Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUPE07)

Drug Name
Nicotinamide Drug Info
Synonyms
Aminicotin; Amixicotyn; Amnicotin; Benicot; Dipegyl; Endobion; Enduramide; Hansamid; Mediatric; Niacevit; Niacinamide; Niacotinamide; Niamide; Nicamina; Nicamindon; Nicasir; Nicobion; Nicofort; Nicogen; Nicomidol; Nicosylamide; Nicota; Nicotamide; Nicotilamide; Nicotililamido; Nicotinamid; Nicotinamida; Nicotinamidum; Nicotinsaeureamid; Nicotinsaureamid; Nicotol; Nicotylamide; Nicotylamidum; Nicovit; Nicovitina; Nicovitol; Nicozymin; Nikasan; Nikazan; Nikotinamid; Nikotinsaeureamid; Niocinamide; Niozymin; Papulex; Pelmin; Pelmine; Savacotyl; Amid kyseliny nikotinove; Amid kyseliny nikotinove [Czech]; Amide PP; Astra Brand of Niacinamide; Austrovit PP; Delonin amide; Factor pp; Inovitan PP; Jenapharm Brand of Niacinamide; Merck Brand of Niacinamide; Niacinamide Astra Brand; Niacinamide Jenapharm Brand; Niacinamide Merck Brand; Niacinamide Pharmagenix Brand; Niacinamide [USAN]; Niavit PP; Nicotine acid amide; Nicotine amide; Nicotinic acid amide; Nicotinic amide; Nicotinsaureamid Jenapharm; Nicotinsaureamid [German]; Nikotinsaeureamid [German]; Pelonin amide; Pharmagenix Brand of Niacinamide; Vitamin B; Vitamin PP; Witamina PP; Nicosan 2; Vitamin H1; B 3, Vitamin; B3, Vitamin; Beta-Pyridinecarboxamide; Jenapharm, Nicotinsaureamid; Nandervit-N; Niacin-Vitamin B3; Niacinamide (USP); Nicotinamida [INN-Spanish]; Nicotinamide (Niacinamide); Nicotinamidum [INN-Latin]; Niko-tamin; PP-Faktor; Vi-Nicotyl; Vitamin B (VAN); M-(Aminocarbonyl)pyridine; Niacinamide, Nicotinic acid amide, Nicotinamide; Nicotinamide (JP15/INN); Nicotinamide, niacin, vitamin B3; Nicotinamide-carbonyl-14C; Pyridine-3-carboxamide; Pyridine-3-carboxylic acid amide; 3 Pyridinecarboxamide; 3-Carbamoylpyridine; 3-Pyridinecarboxamide; 3-Pyridinecarboxylic acid amide
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Clear cell renal carcinoma Approved [2]
Inflammatory skin condition EF20.Y Approved [3]
Pellagra Approved [4]
Primary hypercholesterolemia 5C80.00 Approved [5]
Psoriasis EA90 Approved [6]
Thyroid cancer 2D10 Approved [7]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
936
ChEBI ID
CHEBI:17154
CAS Number
CAS 98-92-0
TTD Drug ID
DMUPE07
INTEDE Drug ID
DR1147

