Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFHCV9)

Drug Name
hydroxycitronellal Drug Info
Synonyms
Hydroxycitronellal; 7-Hydroxy-3,7-dimethyloctanal; 107-75-5; 7-Hydroxycitronellal; Citronellal hydrate; 3,7-Dimethyl-7-hydroxyoctanal; Phixia; Laurine; Cyclosia; Cyclalia; Fixol; Lilyl aldehyde; Muguet synthetic; Musuet synthetic; Musuettine principle; Muguettine principle; Octanal, 7-hydroxy-3,7-dimethyl-; Citronellal, hydroxy-; hydroxy citronellal; Oxydihydrocitronellal; 7-Hydroxy-3,7-dimethyloctan-1-al; NSC 406740; FEMA No. 2583; CHEBI:53459; 1-OCTANAL, 3,7-DIMETHYL-7-HYDROXY-; EINECS 203-518-7; BRN 1721290; AI3-05823
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
7888
ChEBI ID
CHEBI:53459
CAS Number
CAS 107-75-5
TTD Drug ID
DMFHCV9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Long transient receptor potential channel 8 (TRPM8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Menthol DMG2KW7 Back pain ME84.Z Approved [7]
D-3263 DM7V2OM Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
PF-05105679 DM4QPT0 Pain MG30-MG3Z Phase 1 [9]
2-APB DM9AKVR Discovery agent N.A. Investigative [10]
ACAA DMACYPW Discovery agent N.A. Investigative [11]
5-METHOXYTRYPTAMINE DMARCKD Discovery agent N.A. Investigative [12]
icilin DMYVOL9 Discovery agent N.A. Investigative [13]
2-(5-fluoro-1H-indol-3-yl)ethanamine DMHW5FT Discovery agent N.A. Investigative [12]
NADA DM3ORGM Discovery agent N.A. Investigative [11]
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine DMD2QVO Discovery agent N.A. Investigative [12]
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Drug(s) Affected By Metallothionein-2 (MT2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [15]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [16]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [19]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [20]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [21]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [22]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [23]
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Drug(s) Affected By Metallothionein-1A (MT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [14]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [4]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [25]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [26]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [27]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [4]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [4]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [28]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [29]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [30]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [32]
Verapamil DMA7PEW Angina pectoris BA40 Approved [33]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [35]
Selenium DM25CGV N. A. N. A. Approved [36]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [37]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
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Drug(s) Affected By Transcription factor MafF (MAFF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [43]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [47]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [48]
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Drug(s) Affected By Toll-like receptor 2 (TLR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [53]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [54]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [55]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [50]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [57]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [58]
Fructose DM43AN2 Vomiting MD90 Approved [59]
Ketoprofen DMRKXPT Bursitis Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [61]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [62]
Gefitinib DM15F0X Colon adenocarcinoma Approved [63]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [65]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [66]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [67]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [68]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [32]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [69]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [34]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [72]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [70]
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Drug(s) Affected By C-C chemokine receptor type 7 (CCR7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [43]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [73]
Leflunomide DMR8ONJ Arthritis FA20 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [56]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [75]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [76]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [77]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [76]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [29]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [78]
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Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [80]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [81]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [82]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [83]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [76]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [84]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [76]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [85]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [86]
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Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [88]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [50]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [89]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [91]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [92]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Long transient receptor potential channel 8 (TRPM8) TTXDKTO TRPM8_HUMAN Activator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
C-C chemokine receptor type 7 (CCR7) OTHFUOYE CCR7_HUMAN Gene/Protein Processing [3]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Gene/Protein Processing [4]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Protein Interaction/Cellular Processes [5]
Metallothionein-1A (MT1A) OTKBH52X MT1A_HUMAN Gene/Protein Processing [4]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Gene/Protein Processing [4]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Gene/Protein Processing [3]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Gene/Protein Processing [6]
Thioredoxin OT6XU6VW THIO_HUMAN Gene/Protein Processing [4]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Gene/Protein Processing [3]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Gene/Protein Processing [4]

References

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39 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
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60 CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
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62 Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010 Jul 1;19(7):661-6. doi: 10.1111/j.1600-0625.2010.01076.x. Epub 2010 Feb 25.
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65 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
66 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
67 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
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69 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
70 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
71 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
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73 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
74 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
75 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
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77 THP-1 monocytes but not macrophages as a potential alternative for CD34+ dendritic cells to identify chemical skin sensitizers. Toxicol Appl Pharmacol. 2009 Apr 15;236(2):221-30.
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