variation	[16]
NHS	OTKE8QAT	Strong	Biomarker	[64]
PBX3	OT8WMVM4	Strong	Genetic Variation	[16]
PRH1	OTQZ6HX0	Strong	Genetic Variation	[41]
PRUNE2	OTGW2974	Strong	Genetic Variation	[16]
STAG1	OT564IX4	Strong	Genetic Variation	[16]
SYT14	OTE1V1OW	Strong	Genetic Variation	[16]
TAS1R2	OT53VYMN	Strong	Genetic Variation	[65]
TAS2R38	OTX5MM36	Strong	Genetic Variation	[66]
TMEM59L	OTSN3KG4	Strong	Genetic Variation	[16]
TRIM46	OTFE7WZW	Strong	Genetic Variation	[16]

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