Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYN8MA)

Drug Name
Tianeptine Drug Info
Synonyms
Tianeptina; Tianeptinum; Tianeptine Acid; Tianeptine [INN]; Stablon (TN); Tianeptine (INN); (1)-7-((3-Chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoic acid S,S-dioxide; 7-[(3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid; 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid
Indication
Disease Entry ICD 11 Status REF
Major depressive disorder 6A70.3 Approved [1]
Cross-matching ID
PubChem CID
68870
ChEBI ID
CHEBI:91749
CAS Number
CAS 72797-41-2
TTD Drug ID
DMYN8MA
VARIDT Drug ID
DR01101
INTEDE Drug ID
DR1589

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Serotonin transporter (SERT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [6]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [7]
Fluoxetine DM3PD2C Bipolar depression Approved [8]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [9]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [10]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [11]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [12]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [8]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [8]
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [8]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [13]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [14]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [15]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [16]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [17]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [18]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [19]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [20]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [14]
Verapamil DMA7PEW Angina pectoris BA40 Approved [21]
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Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [22]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [24]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [25]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [26]
Testosterone DM7HUNW Hot flushes GA30 Approved [27]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [27]
Leflunomide DMR8ONJ Arthritis FA20 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
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Drug(s) Affected By Mu-type opioid receptor (OPRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alvimopan DMHR8KW Gastrointestinal disease DE2Z Approved [30]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [31]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [34]
Butorphanol DM5KYPJ Pain MG30-MG3Z Approved [5]
Oliceridine DM6MDCF Acute pain MG31 Approved [31]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [37]
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Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [38]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [39]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [42]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [43]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [46]
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Drug(s) Affected By Angiopoietin-related protein 3 (ANGPTL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [47]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [47]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [4]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Allopurinol DMLPAOB Gout FA25 Approved [47]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [4]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [48]
Indomethacin DMSC4A7 Bursitis Approved [47]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Serotonin transporter (SERT) TT3ROYC SC6A4_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Angiopoietin-related protein 3 (ANGPTL3) OTCD5Z9W ANGL3_HUMAN Gene/Protein Processing [4]
Insulin-like growth factor-binding protein 1 (IGFBP1) OT6UQV2K IBP1_HUMAN Gene/Protein Processing [4]
Mu-type opioid receptor (OPRM1) OT16AAT8 OPRM_HUMAN Gene/Protein Processing [5]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Gene/Protein Processing [4]

References

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