Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRGQVZ)

Drug Name
Antroquinonol Drug Info
Synonyms Hocena; Fungal extract (cancer), Golden Biotechnology
Indication
Disease Entry ICD 11 Status REF
Non-small-cell lung cancer 2C25.Y Phase 2 [1]
Pancreatic cancer 2C10 Phase 2 [2]
Cross-matching ID
PubChem CID
24875259
ChEBI ID
CHEBI:65415
CAS Number
CAS 1010081-09-0
TTD Drug ID
DMRGQVZ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA [cytosine-5]-methyltransferase 1 (DNMT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CC-486 DMTNQB0 Acute myeloid leukaemia 2A60 Phase 3 [6]
S-110 DMXY34J Acute myeloid leukaemia 2A60 Phase 3 [7]
SGI110 DM1NQDW Acute myeloid leukaemia 2A60 Phase 3 [8]
Guadecitabine DM9Y3EG Myelodysplastic syndrome 2A37 Phase 3 [2]
Palifosfamide DMMIYZ7 Soft tissue sarcoma 2B57 Phase 2 [9]
RX-3117 DME8ARP Bladder cancer 2C94 Phase 2 [10]
GSK4172239 DM930LE Sickle-cell disorder 3A51 Phase 1 [11]
PMID27376512-Compound-MTC-424 DMGNRZU N. A. N. A. Patented [12]
PMID27376512-Compound-MTC-427 DMWXEZD N. A. N. A. Patented [12]
PMID27376512-Compound-MTC-422 DM1MVQD N. A. N. A. Patented [12]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [13]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [14]
Fructose DM43AN2 Vomiting MD90 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [16]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [17]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [18]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [20]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [22]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [23]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [26]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [27]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [28]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [29]
Gefitinib DM15F0X Colon adenocarcinoma Approved [30]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [33]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [34]
Paclitaxel DMLB81S Breast carcinoma Approved [35]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [23]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [26]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [27]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [38]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [40]
Gefitinib DM15F0X Colon adenocarcinoma Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [43]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [47]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [37]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [48]
Selenium DM25CGV N. A. N. A. Approved [49]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [50]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [51]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [56]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [43]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [61]
Testosterone DM7HUNW Hot flushes GA30 Approved [62]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [65]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA [cytosine-5]-methyltransferase 1 (DNMT1) TT6S2FE DNMT1_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Post-Translational Modifications [4]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [5]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [5]
Serine/threonine-protein kinase mTOR (MTOR) OTHH8KU7 MTOR_HUMAN Post-Translational Modifications [4]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Gene/Protein Processing [5]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Post-Translational Modifications [5]

References

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2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential. J Agric Food Chem. 2014 Jun 18;62(24):5625-35.
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21 Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
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29 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
30 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
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33 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
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