Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM03CP7)

Drug Name
Calcipotriol Drug Info
Synonyms
Calcipotriene; Divonex; Dovonex; BMS-181161; Daivonex (TN); Dovonex (TN); MC-903; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol; (1S,5Z,7Z,17ALPHA,22E)-24-CYCLOPROPYL-9,10-SECOCHOLA-5,7,10,22-TETRAENE-1,3,24-TRIOL; 1-ALPHA,24S-(OH)2-22-ENE-26,27-DEHYDROVITAMIN D3
Indication
Disease Entry ICD 11 Status REF
Psoriasis EA90 Approved [1]
Psoriasis vulgaris EA90 Approved [2]
Therapeutic Class
Antipsoriatic Agents
Cross-matching ID
PubChem CID
5288783
ChEBI ID
CHEBI:50749
CAS Number
CAS 112965-21-6
TTD Drug ID
DM03CP7
ACDINA Drug ID
D00905

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Vitamin D3 receptor (VDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergocalciferol DMHO0AR Hypoparathyroidism 5A50 Approved [8]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [9]
Calcidiol DMN4CV5 Hypophosphatemia Approved [8]
Doxercalciferol DM6FG1P Chronic kidney disease GB61 Approved [10]
Falecalcitrol DMBI9ZJ Hyperparathyroidism 5A51 Approved [11]
Dihydrotachysterol DMFB97P Hypocalcemia 5B5K.1 Approved [12]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [13]
Paricalcitol DMYBV3G Hyperparathyroidism 5A51 Approved [14]
Seocalcitol DMKL9QO Rickets 5B57 Phase 3 [15]
S-06911 DMAYTIH Osteoporosis FB83.0 Phase 3 [16]
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Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [17]
Calcidiol DMN4CV5 Hypophosphatemia Approved [18]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [23]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [24]
Testosterone DM7HUNW Hot flushes GA30 Approved [25]
Leflunomide DMR8ONJ Arthritis FA20 Approved [26]
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Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [27]
Methotrexate DM2TEOL Anterior urethra cancer Approved [28]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [29]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [30]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Prednisone DM2HG4X Acute asthma CA23 Approved [33]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [34]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [35]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [36]
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Drug(s) Affected By Involucrin (IVL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [40]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [7]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [41]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [42]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [43]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [37]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [40]
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Drug(s) Affected By Keratin, type I cytoskeletal 16 (KRT16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [45]
Testosterone DM7HUNW Hot flushes GA30 Approved [25]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [46]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
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Drug(s) Affected By Keratin, type I cytoskeletal 10 (KRT10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [53]
Testosterone DM7HUNW Hot flushes GA30 Approved [25]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [55]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [49]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [53]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [56]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [57]
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Drug(s) Affected By Filaggrin (FLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [53]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [40]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [7]
Folic Acid DMEMBJC Colorectal carcinoma Approved [58]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [43]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [59]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [40]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [60]
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Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [61]
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [63]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [64]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [66]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [67]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [68]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [63]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [69]
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Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [70]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [71]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [53]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [7]
Leflunomide DMR8ONJ Arthritis FA20 Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [48]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [53]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [73]
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Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [74]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Methotrexate DM2TEOL Anterior urethra cancer Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [77]
Fluoxetine DM3PD2C Bipolar depression Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [81]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [82]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [83]
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Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [84]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [19]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [61]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [84]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [86]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
Fluoxetine DM3PD2C Bipolar depression Approved [84]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [64]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Vitamin D3 receptor (VDR) TTK59TV VDR_HUMAN Antagonist [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Gene/Protein Processing [4]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Gene/Protein Processing [5]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Gene/Protein Processing [6]
Cytochrome P450 7A1 (CYP7A1) OT8Z5KLD CP7A1_HUMAN Gene/Protein Processing [5]
Filaggrin (FLG) OTE9QDV6 FILA_HUMAN Gene/Protein Processing [7]
Involucrin (IVL) OT4VPNGY INVO_HUMAN Gene/Protein Processing [7]
Keratin, type I cytoskeletal 10 (KRT10) OTSVRD3Q K1C10_HUMAN Gene/Protein Processing [7]
Keratin, type I cytoskeletal 16 (KRT16) OTGA0EQN K1C16_HUMAN Gene/Protein Processing [7]
Keratin, type I cytoskeletal 17 (KRT17) OT6Y1DPK K1C17_HUMAN Gene/Protein Processing [7]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Gene/Protein Processing [5]

References

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31 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
32 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
33 Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):229-34. doi: 10.1016/j.jsbmb.2005.03.004.
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40 Retinoic acid and hydroquinone induce inverse expression patterns on cornified envelope-associated proteins: implication in skin irritation. J Dermatol Sci. 2014 Nov;76(2):112-9. doi: 10.1016/j.jdermsci.2014.08.003. Epub 2014 Aug 26.
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44 Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
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46 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
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49 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
50 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
51 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
52 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
53 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
54 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
55 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
56 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
57 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
58 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
59 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
60 Effects of low-dose Bisphenol A on calcium ion influx and on genes of proliferation and differentiation in immortalized human gingival cells in vitro: The role of estrogen receptor beta. Dent Mater. 2017 Sep;33(9):1021-1032. doi: 10.1016/j.dental.2017.06.011. Epub 2017 Jul 9.
61 Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
62 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
63 The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion. J Biol Chem. 2004 Mar 5;279(10):8856-61. doi: 10.1074/jbc.M306422200. Epub 2003 Dec 18.
64 The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes. Mol Pharmacol. 2005 Aug;68(2):551-8. doi: 10.1124/mol.105.012104. Epub 2005 May 23.
65 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
66 Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. Hepatology. 2011 Feb;53(2):548-57. doi: 10.1002/hep.24047. Epub 2010 Dec 10.
67 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
68 Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Arch Biochem Biophys. 2005 Feb 1;434(1):75-85.
69 A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol. 2010 Jun;24(6):1151-64.
70 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
71 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
72 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
73 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
74 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
75 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
76 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
77 Multitarget effects of quercetin in leukemia. Cancer Prev Res (Phila). 2014 Dec;7(12):1240-50. doi: 10.1158/1940-6207.CAPR-13-0383. Epub 2014 Oct 7.
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