Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJAPE7)

Drug Name
Methylene blue Drug Info
Synonyms
methylene blue; 61-73-4; Methylthioninium chloride; Swiss Blue; Chromosmon; Methylene Blue N; Methylenium ceruleum; Urolene blue; Methylene Blue chloride; Solvent blue 8; Bleu de methylene; Methylene Blue G; Methylene Blue A; External Blue 1; Methylene Blue D; Methylene Blue B; Methylene Blue anhydrous; CI Basic Blue 9; Methylene Blue ZF; Methylene Blue SP; Methylene Blue NZ; Methylene Blue BX; Methylene Blue BD; Methylene Blue SG; Tetramethylene Blue; Methylene Blue ZX; Methylene Blue FZ; Methylene Blue BP; Calcozine; 3,7-Bis-dimethylamino-phenothiazin-5-ylium
Indication
Disease Entry ICD 11 Status REF
Acquired methemoglobinemia 3A93 Approved [1]
Cross-matching ID
PubChem CID
6099
ChEBI ID
CHEBI:6872
CAS Number
CAS 61-73-4
TTD Drug ID
DMJAPE7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Patented Agent(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Monoamine oxidase (MAO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Moclobemide DMNZWL7 Depression 6A70-6A7Z Approved [4]
Phenelzine DMHIDUE Depression 6A70-6A7Z Approved [4]
Tranylcypromine DMGB5RE Major depressive disorder 6A70.3 Approved [4]
Selegiline DM6034S Major depressive disorder 6A70.3 Approved [4]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [4]
Pargyline DMM0HR1 Hypertension BA00-BA04 Approved [4]
Ergoloid mesylate DMORPBA Alzheimer disease 8A20 Approved [5]
Cyclopropylamine derivative 11 DMMJ0YN N. A. N. A. Patented [6]
PMID27019002-Compound-20a DMRX748 N. A. N. A. Patented [6]
Cyclopropylamine derivative 9 DMX7YAL N. A. N. A. Patented [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Guanylate cyclase (GC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Respiratory failure CB41 Approved [7]
Isosorbide dinitrate DMBI4JG Anal fissure DB50.0 Approved [7]
Isosorbide mononitrate DMYLMU0 Hydrocephalus 8D64 Approved [7]
Erythrityl Tetranitrate DMFGQ2S Angina pectoris BA40 Approved [7]
Pirsidomine DMHI6GE Angina pectoris BA40 Phase 2 [8]
IW-1701 DM457XO Sickle-cell disorder 3A51 Phase 2 [9]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Guanylate cyclase (GC) TT6HPVC NOUNIPROTAC Inhibitor [2]
Monoamine oxidase (MAO) TT32XQJ NOUNIPROTAC Not Available [3]

References

1 Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blue. FEBS Lett. 1998 Feb 6;422(3):311-4.
2 Curcumin ameliorates high glucose-induced acute vascular endothelial dysfunction in rat thoracic aorta. Clin Exp Pharmacol Physiol. 2009 Dec;36(12):1177-82.
3 Photoluminescence of CdTe nanocrystals modulated by methylene blue and DNA. A label-free luminescent signaling nanohybrid platform. Phys Chem Chem Phys. 2009 Jul 7;11(25):5062-9.
4 Novel monoamine oxidase inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):91-110.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80.
7 Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem. 2010 Jan;333(1-2):191-201.
8 Activation of soluble guanylyl cyclase by the nitrovasodilator 3-morpholinosydnonimine involves formation of S-nitrosoglutathione. Mol Pharmacol. 1998 Jul;54(1):207-12.
9 Clinical pipeline report, company report or official report of Cyclerion Therapeutics.