Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJQDUC)

Drug Name

Aminoguanidine Drug Info

Synonyms

aminoguanidine; Pimagedine; Hydrazinecarboximidamide; Guanyl hydrazine; Monoaminoguanidine; 2-aminoguanidine; 79-17-4; Imino semicarbazide; Aminate base; 2-azanylguanidine; Pimagedine [INN]; GUANIDINE, AMINO-; 1-aminoguanidine; UNII-SCQ4EZQ113; Hydrazinecarboximidamide(9CI); CCRIS 3511; EINECS 201-183-1; Aminoguanidine, Hemisulfate; SCQ4EZQ113; CHEMBL225304; CHEBI:40618; HAMNKKUPIHEESI-UHFFFAOYSA-N; guanylhydrazine; GER-11; AGU; amino guanidine; 1-amino-guanidine; Aminoguanidine (AG); Tocris-0787; Carbonohydrazonic diamide; INCB3284

Indication

Disease Entry	ICD 11	Status	REF
Diabetic retinopathy	9B71.0	Phase 1	[1]
Insulin-resistant disorder	5A44	Discontinued in Phase 2	[2]
Rheumatoid arthritis	FA20	Discontinued in Phase 2	[2]

Cross-matching ID

PubChem CID: 2146
ChEBI ID: CHEBI:40618
CAS Number: CAS 79-17-4
TTD Drug ID: DMJQDUC

Molecule-Related Drug Atlas

Molecule Type:

DTT

DOT

Drug Status:

Clinical Trial Drug(s)

Approved Drug(s)

Patented Agent(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Nitric-oxide synthase inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
SD-6010	DM9DEYL	Osteoarthritis	FA00-FA05	Phase 3	[9]
MPL-S	DMNDCFY	Endotoxic shock	1G41	Phase 3	[10]
Pimagedine HCl	DMPWH30	Diabetic kidney disease	GB61.Z	Phase 2/3	[11]
GW274150	DMZMCB1	Asthma	CA23	Phase 2	[12]
BXT-51072	DMD8GNB	Cardiovascular disease	BA00-BE2Z	Phase 2	[13]
HP-228	DMNZ35F	Postoperative pain	MG30-MG3Z	Phase 2	[14]
CR-3294	DMHJEZS	Diarrhea	ME05.1	Phase 2	[15]
KD-7040	DME1WV2	Pain	MG30-MG3Z	Phase 2	[16]
LT-1951	DM5N04G	Coronary artery disease	BA80	Phase 1/2	[17]
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Drug(s) Targeting C-C chemokine receptor type 2 (CCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cenicriviroc	DM4V8WF	Human immunodeficiency virus infection	1C62	Phase 2	[18]
MLN1202	DM24SOL	Metastatic cancer	2D50-2E2Z	Phase 2	[19]
BMS-813160	DMKY638	Diabetic nephropathy	GB61.Z	Phase 2	[20]
CCX-140	DMJ9XCO	Diabetic nephropathy	GB61.Z	Phase 2	[21]
AZD-2423	DMF34UY	Chronic obstructive pulmonary disease	CA22	Phase 2	[22]
CCX872	DMPVAUT	Pancreatic tumour	2C10	Phase 2	[23]
MK-0812	DMRT8K4	Multiple sclerosis	8A40	Phase 2	[24]
TAK-202	DMVYEFZ	Melanoma	2C30	Phase 1	[25]
OPL-CCL2-LPM	DM3HOUX	Arthritis	FA20	Phase 1	[26]
CNTX-6970	DMCOJM7	Inflammatory pain	MG30.42	Phase 1	[27]
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Drug(s) Affected By Diamine oxidase (AOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[33]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[34]
Putrescine	DMWE6V1	Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[7]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[35]
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Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Haloperidol	DM96SE0	Delirium		Approved	[37]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[38]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[41]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
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Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[46]
Haloperidol	DM96SE0	Delirium		Approved	[37]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[49]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[54]
Selenium	DM25CGV	N. A.	N. A.	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[57]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[59]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
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Drug(s) Affected By Hematopoietic progenitor cell antigen CD34 (CD34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[67]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[65]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[70]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[71]
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Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Indomethacin	DMSC4A7	Bursitis		Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[77]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[78]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[79]
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Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[84]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[87]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[88]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[89]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[92]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[38]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[93]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[96]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[97]
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Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[98]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[6]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 2 (CCR2)	TTFZYTO	CCR2_HUMAN	Antagonist	[3]
Nitric-oxide synthase inducible (NOS2)	TTF10I9	NOS2_HUMAN	Inhibitor	[4]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[5]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[5]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Gene/Protein Processing	[6]
Diamine oxidase (AOC1)	OTRC220K	AOC1_HUMAN	Gene/Protein Processing	[7]
Hematopoietic progenitor cell antigen CD34 (CD34)	OT1MOFLZ	CD34_HUMAN	Gene/Protein Processing	[5]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Gene/Protein Processing	[5]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Gene/Protein Processing	[5]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Gene/Protein Processing	[5]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Gene/Protein Processing	[5]

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