Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOBIKY)

Drug Name
Bexarotene Drug Info
Synonyms
Bexaroteno; Bexarotenum; Targret; Targretin; Targretyn; Targrexin; Bexarotene [USAN]; Elan brand of bexarotene;Ligand brand of bexarotene; LG 1069; LG100069; LG1069; LG69 compound; LGD 1069; LGD1069; LG-100069; LGD-1069; Targretin (TN); Targretin-gel; Bexarotene (USAN/INN); P-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)vinyl)benzoic acid; 3-methyl-TTNEB; 4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl)benzoic acid; 4-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic acid; 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)ethenyl]benzoic acid; 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl]benzoic acid; 4-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethenyl]benzoic acid; 4-[1-3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthaleneyl)vinyl]benzene carboxylic acid; 9RA
Indication
Disease Entry ICD 11 Status REF
Cutaneous T-cell lymphoma 2B01 Approved [1]
Plasma cell myeloma 2A83.1 Approved [2]
Primary cutaneous T-cell lymphoma Approved [2]
Schizoaffective disorder 6A21 Approved [2]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
82146
ChEBI ID
CHEBI:50859
CAS Number
CAS 153559-49-0
TTD Drug ID
DMOBIKY
INTEDE Drug ID
DR0208
ACDINA Drug ID
D00068

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Retinoic acid receptor RXR-alpha (RXRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [9]
2-chloro-5-nitro-N-phenylbenzamide DMUGQIV Discovery agent N.A. Investigative [10]
AGN-34 DM5ECDM Discovery agent N.A. Investigative [11]
LG100754 DMEK4FY Discovery agent N.A. Investigative [12]
(5BETA)-PREGNANE-3,20-DIONE DMVQ6RN Discovery agent N.A. Investigative [10]
phytanic acid DMSZ1RB Discovery agent N.A. Investigative [13]
CD3254 DM38MU1 Discovery agent N.A. Investigative [14]
UVI3003 DM95UI1 Discovery agent N.A. Investigative [15]
Tributylstannanyl DMHN7CB Discovery agent N.A. Investigative [10]
methoprene acid DM58A0W Discovery agent N.A. Investigative [16]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Selenium DM25CGV N. A. N. A. Approved [35]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [37]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Acitretin DM8BKU9 Psoriasis vulgaris EA90 Approved [40]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [42]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [41]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [17]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [18]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [19]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [20]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [22]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [23]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [24]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [18]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [26]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [4]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [4]
Verapamil DMA7PEW Angina pectoris BA40 Approved [30]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [31]
Estrone DM5T6US Acne vulgaris ED80 Approved [32]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [33]
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Drug(s) Affected By Keratin, type I cytoskeletal 14 (KRT14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Folic Acid DMEMBJC Colorectal carcinoma Approved [48]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [44]
Methamphetamine DMPM4SK Anxiety Approved [49]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [50]
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Drug(s) Affected By Involucrin (IVL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [51]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [45]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [54]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [55]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [56]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [57]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [52]
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Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [44]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [61]
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Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase K (TGM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [65]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [66]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [67]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [68]
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Drug(s) Affected By Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [71]
Panobinostat DM58WKG Chronic graft versus host disease Approved [72]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
Testosterone enanthate DMB6871 N. A. N. A. Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Ethanol DMDRQZU Chronic pain MG30 Approved [73]
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Drug(s) Affected By CCN family member 1 (CCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [77]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
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Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [83]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [84]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [84]
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [86]
Fluoxetine DM3PD2C Bipolar depression Approved [84]
Fructose DM43AN2 Vomiting MD90 Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [84]
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Drug(s) Affected By Period circadian protein homolog 2 (PER2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [89]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [90]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [92]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [34]
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Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [93]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [94]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [93]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Dolutegravir DMCZGRE Human immunodeficiency virus infection 1C62 Approved [97]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [93]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [98]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [99]
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Drug(s) Affected By E3 ubiquitin-protein ligase SIAH2 (SIAH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Estrone DM5T6US Acne vulgaris ED80 Approved [100]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [103]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [41]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
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Drug(s) Affected By Integral membrane protein 2A (ITM2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [105]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [108]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [109]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [110]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [111]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [72]
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Drug(s) Affected By Transcription factor Maf (MAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [113]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [114]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [115]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [34]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [116]
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Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [117]
Panobinostat DM58WKG Chronic graft versus host disease Approved [72]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [119]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [120]
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Drug(s) Affected By PRA1 family protein 3 (ARL6IP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [103]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [123]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [124]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [125]
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Drug(s) Affected By Dickkopf-related protein 1 (DKK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [129]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
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Drug(s) Affected By Cytochrome c oxidase subunit 2 (COX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Quercetin DM3NC4M Obesity 5B81 Approved [131]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [132]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [133]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [122]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [133]
Menthol DMG2KW7 Back pain ME84.Z Approved [135]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [136]
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Drug(s) Affected By Tissue-type plasminogen activator (PLAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [138]
Etretinate DM2CZFA Keratosis ED56 Approved [139]
Prednisone DM2HG4X Acute asthma CA23 Approved [140]
Methotrexate DM2TEOL Anterior urethra cancer Approved [141]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [142]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [143]
Fructose DM43AN2 Vomiting MD90 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
