Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7V9CT)

Drug Name
GM6001 Drug Info
Synonyms
Ilomastat; Galardin; 142880-36-2; GM 6001; Illomastat; CS 610; GM-6001; UNII-I0403ML141; CHEMBL19611; Ilomastat (GM6001, Galardin); I0403ML141; NCGC00163450-02; 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE; (R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide; N-[(2R)-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl]-L-tryptophan Methylamide; (R)-N(sup 1)-Hydroxy-N-((S)-2-indol-3-yl-1-(methylcarbamoyl)ethyl)-2-isobutylsuccinamide; (S-(R*,S*))-N(sup 4)-Hydroxy-N(sup; ILOMASTAT
Indication
Disease Entry ICD 11 Status REF
Corneal ulcer 9A76 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
132519
ChEBI ID
CHEBI:137236
CAS Number
CAS 142880-36-2
TTD Drug ID
DM7V9CT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Approved Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Matrix metalloproteinase-12 (MMP-12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Neovastat DMXTYWJ Non-small-cell lung cancer 2C25.Y Phase 1 [11]
FP-025 DMH1NXO Asthma CA23 Phase 1 [12]
PMID29130358-Compound-Figure17(12) DMML4PA N. A. N. A. Patented [13]
PMID29130358-Compound-Figure17(10) DMVA15O N. A. N. A. Patented [13]
PMID29130358-Compound-Figure17(11) DMSZA9L N. A. N. A. Patented [13]
AZD1236 DML3RSF Chronic obstructive pulmonary disease CA22 Discontinued in Phase 2 [14]
V85546 DMLFMSY Inflammation 1A00-CA43.1 Discontinued in Phase 1 [15]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [2]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J Discovery agent N.A. Investigative [16]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 Discovery agent N.A. Investigative [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Matrix metalloproteinase-8 (MMP-8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CIPEMASTAT DM803GL Rheumatoid arthritis FA20 Phase 3 [17]
SC-44463 DMBPNKT N. A. N. A. Terminated [18]
BB-1101 DM7GH5Z Multiple sclerosis 8A40 Terminated [19]
MMI270 DM38N2K Discovery agent N.A. Investigative [20]
IK-862 DMJA4UE Discovery agent N.A. Investigative [21]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J Discovery agent N.A. Investigative [16]
SL422 DM3I2US Discovery agent N.A. Investigative [22]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 Discovery agent N.A. Investigative [16]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN Discovery agent N.A. Investigative [16]
Ro-37-9790 DM83QMZ Discovery agent N.A. Investigative [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Matrix metalloproteinase-13 (MMP-13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [24]
Apratastat DM8W4N9 Rheumatoid arthritis FA20 Phase 2 [25]
PMID17935984C1 DMO1IHL Pain MG30-MG3Z Clinical trial [26]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [13]
PMID29130358-Compound-Figure16(9b) DMPAQLZ N. A. N. A. Patented [13]
PMID29130358-Compound-Figure16(9a) DMKX5R8 N. A. N. A. Patented [13]
PMID29130358-Compound-Figure18(14) DM7WXJ9 N. A. N. A. Patented [13]
PMID29130358-Compound-Figure16(9c) DM0ZRI9 N. A. N. A. Patented [13]
RS-130830 DMOTANY Hepatitis C virus infection 1E51.1 Discontinued in Phase 2 [27]
MMI270 DM38N2K Discovery agent N.A. Investigative [28]
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Drug(s) Targeting Matrix metalloproteinase-1 (MMP-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prinomastat DM9HOKG Lung cancer 2C25.0 Approved [29]
Marimastat DM6V34C Pancreatic cancer 2C10 Phase 3 [30]
CIPEMASTAT DM803GL Rheumatoid arthritis FA20 Phase 3 [17]
Apratastat DM8W4N9 Rheumatoid arthritis FA20 Phase 2 [25]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [13]
PMID29130358-Compound-Figure10(2a) DMFWXPS N. A. N. A. Patented [13]
BMS 275291 DMKSFPE Kaposi sarcoma 2B57 Discontinued in Phase 3 [31]
RS-130830 DMOTANY Hepatitis C virus infection 1E51.1 Discontinued in Phase 2 [27]
XL784 DMICR39 Diabetic nephropathy GB61.Z Discontinued in Phase 2 [32]
SC-44463 DMBPNKT N. A. N. A. Terminated [33]
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Drug(s) Targeting Matrix metalloproteinase-9 (MMP-9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [34]
DP-b99 DM97S10 Stroke 8B20 Phase 3 [35]
