Details of the Drug

General Information of Drug (ID: DM5PVQE)

Drug Name

Paroxetine

Synonyms

Seroxat (TN)

Indication

Disease Entry	ICD 11	Status	REF
Anxiety disorder	6B00-6B0Z	Approved	[1]
Depression	6A70-6A7Z	Approved	[2]
Hot flushes	GA30	Approved	[1]
Major depressive disorder	6A70.3	Approved	[1]
Obsessive compulsive disorder	6B20	Approved	[1]
Panic disorder	6B01	Approved	[1]
Post-traumatic stress disorder	6B40	Approved	[1]
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Therapeutic Class

Antidepressants

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

329.4

Logarithm of the Partition Coefficient (xlogp)

3.5

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

Absorption Cmax: The maximum plasma concentration (Cmax) of drug is 229.9 mcg/L [3]
Absorption Tmax: The time to maximum plasma concentration (Tmax) is 0.67 h [3]
BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [4]
Bioavailability: The bioavailability of drug is 69.6% [3]
Clearance: The apparent oral clearance of drug is 167 L/h [5]
Elimination: Almost all of the dose is eliminated as metabolites; 3% is found to be excreted as unchanged paroxetine [6]
Half-life: The concentration or amount of drug in body reduced by one-half in 21 hours [7]
Metabolism: The drug is metabolized via the liver [8]
MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 2.52904 micromolar/kg/day [9]
Unbound Fraction: The unbound fraction of drug in plasma is 0.06% [10]
Vd: Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 18 L/kg [10]
Water Solubility: The ability of drug to dissolve in water is measured as 5.4 mg/mL [4]

Chemical Identifiers

Formula: C19H20FNO3
IUPAC Name: (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine
Canonical SMILES: C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4
InChI: InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
InChIKey: AHOUBRCZNHFOSL-YOEHRIQHSA-N

Cross-matching ID

PubChem CID: 43815
ChEBI ID: CHEBI:7936
CAS Number: 61869-08-7
DrugBank ID: DB00715
TTD ID: D06GDY
VARIDT ID: DR00403
INTEDE ID: DR1245
ACDINA ID: D00511

Combinatorial Drugs (CBD)

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Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Modulator	[11]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[12]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[13]
Cytochrome P450 2D6 (CYP2D6)_{Main DME}	DECB0K3	CP2D6_HUMAN	Substrate	[14]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[15]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[16]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Drug Response	[17]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[18]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Gene/Protein Processing	[19]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Drug Response	[20]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Gene/Protein Processing	[21]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Gene/Protein Processing	[22]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Gene/Protein Processing	[22]
Interleukin-17A (IL17A)	OTY72FT2	IL17_HUMAN	Gene/Protein Processing	[22]
Neural cell adhesion molecule L1-like protein (CHL1)	OT6E6E8P	NCHL1_HUMAN	Drug Response	[23]
Platelet basic protein (PPBP)	OT1FHGQS	CXCL7_HUMAN	Gene/Protein Processing	[24]

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Molecular Interaction Atlas (MIA)

MIA Detail

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Molecular Expression Atlas of This Drug

The Studied Disease

Anxiety disorder

ICD Disease Classification

6B00-6B0Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Serotonin transporter (SERT)	DTT	SLC6A4	7.90E-01	0.04	0.14
Serotonin transporter (SERT)	DTT	SLC6A4	4.98E-01	0.04	0.7
P-glycoprotein 1 (ABCB1)	DTP	P-GP	1.19E-01	-1.32E-01	-2.77E-01
P-glycoprotein 1 (ABCB1)	DTP	P-GP	1.65E-01	-1.47E-01	-4.48E-01
Cytochrome P450 1A2 (CYP1A2)	DME	CYP1A2	6.73E-02	6.49E-02	3.07E-01
Cytochrome P450 1A2 (CYP1A2)	DME	CYP1A2	6.45E-01	2.07E-02	1.74E-01
Mephenytoin 4-hydroxylase (CYP2C19)	DME	CYP2C19	7.39E-01	1.54E-02	4.74E-02
Mephenytoin 4-hydroxylase (CYP2C19)	DME	CYP2C19	4.64E-02	-8.21E-02	-7.11E-01
Cytochrome P450 2D6 (CYP2D6)	DME	CYP2D6	2.59E-01	6.29E-02	3.14E-01
Cytochrome P450 2D6 (CYP2D6)	DME	CYP2D6	4.84E-01	-8.38E-02	-8.46E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	4.66E-01	4.25E-02	1.20E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	4.75E-01	5.15E-02	3.64E-01

Molecular Expression Atlas (MEA)

MEA Detail

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Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Paroxetine