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Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [146]
Etretinate DM2CZFA Keratosis ED56 Approved [147]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [148]
Methotrexate DM2TEOL Anterior urethra cancer Approved [141]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [149]
Quercetin DM3NC4M Obesity 5B81 Approved [150]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
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Drug(s) Affected By Protein S100-A9 (S100A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [153]
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [54]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [122]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [154]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
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Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [155]
Bambuterol DMKLSHF Asthma CA23 Approved [156]
Terbutaline DMD4381 Asthma CA23 Approved [157]
Salbutamol DMN9CWF Acute asthma CA23 Approved [158]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [159]
Methotrexate DM2TEOL Anterior urethra cancer Approved [160]
Epinephrine DM3KJBC Acute asthma CA23 Approved [161]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [162]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [163]
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Drug(s) Affected By Asparagine synthetase (ASNS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [164]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [165]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [166]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [165]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [167]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [168]
Fluoxetine DM3PD2C Bipolar depression Approved [165]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
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Drug(s) Affected By SPARC (SPARC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [169]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [170]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [171]
Ethanol DMDRQZU Chronic pain MG30 Approved [172]
Folic Acid DMEMBJC Colorectal carcinoma Approved [173]
Paclitaxel DMLB81S Breast carcinoma Approved [174]
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Drug(s) Affected By Pro-cathepsin H (CTSH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [124]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [89]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor beta (RARB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [175]
Panobinostat DM58WKG Chronic graft versus host disease Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [176]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Ethanol DMDRQZU Chronic pain MG30 Approved [177]
Folic Acid DMEMBJC Colorectal carcinoma Approved [178]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [179]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ornithine decarboxylase (ODC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [180]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [181]
Methotrexate DM2TEOL Anterior urethra cancer Approved [182]
Quercetin DM3NC4M Obesity 5B81 Approved [183]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [44]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [184]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [122]
Propranolol DM79NTF Angina pectoris BA40 Approved [185]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [186]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [187]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [187]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [123]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin beta-6 (ITGB6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Paclitaxel DMLB81S Breast carcinoma Approved [174]
Bortezomib DMNO38U Leukemia Approved [189]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [190]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [66]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [191]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type I cytoskeletal 15 (KRT15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [58]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
Etretinate DM2CZFA Keratosis ED56 Approved [193]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [194]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Ethanol DMDRQZU Chronic pain MG30 Approved [196]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [119]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 6 (IGFBP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [69]
Methotrexate DM2TEOL Anterior urethra cancer Approved [141]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [197]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [198]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [200]
Menthol DMG2KW7 Back pain ME84.Z Approved [201]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [180]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [202]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [203]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [204]
Methotrexate DM2TEOL Anterior urethra cancer Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [206]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [207]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [208]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ephrin type-A receptor 2 (EPHA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Testosterone DM7HUNW Hot flushes GA30 Approved [209]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [200]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [210]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane 4 L6 family member 1 (TM4SF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [211]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High affinity cationic amino acid transporter 1 (SLC7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [213]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystathionine gamma-lyase (CTH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [164]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [169]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [214]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [213]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [215]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [216]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [164]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-15 (IL15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [217]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [218]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [56]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [219]
Bortezomib DMNO38U Leukemia Approved [189]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [66]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [220]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [221]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Selenium DM25CGV N. A. N. A. Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [222]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [216]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycine--tRNA ligase (GARS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [223]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [224]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [225]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [41]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [41]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 1 (EIF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [226]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [122]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [41]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [227]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [56]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [228]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [229]
Diazepam DM08E9O Alcohol withdrawal Approved [230]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [231]
Desogestrel DM27U4Y Contraception QA21 Approved [231]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [229]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [229]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [232]
Quercetin DM3NC4M Obesity 5B81 Approved [233]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein gamma (CEBPG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [200]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [108]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [234]
Arsenic DMTL2Y1 N. A. N. A. Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [236]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [237]
Gefitinib DM15F0X Colon adenocarcinoma Approved [238]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [239]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [240]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [241]
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [242]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/arginine-rich splicing factor 2 (SRSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [245]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [246]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [234]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Selenium DM25CGV N. A. N. A. Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [247]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [214]