GS-5745 DMP8MDW Gastric adenocarcinoma 2B72 Phase 3 [36]
Andecaliximab DMLDB1X Gastric adenocarcinoma 2B72 Phase 3 [37]
BLZ-100 DMFKA4G Glioma 2A00.0 Phase 1/2 [38]
Neovastat DMXTYWJ Non-small-cell lung cancer 2C25.Y Phase 1 [11]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [13]
PMID29130358-Compound-Figure17(12) DMML4PA N. A. N. A. Patented [13]
PMID29130358-Compound-Figure17(10) DMVA15O N. A. N. A. Patented [13]
PMID29130358-Compound-SB-3CT DMC64XQ N. A. N. A. Patented [13]
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Drug(s) Targeting Matrix metalloproteinase-14 (MMP-14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [39]
BT1718 DMTXBUV Solid tumour/cancer 2A00-2F9Z Phase 1/2a [40]
MMI270 DM38N2K Discovery agent N.A. Investigative [41]
IK-862 DMJA4UE Discovery agent N.A. Investigative [21]
SR-973 DMU48OD Discovery agent N.A. Investigative [42]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J Discovery agent N.A. Investigative [16]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 Discovery agent N.A. Investigative [16]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN Discovery agent N.A. Investigative [16]
UK-356618 DM02FGH Discovery agent N.A. Investigative [33]
PMID23631440C29e DMM92IB Discovery agent N.A. Investigative [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Matrix metalloproteinase-2 (MMP-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prinomastat DM9HOKG Lung cancer 2C25.0 Approved [29]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [39]
Marimastat DM6V34C Pancreatic cancer 2C10 Phase 3 [30]
Neovastat DMXTYWJ Non-small-cell lung cancer 2C25.Y Phase 1 [11]
Metastat DMTQ4PN Acne vulgaris ED80 Phase 1 [44]
PMID29130358-Compound-Figure18(14a) DMHIBTZ N. A. N. A. Patented [13]
PMID29130358-Compound-Figure10(2a) DMFWXPS N. A. N. A. Patented [13]
PMID29130358-Compound-Figure16(9b) DMPAQLZ N. A. N. A. Patented [13]
PMID29130358-Compound-SB-3CT DMC64XQ N. A. N. A. Patented [13]
PMID29130358-Compound-Figure16(9a) DMKX5R8 N. A. N. A. Patented [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Matrix metalloproteinase-21 (MMP-21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
IK-862 DMJA4UE Discovery agent N.A. Investigative [21]
SR-973 DMU48OD Discovery agent N.A. Investigative [42]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide DMCNV5J Discovery agent N.A. Investigative [16]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid DM37C25 Discovery agent N.A. Investigative [16]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide DM4VADN Discovery agent N.A. Investigative [16]
3-(4-(2-phenylethynyl)benzoyl)pentanoic acid DMQDPHT Discovery agent N.A. Investigative [4]
N-hydroxy-2,3-bis(phenylsulfonamido)propanamide DMZWIVJ Discovery agent N.A. Investigative [45]
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Drug(s) Targeting Bacterial Lethal factor (Bact lef)
Drug Name Drug ID Indication ICD 11 Highest Status REF
IQ-DAA DMHP71R Bacillus anthracis infection 1G40 Phase 1 [46]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [47]
MMI270 DM38N2K Discovery agent N.A. Investigative [48]
NSC-622445 DME35CB Discovery agent N.A. Investigative [49]
N-(Sulfanylacetyl)Tyrosylprolylmethioninamide DMWJDYZ Discovery agent N.A. Investigative [2]
N-(3,4-dihydroxybenzyl)oleamide DM67XSW Discovery agent N.A. Investigative [50]
N,N'-Bis(4-Amino-2-Methylquinolin-6-Yl)Urea DMT4USP Discovery agent N.A. Investigative [2]
N-hydroxy-4-(oleamidomethyl)benzamide DMUSHZK Discovery agent N.A. Investigative [50]
N-(3,4,5-trihydroxyphenethyl)oleamide DMQ5USA Discovery agent N.A. Investigative [51]
N-oleoyl-dopamine DM1AVCZ Discovery agent N.A. Investigative [51]
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Drug(s) Targeting Matrix metalloproteinase-3 (MMP-3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID29130358-Compound-Figure10(2a) DMFWXPS N. A. N. A. Patented [13]
RS-130830 DMOTANY Hepatitis C virus infection 1E51.1 Discontinued in Phase 2 [27]
PG-530742 DMELXBQ Myocardial infarction BA41-BA43 Discontinued in Phase 2 [52]
Batimastat DM92VRP Idiopathic pulmonary fibrosis CB03.4 Preclinical [53]
SC-44463 DMBPNKT N. A. N. A. Terminated [54]
