Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTV42K)

• Drug Name: G1 Drug Info
• Synonyms: CHEMBL569766; 1-[(3aS,4R,9bR)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone; 1-(4-(6-Bromobenzo[1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl)-ethanone; SR-01000506928; AC1NT1SF; GTPL1014; SCHEMBL12700948; cid_5322399; cid_3136849; MolPort-003-004-976; ML051; HMS3650I22; ZINC4172149; BDBM50303803; STK330808; AKOS015969580; HY-107216; CS-0027669; UNM000011063001; UNM000000675701; SR-01000506928-1; SR-01000506928-3; 925419-53-0

Indication

Disease Entry	ICD 11	Status	REF
Lymphoma	2A80-2A86	Phase 1/2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]

• Cross-matching ID:
  PubChem CID: 5322399
  ChEBI ID: CHEMBL569766
  CAS Number: CAS 881639-98-1
  TTD Drug ID: DMTV42K

Molecule-Related Drug Atlas

Drug(s) Targeting G-protein coupled estrogen receptor 1 (GPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Segesterone acetate; ethinyl estradiol	DMFEGB0	Contraception	QA21	Approved	[5]
G15	DMMEC9D	Discovery agent	N.A.	Investigative	[6]
G36	DMDJCIP	Discovery agent	N.A.	Investigative	[7]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[9]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[10]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[11]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[10]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[12]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[13]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]

Drug(s) Affected By PDZ domain-containing protein GIPC1 (GIPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[3]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[24]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[25]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 12A (PPP1R12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[28]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[32]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[4]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[38]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[39]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Tripartite motif-containing protein 16 (TRIM16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[46]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[47]
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[49]

Drug(s) Affected By Serine/threonine-protein kinase PAK 4 (PAK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[50]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[51]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[53]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[54]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[26]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[55]

Drug(s) Affected By Vasopressin-neurophysin 2-copeptin (AVP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[57]
Oxprenolol	DM51OQW	Anxiety		Approved	[58]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[60]
Luvox	DMJKROX	Anxiety disorder	6B00-6B0Z	Approved	[61]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[62]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[57]
Chlorpropamide	DMPHZQE	Non-insulin dependent diabetes	5A11	Approved	[63]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[67]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[75]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[76]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[77]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[79]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[81]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[82]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[83]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[84]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[85]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[88]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[79]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[89]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[90]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[81]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[82]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[98]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[98]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]

Drug(s) Affected By Paxillin (PXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[100]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[103]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[104]

Drug(s) Affected By Choline-phosphate cytidylyltransferase A (PCYT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[109]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[110]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[98]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]

Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[19]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[118]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit B (EIF3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[21]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[120]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein K (HNRNPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Haloperidol	DM96SE0	Delirium		Approved	[123]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[125]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[122]

Drug(s) Affected By Small ribosomal subunit protein RACK1 (RACK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[123]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[123]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[130]

Drug(s) Affected By General transcription factor II-I (GTF2I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[117]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[3]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[133]

Drug(s) Affected By Spectrin beta chain, non-erythrocytic 1 (SPTBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[137]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[138]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[139]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[120]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[142]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Ras GTPase-activating protein-binding protein 1 (G3BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[3]

Drug(s) Affected By SNW domain-containing protein 1 (SNW1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[3]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[147]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[53]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[149]

Drug(s) Affected By E2F-associated phosphoprotein (EAPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[3]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[26]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[70]

Drug(s) Affected By EF-hand domain-containing protein D2 (EFHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Selenium	DM25CGV	N. A.	N. A.	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[3]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[154]

Drug(s) Affected By Partitioning defective 6 homolog beta (PARD6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[156]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[154]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[157]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[53]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]

Drug(s) Affected By Golgi reassembly-stacking protein 2 (GORASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[26]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Anillin (ANLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[98]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]

Drug(s) Affected By RNA polymerase I-specific transcription initiation factor RRN3 (RRN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[163]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[50]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[3]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[53]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Protein NDRG2 (NDRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[164]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[138]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[33]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled estrogen receptor 1 (GPER1)	TTDSB34	GPER1_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Post-Translational Modifications	[3]
Choline-phosphate cytidylyltransferase A (PCYT1A)	OTMH0YLN	PCY1A_HUMAN	Post-Translational Modifications	[3]
DNA replication licensing factor MCM2 (MCM2)	OTGGORIQ	MCM2_HUMAN	Post-Translational Modifications	[3]
E2F-associated phosphoprotein (EAPP)	OTDPUE6Y	EAPP_HUMAN	Post-Translational Modifications	[3]
EF-hand domain-containing protein D2 (EFHD2)	OTM9VMN3	EFHD2_HUMAN	Post-Translational Modifications	[3]
Eukaryotic translation initiation factor 3 subunit B (EIF3B)	OTF67VPH	EIF3B_HUMAN	Post-Translational Modifications	[3]
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)	OT2CF1E6	IF4G1_HUMAN	Post-Translational Modifications	[3]
Eukaryotic translation initiation factor 5 (EIF5)	OT79PQUN	IF5_HUMAN	Post-Translational Modifications	[3]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Protein Interaction/Cellular Processes	[4]
General transcription factor II-I (GTF2I)	OTUYL1TQ	GTF2I_HUMAN	Post-Translational Modifications	[3]

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