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Trimipramine	DM1SC8M	Major	Decreased metabolism of Paroxetine caused by Trimipramine mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[25]
Cyclobenzaprine	DM1YBRM	Major	Additive serotonergic effects by the combination of Paroxetine and Cyclobenzaprine.	Depression [6A70-6A7Z]	[26]
Vilazodone	DM4LECQ	Major	Additive serotonergic effects by the combination of Paroxetine and Vilazodone.	Depression [6A70-6A7Z]	[26]
Nefazodone	DM4ZS8M	Major	Additive serotonergic effects by the combination of Paroxetine and Nefazodone.	Depression [6A70-6A7Z]	[26]
Selegiline	DM6034S	Major	Additive serotonergic effects by the combination of Paroxetine and Selegiline.	Depression [6A70-6A7Z]	[27]
Vortioxetine	DM6F1PU	Major	Decreased metabolism of Paroxetine caused by Vortioxetine mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[28]
Isocarboxazid	DMAF1NB	Major	Additive serotonergic effects by the combination of Paroxetine and Isocarboxazid.	Depression [6A70-6A7Z]	[27]
Milnacipran	DMBFE74	Major	Additive serotonergic effects by the combination of Paroxetine and Milnacipran.	Depression [6A70-6A7Z]	[26]
Tranylcypromine	DMGB5RE	Major	Additive serotonergic effects by the combination of Paroxetine and Tranylcypromine.	Depression [6A70-6A7Z]	[27]
Desvenlafaxine	DMHD4PE	Major	Additive serotonergic effects by the combination of Paroxetine and Desvenlafaxine.	Depression [6A70-6A7Z]	[26]
OPC-34712	DMHG57U	Major	Decreased metabolism of Paroxetine caused by OPC-34712 mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[29]
Phenelzine	DMHIDUE	Major	Additive serotonergic effects by the combination of Paroxetine and Phenelzine.	Depression [6A70-6A7Z]	[27]
Clomipramine	DMINRKW	Major	Decreased metabolism of Paroxetine caused by Clomipramine mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[25]
Doxepin	DMPI98T	Major	Decreased metabolism of Paroxetine caused by Doxepin mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[25]
Maprotiline	DMPWB7T	Major	Additive serotonergic effects by the combination of Paroxetine and Maprotiline.	Depression [6A70-6A7Z]	[26]
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⏷ Show the Full List of 15 DDI Information of This Drug

