Details of the Drug Combination

General Information of Drug Combination (ID: DCCXGFS)

Drug Combination Name
Isotretinoin Itraconazole
Indication
Disease Entry Status REF
Tinea Phase 2 [1]
Component Drugs Isotretinoin   DM4QTBN Itraconazole   DMCR1MV
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Isotretinoin
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [2]
Mycosis fungoides 2B01 Approved [3]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [4]
Neuroblastoma 2D11.2 Investigative [3]
Isotretinoin Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Retinoic acid receptor (RAR) TTOD7B3 NOUNIPROTAC Agonist [12]
COVID-19 papain-like proteinase (PL-PRO) TTNHMO8 R1AB_SARS2 (819-2763) Inhibitor [4]
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Isotretinoin Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [13]
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Isotretinoin Interacts with 571 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
AH receptor-interacting protein (AIP) OTDJ3OSV AIP_HUMAN Decreases Expression [7]
Suppressor of cytokine signaling 2 (SOCS2) OTBPNKJQ SOCS2_HUMAN Increases Expression [7]
Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) OTIK337D TGFI1_HUMAN Increases Expression [7]
RNA/RNP complex-1-interacting phosphatase (DUSP11) OTU6C41M DUS11_HUMAN Decreases Expression [7]
Lecithin retinol acyltransferase (LRAT) OTB7CJKY LRAT_HUMAN Increases Expression [7]
Keratin, type II cytoskeletal 75 (KRT75) OT28B9E6 K2C75_HUMAN Decreases Expression [7]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Increases Expression [7]
Keratin, type I cytoskeletal 14 (KRT14) OTUVZ1DW K1C14_HUMAN Decreases Expression [7]
Keratin, type II cytoskeletal 6A (KRT6A) OT392M5T K2C6A_HUMAN Decreases Expression [7]
Keratin, type II cytoskeletal 1 (KRT1) OTIOJWA4 K2C1_HUMAN Decreases Expression [7]
Protein S100-A8 (S100A8) OTVMOB3F S10A8_HUMAN Increases Expression [7]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Decreases Expression [7]
Fibroblast growth factor 1 (FGF1) OT8I64X8 FGF1_HUMAN Decreases Expression [7]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [7]
Neurofilament light polypeptide (NEFL) OTQESJV4 NFL_HUMAN Decreases Expression [7]
Keratin, type II cytoskeletal 7 (KRT7) OTLT3JFN K2C7_HUMAN Increases Expression [7]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Decreases Expression [7]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [7]
Collagen alpha-1(VI) chain (COL6A1) OTYKSCOB CO6A1_HUMAN Decreases Expression [7]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Decreases Expression [7]
Keratin, type I cytoskeletal 10 (KRT10) OTSVRD3Q K1C10_HUMAN Decreases Expression [7]
Keratin, type II cytoskeletal 5 (KRT5) OTVGI9HT K2C5_HUMAN Decreases Expression [7]
Keratin, type I cytoskeletal 15 (KRT15) OTS6WLF7 K1C15_HUMAN Increases Expression [7]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Increases Expression [7]
Filaggrin (FLG) OTE9QDV6 FILA_HUMAN Decreases Expression [7]
Cornifin-B (SPRR1B) OTXNW3P6 SPR1B_HUMAN Increases Expression [7]
Protein S100-A1 (S100A1) OT1F2G4J S10A1_HUMAN Decreases Expression [7]
Laminin subunit alpha-2 (LAMA2) OTFROQWE LAMA2_HUMAN Decreases Expression [7]
Collagen alpha-2(VIII) chain (COL8A2) OTASWJ69 CO8A2_HUMAN Decreases Expression [7]
Protein S100-A7 (S100A7) OTJFVJRF S10A7_HUMAN Increases Expression [7]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) OTBDF9HJ ODO2_HUMAN Increases Expression [7]
