Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM15P2G)

Drug Name
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol Drug Info
Synonyms
Lificiguat; yc-1; 170632-47-0; 3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole; YC 1; UNII-515CC1WPTE; Lificiguat(YC-1); 154453-18-6; [5-(1-benzyl-1h-indazol-3-yl)-2-furyl]methanol; 515CC1WPTE; CHEMBL333985; OQQVFCKUDYMWGV-UHFFFAOYSA-N; C19H16N2O2; 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole; 1-Benzyl-3-(5-hydroxymethyl-2-furyl)indazole; [5-(1-benzyl-1H-indazol-3-yl)furan-2-yl]methanol; 5-[1-(Phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol; YC-1
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1] , [2]
Cross-matching ID
PubChem CID
5712
ChEBI ID
CHEBI:93060
CAS Number
CAS 170632-47-0
TTD Drug ID
DM15P2G

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting HIF1-alpha messenger RNA (HIF1A mRNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PT2385 DMCSN69 Recurrent glioblastoma 2A00.00 Phase 2 [4]
ISIS 298697 DM0WH1L Discovery agent N.A. Investigative [5]
ISIS 298744 DM8VMQ4 Discovery agent N.A. Investigative [5]
ISIS 298746 DMHOJ0Z Discovery agent N.A. Investigative [5]
ISIS 298745 DM9YMPI Discovery agent N.A. Investigative [5]
ISIS 298743 DMD3NSQ Discovery agent N.A. Investigative [5]
ISIS 298702 DM4L7NE Discovery agent N.A. Investigative [5]
ISIS 298700 DM3DE98 Discovery agent N.A. Investigative [5]
ISIS 175510 DMPAXR4 Discovery agent N.A. Investigative [5]
ISIS 298699 DMB28JW Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Soluble guanylate cyclase (GCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Respiratory failure CB41 Approved [6]
Nitroglycerin DMQ2491 Angina pectoris BA40 Approved [3]
Sodium nitroprusside DMGA9X0 Hypertension BA00-BA04 Approved [7]
IW-1973 DMK2T7J Heart failure BD10-BD13 Phase 2 [8]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
HIF1-alpha messenger RNA (HIF1A mRNA) TTSN6QU HIF1A_HUMAN Inhibitor [2]
Soluble guanylate cyclase (GCS) TT23PYC GCYA1_HUMAN; GCYB1_HUMAN Activator [3]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5291).
2 Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6305-10.
3 Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction. Int J Impot Res. 2002 Feb;14(1):8-14.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 US patent application no. 7,217,572, Modulation of HIF1.alpha. and HIF2.alpha. expression.
6 Nitric oxide and nitrovasodilators: similarities, differences, and interactions. Am J Cardiol. 1996 May 30;77(13):2C-7C.
7 Stimulators and activators of soluble guanylate cyclase: review and potential therapeutic indications.Crit Care Res Pract.2012;2012:290805.
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)