Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8VUX3)

• Drug Name: 15-deoxy-Delta(12, 14)-prostaglandin J(2) Drug Info
• Synonyms: 15d-PGJ2; 15-Deoxy-PGJ2; 15-Deoxy-delta-12,14-prostaglandin J2; 15-deoxy-delta12,14-prostaglandin J2; delta12,14-PGJ 2; UNII-ALI977775J; 87893-55-8; CHEMBL482477; CHEBI:34159; (5Z,12E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid; ALI977775J; delta-12,14-15-Deoxy-PGJ2; 15-Deoxy-delta12,14-prostaglandin; 15-deoxy-Delta(12,14)-prostaglandin J2; Prostaglandin J2, 15-Deoxy-Delta12,14; 15-Deoxy-delta 12, 14-Prostaglandin J2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5311211
  ChEBI ID: CHEMBL482477
  CAS Number: CAS 87893-55-8
  TTD Drug ID: DM8VUX3

Molecule-Related Drug Atlas

Drug(s) Targeting Peroxisome proliferator-activated receptor gamma (PPAR-gamma)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[2]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[9]
Lobeglitazone	DMHY3IP	Type-2 diabetes	5A11	Approved	[10]
Rosiglitazone XR	DMT45MU	Type-2 diabetes	5A11	Approved	[11]
Thiazolidinedione	DMC1NBW	Alzheimer disease	8A20	Approved	[9]
Glitazone	DMDN4A1	N. A.	N. A.	Phase 4	[12]
MURAGLITAZAR	DMG3NFZ	N. A.	N. A.	Phase 3	[13]
Rivoglitazone	DMBY31K	Ocular inflammation	9C61.24	Phase 3	[14]
Balaglitazone	DMXBHR6	Type-1 diabetes	5A10	Phase 3	[15]
Ragaglitazar	DMFSHEM	Type-1 diabetes	5A10	Phase 3	[16]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[17]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[19]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[20]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[21]
Haloperidol	DM96SE0	Delirium		Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[25]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[27]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[6]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[29]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[39]
Fructose	DM43AN2	Vomiting	MD90	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[41]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[42]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[43]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[46]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[43]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[43]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[43]

Drug(s) Affected By Proline dehydrogenase 1, mitochondrial (PRODH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[47]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[53]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[54]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[62]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[63]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[68]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[69]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[70]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[44]

Drug(s) Affected By Thyroglobulin (TG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[73]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[50]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[75]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[79]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Selenium	DM25CGV	N. A.	N. A.	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[89]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[90]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[93]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Selenium	DM25CGV	N. A.	N. A.	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[35]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[108]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[109]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[108]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[113]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[116]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[117]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[121]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[119]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[122]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[128]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[50]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[132]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[133]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[135]

Drug(s) Affected By ATP synthase-coupling factor 6, mitochondrial (ATP5PF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[98]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[3]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[139]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[142]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[143]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[147]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[149]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[152]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[154]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[157]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[158]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[161]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[152]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[162]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[163]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[154]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[155]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[125]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[176]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[169]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[178]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[179]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[181]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[182]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[109]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[183]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[173]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[193]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[193]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[195]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[193]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[193]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[98]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[197]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[150]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[201]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[202]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[203]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[206]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[202]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[203]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[208]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[209]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[206]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[212]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[214]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[215]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[216]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[219]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[220]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Peroxisome proliferator-activated receptor gamma (PPAR-gamma)	TTZMAO3	PPARG_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP synthase-coupling factor 6, mitochondrial (ATP5PF)	OTDAE8FP	ATP5J_HUMAN	Gene/Protein Processing	[3]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Regulation of Drug Effects	[4]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Gene/Protein Processing	[5]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Gene/Protein Processing	[5]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Gene/Protein Processing	[5]
Choriogonadotropin subunit beta 3 (CGB3)	OTVM2SU3	CGB3_HUMAN	Gene/Protein Processing	[6]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[7]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Gene/Protein Processing	[7]
Cytochrome P450 4A11 (CYP4A11)	OTPU5J0S	CP4AB_HUMAN	Gene/Protein Processing	[8]
E3 ubiquitin-protein ligase XIAP	OT24GP9B	XIAP_HUMAN	Gene/Protein Processing	[5]

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