Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTKJBEMD)

DOT Name CCN family member 1 (CCN1)
Synonyms Cellular communication network factor 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein CYR61; Protein GIG1
Gene Name CCN1
UniProt ID
CCN1_HUMAN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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PDB ID
4D0Z; 4D11
Pfam ID
PF00007 ; PF00219 ; PF19035 ; PF00093
Sequence
MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQL
NEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQ
CTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLG
KELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCS
KTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTY
AGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCP
HANEAAFPFYRLFNDIHKFRD
Function
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Reactome Pathway
Post-translational protein phosphorylation (R-HSA-8957275 )
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (R-HSA-381426 )

Molecular Interaction Atlas (MIA) of This DOT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DOT
This DOT Affected the Drug Response of 2 Drug(s)
Drug Name Drug ID Highest Status Interaction REF
Irinotecan DMP6SC2 Approved CCN family member 1 (CCN1) decreases the response to substance of Irinotecan. [48]
Paclitaxel DMLB81S Approved CCN family member 1 (CCN1) increases the response to substance of Paclitaxel. [48]
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54 Drug(s) Affected the Gene/Protein Processing of This DOT
Drug Name Drug ID Highest Status Interaction REF
Valproate DMCFE9I Approved Valproate increases the expression of CCN family member 1 (CCN1). [1]
Ciclosporin DMAZJFX Approved Ciclosporin decreases the expression of CCN family member 1 (CCN1). [2]
Tretinoin DM49DUI Approved Tretinoin increases the expression of CCN family member 1 (CCN1). [3]
Acetaminophen DMUIE76 Approved Acetaminophen increases the expression of CCN family member 1 (CCN1). [4]
Cupric Sulfate DMP0NFQ Approved Cupric Sulfate increases the expression of CCN family member 1 (CCN1). [5]
Estradiol DMUNTE3 Approved Estradiol decreases the expression of CCN family member 1 (CCN1). [6]
Ivermectin DMDBX5F Approved Ivermectin decreases the expression of CCN family member 1 (CCN1). [7]
Quercetin DM3NC4M Approved Quercetin increases the expression of CCN family member 1 (CCN1). [8]
Temozolomide DMKECZD Approved Temozolomide increases the expression of CCN family member 1 (CCN1). [9]
Arsenic trioxide DM61TA4 Approved Arsenic trioxide decreases the expression of CCN family member 1 (CCN1). [10]
Hydrogen peroxide DM1NG5W Approved Hydrogen peroxide increases the expression of CCN family member 1 (CCN1). [11]
Calcitriol DM8ZVJ7 Approved Calcitriol decreases the expression of CCN family member 1 (CCN1). [12]
Carbamazepine DMZOLBI Approved Carbamazepine affects the expression of CCN family member 1 (CCN1). [13]
Methotrexate DM2TEOL Approved Methotrexate increases the expression of CCN family member 1 (CCN1). [14]
Zoledronate DMIXC7G Approved Zoledronate decreases the expression of CCN family member 1 (CCN1). [15]
Phenobarbital DMXZOCG Approved Phenobarbital affects the expression of CCN family member 1 (CCN1). [16]
Menadione DMSJDTY Approved Menadione increases the expression of CCN family member 1 (CCN1). [11]
Fluorouracil DMUM7HZ Approved Fluorouracil increases the expression of CCN family member 1 (CCN1). [17]
Troglitazone DM3VFPD Approved Troglitazone decreases the expression of CCN family member 1 (CCN1). [18]
Hydroquinone DM6AVR4 Approved Hydroquinone affects the expression of CCN family member 1 (CCN1). [19]
Azathioprine DMMZSXQ Approved Azathioprine increases the expression of CCN family member 1 (CCN1). [14]
