Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLGS82)

Drug Name
Caprylic acid Drug Info
Synonyms
octanoic acid; caprylic acid; 124-07-2; n-octanoic acid; n-caprylic acid; Octylic acid; octoic acid; n-octylic acid; n-Octoic acid; neo-fat 8; 1-heptanecarboxylic acid; Enantic acid; Octic acid; C-8 acid; Caprylsaeure; capryloate; Kaprylsaeure; Hexacid 898; Acido octanoico; Acide octanoique; 0ctanoic acid; Acidum octanocium; Caprylic acid (natural); Kyselina kaprylova; Fatty acids, C6-10; octylate; Octansaeure; Acide octanoique [French]; 1-octanoic acid; Acidum octanocium [Latin]; Acido octanoico [Spanish]; NSC 5024; Kyselina kaprylova [C
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
379
ChEBI ID
CHEBI:28837
CAS Number
CAS 124-07-2
TTD Drug ID
DMLGS82

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Mycobacterium 3-oxoacyl-[acyl-carrier-protein] synthase 1 (MycB kasA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lauric Acid DM9C8KQ Discovery agent N.A. Investigative [7]
Decanoic Acid DM8FMYL Discovery agent N.A. Investigative [7]
2-PHENYLAMINO-4-METHYL-5-ACETYL THIAZOLE DM60AJ2 Discovery agent N.A. Investigative [8]
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [9]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [10]
Gefitinib DM15F0X Colon adenocarcinoma Approved [11]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [12]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [13]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [12]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [14]
Selenium DM25CGV N. A. N. A. Approved [15]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [16]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [18]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [18]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [19]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [20]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [21]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [22]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [23]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [24]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [3]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [25]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [26]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [27]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [28]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [29]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [30]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [10]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [12]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [13]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [31]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [12]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [34]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [36]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [37]
Quercetin DM3NC4M Obesity 5B81 Approved [38]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [39]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [41]
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Drug(s) Affected By Caspase-1 (CASP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [9]
Gefitinib DM15F0X Colon adenocarcinoma Approved [11]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [14]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [3]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [47]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [53]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [56]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [57]
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Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [59]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [40]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [63]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [60]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [64]
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Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [56]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [67]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [69]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [71]
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Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-15 (GNA15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [72]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [73]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [74]
Azelaic Acid DMHVL0J Acne vulgaris ED80 Approved [5]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [75]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [76]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [77]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [73]
geraniol DMS3CBD Discovery agent N.A. Investigative [5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mycobacterium 3-oxoacyl-[acyl-carrier-protein] synthase 1 (MycB kasA) TTPH97Y FAB1_MYCTU Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Post-Translational Modifications [3]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Gene/Protein Processing [4]
Guanine nucleotide-binding protein subunit alpha-15 (GNA15) OTFYRZGV GNA15_HUMAN Drug Response [5]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Gene/Protein Processing [3]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Gene/Protein Processing [3]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [4]
Peroxisome proliferator-activated receptor alpha (PPARA) OTK095PP PPARA_HUMAN Protein Interaction/Cellular Processes [6]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Protein Interaction/Cellular Processes [6]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Gene/Protein Processing [3]

References

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33 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
34 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
35 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
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37 Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
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45 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
46 Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
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52 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
53 Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1. J Rheumatol. 2012 Mar;39(3):635-44. doi: 10.3899/jrheum.110621. Epub 2011 Nov 15.
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58 Responsiveness of human monocyte-derived dendritic cells to thimerosal and mercury derivatives. Toxicol Appl Pharmacol. 2010 Jul;246(1-2):66-73. doi: 10.1016/j.taap.2010.04.007. Epub 2010 Apr 22.
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61 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
62 Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
63 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
64 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
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66 Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells. Acta Biochim Biophys Sin (Shanghai). 2011 Mar;43(3):204-9. doi: 10.1093/abbs/gmq130. Epub 2011 Jan 21.
67 Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators. Mol Pharmacol. 2008 Mar;73(3):968-76. doi: 10.1124/mol.107.036780. Epub 2007 Dec 13.
68 (9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARalpha in MDA-MB-231 breast cancer cells. Toxicology. 2014 Dec 4;326:18-24.
69 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
70 Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. Anticancer Res. 2009 Sep;29(9):3647-58.
71 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
72 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
73 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
74 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
75 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
76 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
77 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.