Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1EK5D)

Drug Name
Ortataxel Drug Info
Synonyms
UNII-8H61Y4E29N; 186348-23-2; 8H61Y4E29N; IDN-5109; IDN 5109; Ortataxel [INN]; Bay-59-8862; SB-T-101131; SB-T 101131; idn5109; SCHEMBL9932772; CHEMBL382300; BAY-59; IND-5109; DB11669; Z-3102; Hexanoic acid, 3-(((1,1-dimethylethoxy)carbonyl)amino)-2-hydroxy-5-methyl-,; Hexanoic acid; IND5109; 13-(N-tert-butoxycarbonyl-beta-isobutyisoserinyl)-14-hydroxy-baccatin-1,14-carbonate; 13-(N-tert-butoxycarbonyl-beta-isobutyisoserinyl)-14-hydroxybaccatin-1,14-carbonate; Genz29155
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Heart transplant rejection NE84 Preclinical [2]
Cross-matching ID
PubChem CID
6918412
CAS Number
CAS 186348-23-2
TTD Drug ID
DM1EK5D
VARIDT Drug ID
DR01287

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Multidrug resistance protein (MDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzquinamide DMU4D5Y Nausea MD90 Approved [6]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [7]
MM36 DM6VPIO Atopic dermatitis EA80 Phase 2 [7]
Valspodar DMXRU9M Acute myeloid leukaemia 2A60 Discontinued in Phase 3 [8]
WK-X-34 DMX0ZBC Discovery agent N.A. Investigative [7]
KP772 DMUZSJ2 Discovery agent N.A. Investigative [7]
Chemosensitizers DMYSG9J Discovery agent N.A. Investigative [9]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Targeting Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [10]
Nafamostat DMU1XOD Pancreatitis DC31-DC34 Approved [11]
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [12]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [13]
Enbrel DM7RNP3 Arthritis FA20 Approved [14]
Golimumab DMHZV7X Psoriatic arthritis FA21 Approved [15]
Certolizumab DM5CL9Z Rheumatoid arthritis FA20 Approved [16]
Etanercept DMCV109 Arthritis FA20 Approved [17]
Adalimumab DMQMV1B Crohn disease DD70 Approved [18]
Infliximab DMH7OIA Crohn disease DD70 Approved [19]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [20]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [23]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [24]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [25]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [25]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [27]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [28]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [29]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [30]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [32]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [37]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [35]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [38]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [39]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [41]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [42]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Verapamil DMA7PEW Angina pectoris BA40 Approved [44]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [45]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [46]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [47]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [48]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [50]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [51]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [52]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [53]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [54]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [55]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [56]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [57]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [38]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [57]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [43]
Verapamil DMA7PEW Angina pectoris BA40 Approved [44]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [58]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [59]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [61]
Meloxicam DM2AR7L Arthritis FA20 Approved [62]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [63]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [66]
Selenium DM25CGV N. A. N. A. Approved [67]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [69]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [70]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [71]
Quercetin DM3NC4M Obesity 5B81 Approved [72]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [73]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Multidrug resistance protein (MDR) TT0JLSD NOUNIPROTAC Modulator [3]
Tumor necrosis factor (TNF) TTF8CQI TNFA_HUMAN Inhibitor [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [4]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [5]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [5]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Gene/Protein Processing [5]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [5]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Protein Interaction/Cellular Processes [5]
Vascular endothelial growth factor A, long form OTIM9MZ3 VEGFA_HUMAN Protein Interaction/Cellular Processes [5]

References

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