Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSL679)

Drug Name
Gatifloxacin Drug Info
Synonyms
Bonoq; GTFX; Gaity; Gatiflo; Gatilox; Gatiquin; Gatispan; Tequin; Zymar; Zymaxid; Zymer; AM 1155; CG 5501;PD 135432; PD135432; AM-1155; BMS 206584-01; BMS-206584; CG-5501; Gatiflo (TN); Gatifloxacin & Gamma Interferon; Gatifloxacin (INN); Gatifloxacin (TN); Gatifloxacin [USAN:INN]; PD-135432; Tequin (TN); Tequin in dextrose 5% in plastic container; Zymar (TN); Zymer (TN); BMS-206584-01; Gatiflo,Tequin and Zymar, Gatifloxacin; AM-1155 (*Sesquihydrate*); (+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Indication
Disease Entry ICD 11 Status REF
Acute gonococcal cervicitis Approved [1]
Mycoplasma pneumoniae pneumonia Approved [1]
Respiratory tract infection CA45 Approved [2]
Staphylococcal pneumonia Approved [1]
Staphylococcus aureus infection Approved [1]
Streptococcal pneumonia Approved [1]
Pneumonia caused by chlamydia Investigative [1]
Therapeutic Class
Antiinfective Agents
Cross-matching ID
PubChem CID
5379
ChEBI ID
CHEBI:5280
CAS Number
CAS 112811-59-3
TTD Drug ID
DMSL679
VARIDT Drug ID
DR01165

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Bacterial DNA gyrase (Bact gyrase)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Grepafloxacin DMGLX0T Chronic bronchitis CA20.1 Approved [8]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [3]
Levofloxacin DMS60RB Acute maxillary sinusitis Approved [3]
Norfloxacin DMIZ6W2 Acute gonococcal cervicitis Approved [3]
Ozenoxacin DM6KZMG Impetigo 1B72 Approved [9]
Sparfloxacin DMB4HCT Bacterial infection 1A00-1C4Z Approved [3]
Gemifloxacin DMHT34O Bacterial infection 1A00-1C4Z Approved [3]
Besifloxacin DMPHXMI Ocular inflammation 9C61.24 Approved [10]
Finafloxacin DMZEONG Urinary tract infection GC08 Approved [11]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [3]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Staphylococcus Topoisomerase IV (Stap-coc parC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [3]
Levofloxacin DMS60RB Acute maxillary sinusitis Approved [3]
Ozenoxacin DM6KZMG Impetigo 1B72 Approved [9]
Sparfloxacin DMB4HCT Bacterial infection 1A00-1C4Z Approved [3]
Gemifloxacin DMHT34O Bacterial infection 1A00-1C4Z Approved [3]
Besifloxacin DMPHXMI Ocular inflammation 9C61.24 Approved [10]
Finafloxacin DMZEONG Urinary tract infection GC08 Approved [11]
Delafloxacin Meglumine DMVTU5Q Acute bacterial skin infection 1C41 Approved [12]
Moxifloxacin DMU8V4S Bacterial infection 1A00-1C4Z Approved [3]
Zabofloxacin DMEY1F3 Pneumonia CA40 Phase 3 [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [14]
Methotrexate DM2TEOL Anterior urethra cancer Approved [15]
Folic Acid DMEMBJC Colorectal carcinoma Approved [16]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [17]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [18]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [19]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [20]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [21]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [22]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [24]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [25]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Folic Acid DMEMBJC Colorectal carcinoma Approved [27]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [26]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [26]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [30]
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Drug(s) Transported By Organic anion transporting polypeptide 1A2 (SLCO1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [34]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [35]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [36]
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [37]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [38]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [39]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-glucagon (GCG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Metoclopramide DMFA5MY Nausea MD90 Approved [43]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [44]
Orlistat DMRJSP8 Obesity 5B81 Approved [45]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [46]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [47]
geraniol DMS3CBD Discovery agent N.A. Investigative [48]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Neuroendocrine convertase 1 (PCSK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [49]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [51]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [52]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [53]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [54]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [55]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [56]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [57]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [47]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Bacterial DNA gyrase (Bact gyrase) TTN6J5F GYRA_STAAU; GYRB_STAAU Modulator [3]
Staphylococcus Topoisomerase IV (Stap-coc parC) TTIXTO3 PARC_STAAS Modulator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [4]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [5]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Neuroendocrine convertase 1 (PCSK1) OTPBRJ54 NEC1_HUMAN Gene/Protein Processing [7]
Pro-glucagon (GCG) OTXU08VF GLUC_HUMAN Gene/Protein Processing [7]

References

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7 Combined contributions of over-secreted glucagon-like peptide 1 and suppressed insulin secretion to hyperglycemia induced by gatifloxacin in rats. Toxicol Appl Pharmacol. 2013 Feb 1;266(3):375-84. doi: 10.1016/j.taap.2012.11.015. Epub 2012 Nov 28.
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