Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5GVHU)

Drug Name

Quinolones Drug Info

Synonyms

AC1MI0KP

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]
Tuberculosis	1B10-1B1Z	Approved	[2]

Cross-matching ID

PubChem CID: 6038
ChEBI ID: CHEBI:16365
CAS Number: CAS 59-31-4
TTD Drug ID: DM5GVHU
VARIDT Drug ID: DR00328

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting DNA topoisomerase II (TOP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[8]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[1]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[9]
Idarubicin	DMM0XGL	Acute myelogenous leukaemia	2A41	Approved	[1]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[1]
Lomefloxacin	DMVRH9C	Bacterial infection	1A00-1C4Z	Approved	[10]
Dexrazoxane	DMD7X1O	Breast cancer	2C60-2C65	Approved	[1]
Podofilox	DMT2EJP	Condyloma	1A95	Approved	[11]
Enoxacin	DMYTE6L	Acute gonococcal cervicitis		Approved	[12]
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Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[13]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[16]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[17]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[18]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[19]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[20]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[21]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[22]
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Drug(s) Affected By Thromboxane-A synthase (TBXAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[24]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[25]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[25]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
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Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[30]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[31]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[34]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[35]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[36]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[38]
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Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[40]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[41]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[42]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[43]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[44]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[45]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[46]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
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Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[51]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[53]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[35]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
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Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[65]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Inhibitor	[2]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 1A2 (SLCO1A2)	DTE2B1D	SO1A2_HUMAN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[4]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Gene/Protein Processing	[5]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Gene/Protein Processing	[6]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Gene/Protein Processing	[6]
Thromboxane-A synthase (TBXAS1)	OTAXZJJ4	THAS_HUMAN	Gene/Protein Processing	[7]
Vascular endothelial growth factor A, long form	OTIM9MZ3	VEGFA_HUMAN	Gene/Protein Processing	[5]

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