Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFOTZ7)

Drug Name
Racecadotril Drug Info
Synonyms Acetorphan; Hidrasec; Tiorfan
Indication
Disease Entry ICD 11 Status REF
Diarrhea ME05.1 Approved [1]
Cross-matching ID
PubChem CID
107751
ChEBI ID
CHEBI:91508
CAS Number
CAS 81110-73-8
TTD Drug ID
DMFOTZ7

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Galectin-1 (LGALS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [4]
Quercetin DM3NC4M Obesity 5B81 Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [6]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [7]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [8]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [9]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [10]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [11]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [12]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [16]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [17]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [18]
Quercetin DM3NC4M Obesity 5B81 Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [22]
Panobinostat DM58WKG Chronic graft versus host disease Approved [23]
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Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [24]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [25]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [15]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [26]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [27]
Fluoxetine DM3PD2C Bipolar depression Approved [26]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
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Drug(s) Affected By Squalene monooxygenase (SQLE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [30]
Quercetin DM3NC4M Obesity 5B81 Approved [5]
Fluoxetine DM3PD2C Bipolar depression Approved [31]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [34]
Leflunomide DMR8ONJ Arthritis FA20 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [37]
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Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [39]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [5]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [41]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [42]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [43]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [46]
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Drug(s) Affected By Arrestin domain-containing protein 3 (ARRDC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [14]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [48]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [8]
Testosterone DM7HUNW Hot flushes GA30 Approved [49]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [49]
Leflunomide DMR8ONJ Arthritis FA20 Approved [35]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [5]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
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Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [22]
Panobinostat DM58WKG Chronic graft versus host disease Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [51]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [52]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [38]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [44]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [53]
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Drug(s) Affected By Transmembrane 6 superfamily member 1 (TM6SF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [22]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [22]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [54]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [55]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [56]
Arsenic DMTL2Y1 N. A. N. A. Approved [57]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [58]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [59]
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Drug(s) Affected By 2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [3]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [36]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [29]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [60]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [61]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [62]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [64]
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Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [65]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [66]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [67]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [66]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [66]
Methotrexate DM2TEOL Anterior urethra cancer Approved [68]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [5]
Fluoxetine DM3PD2C Bipolar depression Approved [22]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [66]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Endopeptidase (ENP) TT8CYO4 NOUNIPROTAC Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1) OTINY3MW AL8A1_HUMAN Gene/Protein Processing [3]
Arrestin domain-containing protein 3 (ARRDC3) OTAKW7R9 ARRD3_HUMAN Gene/Protein Processing [3]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Gene/Protein Processing [3]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Gene/Protein Processing [3]
Galectin-1 (LGALS1) OT8LDFWR LEG1_HUMAN Gene/Protein Processing [3]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Gene/Protein Processing [3]
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1) OT9EROL6 HERP1_HUMAN Gene/Protein Processing [3]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Gene/Protein Processing [3]
Squalene monooxygenase (SQLE) OT0GGRDO ERG1_HUMAN Gene/Protein Processing [3]
Transmembrane 6 superfamily member 1 (TM6SF1) OTQR4I2N TM6S1_HUMAN Gene/Protein Processing [3]

References

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29 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
30 Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation. J Biol Chem. 2019 Feb 15;294(7):2436-2448. doi: 10.1074/jbc.RA118.005069. Epub 2018 Dec 13.
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