Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME9T0A)

Drug Name
RGFP966 Drug Info
Synonyms RGFP-966
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
56650312
ChEBI ID
CHEBI:131163
TTD Drug ID
DME9T0A

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histone deacetylase 3 (HDAC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
CHR-3996 DMIXPNG Lymphoma 2A80-2A86 Phase 1/2 [4]
PMID29671355-Compound-62 DMWRS34 N. A. N. A. Patented [5]
PMID29671355-Compound-43 DMVPMWJ N. A. N. A. Patented [5]
PMID29671355-Compound-25 DMPV0KZ N. A. N. A. Patented [5]
PMID29671355-Compound-21 DMPJN0M N. A. N. A. Patented [5]
PMID29671355-Compound-31 DM3H78D N. A. N. A. Patented [5]
PMID29671355-Compound-56 DM0VBMI N. A. N. A. Patented [5]
PMID29671355-Compound-67 DM1RPL4 N. A. N. A. Patented [5]
PMID29671355-Compound-44 DM80A3V N. A. N. A. Patented [5]
PMID29671355-Compound-61 DMXH1G3 N. A. N. A. Patented [5]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [7]
Methotrexate DM2TEOL Anterior urethra cancer Approved [8]
Quercetin DM3NC4M Obesity 5B81 Approved [9]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [10]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [11]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [12]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [13]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [14]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [15]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [16]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [17]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [18]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [19]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [20]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [24]
Panobinostat DM58WKG Chronic graft versus host disease Approved [25]
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Drug(s) Affected By Replication protein A 32 kDa subunit (RPA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [6]
Etretinate DM2CZFA Keratosis ED56 Approved [26]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [11]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [15]
Testosterone DM7HUNW Hot flushes GA30 Approved [27]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [3]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [27]
Leflunomide DMR8ONJ Arthritis FA20 Approved [28]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [30]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Selenium DM25CGV N. A. N. A. Approved [33]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [34]
Etretinate DM2CZFA Keratosis ED56 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [35]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [36]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [37]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [39]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [44]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [45]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [46]
Gefitinib DM15F0X Colon adenocarcinoma Approved [47]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [50]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [51]
Paclitaxel DMLB81S Breast carcinoma Approved [52]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [53]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [54]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [43]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [44]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [56]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [57]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [58]
Quercetin DM3NC4M Obesity 5B81 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [60]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [61]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [62]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [63]
Testosterone DM7HUNW Hot flushes GA30 Approved [64]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [65]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [66]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Gefitinib DM15F0X Colon adenocarcinoma Approved [69]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [7]
Etretinate DM2CZFA Keratosis ED56 Approved [71]
Prednisone DM2HG4X Acute asthma CA23 Approved [72]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [73]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [74]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [75]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [76]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [77]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [78]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [79]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [80]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [81]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [82]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [83]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [84]
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Drug(s) Affected By Histone H4 (H4C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [85]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [7]
Selenium DM25CGV N. A. N. A. Approved [33]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [86]
Methotrexate DM2TEOL Anterior urethra cancer Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [21]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [11]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Panobinostat DM58WKG Chronic graft versus host disease Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [90]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone deacetylase 3 (HDAC3) TT4YWTO HDAC3_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [2]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [3]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [2]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [3]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Post-Translational Modifications [3]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Post-Translational Modifications [3]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Post-Translational Modifications [3]
Replication protein A 32 kDa subunit (RPA2) OTZ54WAF RFA2_HUMAN Post-Translational Modifications [3]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Gene/Protein Processing [3]

References

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21 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
22 Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
23 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
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27 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
28 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
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30 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
31 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
32 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
33 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
34 Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
35 Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
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40 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
41 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
42 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
43 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
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45 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
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48 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
49 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
50 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
51 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
52 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
53 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
54 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
55 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
56 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
57 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
58 Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
59 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
60 Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
61 Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
62 Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
63 Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
64 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
65 Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
66 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
67 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
68 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
69 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
70 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
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