Panobinostat DM58WKG Chronic graft versus host disease Approved [72]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [248]
Estrone DM5T6US Acne vulgaris ED80 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [249]
Quercetin DM3NC4M Obesity 5B81 Approved [250]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [251]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [152]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [252]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [253]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [51]
Selenium DM25CGV N. A. N. A. Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [51]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [254]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [229]
Diazepam DM08E9O Alcohol withdrawal Approved [230]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [255]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [229]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [229]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [256]
Ethacrynic acid DM60QMR Edema MG29 Approved [255]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Early growth response protein 3 (EGR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [214]
Estrone DM5T6US Acne vulgaris ED80 Approved [257]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [216]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proline-rich nuclear receptor coactivator 1 (PNRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [187]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [245]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [259]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [108]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [211]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Menthol DMG2KW7 Back pain ME84.Z Approved [201]
Capsaicin DMGMF6V Back pain ME84.Z Approved [260]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [261]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [262]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [263]
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Drug(s) Affected By Protein AF1q (MLLT11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [264]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [265]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [200]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [120]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [124]
Bortezomib DMNO38U Leukemia Approved [189]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 10 (KLF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [266]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [267]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [99]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [66]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuronal membrane glycoprotein M6-b (GPM6B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [77]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Testosterone enanthate DMB6871 N. A. N. A. Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [124]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [77]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [266]
Methotrexate DM2TEOL Anterior urethra cancer Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [268]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [269]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [164]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [202]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [270]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [271]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [208]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Racecadotril DMFOTZ7 Diarrhea ME05.1 Approved [272]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adipogenesis regulatory factor (ADIRF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [206]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [261]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [273]
Arsenic DMTL2Y1 N. A. N. A. Approved [235]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [115]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [274]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [275]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [180]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [276]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Panobinostat DM58WKG Chronic graft versus host disease Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [277]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [216]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [41]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [278]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [266]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [164]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [62]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [200]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [56]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [279]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mothers against decapentaplegic homolog 5 (SMAD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Testosterone enanthate DMB6871 N. A. N. A. Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Arsenic DMTL2Y1 N. A. N. A. Approved [280]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [281]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Immediate early response gene 2 protein (IER2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Methotrexate DM2TEOL Anterior urethra cancer Approved [160]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [282]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [122]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [200]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [283]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA-binding protein PNO1 (PNO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Testosterone DM7HUNW Hot flushes GA30 Approved [209]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Bortezomib DMNO38U Leukemia Approved [189]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [108]
Arsenic DMTL2Y1 N. A. N. A. Approved [235]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [274]
Urethane DM7NSI0 N. A. N. A. Phase 4 [284]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein DEPP1 (DEPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [165]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [168]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [285]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [165]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [165]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Fluoxetine DM3PD2C Bipolar depression Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [168]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [164]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [169]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [286]
Methotrexate DM2TEOL Anterior urethra cancer Approved [105]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [287]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [213]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [288]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gamma-adducin (ADD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [266]
Selenium DM25CGV N. A. N. A. Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [273]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [290]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor MafF (MAFF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [291]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [292]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [293]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [80]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [214]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiomotin-like protein 2 (AMOTL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [211]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [294]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [295]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysyl oxidase homolog 2 (LOXL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [160]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [296]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [214]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [112]
Testosterone enanthate DMB6871 N. A. N. A. Approved [74]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Ethanol DMDRQZU Chronic pain MG30 Approved [172]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein p73 (TP73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [297]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [211]
Etretinate DM2CZFA Keratosis ED56 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [299]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [64]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [134]
Menthol DMG2KW7 Back pain ME84.Z Approved [201]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [300]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [302]
Gefitinib DM15F0X Colon adenocarcinoma Approved [303]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [304]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [305]
Etretinate DM2CZFA Keratosis ED56 Approved [8]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [167]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [306]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [307]
