Details of the Drug-Related molecule(s) Interaction Atlas

Aminophenol Drug Info

Benzofur GG; Fouramine OP; Nako Yellow 3GA; Nako Yellow ga; O-AMINOPHENOL; ORTHO AMINO PHENOL; Paradone Olive Green B; Pelagol 3GA; Pelagol Grey GG; 2-Aminophenol; BASF ursol 3GA; Phenol, 2-amino-; Phenol, o-amino-; Questiomycin B; Zoba 3GA; o-Hydroxyaniline; o-Hydroxyphenylamine; ortho-aminophenol; 1-Amino-2-hydroxybenzene; 1-Hydroxy-2-aminobenzene; 2-Amino-1-hydroxybenzene; 2-Aminobenzenol; 2-Hydroxyanaline; 2-Hydroxyaniline; 2-amino-phenol; 95-55-6; C.I. 76520; C.I. Oxidation Base 17; CI Oxidation Base 17; NSC 1534

Cross-matching ID

PubChem CID

5801

ChEBI ID

CHEBI:18112

CAS Number

CAS 95-55-6

TTD Drug ID

DMEMCQ9

INTEDE Drug ID

DR2038

General Information of Drug (ID: DMEMCQ9)

Molecule-Related Drug Atlas

Molecule Type:

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Sulfotransferase 1B1 (SULT1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[5]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[6]
Rotigotine	DMP7X6Q	N. A.	N. A.	Approved	[7]
ABT-751	DMNG35S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
Mononitrophenol	DM4QO9G	N. A.	N. A.	Investigative	[1]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[9]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[10]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[11]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[13]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[14]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[15]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[16]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[17]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[18]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[19]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[22]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[24]
Selenium	DM25CGV	N. A.	N. A.	Approved	[25]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
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Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[29]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[30]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[31]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[21]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[32]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[35]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[33]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[37]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[39]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[41]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[44]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[45]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[2]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[45]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[51]
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Drug(s) Affected By E3 ubiquitin-protein ligase RNF115 (RNF115)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[59]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[52]
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Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[68]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sulfotransferase 1B1 (SULT1B1)^{Main DME}	DED5UR3	ST1B1_HUMAN	Substrate	[1]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[2]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[2]
E3 ubiquitin-protein ligase RNF115 (RNF115)	OT35B6L5	RN115_HUMAN	Drug Response	[3]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Drug Response	[3]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Gene/Protein Processing	[2]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Gene/Protein Processing	[2]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Gene/Protein Processing	[2]
UDP-glucuronosyltransferase 2B11	OTVVH26D	UDB11_HUMAN	Biotransformations	[4]

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