Details of the Drug-Related molecule(s) Interaction Atlas

ANDROSTERONE Drug Info

androsterone; 53-41-8; Androkinine; Androtine; 5alpha-Androsterone; Atromide ICI; 3alpha-Hydroxy-5alpha-androstan-17-one; 3-Epihydroxyetioallocholan-17-one; cis-Androsterone; 3alpha-Hydroxyetioallocholan-17-one; 5alpha-Androstane-3alpha-ol-17-one; 3alpha-Hydroxy-17-androstanone; Androstanon-3-alpha-ol-17-one; 3-alpha-Hydroxy-17-androstanone; 3-alpha-Hydroxyetioallocholan-17-one; 3-alpha-Hydroxy-5-alpha-androstan-17-one; 5-alpha-Androstan-3-alpha-ol-17-one; Caswell No. 051G; Androstan-17-one, 3-hydroxy-, (3alpha,5alpha)-

Cross-matching ID

PubChem CID

5879

ChEBI ID

CHEBI:16032

CAS Number

CAS 53-41-8

TTD Drug ID

DMITJAK

INTEDE Drug ID

DR1916

General Information of Drug (ID: DMITJAK)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Gamma-aminobutyric acid receptor (GAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[11]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[1]
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[12]
Clonazepam	DMTO13J	Absence epilepsy		Approved	[13]
Piperazine	DMTY9LU	Ascariasis	1F62	Approved	[14]
Alpidem	DMN7Y9K	Anxiety disorder	6B00-6B0Z	Approved	[15]
Moxidectin	DMYGHX5	Onchocerciasis	1F6A	Approved	[16]
DP-VPA	DMGOXPQ	Bipolar disorder	6A60	Approved	[17]
ZK-93423	DMFWMKZ	Epileptic seizures	8A61-8A6Z	Phase 3	[18]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[12]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A6 (UGT1A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[21]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[24]
Naproxen	DMZ5RGV	Bursitis		Approved	[25]
Deferiprone	DMS2M7O	Beta thalassemia	3A50.2	Approved	[26]
BCP-13498	DM2BO9W	N. A.	N. A.	Phase 2	[27]
LM-94	DMW3QGJ	N. A.	N. A.	Phase 1/2	[28]
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Drug(s) Metabolized By Aldo-keto reductase 1C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[29]
FENOFIBRIC ACID	DMGO2MC	Cardiovascular disease	BA00-BE2Z	Approved	[30]
Trastuzumab emtansine	DMU1LXS	HER2-positive breast cancer	2C60-2C65	Phase 2	[31]
4-oxo-nonenal	DMPX1J9	Discovery agent	N.A.	Investigative	[32]
Acenaphthenol	DMT3QYZ	N. A.	N. A.	Investigative	[3]
Indan-1-ol	DMMLQZJ	N. A.	N. A.	Investigative	[3]
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Drug(s) Metabolized By Alcohol dehydrogenase class-II (ADH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[33]
octanol	DMBGHPE	Discovery agent	N.A.	Investigative	[33]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[33]
Pyrene-1-aldehyde	DMEF6IP	N. A.	N. A.	Investigative	[33]
Hydroxymethylpyrene	DMPGAR2	N. A.	N. A.	Investigative	[33]
BRN-2330710	DM87VP6	N. A.	N. A.	Investigative	[33]
Pyrenemethanol	DMGJ0RM	N. A.	N. A.	Investigative	[33]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[33]
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Drug(s) Metabolized By Farnesol dehydrogenase (AKR1B15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[4]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[4]
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[4]
Nitrobenzaldehyde	DM4UHB5	N. A.	N. A.	Investigative	[34]
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Drug(s) Affected By Dehydrogenase/reductase SDR family member 11 (DHRS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[6]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[6]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[41]
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Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[42]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[46]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[47]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[48]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[48]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[49]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gamma-aminobutyric acid receptor (GAR)	TTNJYV2	NOUNIPROTAC	Inhibitor	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
UDP-glucuronosyltransferase 1A6 (UGT1A6)	DESD26P	UD16_HUMAN	Substrate	[2]
Aldo-keto reductase 1C3 (AKR1C3)	DEGQTXO	AK1C3_HUMAN	Substrate	[3]
Farnesol dehydrogenase (AKR1B15)	DER0XCH	AK1BF_HUMAN	Substrate	[4]
Alcohol dehydrogenase class-II (ADH4)	DEOCWU3	ADH4_HUMAN	Substrate	[5]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Dehydrogenase/reductase SDR family member 11 (DHRS11)	OTU3J0ZL	DHR11_HUMAN	Biotransformations	[6]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)	OTZKVLVJ	CP17A_HUMAN	Biotransformations	[7]
UDP-glucuronosyltransferase 1A4	OT4PU620	UD14_HUMAN	Biotransformations	[8]
UDP-glucuronosyltransferase 2B17	OTSVIF4E	UDB17_HUMAN	Regulation of Drug Effects	[9]
UDP-glucuronosyltransferase 2B7	OT2Q71VQ	UD2B7_HUMAN	Gene/Protein Processing	[10]

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