Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVYXR8)

Drug Name
Sumatriptan Drug Info
Synonyms
Sumatran; Sumatriptanum; Sumax; GR 43175; GR 43175X; NP101; GR-43175; Imigran (TN); Imitrex (TN); KS-1116; Sumatriptanum [INN-Latin]; Sumatriptan (JAN/USP/INN); (3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide; 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide; 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methylmethanesulfonamide; 1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide; 3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide; 3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide; 3-[2-(Dimethylamino)ethyl]-N-methylindole-5-methanesulfonamide
Indication
Disease Entry ICD 11 Status REF
Cluster headache 8A81.0 Approved [1]
Migraine 8A80 Approved [2]
Migraine disorder Approved [1]
Therapeutic Class
Vasoconstrictor Agents
Cross-matching ID
PubChem CID
5358
ChEBI ID
CHEBI:10650
CAS Number
CAS 103628-46-2
TTD Drug ID
DMVYXR8
VARIDT Drug ID
DR00331
ACDINA Drug ID
D00645

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting 5-HT 1D receptor (HTR1D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [10]
Eletriptan DMW649X Migraine 8A80 Approved [11]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [11]
Frovatriptan DM7RE8P Migraine 8A80 Approved [11]
Rizatriptan DMDJMA3 Migraine 8A80 Approved [12]
Almogran DM7I64Z Migraine 8A80 Approved [13]
Neu-P11 DMIQDFW Alzheimer disease 8A20 Phase 2 [14]
FKB01MD DM2O7NM N. A. N. A. Phase 2 [15]
NXN-188 DMMBAIH Migraine 8A80 Phase 2 [16]
TGBA01AD DMJ2FTU Mood disorder 6A60-6E23 Phase 2 [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [18]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [20]
Folic Acid DMEMBJC Colorectal carcinoma Approved [21]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [20]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [20]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [22]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [20]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [23]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [25]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [27]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [28]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [29]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [30]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [31]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [32]
Propranolol DM79NTF Angina pectoris BA40 Approved [33]
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Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [34]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [8]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [37]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [8]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [38]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Fluoxetine DM3PD2C Bipolar depression Approved [8]
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Drug(s) Affected By Pro-opiomelanocortin (POMC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [41]
Prednisone DM2HG4X Acute asthma CA23 Approved [42]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [43]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [44]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [45]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [46]
Triamcinolone DM98IXF Acute adrenal insufficiency Approved [47]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [48]
Ethanol DMDRQZU Chronic pain MG30 Approved [49]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clozapine DMFC71L Schizophrenia 6A20 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [52]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [53]
Folic Acid DMEMBJC Colorectal carcinoma Approved [54]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [55]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [56]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [57]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [58]
Sibutramine DMFJTDI Obesity 5B81 Approved [59]
Almogran DM7I64Z Migraine 8A80 Approved [7]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 5-hydroxytryptamine receptor 1F (HTR1F)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [60]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [61]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [62]
Milchsaure DM462BT Pruritus EC90 Investigative [63]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1D receptor (HTR1D) TT6MSOK 5HT1D_HUMAN Agonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [4]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
5-hydroxytryptamine receptor 1F (HTR1F) OTALAXPA 5HT1F_HUMAN Drug Response [6]
Calcitonin gene-related peptide 1 (CALCA) OTQSXM9Z CALCA_HUMAN Drug Response [6]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3) OTA6HYBA GBB3_HUMAN Drug Response [7]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Gene/Protein Processing [8]
Pro-opiomelanocortin (POMC) OTV41F7T COLI_HUMAN Gene/Protein Processing [9]

References

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7 G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007 Oct;82(4):396-401. doi: 10.1038/sj.clpt.6100159. Epub 2007 Mar 14.
8 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
9 The effects of oral sumatriptan, a 5-HT1 receptor agonist, on circulating ACTH and cortisol concentrations in man. Br J Clin Pharmacol. 1995 Apr;39(4):389-95. doi: 10.1111/j.1365-2125.1995.tb04467.x.
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29 Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33.
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34 Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
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37 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
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