Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT2EJP)

Drug Name
Podofilox Drug Info
Synonyms
podophyllotoxin; 518-28-5; Condylox; Condyline; Wartec; Podophyllotoxin 7; Podophyllinic acid lactone; Warticon; (-)-Podophyllotoxin; Podofilox [USAN]; CCRIS 565; UNII-L36H50F353; Podophyllotoxin, 95%; HSDB 7238; NSC24818; CHEMBL61; EINECS 208-250-4; NSC 24818; (5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one; MLS000069495; AI3-50456; CHEBI:50305; Podofilox (USAN); L36H50F353; Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one,; Podophyllotoxin
Indication
Disease Entry ICD 11 Status REF
Condyloma 1A95 Approved [1]
External genital and perianal wart 1A95 Approved [1]
Verruca vulgaris 1E80 Approved [1]
Cross-matching ID
PubChem CID
10607
ChEBI ID
CHEBI:50305
CAS Number
CAS 518-28-5
TTD Drug ID
DMT2EJP
INTEDE Drug ID
DR1310
ACDINA Drug ID
D01348

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase II (TOP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [6]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [7]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [6]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [8]
Idarubicin DMM0XGL Acute myelogenous leukaemia 2A41 Approved [6]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [6]
Lomefloxacin DMVRH9C Bacterial infection 1A00-1C4Z Approved [9]
Dexrazoxane DMD7X1O Breast cancer 2C60-2C65 Approved [6]
Enoxacin DMYTE6L Acute gonococcal cervicitis Approved [10]
Amsacrine DMZKYIV Acute lymphoblastic leukaemia 2A85 Approved [11]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [12]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [13]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [14]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [15]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [16]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [17]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [18]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [19]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [13]
Verapamil DMA7PEW Angina pectoris BA40 Approved [20]
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Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [21]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [22]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [23]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [25]
Verapamil DMA7PEW Angina pectoris BA40 Approved [26]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [29]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [30]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Gefitinib DM15F0X Colon adenocarcinoma Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [33]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [34]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [35]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [36]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [35]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [37]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [38]
Methotrexate DM2TEOL Anterior urethra cancer Approved [39]
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Drug(s) Affected By Microtubule-associated protein tau (MAPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [40]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [42]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [5]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [46]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [47]
Testosterone enanthate DMB6871 N. A. N. A. Approved [48]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [50]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [51]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [52]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [53]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [54]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [55]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [56]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [57]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [58]
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Drug(s) Affected By Caspase-2 (CASP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Methotrexate DM2TEOL Anterior urethra cancer Approved [61]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [64]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [65]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [66]
Leflunomide DMR8ONJ Arthritis FA20 Approved [46]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [67]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [67]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [68]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [59]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [70]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [34]
Meloxicam DM2AR7L Arthritis FA20 Approved [71]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [72]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [73]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [3]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Gene/Protein Processing [4]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [4]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Gene/Protein Processing [5]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [4]

References

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