BB-1101 DM7GH5Z Multiple sclerosis 8A40 Terminated [55]
L-696418 DMV785R N. A. N. A. Terminated [56]
RO-319790 DML3NEU Rheumatoid arthritis FA20 Terminated [57]
MMI270 DM38N2K Discovery agent N.A. Investigative [44]
IK-862 DMJA4UE Discovery agent N.A. Investigative [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Selenium DM25CGV N. A. N. A. Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [60]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [61]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [62]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [64]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [67]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [69]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [70]
Quercetin DM3NC4M Obesity 5B81 Approved [71]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [72]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [73]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [75]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [76]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [77]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Gefitinib DM15F0X Colon adenocarcinoma Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Selenium DM25CGV N. A. N. A. Approved [69]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [82]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [84]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [85]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [86]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [87]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [88]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [90]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [91]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [92]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [94]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [95]
Quercetin DM3NC4M Obesity 5B81 Approved [96]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [97]
Gefitinib DM15F0X Colon adenocarcinoma Approved [98]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Epinephrine DM3KJBC Acute asthma CA23 Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [101]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [102]
Fructose DM43AN2 Vomiting MD90 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [104]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [105]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [106]
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Drug(s) Affected By Amyloid beta precursor like protein 2 (APLP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [110]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [111]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [112]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [113]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [114]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [115]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial Lethal factor (Bact lef) TTIQSC1 LEF_BACAN Inhibitor [2]
Matrix metalloproteinase-1 (MMP-1) TTMX39J MMP1_HUMAN Inhibitor [3]
Matrix metalloproteinase-12 (MMP-12) TTXZ0KQ MMP12_HUMAN Inhibitor [4]
Matrix metalloproteinase-13 (MMP-13) TTHY57M MMP13_HUMAN Inhibitor [5]
Matrix metalloproteinase-14 (MMP-14) TTJ4QE7 MMP14_HUMAN Inhibitor [3]
Matrix metalloproteinase-2 (MMP-2) TTLM12X MMP2_HUMAN Inhibitor [3]
Matrix metalloproteinase-21 (MMP-21) TTYRF5E MMP21_HUMAN Inhibitor [4]
Matrix metalloproteinase-3 (MMP-3) TTUZ2L5 MMP3_HUMAN Inhibitor [3]
Matrix metalloproteinase-8 (MMP-8) TTGA1IV MMP8_HUMAN Inhibitor [6]
Matrix metalloproteinase-9 (MMP-9) TT6X50U MMP9_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [7]
Amyloid beta precursor like protein 2 (APLP2) OTTFE53M APLP2_HUMAN Protein Interaction/Cellular Processes [8]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Protein Interaction/Cellular Processes [8]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Gene/Protein Processing [9]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Gene/Protein Processing [9]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Gene/Protein Processing [10]

References

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