Coadministration of a Drug Treating the Disease Different from Paroxetine (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Methylene blue	DMJAPE7	Major	Additive serotonergic effects by the combination of Paroxetine and Methylene blue.	Acquired methaemoglobinaemia [3A93]	[30]
Repaglinide	DM5SXUV	Moderate	Increased risk of hypoglycemia by the combination of Paroxetine and Repaglinide.	Acute diabete complication [5A2Y]	[31]
Glibenclamide	DM8JXPZ	Moderate	Increased risk of hypoglycemia by the combination of Paroxetine and Glibenclamide.	Acute diabete complication [5A2Y]	[31]
Tolazamide	DMIHRNA	Moderate	Increased risk of hypoglycemia by the combination of Paroxetine and Tolazamide.	Acute diabete complication [5A2Y]	[31]
Nateglinide	DMLK2QH	Moderate	Increased risk of hypoglycemia by the combination of Paroxetine and Nateglinide.	Acute diabete complication [5A2Y]	[31]
Insulin-glulisine	DMQI0FU	Moderate	Increased risk of hypoglycemia by the combination of Paroxetine and Insulin-glulisine.	Acute diabete complication [5A2Y]	[31]
Insulin-aspart	DMX7V28	Moderate	Increased risk of hypoglycemia by the combination of Paroxetine and Insulin-aspart.	Acute diabete complication [5A2Y]	[32]
Glipizide	DMZA5PQ	Moderate	Increased risk of hypoglycemia by the combination of Paroxetine and Glipizide.	Acute diabete complication [5A2Y]	[31]
Oliceridine	DM6MDCF	Major	Decreased metabolism of Paroxetine caused by Oliceridine mediated inhibition of CYP450 enzyme.	Acute pain [MG31]	[33]
Donepezil	DMIYG7Z	Minor	Decreased metabolism of Paroxetine caused by Donepezil mediated inhibition of CYP450 enzyme.	Alzheimer disease [8A20]	[34]
Inotersen	DMJ93CT	Moderate	Increased risk of bleeding by the combination of Paroxetine and Inotersen.	Amyloidosis [5D00]	[35]
Dronedarone	DMA8FS5	Moderate	Decreased metabolism of Paroxetine caused by Dronedarone mediated inhibition of CYP450 enzyme.	Angina pectoris [BA40]	[36]
Methylphenobarbital	DMDSWAG	Moderate	Antagonize the effect of Paroxetine when combined with Methylphenobarbital.	Anxiety disorder [6B00-6B0Z]	[37]
Cilostazol	DMZMSCT	Moderate	Increased risk of bleeding by the combination of Paroxetine and Cilostazol.	Arterial occlusive disease [BD40]	[35]
Desipramine	DMT2FDC	Major	Decreased metabolism of Paroxetine caused by Desipramine mediated inhibition of CYP450 enzyme.	Attention deficit hyperactivity disorder [6A05]	[25]
Clarithromycin	DM4M1SG	Moderate	Decreased metabolism of Paroxetine caused by Clarithromycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[38]
Troleandomycin	DMUZNIG	Moderate	Decreased metabolism of Paroxetine caused by Troleandomycin mediated inhibition of CYP450 enzyme.	Bacterial infection [1A00-1C4Z]	[38]
Retigabine	DMGNYIH	Moderate	Antagonize the effect of Paroxetine when combined with Retigabine.	Behcet disease [4A62]	[37]
Trastuzumab Emtansine	DMU1LXS	Moderate	Increased risk of bleeding by the combination of Paroxetine and Trastuzumab Emtansine.	Breast cancer [2C60-2C6Y]	[39]
Mannitol	DMSCDY9	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Mannitol.	Bronchiectasis [CA24]	[40]
Phenylbutazone	DMAYL0T	Moderate	Increased risk of bleeding by the combination of Paroxetine and Phenylbutazone.	Chronic pain [MG30]	[35]
Dihydrocodeine	DMB0FWL	Moderate	Additive CNS depression effects by the combination of Paroxetine and Dihydrocodeine.	Chronic pain [MG30]	[41]
Ketoprofen	DMRKXPT	Moderate	Increased risk of bleeding by the combination of Paroxetine and Ketoprofen.	Chronic pain [MG30]	[35]
Levetiracetam	DMTGDN8	Moderate	Antagonize the effect of Paroxetine when combined with Levetiracetam.	Chronic pain [MG30]	[37]
Levomilnacipran	DMV26S8	Major	Additive serotonergic effects by the combination of Paroxetine and Levomilnacipran.	Chronic pain [MG30]	[26]
Anisindione	DM2C48U	Moderate	Increased risk of bleeding by the combination of Paroxetine and Anisindione.	Coagulation defect [3B10]	[35]
Regorafenib	DMHSY1I	Moderate	Increased risk of bleeding by the combination of Paroxetine and Regorafenib.	Colorectal cancer [2B91]	[35]
Olopatadine	DMKMWQG	Moderate	Additive CNS depression effects by the combination of Paroxetine and Olopatadine.	Conjunctiva disorder [9A60]	[42]
Alfentanil	DMVO0UB	Major	Additive serotonergic effects by the combination of Paroxetine and Alfentanil.	Corneal disease [9A76-9A78]	[26]
Remifentanil	DMZTXCH	Major	Additive serotonergic effects by the combination of Paroxetine and Remifentanil.	Corneal disease [9A76-9A78]	[26]
Ardeparin	DMYRX8B	Moderate	Increased risk of bleeding by the combination of Paroxetine and Ardeparin.	Coronary thrombosis [BA43]	[35]
Ethanol	DMDRQZU	Moderate	Additive CNS depression effects by the combination of Paroxetine and Ethanol.	Cystitis [GC00]	[42]
