Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5GVHU)

• Drug Name: Quinolones Drug Info
• Synonyms: AC1MI0KP

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]
Tuberculosis	1B10-1B1Z	Approved	[2]

• Cross-matching ID:
  PubChem CID: 6038
  ChEBI ID: CHEBI:16365
  CAS Number: CAS 59-31-4
  TTD Drug ID: DM5GVHU
  VARIDT Drug ID: DR00328

Molecule-Related Drug Atlas

Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[4]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[5]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[6]
Atorvastatin	DMF28YC	Cardiovascular disease	BA00-BE2Z	Approved	[7]
Pitavastatin calcium	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[8]
Rosuvastatin	DMMIQ7G	Hypercholesterolaemia	5C80.0	Approved	[9]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[10]
Enalapril	DMNFUZR	Hypertension	BA00-BA04	Approved	[11]
Cholic acid	DM7OKQV	Peroxisomal disorder	5C57	Approved	[12]
Liothyronine	DM6IR3P	Hypothyroidism	5A00	Approved	[13]

Drug(s) Targeting DNA topoisomerase II (TOP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[1]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[14]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[1]
Mitoxantrone	DMM39BF	Solid tumour/cancer	2A00-2F9Z	Approved	[15]
Idarubicin	DMM0XGL	Acute myeloid leukaemia	2A60	Approved	[1]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[1]
Lomefloxacin	DMVRH9C	Bacterial infection	1A00-1C4Z	Approved	[16]
Dexrazoxane	DMD7X1O	Breast cancer	2C60-2C65	Approved	[1]
Podofilox	DMT2EJP	Condyloma	1A95	Approved	[17]
Enoxacin	DMYTE6L	Urinary tract infection	GC08	Approved	[18]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Inhibitor	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 1A2 (SLCO1A2)	DTE2B1D	SO1A2_HUMAN	Substrate	[3]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [2] The magic bullets and tuberculosis drug targets. Annu Rev Pharmacol Toxicol. 2005;45:529-64.
• [3] The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.60.1.14)
• [4] Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. J Pharmacol Exp Ther. 2006 Aug;318(2):521-9.
• [5] Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Arch. 2001 Nov;443(2):188-95.
• [6] Environmental and genetic factors affecting transport of imatinib by OATP1A2. Clin Pharmacol Ther. 2011 Jun;89(6):816-20.
• [7] Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochem Pharmacol. 2010 Dec 1;80(11):1746-53.
• [8] Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase. J Pharm Pharmacol. 2005 Oct;57(10):1305-11.
• [9] Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Gastroenterology. 2006 May;130(6):1793-806.
• [10] Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells. Mol Pharm. 2004 Jan 12;1(1):49-56.
• [11] Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Drug Metab Dispos. 2000 Jul;28(7):801-6.
• [12] Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82.
• [13] Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology. 2001 May;142(5):2005-12.
• [14] Etoposide, topoisomerase II and cancer.Curr Med Chem Anticancer Agents.2005 Jul;5(4):363-72.
• [15] Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.
• [16] Inhibition of human topoisomerase IIalpha by fluoroquinolones and ultraviolet A irradiation. Toxicol Sci. 2002 Sep;69(1):16-22.
• [17] Antitumor properties of podophyllotoxin and related compounds. Curr Pharm Des. 2000 Dec;6(18):1811-39.
• [18] Clinical pharmacokinetics of the newer antibacterial 4-quinolones. Clin Pharmacokinet. 1988 Feb;14(2):96-121.