Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW3QAK)

Drug Name
NSC-654077 Drug Info
Synonyms
DIBA-1; PD 22551; NSC-654077; PD-22551; PD022551; CHEMBL418037; 171744-39-1; 2,2'-Dithiobis-(N-(4-sulfamoylphenyl)-benzamide); NSC654077; DIBA (Antineoplastic); N-(4-sulfamoylphenyl)-2-[[2-[(4-sulfamoylphenyl)carbamoyl]phenyl]disulfanyl]benzamide; 2,2'-Dithiobis-[N-(4-sulfamoylphenyl)-benzamide]; NSC 654077; N-(4-sulfamoylphenyl)-2-({2-[(4-sulfamoylphenyl)carbamoyl]phenyl}disulfanyl)benzamide; AC1L8BKK; AC1Q6VC8; SCHEMBL6223450; BDBM11052; disulfide-containing sulfonamide 5a
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
375084
CAS Number
CAS 171744-39-1
TTD Drug ID
DMW3QAK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Carbonic anhydrase I (CA-I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [3]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [4]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [4]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [5]
Acetazolamide DM1AF5U Absence epilepsy Approved [4]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [6]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [7]
CG-100649 DMIKMA9 Arthritis FA20 Phase 3 [8]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [6]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [9]
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Drug(s) Targeting Carbonic anhydrase II (CA-II)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [3]
Sulfamylon DMIO1K0 Bacterial infection 1A00-1C4Z Approved [10]
Dorzolamide DMA17D0 Ocular hypertension 9C61.01 Approved [11]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [12]
Ethoxzolamide DMVO4ED Glaucoma/ocular hypertension 9C61 Approved [13]
Dichlorphenamide DMH7IDQ Chronic glaucoma 9C61.0Z Approved [13]
Cyclothiazide DMJ4AWC Congestive heart failure BD10 Approved [14]
Ethinamate DMK57GB Insomnia 7A00-7A0Z Approved [15]
Benzthiazide DMQWZ0H High blood pressure BA00 Approved [16]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [6]
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Drug(s) Targeting Carbonic anhydrase IX (CA-IX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [6]
PARABEN DMEW5Z8 N. A. N. A. Phase 3 [7]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [6]
Coumate DMVKW0N Breast cancer 2C60-2C65 Phase 2 [9]
INDISULAM DM9SX6Y Lymphoma 2A80-2A86 Phase 2 [17]
Girentuximab I-124 DMG3O2Z Renal cell carcinoma 2C90 Phase 2 [18]
SULFAMIDE DMMAS3K N. A. N. A. Phase 1 [19]
BAY 79-4620 DM14XQN Solid tumour/cancer 2A00-2F9Z Phase 1 [20]
90Y-cG250 DMJR6TC Solid tumour/cancer 2A00-2F9Z Phase 1 [21]
FERULIC ACID DMJC7NF Discovery agent N.A. Patented [7]
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Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [22]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [23]
Gefitinib DM15F0X Colon adenocarcinoma Approved [24]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [26]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [25]
Estrone DM5T6US Acne vulgaris ED80 Approved [30]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [31]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [32]
Gefitinib DM15F0X Colon adenocarcinoma Approved [33]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [36]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [37]
Methotrexate DM2TEOL Anterior urethra cancer Approved [38]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
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Drug(s) Affected By Transcription factor E2F1 (E2F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [2]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [42]
Gefitinib DM15F0X Colon adenocarcinoma Approved [43]
Selenium DM25CGV N. A. N. A. Approved [44]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [45]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [37]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [49]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [50]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Verapamil DMA7PEW Angina pectoris BA40 Approved [51]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [53]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Meloxicam DM2AR7L Arthritis FA20 Approved [54]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [55]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [58]
Selenium DM25CGV N. A. N. A. Approved [44]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [61]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
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Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [65]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [66]
Leflunomide DMR8ONJ Arthritis FA20 Approved [67]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [68]
Testosterone enanthate DMB6871 N. A. N. A. Approved [69]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [70]
Menthol DMG2KW7 Back pain ME84.Z Approved [71]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [72]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [73]
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Drug(s) Affected By Transcription factor E2F2 (E2F2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [75]
Panobinostat DM58WKG Chronic graft versus host disease Approved [76]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Testosterone DM7HUNW Hot flushes GA30 Approved [78]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [78]
Leflunomide DMR8ONJ Arthritis FA20 Approved [67]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [2]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [2]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Gene/Protein Processing [2]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Gene/Protein Processing [2]
Retinoblastoma-like protein 2 (RBL2) OTBQSOE6 RBL2_HUMAN Gene/Protein Processing [2]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Gene/Protein Processing [2]
Transcription factor E2F2 (E2F2) OTO75RM7 E2F2_HUMAN Gene/Protein Processing [2]

References

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41 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
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60 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
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63 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
64 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
65 Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid. Oncogene. 2006 Aug 28;25(38):5315-25. doi: 10.1038/sj.onc.1209679.
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67 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
68 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
69 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
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71 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
72 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
73 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
74 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
75 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
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77 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
78 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.