Danaparoid	DM6CLBN	Moderate	Increased risk of bleeding by the combination of Paroxetine and Danaparoid.	Deep vein thrombosis [BD71]	[35]
Rivaroxaban	DMQMBZ1	Moderate	Increased risk of bleeding by the combination of Paroxetine and Rivaroxaban.	Deep vein thrombosis [BD71]	[35]
5-hydroxy-L-tryptophan	DMDWZGJ	Major	Additive serotonergic effects by the combination of Paroxetine and 5-hydroxy-L-tryptophan.	Discovery agent [N.A.]	[43]
Tetrabenazine	DMYWQ0O	Major	Decreased metabolism of Paroxetine caused by Tetrabenazine mediated inhibition of CYP450 enzyme.	Dissociative neurological symptom disorder [6B60]	[44]
Deutetrabenazine	DMUPFLI	Major	Decreased metabolism of Paroxetine caused by Deutetrabenazine mediated inhibition of CYP450 enzyme.	Dystonic disorder [8A02]	[45]
Ingrezza	DMVPLNC	Major	Decreased metabolism of Paroxetine caused by Ingrezza mediated inhibition of CYP450 enzyme.	Dystonic disorder [8A02]	[46]
Zonisamide	DM0DTF7	Moderate	Antagonize the effect of Paroxetine when combined with Zonisamide.	Epilepsy/seizure [8A61-8A6Z]	[37]
Felbamate	DM1V5ZS	Moderate	Antagonize the effect of Paroxetine when combined with Felbamate.	Epilepsy/seizure [8A61-8A6Z]	[37]
Oxcarbazepine	DM5PU6O	Moderate	Antagonize the effect of Paroxetine when combined with Oxcarbazepine.	Epilepsy/seizure [8A61-8A6Z]	[37]
Methsuximide	DM6L5VO	Moderate	Antagonize the effect of Paroxetine when combined with Methsuximide.	Epilepsy/seizure [8A61-8A6Z]	[37]
Gabapentin	DM6T924	Moderate	Antagonize the effect of Paroxetine when combined with Gabapentin.	Epilepsy/seizure [8A61-8A6Z]	[37]
Tiagabine	DMKSQG0	Moderate	Antagonize the effect of Paroxetine when combined with Tiagabine.	Epilepsy/seizure [8A61-8A6Z]	[37]
Stiripentol	DMMSDOY	Moderate	Decreased metabolism of Paroxetine caused by Stiripentol mediated inhibition of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[47]
Phenacemide	DMOHS9P	Moderate	Antagonize the effect of Paroxetine when combined with Phenacemide.	Epilepsy/seizure [8A61-8A6Z]	[37]
Fosphenytoin	DMOX3LB	Moderate	Antagonize the effect of Paroxetine when combined with Fosphenytoin.	Epilepsy/seizure [8A61-8A6Z]	[37]
Brivaracetam	DMSEPK8	Moderate	Antagonize the effect of Paroxetine when combined with Brivaracetam.	Epilepsy/seizure [8A61-8A6Z]	[37]
Lacosamide	DMVM6QR	Moderate	Antagonize the effect of Paroxetine when combined with Lacosamide.	Epilepsy/seizure [8A61-8A6Z]	[37]
Rufinamide	DMWE60C	Moderate	Antagonize the effect of Paroxetine when combined with Rufinamide.	Epilepsy/seizure [8A61-8A6Z]	[37]
Ethotoin	DMXWOCP	Moderate	Antagonize the effect of Paroxetine when combined with Ethotoin.	Epilepsy/seizure [8A61-8A6Z]	[37]
Phenobarbital	DMXZOCG	Moderate	Antagonize the effect of Paroxetine when combined with Phenobarbital.	Epilepsy/seizure [8A61-8A6Z]	[37]
Vigabatrin	DMYT0OG	Moderate	Antagonize the effect of Paroxetine when combined with Vigabatrin.	Epilepsy/seizure [8A61-8A6Z]	[37]
Eslicarbazepine	DMZREFQ	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Eslicarbazepine.	Epilepsy/seizure [8A61-8A6Z]	[37]
Ethacrynic acid	DM60QMR	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Ethacrynic acid.	Essential hypertension [BA00]	[40]
Mefenamic acid	DMK7HFI	Moderate	Increased risk of bleeding by the combination of Paroxetine and Mefenamic acid.	Female pelvic pain [GA34]	[35]
Tazemetostat	DMWP1BH	Moderate	Increased risk of bleeding by the combination of Paroxetine and Tazemetostat.	Follicular lymphoma [2A80]	[35]
Mirabegron	DMS1GYT	Moderate	Decreased metabolism of Paroxetine caused by Mirabegron mediated inhibition of CYP450 enzyme.	Functional bladder disorder [GC50]	[48]
Tolterodine	DMSHPW8	Minor	Decreased metabolism of Paroxetine caused by Tolterodine mediated inhibition of CYP450 enzyme.	Functional bladder disorder [GC50]	[49]
Terbinafine	DMI6HUW	Moderate	Decreased metabolism of Paroxetine caused by Terbinafine mediated inhibition of CYP450 enzyme.	Fungal infection [1F29-1F2F]	[50]
Avapritinib	DMK2GZX	Moderate	Increased risk of bleeding by the combination of Paroxetine and Avapritinib.	Gastrointestinal stromal tumour [2B5B]	[35]
Acetazolamide	DM1AF5U	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Acetazolamide.	Glaucoma [9C61]	[40]
Dichlorphenamide	DMH7IDQ	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Dichlorphenamide.	Glaucoma [9C61]	[40]
Sulfinpyrazone	DMEV954	Moderate	Increased risk of bleeding by the combination of Paroxetine and Sulfinpyrazone.	Gout [FA25]	[35]
Carvedilol	DMHTEAO	Moderate	Decreased metabolism of Paroxetine caused by Carvedilol mediated inhibition of CYP450 enzyme.	Heart failure [BD10-BD1Z]	[51]
Chlorothiazide	DMLHESP	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Chlorothiazide.	Heart failure [BD10-BD1Z]	[40]
