Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUPE07)

Drug Name
Nicotinamide Drug Info
Synonyms
Aminicotin; Amixicotyn; Amnicotin; Benicot; Dipegyl; Endobion; Enduramide; Hansamid; Mediatric; Niacevit; Niacinamide; Niacotinamide; Niamide; Nicamina; Nicamindon; Nicasir; Nicobion; Nicofort; Nicogen; Nicomidol; Nicosylamide; Nicota; Nicotamide; Nicotilamide; Nicotililamido; Nicotinamid; Nicotinamida; Nicotinamidum; Nicotinsaeureamid; Nicotinsaureamid; Nicotol; Nicotylamide; Nicotylamidum; Nicovit; Nicovitina; Nicovitol; Nicozymin; Nikasan; Nikazan; Nikotinamid; Nikotinsaeureamid; Niocinamide; Niozymin; Papulex; Pelmin; Pelmine; Savacotyl; Amid kyseliny nikotinove; Amid kyseliny nikotinove [Czech]; Amide PP; Astra Brand of Niacinamide; Austrovit PP; Delonin amide; Factor pp; Inovitan PP; Jenapharm Brand of Niacinamide; Merck Brand of Niacinamide; Niacinamide Astra Brand; Niacinamide Jenapharm Brand; Niacinamide Merck Brand; Niacinamide Pharmagenix Brand; Niacinamide [USAN]; Niavit PP; Nicotine acid amide; Nicotine amide; Nicotinic acid amide; Nicotinic amide; Nicotinsaureamid Jenapharm; Nicotinsaureamid [German]; Nikotinsaeureamid [German]; Pelonin amide; Pharmagenix Brand of Niacinamide; Vitamin B; Vitamin PP; Witamina PP; Nicosan 2; Vitamin H1; B 3, Vitamin; B3, Vitamin; Beta-Pyridinecarboxamide; Jenapharm, Nicotinsaureamid; Nandervit-N; Niacin-Vitamin B3; Niacinamide (USP); Nicotinamida [INN-Spanish]; Nicotinamide (Niacinamide); Nicotinamidum [INN-Latin]; Niko-tamin; PP-Faktor; Vi-Nicotyl; Vitamin B (VAN); M-(Aminocarbonyl)pyridine; Niacinamide, Nicotinic acid amide, Nicotinamide; Nicotinamide (JP15/INN); Nicotinamide, niacin, vitamin B3; Nicotinamide-carbonyl-14C; Pyridine-3-carboxamide; Pyridine-3-carboxylic acid amide; 3 Pyridinecarboxamide; 3-Carbamoylpyridine; 3-Pyridinecarboxamide; 3-Pyridinecarboxylic acid amide
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Clear cell renal carcinoma Approved [2]
Inflammatory skin condition EF20.Y Approved [3]
Pellagra Approved [4]
Primary hypercholesterolemia 5C80.00 Approved [5]
Psoriasis EA90 Approved [6]
Thyroid cancer 2D10 Approved [7]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
936
ChEBI ID
CHEMBL17154
CAS Number
CAS 98-92-0
TTD Drug ID
DMUPE07
INTEDE Drug ID
DR1147