Ethanol DMDRQZU Approved Ethanol decreases the expression of CCN family member 1 (CCN1). [20]
Diclofenac DMPIHLS Approved Diclofenac increases the expression of CCN family member 1 (CCN1). [14]
Piroxicam DMTK234 Approved Piroxicam increases the expression of CCN family member 1 (CCN1). [14]
Sodium lauryl sulfate DMLJ634 Approved Sodium lauryl sulfate increases the expression of CCN family member 1 (CCN1). [21]
Simvastatin DM30SGU Approved Simvastatin decreases the expression of CCN family member 1 (CCN1). [22]
Fenofibrate DMFKXDY Approved Fenofibrate decreases the expression of CCN family member 1 (CCN1). [23]
Palbociclib DMD7L94 Approved Palbociclib increases the expression of CCN family member 1 (CCN1). [24]
Prednisolone DMQ8FR2 Approved Prednisolone increases the expression of CCN family member 1 (CCN1). [14]
Methylprednisolone DM4BDON Approved Methylprednisolone increases the expression of CCN family member 1 (CCN1). [14]
Bexarotene DMOBIKY Approved Bexarotene decreases the expression of CCN family member 1 (CCN1). [25]
Ampicillin DMHWE7P Approved Ampicillin increases the expression of CCN family member 1 (CCN1). [8]
Capecitabine DMTS85L Approved Capecitabine decreases the expression of CCN family member 1 (CCN1). [26]
Urethane DM7NSI0 Phase 4 Urethane decreases the expression of CCN family member 1 (CCN1). [27]
Seocalcitol DMKL9QO Phase 3 Seocalcitol decreases the expression of CCN family member 1 (CCN1). [28]
Genistein DM0JETC Phase 2/3 Genistein decreases the expression of CCN family member 1 (CCN1). [29]
Belinostat DM6OC53 Phase 2 Belinostat increases the expression of CCN family member 1 (CCN1). [30]
Afimoxifene DMFORDT Phase 2 Afimoxifene increases the expression of CCN family member 1 (CCN1). [31]
Benzo(a)pyrene DMN7J43 Phase 1 Benzo(a)pyrene increases the expression of CCN family member 1 (CCN1). [32]
(+)-JQ1 DM1CZSJ Phase 1 (+)-JQ1 increases the expression of CCN family member 1 (CCN1). [33]
Leflunomide DMR8ONJ Phase 1 Trial Leflunomide increases the expression of CCN family member 1 (CCN1). [34]
Torcetrapib DMDHYM7 Discontinued in Phase 2 Torcetrapib increases the expression of CCN family member 1 (CCN1). [36]
THAPSIGARGIN DMDMQIE Preclinical THAPSIGARGIN increases the expression of CCN family member 1 (CCN1). [37]
Bisphenol A DM2ZLD7 Investigative Bisphenol A decreases the expression of CCN family member 1 (CCN1). [38]
Trichostatin A DM9C8NX Investigative Trichostatin A increases the expression of CCN family member 1 (CCN1). [39]
Formaldehyde DM7Q6M0 Investigative Formaldehyde increases the expression of CCN family member 1 (CCN1). [40]
Milchsaure DM462BT Investigative Milchsaure increases the expression of CCN family member 1 (CCN1). [41]
methyl p-hydroxybenzoate DMO58UW Investigative methyl p-hydroxybenzoate decreases the expression of CCN family member 1 (CCN1). [42]
Paraquat DMR8O3X Investigative Paraquat increases the expression of CCN family member 1 (CCN1). [43]
Phencyclidine DMQBEYX Investigative Phencyclidine increases the expression of CCN family member 1 (CCN1). [44]
OXYQUINOLINE DMZVS9Y Investigative OXYQUINOLINE increases the expression of CCN family member 1 (CCN1). [8]
CH-223191 DMMJZYC Investigative CH-223191 increases the expression of CCN family member 1 (CCN1). [45]
LICOAGROCHACONE A DMWY0TN Investigative LICOAGROCHACONE A decreases the expression of CCN family member 1 (CCN1). [46]
Ginsenoside RG3 DMFN58T Investigative Ginsenoside RG3 decreases the expression of CCN family member 1 (CCN1). [47]
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⏷ Show the Full List of 54 Drug(s)
1 Drug(s) Affected the Post-Translational Modifications of This DOT
Drug Name Drug ID Highest Status Interaction REF
TAK-243 DM4GKV2 Phase 1 TAK-243 increases the sumoylation of CCN family member 1 (CCN1). [35]
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