Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5ZOX8)

Drug Name

Benoxaprofen Drug Info

Synonyms

Benoxaprofene; Benoxaprofeno; Benoxaprofenum; Coxigon; Inflamid; Opren; Oraflex; Uniprofen; LRCL3794; Lilly 90459; Benoxaprofene [INN-French]; Benoxaprofeno [INN-Spanish]; Benoxaprofenum [INN-Latin]; Dl-Benoxaprofen; Oraflex (TN); Benoxaprofen (USAN/INN); Benoxaprofen [USAN:INN:BAN]; (+-)-2-(p-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid; (-)-2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid; (-)-Benoxaprofen; (1)-2-(4-Chlorophenyl)benzoxazole-5-propionic acid; 2-(2-(4-Chlorophenyl)-1,3-benzoxazol-5-yl)propanoic acid; 2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid; 2-(p-Chlorophenyl)-.alpha.-methyl-5-benzoxazoleacetic acid; 2-[2-(4-Chlorophenyl)-1,3-benzoxazol-5-yl]propanoic acid

Indication

Disease Entry	ICD 11	Status	REF
Inflammation	1A00-CA43.1	Withdrawn from market	[1]

Cross-matching ID

PubChem CID: 39941
ChEBI ID: CHEBI:76114
CAS Number: CAS 51234-28-7
TTD Drug ID: DM5ZOX8

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Acetoacetyl-CoA thiolase (ACAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ATR-01	DMU67HD	Adrenocortical carcinoma	2D11.Z	Phase 1	[9]
PMID25470667-Compound-K-604	DMYZ2UA	N. A.	N. A.	Patented	[10]
PMID16242323C18a	DMI5WPQ	Discovery agent	N.A.	Investigative	[11]
PMID16242323C16	DM2Q79X	Discovery agent	N.A.	Investigative	[11]
PMID16242323C22c	DMFDRMH	Discovery agent	N.A.	Investigative	[11]
PMID16242323C26a	DMD0Q7K	Discovery agent	N.A.	Investigative	[11]
Nonanoic acid biphenyl-2-ylamide	DM951PF	Discovery agent	N.A.	Investigative	[12]
Octanoic acid biphenyl-2-ylamide	DM4RGCX	Discovery agent	N.A.	Investigative	[12]
PMID16242323C22d	DMJICNL	Discovery agent	N.A.	Investigative	[11]
PMID16242323C15a	DMM4A7P	Discovery agent	N.A.	Investigative	[11]
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Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[15]
Fructose	DM43AN2	Vomiting	MD90	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[17]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[20]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[21]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[22]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[23]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[5]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[24]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[29]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[30]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[31]
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Drug(s) Affected By Beta-glucuronidase (GUSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[35]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[36]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[39]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[40]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[5]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[42]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[43]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[44]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[45]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[46]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[47]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[48]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[49]
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Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[50]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[51]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[52]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[53]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[54]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[55]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[56]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[57]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetoacetyl-CoA thiolase (ACAT1)	TTK3C21	THIL_HUMAN	Inhibitor	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Drug Response	[3]
Beta-glucuronidase (GUSB)	OT9N1DK3	BGLR_HUMAN	Protein Interaction/Cellular Processes	[4]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[5]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Gene/Protein Processing	[5]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)	OT7FOIK2	LOX5_HUMAN	Gene/Protein Processing	[6]
UDP-glucuronosyltransferase 1A3	OTUEOER3	UD13_HUMAN	Drug Response	[7]
UDP-glucuronosyltransferase 1A9	OTPCHAFX	UD19_HUMAN	Drug Response	[7]
UDP-glucuronosyltransferase 2B7	OT2Q71VQ	UD2B7_HUMAN	Biotransformations	[8]

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