Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM37NYK)

Drug Name	Citrate Drug Info
Cross-matching ID	PubChem CID 311 ChEBI ID CHEBI:30769 CAS Number CAS 77-92-9 TTD Drug ID DM37NYK VARIDT Drug ID DR01247

Molecule-Related Drug Atlas

Molecule Type:

DTP

DOT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Transported By Sodium-coupled citrate transporter (SLC13A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
alpha-ketoglutaric acid	DM5LFYN	Discovery agent	N.A.	Investigative	[1]
Succinate	DMPY09A	N. A.	N. A.	Investigative	[1]
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Drug(s) Affected By Na(+)/citrate cotransporter (SLC13A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[10]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[11]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[12]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[13]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
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Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Haloperidol	DM96SE0	Delirium		Approved	[22]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[23]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[25]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[10]
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Drug(s) Affected By Biotin--protein ligase (HLCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[3]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[31]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[34]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[29]
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Drug(s) Affected By Mucin-5AC (MUC5AC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[37]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[6]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[35]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[38]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[35]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[39]
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Drug(s) Affected By Transient receptor potential cation channel subfamily V member 1 (TRPV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[45]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[46]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[47]
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Drug(s) Affected By Kallikrein-5 (KLK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[17]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[49]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[51]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[53]
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Drug(s) Affected By Angiopoietin-related protein 3 (ANGPTL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[2]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[54]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[2]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[55]
Indomethacin	DMSC4A7	Bursitis		Approved	[54]
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Drug(s) Affected By Solute carrier family 13 member 2 (SLC13A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium-coupled citrate transporter (SLC13A5)	DTFPWJ9	S13A5_HUMAN	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Angiopoietin-related protein 3 (ANGPTL3)	OTCD5Z9W	ANGL3_HUMAN	Gene/Protein Processing	[2]
Biotin--protein ligase (HLCS)	OTPDUX30	BPL1_HUMAN	Gene/Protein Processing	[3]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[4]
Kallikrein-5 (KLK5)	OT2TQXS7	KLK5_HUMAN	Gene/Protein Processing	[5]
Mucin-5AC (MUC5AC)	OTJV8O04	MUC5A_HUMAN	Protein Interaction/Cellular Processes	[6]
Na(+)/citrate cotransporter (SLC13A5)	OTPH1TA7	S13A5_HUMAN	Regulation of Drug Effects	[7]
Solute carrier family 13 member 2 (SLC13A2)	OTM49E8O	S13A2_HUMAN	Regulation of Drug Effects	[8]
Transient receptor potential cation channel subfamily V member 1 (TRPV1)	OTHHDR03	TRPV1_HUMAN	Gene/Protein Processing	[6]
Vascular endothelial growth factor A, long form	OTIM9MZ3	VEGFA_HUMAN	Drug Response	[9]

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