Quercetin DM3NC4M Obesity 5B81 Approved [308]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein A-II (APOA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [36]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [267]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [7]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [310]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [7]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [310]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [91]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [311]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [312]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [313]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [314]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [315]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [316]
Prednisone DM2HG4X Acute asthma CA23 Approved [317]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [318]
Methotrexate DM2TEOL Anterior urethra cancer Approved [85]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [319]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [321]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [322]
Gefitinib DM15F0X Colon adenocarcinoma Approved [323]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [324]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [325]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [326]
Methotrexate DM2TEOL Anterior urethra cancer Approved [327]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [328]
Quercetin DM3NC4M Obesity 5B81 Approved [329]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [330]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [302]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Selenium DM25CGV N. A. N. A. Approved [331]
Etretinate DM2CZFA Keratosis ED56 Approved [8]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [332]
Methotrexate DM2TEOL Anterior urethra cancer Approved [141]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [78]
Quercetin DM3NC4M Obesity 5B81 Approved [329]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [145]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [330]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [333]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [34]
Selenium DM25CGV N. A. N. A. Approved [331]
Etretinate DM2CZFA Keratosis ED56 Approved [8]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [334]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [335]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [167]
Methotrexate DM2TEOL Anterior urethra cancer Approved [336]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [337]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [338]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [339]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [340]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [341]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [342]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [343]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [344]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [345]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [346]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor RXR-beta (RXRB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [347]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Testosterone enanthate DMB6871 N. A. N. A. Approved [74]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [348]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Capsaicin DMGMF6V Back pain ME84.Z Approved [349]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [350]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [351]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [352]
Arsenic DMTL2Y1 N. A. N. A. Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [79]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [353]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [52]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [354]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [83]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [355]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [36]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [357]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [226]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [333]
Gefitinib DM15F0X Colon adenocarcinoma Approved [303]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [324]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Etretinate DM2CZFA Keratosis ED56 Approved [8]
Prednisone DM2HG4X Acute asthma CA23 Approved [358]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [334]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [286]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor RXR-gamma (RXRG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [211]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [359]
Ethanol DMDRQZU Chronic pain MG30 Approved [360]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [350]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [228]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [350]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [361]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [362]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [363]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [364]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [365]
Testosterone DM7HUNW Hot flushes GA30 Approved [118]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [192]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [366]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [367]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [368]
Ethanol DMDRQZU Chronic pain MG30 Approved [369]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [370]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [96]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [371]
Ethanol DMDRQZU Chronic pain MG30 Approved [372]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [371]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [373]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [374]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [124]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [375]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [376]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [377]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [378]
Etretinate DM2CZFA Keratosis ED56 Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [379]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [127]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [380]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [213]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [381]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 9 (KLF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [266]
Selenium DM25CGV N. A. N. A. Approved [69]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [382]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [383]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [382]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [382]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [384]
Leflunomide DMR8ONJ Arthritis FA20 Approved [63]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sonic hedgehog protein (SHH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [385]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [386]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [387]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [388]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
Folic Acid DMEMBJC Colorectal carcinoma Approved [389]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [66]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [390]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [294]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [391]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [392]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [165]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [292]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [365]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [83]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [165]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [168]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [393]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Fluoxetine DM3PD2C Bipolar depression Approved [165]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Retinoic acid receptor RXR-alpha (RXRA) TT6PEUO RXRA_HUMAN Modulator [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Gene/Protein Processing [5]
Adipogenesis regulatory factor (ADIRF) OTTJP8D4 ADIRF_HUMAN Gene/Protein Processing [6]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [6]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [6]
Angiomotin-like protein 2 (AMOTL2) OTRCTKV9 AMOL2_HUMAN Gene/Protein Processing [6]
Apolipoprotein A-II (APOA2) OTQ3HGTC APOA2_HUMAN Gene/Protein Processing [7]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Gene/Protein Processing [6]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [8]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) OTVZD4H6 BNIP2_HUMAN Gene/Protein Processing [6]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Gene/Protein Processing [6]

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111 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
112 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
113 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
114 A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med. 2006 Dec;3(12):e486. doi: 10.1371/journal.pmed.0030486.
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