Bumetanide	DMRV7H0	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Bumetanide.	Heart failure [BD10-BD1Z]	[40]
Hydroflumethiazide	DMVPUQI	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Hydroflumethiazide.	Heart failure [BD10-BD1Z]	[40]
Procarbazine	DMIK367	Major	Additive serotonergic effects by the combination of Paroxetine and Procarbazine.	Hodgkin lymphoma [2B30]	[27]
Cobicistat	DM6L4H2	Moderate	Decreased metabolism of Paroxetine caused by Cobicistat mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[52]
Cinacalcet	DMCX0K3	Moderate	Decreased metabolism of Paroxetine caused by Cinacalcet mediated inhibition of CYP450 enzyme.	Hyper-parathyroidism [5A51]	[53]
Nebivolol	DM7F1PA	Moderate	Decreased metabolism of Paroxetine caused by Nebivolol mediated inhibition of CYP450 enzyme.	Hypertension [BA00-BA04]	[51]
Indapamide	DMGN1PW	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Indapamide.	Hypertension [BA00-BA04]	[40]
Trichlormethiazide	DMHAQCO	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Trichlormethiazide.	Hypertension [BA00-BA04]	[40]
Hydrochlorothiazide	DMUSZHD	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Hydrochlorothiazide.	Hypertension [BA00-BA04]	[40]
Dipyridamole	DMXY30O	Moderate	Increased risk of bleeding by the combination of Paroxetine and Dipyridamole.	Hypertension [BA00-BA04]	[35]
Pirfenidone	DM6VZFQ	Moderate	Decreased metabolism of Paroxetine caused by Pirfenidone mediated inhibition of CYP450 enzyme.	Idiopathic interstitial pneumonitis [CB03]	[54]
Givosiran	DM5PFIJ	Moderate	Decreased metabolism of Paroxetine caused by Givosiran mediated inhibition of CYP450 enzyme.	Inborn porphyrin/heme metabolism error [5C58]	[55]
Meclofenamic acid	DM05FXR	Moderate	Increased risk of bleeding by the combination of Paroxetine and Meclofenamic acid.	Inflammatory spondyloarthritis [FA92]	[39]
Berotralstat	DMWA2DZ	Moderate	Decreased metabolism of Paroxetine caused by Berotralstat mediated inhibition of CYP450 enzyme.	Innate/adaptive immunodeficiency [4A00]	[56]
Amobarbital	DM0GQ8N	Minor	Increased metabolism of Paroxetine caused by Amobarbital mediated induction of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[57]
Propiomazine	DMKY8V1	Moderate	Decreased metabolism of Paroxetine caused by Propiomazine mediated inhibition of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[58]
Polyethylene glycol	DM4I1JP	Moderate	Increased risk of lowers seizure threshold by the combination of Paroxetine and Polyethylene glycol.	Irritable bowel syndrome [DD91]	[59]
Eluxadoline	DMYZ0P1	Moderate	Decreased metabolism of Paroxetine caused by Eluxadoline mediated inhibition of CYP450 enzyme.	Irritable bowel syndrome [DD91]	[60]
Glycerol phenylbutyrate	DMDGRQO	Moderate	Decreased metabolism of Paroxetine caused by Glycerol phenylbutyrate mediated inhibition of CYP450 enzyme.	Liver disease [DB90-DB9Z]	[54]
Dacomitinib	DMOH8VY	Moderate	Decreased metabolism of Paroxetine caused by Dacomitinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[61]
Lumefantrine	DM29GAD	Moderate	Decreased metabolism of Paroxetine caused by Lumefantrine mediated inhibition of CYP450 enzyme.	Malaria [1F40-1F45]	[53]
Acalabrutinib	DM7GCVW	Moderate	Increased risk of bleeding by the combination of Paroxetine and Acalabrutinib.	Mature B-cell lymphoma [2A85]	[35]
Ibrutinib	DMHZCPO	Moderate	Increased risk of bleeding by the combination of Paroxetine and Ibrutinib.	Mature B-cell lymphoma [2A85]	[35]
Ponatinib	DMYGJQO	Moderate	Increased risk of bleeding by the combination of Paroxetine and Ponatinib.	Mature B-cell lymphoma [2A85]	[35]
Vemurafenib	DM62UG5	Moderate	Decreased metabolism of Paroxetine caused by Vemurafenib mediated inhibition of CYP450 enzyme.	Melanoma [2C30]	[62]
Allopregnanolone	DMNLHAC	Moderate	Additive CNS depression effects by the combination of Paroxetine and Allopregnanolone.	Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]	[63]
Almogran	DM7I64Z	Major	Additive serotonergic effects by the combination of Paroxetine and Almogran.	Migraine [8A80]	[26]
Frovatriptan	DM7RE8P	Major	Additive serotonergic effects by the combination of Paroxetine and Frovatriptan.	Migraine [8A80]	[26]
Rizatriptan	DMDJMA3	Major	Additive serotonergic effects by the combination of Paroxetine and Rizatriptan.	Migraine [8A80]	[26]
Naratriptan	DMO50U2	Major	Additive serotonergic effects by the combination of Paroxetine and Naratriptan.	Migraine [8A80]	[26]
Exjade	DMHPRWG	Moderate	Increased risk of bleeding by the combination of Paroxetine and Exjade.	Mineral absorption/transport disorder [5C64]	[35]
