Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM15P2G)

Drug Name

(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol Drug Info

Synonyms

Lificiguat; yc-1; 170632-47-0; 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole; YC 1; UNII-515CC1WPTE; Lificiguat(YC-1); 154453-18-6; [5-(1-benzyl-1h-indazol-3-yl)-2-furyl]methanol; 515CC1WPTE; CHEMBL333985; OQQVFCKUDYMWGV-UHFFFAOYSA-N; C19H16N2O2; 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole; 1-Benzyl-3-(5-hydroxymethyl-2-furyl)indazole; [5-(1-benzyl-1H-indazol-3-yl)furan-2-yl]methanol; 5-[1-(Phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol; YC-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5712
ChEBI ID: CHEBI:93060
CAS Number: CAS 170632-47-0
TTD Drug ID: DM15P2G

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Approved Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting HIF1-alpha messenger RNA (HIF1A mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PT2385	DMCSN69	Recurrent glioblastoma	2A00.00	Phase 2	[8]
ISIS 298697	DM0WH1L	Discovery agent	N.A.	Investigative	[9]
ISIS 298744	DM8VMQ4	Discovery agent	N.A.	Investigative	[9]
ISIS 298746	DMHOJ0Z	Discovery agent	N.A.	Investigative	[9]
ISIS 298745	DM9YMPI	Discovery agent	N.A.	Investigative	[9]
ISIS 298743	DMD3NSQ	Discovery agent	N.A.	Investigative	[9]
ISIS 298702	DM4L7NE	Discovery agent	N.A.	Investigative	[9]
ISIS 298700	DM3DE98	Discovery agent	N.A.	Investigative	[9]
ISIS 175510	DMPAXR4	Discovery agent	N.A.	Investigative	[9]
ISIS 298699	DMB28JW	Discovery agent	N.A.	Investigative	[9]
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Drug(s) Targeting Soluble guanylate cyclase (GCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[10]
Nitroglycerin	DMQ2491	Angina pectoris	BA40	Approved	[3]
Sodium nitroprusside	DMGA9X0	Hypertension	BA00-BA04	Approved	[11]
IW-1973	DMK2T7J	Heart failure	BD10-BD13	Phase 2	[12]
CTI-1601	DMM4JMB	Friedreich's ataxia	8A03.10	Phase 2	[13]
Runcaciguat	DMCFTTN	Chronic kidney disease	GB61	Phase 2	[14]
MK-5475	DMIIZ4R	Pulmonary arterial hypertension	BB01.0	Phase 2	[15]
CY6463	DM84AVQ	Alzheimer disease	8A20	Phase 2	[16]
CY6463	DM84AVQ	Alzheimer disease	8A20	Phase 2	[17]
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Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[19]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[20]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[21]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[25]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[22]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[26]
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Drug(s) Affected By cGMP-dependent protein kinase 1 (PRKG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[29]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[30]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[31]
Methamphetamine	DMPM4SK	Anxiety		Approved	[32]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[5]
CP-461	DMEYMTX	Inflammatory bowel disease	DD72	Phase 2	[5]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[33]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[34]
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Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX15 (ALOX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[40]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[31]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[41]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[42]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[43]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[47]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[49]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[50]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[52]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[53]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[54]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[57]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[60]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[61]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[62]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[63]
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Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[66]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[67]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[68]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[69]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[70]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[71]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[72]
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Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[75]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[81]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[54]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[60]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[82]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[76]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[83]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[85]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[86]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HIF1-alpha messenger RNA (HIF1A mRNA)	TTSN6QU	HIF1A_HUMAN	Inhibitor	[2]
Soluble guanylate cyclase (GCS)	TT23PYC	GCYA1_HUMAN; GCYB1_HUMAN	Activator	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[4]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[4]
cGMP-dependent protein kinase 1 (PRKG1)	OTPAS4LF	KGP1_HUMAN	Gene/Protein Processing	[5]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Protein Interaction/Cellular Processes	[4]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Gene/Protein Processing	[6]
Polyunsaturated fatty acid lipoxygenase ALOX15 (ALOX15)	OT0RTR7M	LOX15_HUMAN	Gene/Protein Processing	[7]

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References

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