Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5L7D3)

Drug Name
[3H]oxotremorine-M Drug Info
Synonyms
Oxotremorine M; oxotremorine-M; CHEBI:38322; N,N,N-trimethyl-4-(2-oxopyrrolidin-1-yl)but-2-yn-1-aminium; 63939-65-1; trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium; N,N,N-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-aminium; 2-Butyn-1-aminium, N,N,N-trimethyl-4-(2-oxo-1-pyrrolidinyl)-; CHEMBL23957; Tocris-1067; Spectrum_001982; OXO-M; Lopac-O-100; AC1L1ILG; AC1Q6FK0; Lopac0_000954; GTPL303; KBioSS_002548; CHEMBL44674; DivK1c_000379; SCHEMBL4542695; GTPL8595; KBio2_005107; KBio2_002539; KBio1_000379
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
4629
ChEBI ID
CHEBI:38322
CAS Number
CAS 63939-65-1
TTD Drug ID
DM5L7D3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Muscarinic acetylcholine receptor (CHRM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetylcholine DMDF79Z Cataract 9B10 Approved [5]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [6]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [7]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [8]
Clidinium DMUMQZ0 Abdominal stomach pain DD91.4 Approved [9]
Oxybutynin hydrochloride DMF2KLU Urinary incontinence MF50.2 Approved [10]
Incruse Ellipta DM32GSJ Chronic obstructive pulmonary disease CA22 Approved [11]
Revefenacin DMMP5SI Chronic obstructive pulmonary disease CA22 Approved [12]
Scopolamine DMOM8AL Addictive disorder 6C50-6C5Z Approved [13]
Isopropamide iodide DMQYV60 Allergic rhinitis CA08.0 Approved [14]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Muscarinic acetylcholine receptor M3 (CHRM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolterodine DMSHPW8 Overactive bladder GC50.0 Approved [15]
ACECLIDINE DMOLNCZ Glaucoma/ocular hypertension 9C61 Approved [16]
Tiotropium DMFDC0Q Chronic obstructive pulmonary disease CA22 Approved [17]
Ipratropium DMFQ320 Obstructive lung disease CA22.Z Approved [18]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [19]
Methacholine Chloride DMGS4QH Asthma CA23 Approved [20]
SMT-D002 DM1I93C Seborrhea ED91.2 Approved [21]
Solifenacin DMG592Q Overactive bladder GC50.0 Approved [22]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [23]
Cevimeline DMWSMND Sjogren syndrome 4A43.20 Approved [24]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [2]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Panobinostat DM58WKG Chronic graft versus host disease Approved [27]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [28]
Testosterone DM7HUNW Hot flushes GA30 Approved [29]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [30]
Acetylcholine DMDF79Z Cataract 9B10 Approved [31]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [31]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [35]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [34]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [36]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paxillin (PXN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [43]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [44]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [48]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [49]
Terbinafine DMI6HUW Fungal infection 1F29-1F2F Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breast cancer anti-estrogen resistance protein 1 (BCAR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Benzatropine DMF7EXL Parkinsonian disorder Approved [55]
Clozapine DMFC71L Schizophrenia 6A20 Approved [55]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [56]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [57]
Arsenic DMTL2Y1 N. A. N. A. Approved [58]
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Drug(s) Affected By Focal adhesion kinase 1 (PTK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [63]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [64]
Testosterone DM7HUNW Hot flushes GA30 Approved [65]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [67]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Muscarinic acetylcholine receptor M4 (CHRM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ALCURONIUM DM2U4XQ Anaesthesia 9A78.6 Approved [69]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [54]
Acetylcholine DMDF79Z Cataract 9B10 Approved [70]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [69]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [72]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [2]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [2]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [73]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [74]
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Drug(s) Affected By Muscarinic acetylcholine receptor M1 (CHRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pirenzepine DMP6M1N Peptic ulcer DA61 Approved [75]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [76]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [77]
Acetylcholine DMDF79Z Cataract 9B10 Approved [78]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [31]
Clozapine DMFC71L Schizophrenia 6A20 Approved [79]
Olanzapine DMPFN6Y Bipolar depression Approved [80]
Gallamine Triethiodide DMPO0MS Stabilize muscle contraction FB3Z Approved [81]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [78]
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [2]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Muscarinic acetylcholine receptor M2 (CHRM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylscopolamine DM5VWOB Peptic ulcer DA61 Approved [82]
Gallamine Triethiodide DMPO0MS Stabilize muscle contraction FB3Z Approved [82]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Acetylcholine DMDF79Z Cataract 9B10 Approved [70]
Omadacycline DMR2J95 Acute bacterial skin infection 1C41 Approved [83]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [84]
Carbachol DMX9K8F Glaucoma/ocular hypertension 9C61 Approved [2]
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [85]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [73]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Muscarinic acetylcholine receptor (CHRM) TTOXS3C NOUNIPROTAC Agonist [2]
Muscarinic acetylcholine receptor M3 (CHRM3) TTQ13Z5 ACM3_HUMAN Agonist [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Breast cancer anti-estrogen resistance protein 1 (BCAR1) OTKT2C2N BCAR1_HUMAN Post-Translational Modifications [3]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Post-Translational Modifications [3]
Muscarinic acetylcholine receptor M1 (CHRM1) OTKW3E6B ACM1_HUMAN Drug Response [2]
Muscarinic acetylcholine receptor M2 (CHRM2) OTUMZ2WR ACM2_HUMAN Drug Response [2]
Muscarinic acetylcholine receptor M3 (CHRM3) OTKSD095 ACM3_HUMAN Drug Response [2]
Muscarinic acetylcholine receptor M4 (CHRM4) OTF0F0FF ACM4_HUMAN Drug Response [2]
Paxillin (PXN) OTVMMUOF PAXI_HUMAN Post-Translational Modifications [3]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Gene/Protein Processing [4]