Flibanserin	DM70DTN	Moderate	Decreased metabolism of Paroxetine caused by Flibanserin mediated inhibition of CYP450 enzyme.	Mood disorder [6A60-6E23]	[64]
Panobinostat	DM58WKG	Major	Increased risk of bleeding by the combination of Paroxetine and Panobinostat.	Multiple myeloma [2A83]	[35]
Thalidomide	DM70BU5	Moderate	Additive CNS depression effects by the combination of Paroxetine and Thalidomide.	Multiple myeloma [2A83]	[65]
Ozanimod	DMT6AM2	Moderate	Additive serotonergic effects by the combination of Paroxetine and Ozanimod.	Multiple sclerosis [8A40]	[66]
Fedratinib	DM4ZBK6	Moderate	Increased risk of bleeding by the combination of Paroxetine and Fedratinib.	Myeloproliferative neoplasm [2A20]	[39]
Nilotinib	DM7HXWT	Moderate	Decreased metabolism of Paroxetine caused by Nilotinib mediated inhibition of CYP450 enzyme.	Myeloproliferative neoplasm [2A20]	[67]
Ruxolitinib	DM7Q98D	Moderate	Increased risk of bleeding by the combination of Paroxetine and Ruxolitinib.	Myeloproliferative neoplasm [2A20]	[35]
Dasatinib	DMJV2EK	Moderate	Increased risk of bleeding by the combination of Paroxetine and Dasatinib.	Myeloproliferative neoplasm [2A20]	[35]
Prasugrel	DM7MT6E	Moderate	Increased risk of bleeding by the combination of Paroxetine and Prasugrel.	Myocardial infarction [BA41-BA43]	[35]
Vorapaxar	DMA16BR	Moderate	Increased risk of bleeding by the combination of Paroxetine and Vorapaxar.	Myocardial infarction [BA41-BA43]	[35]
Tirofiban	DMQG17S	Moderate	Increased risk of bleeding by the combination of Paroxetine and Tirofiban.	Myocardial infarction [BA41-BA43]	[35]
Promethazine	DM6I5GR	Moderate	Decreased metabolism of Paroxetine caused by Promethazine mediated inhibition of CYP450 enzyme.	Nausea/vomiting [MD90]	[58]
Rolapitant	DM8XP26	Moderate	Decreased metabolism of Paroxetine caused by Rolapitant mediated inhibition of CYP450 enzyme.	Nausea/vomiting [MD90]	[68]
Granisetron	DMIUW25	Major	Additive serotonergic effects by the combination of Paroxetine and Granisetron.	Nausea/vomiting [MD90]	[69]
Dolasetron	DMMG26Z	Major	Additive serotonergic effects by the combination of Paroxetine and Dolasetron.	Nausea/vomiting [MD90]	[69]
Ondansetron	DMOTQ1I	Major	Increased risk of prolong QT interval by the combination of Paroxetine and Ondansetron.	Nausea/vomiting [MD90]	[69]
E-2007	DMJDYNQ	Moderate	Antagonize the effect of Paroxetine when combined with E-2007.	Neuropathy [8C0Z]	[37]
Bupropion	DM5PCS7	Major	Increased risk of lowers seizure threshold by the combination of Paroxetine and Bupropion.	Nicotine use disorder [6C4A]	[69]
Sibutramine	DMFJTDI	Major	Additive serotonergic effects by the combination of Paroxetine and Sibutramine.	Obesity [5B80-5B81]	[70]
Lorcaserin	DMG6OYJ	Major	Additive serotonergic effects by the combination of Paroxetine and Lorcaserin.	Obesity [5B80-5B81]	[71]
Dexfenfluramine	DMJ7YDS	Major	Additive serotonergic effects by the combination of Paroxetine and Dexfenfluramine.	Obesity [5B80-5B81]	[26]
Polythiazide	DMCH80F	Moderate	Increased risk of hyponatremia by the combination of Paroxetine and Polythiazide.	Oedema [MG29]	[40]
Levomethadyl Acetate	DM06HG5	Major	Additive CNS depression effects by the combination of Paroxetine and Levomethadyl Acetate.	Opioid use disorder [6C43]	[64]
Naproxen	DMZ5RGV	Moderate	Increased risk of bleeding by the combination of Paroxetine and Naproxen.	Osteoarthritis [FA00-FA05]	[35]
Oxymorphone	DM65AGJ	Moderate	Additive serotonergic effects by the combination of Paroxetine and Oxymorphone.	Pain [MG30-MG3Z]	[41]
Aspirin	DM672AH	Moderate	Increased risk of bleeding by the combination of Paroxetine and Aspirin.	Pain [MG30-MG3Z]	[39]
Etodolac	DM6WJO9	Moderate	Increased risk of bleeding by the combination of Paroxetine and Etodolac.	Pain [MG30-MG3Z]	[35]
Diflunisal	DM7EN8I	Moderate	Increased risk of bleeding by the combination of Paroxetine and Diflunisal.	Pain [MG30-MG3Z]	[35]
Ibuprofen	DM8VCBE	Moderate	Increased risk of bleeding by the combination of Paroxetine and Ibuprofen.	Pain [MG30-MG3Z]	[35]
Levorphanol	DMGS80V	Moderate	Additive serotonergic effects by the combination of Paroxetine and Levorphanol.	Pain [MG30-MG3Z]	[41]
Dezocine	DMJDB0Y	Moderate	Additive serotonergic effects by the combination of Paroxetine and Dezocine.	Pain [MG30-MG3Z]	[41]
Nalbuphine	DMOSQGU	Moderate	Additive serotonergic effects by the combination of Paroxetine and Nalbuphine.	Pain [MG30-MG3Z]	[41]
Buprenorphine	DMPRI8G	Moderate	Additive serotonergic effects by the combination of Paroxetine and Buprenorphine.	Pain [MG30-MG3Z]	[41]
Hydrocodone	DMQ2JO5	Moderate	Additive serotonergic effects by the combination of Paroxetine and Hydrocodone.	Pain [MG30-MG3Z]	[41]
Safinamide	DM0YWJC	Moderate	Additive serotonergic effects by the combination of Paroxetine and Safinamide.	Parkinsonism [8A00]	[66]
