Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFKRQE)

Drug Name

tauroursodeoxycholic acid Drug Info

Synonyms

tauroursodeoxycholate; TUDCA

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9848818
ChEBI ID: CHEBI:80774
CAS Number: CAS 14605-22-2
TTD Drug ID: DMFKRQE
VARIDT Drug ID: DR00519

Molecule-Related Drug Atlas

Molecule Type:

DTP

DOT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[9]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[10]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[12]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[13]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[14]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[15]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[16]
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Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[18]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[20]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[21]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[22]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[23]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[24]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[3]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[25]
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Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[29]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[33]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[34]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[35]
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Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[39]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[4]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[42]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[43]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[44]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[48]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[49]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[50]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[51]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
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Drug(s) Affected By G-protein coupled bile acid receptor 1 (GPBAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[54]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[55]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[54]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[58]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[60]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[61]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[63]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[64]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[65]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[66]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[2]
Organic anion transporting polypeptide 1A2 (SLCO1A2)	DTE2B1D	SO1A2_HUMAN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Gene/Protein Processing	[4]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Biotransformations	[5]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Gene/Protein Processing	[6]
Fatty acid-binding protein, adipocyte (FABP4)	OT3DKFOU	FABP4_HUMAN	Gene/Protein Processing	[4]
G-protein coupled bile acid receptor 1 (GPBAR1)	OT4BKEJ9	GPBAR_HUMAN	Gene/Protein Processing	[4]

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References

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