Details of the Drug-Related molecule(s) Interaction Atlas

GUAIACOL Drug Info

guaiacol; 2-Methoxyphenol; 90-05-1; o-Methoxyphenol; 2-Hydroxyanisole; Phenol, 2-methoxy-; Pyrocatechol monomethyl ether; Methylcatechol; Guaiastil; Guaicol; 1-Hydroxy-2-methoxybenzene; Pyroguaiac acid; o-Guaiacol; o-Hydroxyanisole; Guaicolina; Guajol; Guasol; Anastil; Phenol, o-methoxy-; Catechol monomethyl ether; O-Methyl catechol; CREOSOTE, WOOD; Methoxyphenol; Guajakol; Wood creosote; 2-Methoxy-Phenol; Creosote, beechwood; Guajacol; Methyl Catechol; Phenol, methoxy-; Guajakol [Czech]; Guaiacol (natural); 8021-39-4; Methylcatachol

Cross-matching ID

PubChem CID

460

ChEBI ID

CHEMBL13766

CAS Number

CAS 8021-39-4

TTD Drug ID

DMN4E7T

INTEDE Drug ID

DR2100

General Information of Drug (ID: DMN4E7T)

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[6]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[7]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[8]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[9]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[10]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[10]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[11]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[12]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[13]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
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Drug(s) Affected By Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[20]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[3]
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Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[21]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[22]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[23]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[24]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[27]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[28]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[23]
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Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[31]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[35]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
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Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Selenium	DM25CGV	N. A.	N. A.	Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
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Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[49]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[50]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
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Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[58]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[58]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[62]
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Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Selenium	DM25CGV	N. A.	N. A.	Approved	[66]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[70]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[71]
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Drug(s) Affected By Fibrillin-1 (FBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[76]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[20]
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Drug(s) Affected By Fibrillin-2 (FBN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[79]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[81]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[82]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[20]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[84]
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Drug(s) Affected By Melanocyte-stimulating hormone receptor (MC1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[23]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[87]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[88]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[3]
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Drug(s) Affected By Cytoglobin (CYGB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[20]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[84]
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Drug(s) Affected By Hyaluronan synthase 1 (HAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[94]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[84]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[95]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[3]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[96]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[3]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[97]
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Drug(s) Affected By Klotho (KL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[100]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[101]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[102]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[3]
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Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[29]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[103]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[104]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[105]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[106]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[107]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
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Drug(s) Affected By Cell division control protein 42 homolog (CDC42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[112]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[114]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[115]
Bortezomib	DMNO38U	Leukemia		Approved	[76]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Thyroid peroxidase (TPO)^{Main DME}	DEXL6TZ	PERT_HUMAN	Substrate	[2]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5,6-dihydroxyindole-2-carboxylic acid oxidase	OTRK49R4	TYRP1_HUMAN	Gene/Protein Processing	[3]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[4]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[3]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Gene/Protein Processing	[3]
Cell division control protein 42 homolog (CDC42)	OT5QBC5M	CDC42_HUMAN	Gene/Protein Processing	[5]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Gene/Protein Processing	[3]
Cytochrome c oxidase subunit 1 (COX1)	OTG3O9BN	COX1_HUMAN	Gene/Protein Processing	[3]
Cytoglobin (CYGB)	OTX153DQ	CYGB_HUMAN	Gene/Protein Processing	[3]
Fibrillin-1 (FBN1)	OTYCJT63	FBN1_HUMAN	Gene/Protein Processing	[3]
Fibrillin-2 (FBN2)	OT3KYJQL	FBN2_HUMAN	Gene/Protein Processing	[3]

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