Rasagiline	DM3WKQ4	Major	Additive serotonergic effects by the combination of Paroxetine and Rasagiline.	Parkinsonism [8A00]	[27]
Choline salicylate	DM8P137	Moderate	Increased risk of bleeding by the combination of Paroxetine and Choline salicylate.	Postoperative inflammation [1A00-CA43]	[35]
Bromfenac	DMKB79O	Moderate	Increased risk of bleeding by the combination of Paroxetine and Bromfenac.	Postoperative inflammation [1A00-CA43]	[35]
ABIRATERONE	DM8V75C	Moderate	Decreased metabolism of Paroxetine caused by ABIRATERONE mediated inhibition of CYP450 enzyme.	Prostate cancer [2C82]	[72]
Levomepromazine	DMIKFEL	Moderate	Decreased metabolism of Paroxetine caused by Levomepromazine mediated inhibition of CYP450 enzyme.	Psychotic disorder [6A20-6A25]	[58]
Epoprostenol	DMUTYR2	Moderate	Increased risk of bleeding by the combination of Paroxetine and Epoprostenol.	Pulmonary hypertension [BB01]	[35]
Iloprost	DMVPZBE	Moderate	Increased risk of bleeding by the combination of Paroxetine and Iloprost.	Pulmonary hypertension [BB01]	[35]
Meloxicam	DM2AR7L	Moderate	Increased risk of bleeding by the combination of Paroxetine and Meloxicam.	Rheumatoid arthritis [FA20]	[35]
Oxaprozin	DM9UB0P	Moderate	Increased risk of bleeding by the combination of Paroxetine and Oxaprozin.	Rheumatoid arthritis [FA20]	[35]
Mesoridazine	DM2ZGAN	Moderate	Decreased metabolism of Paroxetine caused by Mesoridazine mediated inhibition of CYP450 enzyme.	Schizophrenia [6A20]	[58]
Aripiprazole	DM3NUMH	Moderate	Decreased metabolism of Paroxetine caused by Aripiprazole mediated inhibition of CYP450 enzyme.	Schizophrenia [6A20]	[73]
Iloperidone	DM6AUFY	Major	Decreased metabolism of Paroxetine caused by Iloperidone mediated inhibition of CYP450 enzyme.	Schizophrenia [6A20]	[74]
Perphenazine	DMA4MRX	Moderate	Decreased metabolism of Paroxetine caused by Perphenazine mediated inhibition of CYP450 enzyme.	Schizophrenia [6A20]	[58]
Trifluoperazine	DMKBYWI	Moderate	Decreased metabolism of Paroxetine caused by Trifluoperazine mediated inhibition of CYP450 enzyme.	Schizophrenia [6A20]	[58]
Pimozide	DMW83TP	Major	Decreased metabolism of Paroxetine caused by Pimozide mediated inhibition of CYP450 enzyme.	Schizophrenia [6A20]	[75]
Salicyclic acid	DM2F8XZ	Moderate	Increased risk of bleeding by the combination of Paroxetine and Salicyclic acid.	Seborrhoeic dermatitis [EA81]	[39]
Fentanyl	DM8WAHT	Major	Additive serotonergic effects by the combination of Paroxetine and Fentanyl.	Sensation disturbance [MB40]	[26]
Pitolisant	DM8RFNJ	Major	Decreased metabolism of Paroxetine caused by Pitolisant mediated inhibition of CYP450 enzyme.	Somnolence [MG42]	[54]
Plicamycin	DM7C8YV	Moderate	Increased risk of bleeding by the combination of Paroxetine and Plicamycin.	Testicular cancer [2C80]	[35]
Caplacizumab	DMPUKA7	Moderate	Increased risk of bleeding by the combination of Paroxetine and Caplacizumab.	Thrombocytopenia [3B64]	[35]
Apixaban	DM89JLN	Moderate	Increased risk of bleeding by the combination of Paroxetine and Apixaban.	Thrombosis [DB61-GB90]	[35]
Cangrelor	DM8JRH0	Moderate	Increased risk of bleeding by the combination of Paroxetine and Cangrelor.	Thrombosis [DB61-GB90]	[35]
Brilinta	DMBR01X	Moderate	Increased risk of bleeding by the combination of Paroxetine and Brilinta.	Thrombosis [DB61-GB90]	[35]
Clopidogrel	DMOL54H	Moderate	Increased risk of bleeding by the combination of Paroxetine and Clopidogrel.	Thrombosis [DB61-GB90]	[35]
Cabozantinib	DMIYDT4	Moderate	Increased risk of bleeding by the combination of Paroxetine and Cabozantinib.	Thyroid cancer [2D10]	[35]
Tolbutamide	DM02AWV	Moderate	Increased risk of hypoglycemia by the combination of Paroxetine and Tolbutamide.	Type 2 diabetes mellitus [5A11]	[31]
Insulin-detemir	DMOA4VW	Moderate	Increased risk of hypoglycemia by the combination of Paroxetine and Insulin-detemir.	Type-1/2 diabete [5A10-5A11]	[31]
Insulin degludec	DMPL395	Moderate	Increased risk of hypoglycemia by the combination of Paroxetine and Insulin degludec.	Type-1/2 diabete [5A10-5A11]	[31]
Methdilazine	DMAUHQX	Moderate	Decreased metabolism of Paroxetine caused by Methdilazine mediated inhibition of CYP450 enzyme.	Vasomotor/allergic rhinitis [CA08]	[58]
Betrixaban	DM2C4RF	Moderate	Increased risk of bleeding by the combination of Paroxetine and Betrixaban.	Venous thromboembolism [BD72]	[35]
Propafenone	DMPIBJK	Moderate	Decreased metabolism of Paroxetine caused by Propafenone mediated inhibition of CYP450 enzyme.	Ventricular tachyarrhythmia [BC71]	[76]
Flecainide	DMSQDLE	Moderate	Decreased metabolism of Paroxetine caused by Flecainide mediated inhibition of CYP450 enzyme.	Ventricular tachyarrhythmia [BC71]	[76]
-----------


