Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN4E7T)

• Drug Name: GUAIACOL Drug Info
• Synonyms: guaiacol; 2-Methoxyphenol; 90-05-1; o-Methoxyphenol; 2-Hydroxyanisole; Phenol, 2-methoxy-; Pyrocatechol monomethyl ether; Methylcatechol; Guaiastil; Guaicol; 1-Hydroxy-2-methoxybenzene; Pyroguaiac acid; o-Guaiacol; o-Hydroxyanisole; Guaicolina; Guajol; Guasol; Anastil; Phenol, o-methoxy-; Catechol monomethyl ether; O-Methyl catechol; CREOSOTE, WOOD; Methoxyphenol; Guajakol; Wood creosote; 2-Methoxy-Phenol; Creosote, beechwood; Guajacol; Methyl Catechol; Phenol, methoxy-; Guajakol [Czech]; Guaiacol (natural); 8021-39-4; Methylcatachol
• Cross-matching ID:
  PubChem CID: 460
  ChEBI ID: CHEBI:28591
  CAS Number: CAS 8021-39-4
  TTD Drug ID: DMN4E7T
  INTEDE Drug ID: DR2100

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[6]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[7]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[8]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[9]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[10]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[10]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[11]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[12]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[13]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]

Drug(s) Affected By Carbonic anhydrase 1 (CA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[15]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[16]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[17]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[5]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[18]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[16]
Indomethacin	DMSC4A7	Bursitis		Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[21]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[22]

Drug(s) Affected By Carbonic anhydrase 2 (CA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[19]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[26]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[27]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[28]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[29]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]

Drug(s) Affected By Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[35]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[3]

Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[36]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[37]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[42]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[43]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[38]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[45]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[53]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[57]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[58]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[76]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[80]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[82]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[83]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[84]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[86]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[86]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[86]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[87]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[88]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[89]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[90]
Selenium	DM25CGV	N. A.	N. A.	Approved	[91]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[92]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[94]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[95]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]

Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[73]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[73]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[105]

Drug(s) Affected By Translationally-controlled tumor protein (TPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[111]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[113]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[118]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[122]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[129]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[130]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]

Drug(s) Affected By Progranulin (GRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[116]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Fructose	DM43AN2	Vomiting	MD90	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]

Drug(s) Affected By Aquaporin-1 (AQP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[35]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[150]

Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[152]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[154]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Methyltestosterone	DMWLFGO	Advanced cancer	2A00-2F9Z	Approved	[154]
Finasteride	DMWV3TZ	Baldness, male pattern		Approved	[154]

Drug(s) Affected By Prostaglandin E2 receptor EP1 subtype (PTGER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[3]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[22]

Drug(s) Affected By Fibrillin-1 (FBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[157]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[161]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[162]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[35]

Drug(s) Affected By Fibrillin-2 (FBN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[164]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[165]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[166]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[35]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[167]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[171]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[174]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[175]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[178]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[181]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[182]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[183]

Drug(s) Affected By Melanocyte-stimulating hormone receptor (MC1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[38]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[185]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[116]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[186]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[3]

Drug(s) Affected By Cytoglobin (CYGB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[187]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[188]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[190]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[35]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[167]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[193]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[24]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[197]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[198]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Mestranol	DMG3F94	Contraception	QA21	Approved	[202]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[203]

Drug(s) Affected By Hyaluronan synthase 1 (HAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[204]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[167]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[205]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[3]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[22]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[3]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[206]

Drug(s) Affected By Klotho (KL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[31]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[209]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[210]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[211]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[3]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[3]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[3]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[3]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[34]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[51]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[212]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[213]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[214]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[71]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[215]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[218]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[223]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[225]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[222]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[226]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[228]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[232]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[83]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[233]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[234]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[235]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[236]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[49]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[238]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[239]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[240]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[241]

Drug(s) Affected By Cell division control protein 42 homolog (CDC42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[243]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[32]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[245]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[246]
Bortezomib	DMNO38U	Leukemia		Approved	[161]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[249]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[249]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[250]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[251]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[253]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[254]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Thyroid peroxidase (TPO) Main DME	DEXL6TZ	PERT_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)	OTTG0NFD	S5A2_HUMAN	Gene/Protein Processing	[3]
5,6-dihydroxyindole-2-carboxylic acid oxidase	OTRK49R4	TYRP1_HUMAN	Gene/Protein Processing	[3]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[4]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Gene/Protein Processing	[3]
Aquaporin-1 (AQP1)	OTX5MYX9	AQP1_HUMAN	Gene/Protein Processing	[3]
Aquaporin-3 (AQP3)	OT2J7JPD	AQP3_HUMAN	Gene/Protein Processing	[3]
ATP-citrate synthase (ACLY)	OTRL9ZRP	ACLY_HUMAN	Gene/Protein Processing	[3]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[3]
Carbonic anhydrase 1 (CA1)	OTNFBVVQ	CAH1_HUMAN	Gene/Protein Processing	[5]
Carbonic anhydrase 2 (CA2)	OTJRMUAG	CAH2_HUMAN	Gene/Protein Processing	[5]

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