Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLDBQ5)

Drug Name
SEN-196 Drug Info
Synonyms EX-527; SEN-0014196; SIRT1 inhibitors (Huntingtons disease), Elixir/Siena; Sirtuin-1 inhibitors (oral, Huntington's disease), Elixir/Siena
Indication
Disease Entry ICD 11 Status REF
Huntington disease 8A01.10 Phase 2 [1]
Cross-matching ID
PubChem CID
5113032
ChEBI ID
CHEBI:90369
CAS Number
CAS 49843-98-3
TTD Drug ID
DMLDBQ5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Approved Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting NAD-dependent deacetylase sirtuin-1 (SIRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [11]
GSK2245840 DMG7YQL Chronic obstructive pulmonary disease CA22 Phase 2 [12]
MB-12066 DMRSN2C Obesity 5B81 Phase 2 [13]
SRT2379 DM7DAKX Type-2 diabetes 5A11 Phase 1 [14]
SRT3025 DMRAXFH Type-2 diabetes 5A11 Phase 1 [15]
PMID25435179-Compound-WO2012106509Salermide DMLAH39 N. A. N. A. Patented [11]
CAMBINOL DMW46GY Discovery agent N.A. Patented [16]
PMID25435179-Compound-WO2012106509CAY10602 DM2F1T0 N. A. N. A. Patented [11]
PMID25435179-Compound-WO2012106509Tenovin-6 DMBSOED N. A. N. A. Patented [11]
GSK184072 DMMIR1K Colon cancer 2B90.Z Discontinued in Phase 2 [17]
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Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [18]
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [20]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [21]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [22]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Prednisone DM2HG4X Acute asthma CA23 Approved [25]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [27]
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Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [29]
Etretinate DM2CZFA Keratosis ED56 Approved [30]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [40]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [41]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [42]
Paclitaxel DMLB81S Breast carcinoma Approved [43]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [44]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [46]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [47]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [48]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [49]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [50]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [51]
Cepharanthine DM9Y5JB N. A. N. A. Approved [52]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [53]
Clozapine DMFC71L Schizophrenia 6A20 Approved [54]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [55]
Trifluoperazine DMKBYWI Anxiety Approved [56]
Olanzapine DMPFN6Y Bipolar depression Approved [54]
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Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [58]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
Fructose DM43AN2 Vomiting MD90 Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
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Drug(s) Affected By RE1-silencing transcription factor (REST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
Panobinostat DM58WKG Chronic graft versus host disease Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Leflunomide DMR8ONJ Arthritis FA20 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Folic Acid DMEMBJC Colorectal carcinoma Approved [72]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [74]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [75]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [76]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [77]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [78]
Gefitinib DM15F0X Colon adenocarcinoma Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [83]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [84]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [85]
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Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-2 (SIRT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Ethanol DMDRQZU Chronic pain MG30 Approved [86]
Clozapine DMFC71L Schizophrenia 6A20 Approved [87]
Paclitaxel DMLB81S Breast carcinoma Approved [88]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [89]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [90]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [91]
Nicotinamide DMUPE07 Acne vulgaris ED80 Approved [92]
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Drug(s) Affected By NAD-dependent protein deacylase sirtuin-6 (SIRT6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Testosterone DM7HUNW Hot flushes GA30 Approved [94]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [95]
Paclitaxel DMLB81S Breast carcinoma Approved [88]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [96]
TAK-715 DMZKPI8 Rheumatoid arthritis FA20 Phase 2 [97]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [98]
NORCANTHARIDIN DM9B6Y1 Discovery agent N.A. Investigative [88]
paraquat DMR8O3X Discovery agent N.A. Investigative [99]
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Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [101]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [102]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [71]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [103]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [102]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [104]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [105]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
NAD-dependent deacetylase sirtuin-1 (SIRT1) TTUF2HO SIR1_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Gene/Protein Processing [3]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [3]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Post-Translational Modifications [4]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Gene/Protein Processing [5]
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) OT5Q6SVK SIR2_HUMAN Gene/Protein Processing [6]
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) OTMEF544 SIR3_HUMAN Gene/Protein Processing [7]
NAD-dependent protein deacylase sirtuin-6 (SIRT6) OTF755ZO SIR6_HUMAN Gene/Protein Processing [7]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Post-Translational Modifications [8]
RE1-silencing transcription factor (REST) OTLL92LQ REST_HUMAN Gene/Protein Processing [9]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Protein Interaction/Cellular Processes [10]

References

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9 Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death. Toxicol Appl Pharmacol. 2015 Nov 1;288(3):387-98. doi: 10.1016/j.taap.2015.08.010. Epub 2015 Aug 22.
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28 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
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32 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
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37 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
38 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
39 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
40 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
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43 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
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45 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
46 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
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51 Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
52 Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
53 Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
54 Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
55 Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
56 Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
57 Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244. doi: 10.1002/jat.3809. Epub 2019 May 7.
58 Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
59 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
60 Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity. DNA Cell Biol. 2009 Mar;28(3):119-29.
61 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
62 Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med. 2005 Oct 15;172(8):987-93. doi: 10.1164/rccm.200501-041OC. Epub 2005 Jul 7.
63 A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide. 2005 Mar;12(2):97-104.
64 The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells. J Diabetes Complications. 2006 Sep-Oct;20(5):336-42.
65 Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J Am Soc Nephrol. 2008 Sep;19(9):1712-20.
66 Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway. Circulation. 2005 Aug 2;112(5):727-36. doi: 10.1161/CIRCULATIONAHA.104.500959. Epub 2005 Jul 25.
67 Selective Recognition of H3.1K36 Dimethylation/H4K16 Acetylation Facilitates the Regulation of All-trans-retinoic Acid (ATRA)-responsive Genes by Putative Chromatin Reader ZMYND8. J Biol Chem. 2016 Feb 5;291(6):2664-81. doi: 10.1074/jbc.M115.679985. Epub 2015 Dec 11.
68 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
69 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
70 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
71 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
72 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
73 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
74 Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
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