⏷ Show the Full List of 164 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Allura red AC dye	E00338	33258	Colorant
D&C red no. 30	E00456	3000709	Colorant
FD&C blue no. 1	E00263	19700	Colorant
FD&C blue no. 2	E00446	2723854	Colorant
Hydrazine yellow	E00409	164825	Colorant
Quinoline yellow WS	E00309	24671	Colorant
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sunset yellow FCF	E00255	17730	Colorant
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Brushite	E00392	104805	Diluent
Calcium hydrogenphosphate	E00294	24441	Diluent
Calcium phosphate	E00298	24456	Anticaking agent; Buffering agent; Desiccant; Diluent
Eisenoxyd	E00585	56841934	Colorant
FD&C red no. 3	E00629	Not Available	Colorant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Ferrosoferric oxide	E00231	14789	Colorant
Glyceryl behenate	E00481	5362585	Binding agent; Coating agent; Flavoring agent; Modified-release agent; Viscosity-controlling agent; lubricant
Glyceryl dibehenate	E00537	22477175	Binding agent; Coating agent; Flavoring agent; Modified-release agent; Viscosity-controlling agent; lubricant
Hypromellose	E00634	Not Available	Coating agent
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate	E00208	11177	lubricant
Pigment red 48	E00613	135544134	Colorant
Pigment red 5	E00380	82169	Colorant
Polyethylene glycol 400	E00653	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 4000	E00654	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 6000	E00655	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polysorbate 80	E00665	Not Available	Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Potassium hydroxide	E00233	14797	Alkalizing agent
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Propylene glycol	E00040	1030	Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium alginate	E00671	Not Available	Binding agent; Disintegrant; Suspending agent; Viscosity-controlling agent
Sodium hydroxide	E00234	14798	Alkalizing agent
Soybean lecithin	E00637	Not Available	Other agent
Talc	E00520	16211421	Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Triacetin	E00080	5541	Humectant; Plasticizing agent; Solvent
Triethyl citrate	E00128	6506	Plasticizing agent; Solvent
Vinylpyrrolidone	E00668	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Certolake sunset yellow	E00351	61817	Colorant
Haematite red	E00236	14833	Colorant
--------------------


⏷ Show the Full List of 41 Pharmaceutical Excipients of This Drug

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Paroxetine 12.5 mg tablet	12.5 mg	24 HR Extended Release Oral Tablet	Oral
Paroxetine 25 mg tablet	25 mg	24 HR Extended Release Oral Tablet	Oral
Paroxetine 37.5 mg tablet	37.5 mg	24 HR Extended Release Oral Tablet	Oral
Paroxetine 30 mg tablet	30 mg	Oral Tablet	Oral
Paroxetine 10 mg tablet	10 mg	Oral Tablet	Oral
Paroxetine 20 mg tablet	20 mg	Oral Tablet	Oral
Paroxetine 40 mg tablet	40 mg	Oral Tablet	Oral
Paroxetine Hydrochloride eq 12.5mg base extended release tablet	eq 12.5mg base	Extended Release Tablet	Oral
Paroxetine Hydrochloride eq 10mg base tablet	eq 10mg base	Oral Tablet	Oral
Paroxetine 7.5 mg capsule	7.5 mg	Oral Capsule	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

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