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Poly [ADP-ribose] polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
KU-0058948 DMSA4HZ Ovarian cancer 2C73 Approved [18]
Niraparib Tosylate DMLPSWQ Fallopian tube cancer 2C74 Approved [19]
CC-486 DMTNQB0 Acute myeloid leukaemia 2A60 Phase 3 [20]
Nicaraven DMFBNA3 Cerebrovascular disease 8B2Z Phase 3 [21]
PMID27841036-Compound-37 DM0OVZ2 Ovarian cancer 2C73 Phase 2 [22]
Stenoparib DMKVBL8 Ovarian cancer 2C73 Phase 2 [23]
AG140699 DMA9FKY Melanoma 2C30 Phase 2 [24]
AZD5305 DMW9R1C Prostate cancer 2C82.0 Phase 2 [25]
AMXI 5001 DMR9H6B Solid tumour/cancer 2A00-2F9Z Phase 1/2 [26]
NMS-03305293 DM2XIRW Solid tumour/cancer 2A00-2F9Z Phase 1 [27]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [33]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Estrone DM5T6US Acne vulgaris ED80 Approved [35]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [36]
Ethanol DMDRQZU Chronic pain MG30 Approved [37]
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Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [39]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [41]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [42]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [43]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [44]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [48]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [52]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [53]
Panobinostat DM58WKG Chronic graft versus host disease Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
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Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [58]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [59]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [60]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [43]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [63]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [64]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [65]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [66]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [67]
Fructose DM43AN2 Vomiting MD90 Approved [68]
Ketoprofen DMRKXPT Bursitis Approved [68]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [69]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [70]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [71]
Gefitinib DM15F0X Colon adenocarcinoma Approved [72]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Gefitinib DM15F0X Colon adenocarcinoma Approved [77]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [78]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [80]
Selenium DM25CGV N. A. N. A. Approved [81]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [82]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [83]
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Drug(s) Affected By Ferritin heavy chain (FTH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [85]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [90]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [91]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [92]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [94]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [97]
Paclitaxel DMLB81S Breast carcinoma Approved [98]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [99]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [101]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [102]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [103]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [104]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [106]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [107]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [80]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [109]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [110]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [111]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [106]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [112]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [79]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [113]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [78]
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Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [107]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Gefitinib DM15F0X Colon adenocarcinoma Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [116]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [117]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [118]
Methotrexate DM2TEOL Anterior urethra cancer Approved [94]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [119]
Quercetin DM3NC4M Obesity 5B81 Approved [120]
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Drug(s) Affected By Tissue factor (F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [121]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [122]
Methotrexate DM2TEOL Anterior urethra cancer Approved [123]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [124]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Fructose DM43AN2 Vomiting MD90 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [122]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [129]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Gefitinib DM15F0X Colon adenocarcinoma Approved [72]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [74]
Selenium DM25CGV N. A. N. A. Approved [131]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [132]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [134]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [135]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [136]
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Drug(s) Affected By SHC-transforming protein 1 (SHC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [51]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [47]
Bortezomib DMNO38U Leukemia Approved [140]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [141]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [142]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [143]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [144]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [145]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [146]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [147]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [148]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [149]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [150]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [114]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [78]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [151]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [152]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [153]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [154]
Gefitinib DM15F0X Colon adenocarcinoma Approved [155]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [157]
Etretinate DM2CZFA Keratosis ED56 Approved [158]
Prednisone DM2HG4X Acute asthma CA23 Approved [159]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [160]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [161]
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Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [162]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [163]
Gefitinib DM15F0X Colon adenocarcinoma Approved [164]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [166]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [167]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [169]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [170]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [171]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [172]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [173]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [97]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [174]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [175]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [176]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [177]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [178]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [179]
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Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [182]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [183]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [92]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [184]
Leflunomide DMR8ONJ Arthritis FA20 Approved [185]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [92]
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Drug(s) Affected By Transcription factor SOX-9 (SOX9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [153]
Selenium DM25CGV N. A. N. A. Approved [186]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [187]
Panobinostat DM58WKG Chronic graft versus host disease Approved [54]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [43]
Testosterone DM7HUNW Hot flushes GA30 Approved [184]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [188]
Leflunomide DMR8ONJ Arthritis FA20 Approved [185]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [189]
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Drug(s) Affected By C-C motif chemokine 20 (CCL20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [76]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [190]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [88]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [103]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [188]
Leflunomide DMR8ONJ Arthritis FA20 Approved [185]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [14]
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Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Flucytosine DM13VTW Cryptococcal meningitis Approved [192]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [192]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [193]
Methotrexate DM2TEOL Anterior urethra cancer Approved [194]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [195]
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [95]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [196]
Amifostine DM5FL14 Mucositis CA00 Approved [197]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [198]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [179]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Verapamil DMA7PEW Angina pectoris BA40 Approved [199]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [200]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [201]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [202]
Meloxicam DM2AR7L Arthritis FA20 Approved [203]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [160]
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Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [204]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [206]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [207]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [208]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [209]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [210]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [181]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [211]
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Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [212]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [166]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [213]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [214]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [215]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [216]
Testosterone DM7HUNW Hot flushes GA30 Approved [217]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [218]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [219]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-2 (SIRT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [220]
Ethanol DMDRQZU Chronic pain MG30 Approved [221]
Clozapine DMFC71L Schizophrenia 6A20 Approved [222]
Paclitaxel DMLB81S Breast carcinoma Approved [223]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [224]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [225]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [226]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [228]
Selenium DM25CGV N. A. N. A. Approved [186]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [230]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [231]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [232]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [233]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [234]
Testosterone DM7HUNW Hot flushes GA30 Approved [57]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [236]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [237]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [229]
Methotrexate DM2TEOL Anterior urethra cancer Approved [238]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [239]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [240]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [241]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [242]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pituitary homeobox 2 (PITX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [236]
Quercetin DM3NC4M Obesity 5B81 Approved [243]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [244]
Panobinostat DM58WKG Chronic graft versus host disease Approved [54]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [216]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [220]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [236]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [245]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SOSS complex subunit B1 (NABP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [246]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [247]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [248]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [249]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [247]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [40]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [250]
Fructose DM43AN2 Vomiting MD90 Approved [251]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [252]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [231]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [253]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [254]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [255]
Leflunomide DMR8ONJ Arthritis FA20 Approved [185]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chimeric ERCC6-PGBD3 protein (ERCC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [256]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [220]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [141]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [257]
Arsenic DMTL2Y1 N. A. N. A. Approved [258]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [257]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [259]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [260]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [261]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Poly [ADP-ribose] polymerase 1 (PARP1) TTVDSZ0 PARP1_HUMAN Binder [8]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2E1 (CYP2E1) Main DME DEVDYN7 CP2E1_HUMAN Substrate [9]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Post-Translational Modifications [10]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [11]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Gene/Protein Processing [12]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [12]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [13]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Gene/Protein Processing [14]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [15]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Gene/Protein Processing [16]
Chimeric ERCC6-PGBD3 protein (ERCC6) OT2QZKSF ERPG3_HUMAN Regulation of Drug Effects [17]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [16]

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