References

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42 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
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48 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
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54 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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61 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
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64 Activation of cannabinoid receptors promote periodontal cell adhesion and migration. J Clin Periodontol. 2019 Dec;46(12):1264-1272. doi: 10.1111/jcpe.13190. Epub 2019 Oct 22.
65 Monomeric and oligomeric flavanols are agonists of membrane androgen receptors. Exp Cell Res. 2005 Oct 1;309(2):329-39. doi: 10.1016/j.yexcr.2005.06.011.
66 Disruption of FAK signaling: a side mechanism in cytotoxicity. Toxicology. 2008 Mar 12;245(1-2):1-10. doi: 10.1016/j.tox.2007.12.003. Epub 2007 Dec 15.
67 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
68 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
69 Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors. Mol Pharmacol. 2006 Aug;70(2):736-46. doi: 10.1124/mol.106.024711. Epub 2006 May 18.
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72 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
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74 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
75 Fluorescent pirenzepine derivatives as potential bitopic ligands of the human M1 muscarinic receptor. J Med Chem. 2004 Aug 12;47(17):4300-15. doi: 10.1021/jm040800a.
76 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
77 Evaluation of first generation synthetic cannabinoids on binding at non-cannabinoid receptors and in a battery of in?vivo assays in mice. Neuropharmacology. 2016 Nov;110(Pt A):143-153. doi: 10.1016/j.neuropharm.2016.07.016. Epub 2016 Jul 20.
78 Regional differences in functional receptor distribution and calcium mobilization in the intact human lens. Invest Ophthalmol Vis Sci. 2001 Sep;42(10):2355-63.
79 Increasing D2 affinity results in the loss of clozapine's atypical antipsychotic action. Neuroreport. 2002 May 7;13(6):831-5. doi: 10.1097/00001756-200205070-00019.
80 No evidence for binding of clozapine, olanzapine and/or haloperidol to selected receptors involved in body weight regulation. Pharmacogenomics J. 2007 Aug;7(4):275-81. doi: 10.1038/sj.tpj.6500418. Epub 2006 Sep 19.
81 Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site. Mol Pharmacol. 2000 Jul;58(1):194-207.
82 Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity. Mol Pharmacol. 2006 Jul;70(1):181-93. doi: 10.1124/mol.106.023481. Epub 2006 Apr 26.
83 In Vitro and In Vivo Assessments of Cardiovascular Effects with Omadacycline. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5247-53. doi: 10.1128/AAC.00320-16. Print 2016 Sep.
84 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
85 Characterization of the potent, selective Nrf2 activator, 3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one, in cellular and in vivo models of pulmonary oxidative stress. J Pharmacol Exp Ther. 2017 Oct;363(1):114-125.