Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHDF7B)

Drug Name

Thiamylal Drug Info

Synonyms

Surital; Thioquinalbarbitone; Thioseconal; Thiamylal [USAN]; Surital (TN); Barbituric acid, 5-allyl-5-(1-methylbutyl)-2-thio-(VAN); Barbituric acid, 5-allyl-5-(1-methylbutyl)-2-thio-(VAN) (8CI); Dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione; Dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6-(1H,5H)-pyrimidinedione; 4,6(1H,5H)-Pyrimidinedione, dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-(9CI); 5-(pentan-2-yl)-5-(prop-2-en-1-yl)-2-sulfanylidenedihydropyrimidine-4,6(1H,5H)-dione; 5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid; 5-Allyl-5-(1-methylbutyl)-2-thiobarbitursaeure; 5-Allyl-5-(1-methylbutyl)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione; 5-allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; 5-pentan-2-yl-5-prop-2-enyl-2-sulfanylidene-1,3-diazinane-4,6-dione

Indication

Disease Entry	ICD 11	Status	REF
Anaesthesia	9A78.6	Approved	[1]

Therapeutic Class

Hypnotics and Sedatives

Cross-matching ID

PubChem CID: 3032285
ChEBI ID: CHEBI:9536
CAS Number: CAS 77-27-0
TTD Drug ID: DMHDF7B
INTEDE Drug ID: DR1579

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

DOT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting GABA(A) receptor gamma-3 (GABRG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolpidem	DMWOSKJ	Insomnia	7A00-7A0Z	Approved	[6]
Allopregnanolone	DMNLHAC	Depression	6A70-6A7Z	approved	[7]
Clobazam - Lundbeck	DMW1OQ0	Anxiety disorder	6B00-6B0Z	Approved	[2]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[6]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[8]
Ganaxolone	DMXJMKF	Epileptic seizures	8A61-8A6Z	Approved	[7]
Mebutamate	DM0KYI4	Anxiety disorder	6B00-6B0Z	Approved	[2]
Metharbital	DM5A38V	Epilepsy	8A60-8A68	Approved	[2]
Etomidate	DMZI3WO	Anaesthesia	9A78.6	Approved	[2]
Remimazolam	DMLVSYX	Procedural sedation	JB0C.3	Approved	[9]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[10]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[11]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[13]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[16]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[17]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[11]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[18]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[23]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[24]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[25]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[26]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[27]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[28]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[29]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[25]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[33]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[34]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[37]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[39]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[40]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[41]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[5]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[43]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[46]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[38]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[47]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[48]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[37]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[50]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[40]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[41]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA(A) receptor gamma-3 (GABRG3)	TTEX6LM	GBRG3_HUMAN	Modulator	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[3]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[4]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[3]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Post-Translational Modifications	[5]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Post-Translational Modifications	[5]

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References

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