Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCQUWI)

Drug Name
PI-3065 Drug Info
Synonyms PI 3065
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
24937012
TTD Drug ID
DMCQUWI

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting PI3-kinase beta (PIK3CB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Buparlisib DM1WEHC Breast cancer 2C60-2C65 Phase 3 [3]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [4]
PA-799 DMLSYJQ Colorectal cancer 2B91.Z Phase 1/2 [5]
AZD8186 DMWYF1H Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
GSK2636771 DMCBGLW Prostate cancer 2C82.0 Phase 1 [7]
BAY 1082439 DMLRGX1 Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
AZD6482 DMVP4E5 Thrombosis DB61-GB90 Terminated [9]
PP121 DMU8KTO Discovery agent N.A. Investigative [10]
PIK-75 DM9BQTX Discovery agent N.A. Investigative [11]
KU-0060648 DMQWS6U Discovery agent N.A. Investigative [12]
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Drug(s) Targeting PI3-kinase gamma (PIK3CG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAY 80-6946 DMLOS5R Follicular lymphoma 2A80 Approved [13]
IPI-145 DMWA24P Follicular lymphoma 2A80 Approved [14]
Buparlisib DM1WEHC Breast cancer 2C60-2C65 Phase 3 [3]
Enzastaurin DM5H0R9 Diffuse large B-cell lymphoma 2A81 Phase 3 [15]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [16]
GDC-0032 DMT4QHD Breast cancer 2C60-2C65 Phase 3 [15]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [17]
SAR245409 DMQM7IL Solid tumour/cancer 2A00-2F9Z Phase 2 [18]
XL147 DMML7BE Solid tumour/cancer 2A00-2F9Z Phase 2 [18]
SF1126 DML10K3 Head and neck cancer 2D42 Phase 2 [19]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [20]
Gefitinib DM15F0X Colon adenocarcinoma Approved [21]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [22]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [23]
Etretinate DM2CZFA Keratosis ED56 Approved [24]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [25]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [26]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [34]
Paclitaxel DMLB81S Breast carcinoma Approved [35]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [36]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [38]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [39]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Gefitinib DM15F0X Colon adenocarcinoma Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [23]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [43]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [44]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [43]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [45]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [46]
Methotrexate DM2TEOL Anterior urethra cancer Approved [47]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [48]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [49]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [50]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [51]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Verapamil DMA7PEW Angina pectoris BA40 Approved [53]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [54]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [55]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [56]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [57]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [59]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [60]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [62]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [65]
Panobinostat DM58WKG Chronic graft versus host disease Approved [66]
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Drug(s) Affected By Cadherin-2 (CDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Quercetin DM3NC4M Obesity 5B81 Approved [62]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Panobinostat DM58WKG Chronic graft versus host disease Approved [66]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [72]
Testosterone DM7HUNW Hot flushes GA30 Approved [73]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [74]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [76]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [77]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [34]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [78]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [79]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [80]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [81]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [82]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [83]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [48]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [83]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Verapamil DMA7PEW Angina pectoris BA40 Approved [53]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [57]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [84]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Meloxicam DM2AR7L Arthritis FA20 Approved [86]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [44]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [55]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [57]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [87]
Methotrexate DM2TEOL Anterior urethra cancer Approved [88]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [89]
Quercetin DM3NC4M Obesity 5B81 Approved [90]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [92]
Ethacrynic acid DM60QMR Edema MG29 Approved [93]
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Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [94]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [96]
Quercetin DM3NC4M Obesity 5B81 Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [98]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [99]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [100]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [101]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase beta (PIK3CB) TTTHBCA PK3CB_HUMAN Inhibitor [1]
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [2]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [2]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [2]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [2]
Cadherin-2 (CDH2) OTH0Y56P CADH2_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [2]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [2]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Gene/Protein Processing [2]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [2]

References

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2 PI3K inhibitor PI-3065 induces apoptosis in hepatocellular carcinoma cells by targeting survivin. Chem Biol Interact. 2023 Feb 1;371:110343. doi: 10.1016/j.cbi.2023.110343. Epub 2023 Jan 6.
3 Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug;8(8):627-44.
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5 The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations. Clin Cancer Res. 2011 May 15;17(10):3272-81.
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7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7967).
8 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
9 Human target validation of phosphoinositide 3-kinase (PI3K)beta: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kbeta inhibitor. J Thromb Haemost. 2012 Oct;10(10):2127-36.
10 Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9.
11 Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors. Bioorg Med Chem. 2007 Sep 1;15(17):5837-44.
12 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity. J Med Chem. 2013 Aug 22;56(16):6386-401.
13 BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110 and p110 activities in tumor cell lines and xenograft models.Mol Cancer Ther.2013 Nov;12(11):2319-30.
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15 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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18 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2156).
19 An integrin-targeted, pan-isoform, phosphoinositide-3 kinase inhibitor, SF1126, has activity against multiple myeloma in vivo.Cancer Chemother Pharmacol.2013 Apr;71(4):867-81.
20 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
21 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
22 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
23 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
24 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
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26 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
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28 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
29 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
30 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
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32 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
33 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
34 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
35 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
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37 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
38 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
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40 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
41 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
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44 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
45 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
46 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
47 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
48 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
49 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
50 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
51 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
52 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
53 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
54 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
55 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
56 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
57 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
58 Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
59 Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis. J Vet Med Sci. 2010 Jul;72(7):869-74.
60 Induced differentiation in HT29, a human colon adenocarcinoma cell line. J Cell Sci. 1999 Aug;112 ( Pt 16):2657-66. doi: 10.1242/jcs.112.16.2657.
61 Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
62 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
63 Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
64 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
65 Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
66 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
67 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
68 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
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