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Poly [ADP-ribose] polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
KU-0058948 DMSA4HZ Ovarian cancer 2C73 Approved [18]
Niraparib Tosylate DMLPSWQ Fallopian tube cancer 2C74 Approved [19]
CC-486 DMTNQB0 Acute myeloid leukaemia 2A60 Phase 3 [20]
Nicaraven DMFBNA3 Cerebrovascular disease 8B2Z Phase 3 [21]
PMID27841036-Compound-37 DM0OVZ2 Ovarian cancer 2C73 Phase 2 [22]
Stenoparib DMKVBL8 Ovarian cancer 2C73 Phase 2 [23]
AG140699 DMA9FKY Melanoma 2C30 Phase 2 [24]
AZD5305 DMW9R1C Prostate cancer 2C82.0 Phase 2 [25]
AMXI 5001 DMR9H6B Solid tumour/cancer 2A00-2F9Z Phase 1/2 [26]
NMS-03305293 DM2XIRW Solid tumour/cancer 2A00-2F9Z Phase 1 [27]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [33]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Estrone DM5T6US Acne vulgaris ED80 Approved [35]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [36]
Ethanol DMDRQZU Chronic pain MG30 Approved [37]
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Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [42]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [43]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [48]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [52]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [53]
Panobinostat DM58WKG Chronic graft versus host disease Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
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Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [58]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [59]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [16]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [43]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [61]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [62]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [63]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
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Drug(s) Affected By Ferritin heavy chain (FTH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [66]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [72]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [73]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [74]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [75]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [76]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [77]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [82]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [80]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [83]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [84]
Gefitinib DM15F0X Colon adenocarcinoma Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [86]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [87]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [88]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
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Drug(s) Affected By SHC-transforming protein 1 (SHC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Bortezomib DMNO38U Leukemia Approved [96]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [97]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [98]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [99]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [100]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [101]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [102]
Gefitinib DM15F0X Colon adenocarcinoma Approved [103]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [104]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [105]
Etretinate DM2CZFA Keratosis ED56 Approved [106]
Prednisone DM2HG4X Acute asthma CA23 Approved [107]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [108]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [109]
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Drug(s) Affected By Transcription factor SOX-9 (SOX9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [101]
Selenium DM25CGV N. A. N. A. Approved [110]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [111]
Panobinostat DM58WKG Chronic graft versus host disease Approved [54]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [43]
Testosterone DM7HUNW Hot flushes GA30 Approved [112]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Leflunomide DMR8ONJ Arthritis FA20 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [115]
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Drug(s) Affected By C-C motif chemokine 20 (CCL20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [116]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [118]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [119]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [118]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Leflunomide DMR8ONJ Arthritis FA20 Approved [114]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [13]
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Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [120]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [121]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [122]
Quercetin DM3NC4M Obesity 5B81 Approved [123]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [125]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [126]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [127]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [128]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [129]
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Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [131]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [132]
Methotrexate DM2TEOL Anterior urethra cancer Approved [133]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [134]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [135]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [136]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [137]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [56]
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Drug(s) Affected By Pituitary homeobox 2 (PITX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Quercetin DM3NC4M Obesity 5B81 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Panobinostat DM58WKG Chronic graft versus host disease Approved [54]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [130]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [142]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [95]
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Drug(s) Affected By SOSS complex subunit B1 (NABP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [95]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [143]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [144]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [145]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [146]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [144]
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Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [147]
Fructose DM43AN2 Vomiting MD90 Approved [148]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [149]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [150]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [151]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [152]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [153]
Leflunomide DMR8ONJ Arthritis FA20 Approved [114]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [153]
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Drug(s) Affected By Chimeric ERCC6-PGBD3 protein (ERCC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [154]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [141]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [97]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [155]
Arsenic DMTL2Y1 N. A. N. A. Approved [156]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [155]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [159]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Poly [ADP-ribose] polymerase 1 (PARP1) TTVDSZ0 PARP1_HUMAN Binder [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2E1 (CYP2E1) Main DME DEVDYN7 CP2E1_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Post-Translational Modifications [10]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [11]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [11]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [12]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Gene/Protein Processing [13]
Chimeric ERCC6-PGBD3 protein (ERCC6) OT2QZKSF ERPG3_HUMAN Regulation of Drug Effects [14]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [15]
Cytochrome c oxidase subunit 1 (COX1) OTG3O9BN COX1_HUMAN Gene/Protein Processing [16]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Gene/Protein Processing [16]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Gene/Protein Processing [17]

References

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2 ABAT and ALDH6A1, regulated by transcription factor HNF4A, suppress tumorigenic capability in clear cell renal cell carcinoma. J Transl Med. 2020 Feb 24;18(1):101.
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4 Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation. Antioxidants (Basel). 2021 Aug 21;10(8):1315.
5 Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Hypertensive Patients With Primary Hyperaldosteronemia: Role of 5,6,7,8-Tetrahydrobiopterin Oxidation and Endothelial Nitric Oxide Synthase Uncoupling. Hypertension. 2016 Feb;67(2):430-9.
6 Co-delivery of methotrexate and nicotinamide by cerosomes for topical psoriasis treatment with enhanced efficacy. Int J Pharm. 2021 Aug 10;605:120826.
7 Nicotinamide N-Methyltransferase in Head and Neck Tumors: A Comprehensive Review. Biomolecules. 2021 Oct 28;11(11):1594.
8 beta-1,2,3-Triazolyl-nucleosides as nicotinamide riboside mimics. Nucleosides Nucleotides Nucleic Acids. 2009 Mar;28(3):238-59.
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10 Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun. 2009 Jan 23;378(4):836-41. doi: 10.1016/j.bbrc.2008.11.130. Epub 2008 Dec 9.
11 Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells. Toxicol Appl Pharmacol. 2016 Jan 15;291:70-83. doi: 10.1016/j.taap.2015.12.006. Epub 2015 Dec 19.
12 Nicotinamide inhibits tissue factor expression in isolated human pancreatic islets: implications for clinical islet transplantation. Transplantation. 2003 Nov 15;76(9):1285-8. doi: 10.1097/01.TP.0000098905.86445.0F.
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17 Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells. J Biol Chem. 2014 Aug 8;289(32):22048-62. doi: 10.1074/jbc.M114.568790. Epub 2014 Jun 24.
18 Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3. J Med Chem. 2009 May 14;52(9):3108-11.
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22 PARP inhibitors as antitumor agents: a patent update (2013-2015).Expert Opin Ther Pat. 2017 Mar;27(3):363-382.
23 Clinical pipeline report, company report or official report of Allarity Therapeutics.
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25 Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper. Clin Cancer Res. 2022 Nov 1;28(21):4724-4736.
26 AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers. Am J Cancer Res. 2020 Aug 1;10(8):2649-2676.
27 NMS-P293, a PARP-1 selective inhibitor with no trapping activity and high CNS penetration, possesses potent in vivo efficacy and represents a novel therapeutic option for brain localized metastases and glioblastoma. Cancer Res 2018;78(13 Suppl):Abstract nr 4843.
28 Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G54-63.
29 Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis. Kidney Int. 2003 May;63(5):1687-96.
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