Cyclin-dependent kinase inhibitor 1C (CDKN1C) OTASTJ3Q CDN1C_HUMAN Decreases Expression [7]
Serpin B8 (SERPINB8) OT5T4Y5R SPB8_HUMAN Decreases Expression [7]
Serpin B9 (SERPINB9) OTJ811IF SPB9_HUMAN Decreases Expression [7]
Epithelial membrane protein 1 (EMP1) OTSZHUHQ EMP1_HUMAN Increases Expression [7]
Microfibrillar-associated protein 2 (MFAP2) OTMHVBTV MFAP2_HUMAN Decreases Expression [7]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Decreases Expression [7]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Decreases Expression [7]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Decreases Expression [7]
Desmocollin-1 (DSC1) OTNII6GZ DSC1_HUMAN Decreases Expression [7]
Chromobox protein homolog 3 (CBX3) OTOP9RLD CBX3_HUMAN Decreases Expression [7]
Eukaryotic translation initiation factor 4E-binding protein 2 (EIF4EBP2) OT3M8WEU 4EBP2_HUMAN Decreases Expression [7]
Interleukin-10 receptor subunit alpha (IL10RA) OTOX3D1D I10R1_HUMAN Decreases Expression [7]
Fas-activated serine/threonine kinase (FASTK) OTTHFZMP FASTK_HUMAN Decreases Expression [7]
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) OT8RPSOC FKBP8_HUMAN Decreases Expression [7]
Growth factor receptor-bound protein 7 (GRB7) OTF8Y9XY GRB7_HUMAN Decreases Expression [7]
Laminin subunit alpha-3 (LAMA3) OTFME7HT LAMA3_HUMAN Decreases Expression [7]
E3 ubiquitin-protein ligase RNF5 (RNF5) OTDQGI37 RNF5_HUMAN Decreases Expression [7]
Collagen alpha-1(XVII) chain (COL17A1) OTID5AH2 COHA1_HUMAN Decreases Expression [7]
Laminin subunit gamma-3 (LAMC3) OTKNAYJO LAMC3_HUMAN Increases Expression [7]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Increases Expression [14]
Cytochrome P450 26B1 (CYP26B1) OT92XA92 CP26B_HUMAN Increases Expression [14]
Class E basic helix-loop-helix protein 40 (BHLHE40) OTITX14U BHE40_HUMAN Increases Expression [8]
FYN-binding protein 1 (FYB1) OT6345CH FYB1_HUMAN Increases Expression [8]
Tight junction protein ZO-3 (TJP3) OTC1K8HC ZO3_HUMAN Increases Expression [8]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3) OTQ9ALTR GCNT3_HUMAN Increases Expression [8]
Stress-induced-phosphoprotein 1 (STIP1) OT7TXLOX STIP1_HUMAN Decreases Expression [8]
Cadherin-5 (CDH5) OTVX0E1Q CADH5_HUMAN Increases Expression [8]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A) OTE2KVZV SCNNA_HUMAN Increases Expression [8]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Expression [8]
E3 ubiquitin-protein ligase TRIM22 (TRIM22) OTJBLG5R TRI22_HUMAN Increases Expression [8]
E3 ubiquitin-protein ligase TRIM31 (TRIM31) OT7VW6RP TRI31_HUMAN Increases Expression [8]
Small proline-rich protein 3 (SPRR3) OTN9QJKG SPRR3_HUMAN Decreases Expression [8]
Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (NUDT4) OTA6ICI2 NUD4B_HUMAN Decreases Expression [9]
Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (GATD3) OTBQRU82 GAL3B_HUMAN Decreases Expression [9]
RNA-binding protein 47 (RBM47) OT6W67VM RBM47_HUMAN Decreases Expression [9]
Transcription factor E2F8 (E2F8) OTQKZGFP E2F8_HUMAN Decreases Expression [9]
Protein FAM149A (FAM149A) OTMDM0RI F149A_HUMAN Increases Expression [9]
Potassium channel subfamily K member 1 (KCNK1) OTBXPTKX KCNK1_HUMAN Decreases Expression [9]
NADH dehydrogenase iron-sulfur protein 8, mitochondrial (NDUFS8) OTMEAWKO NDUS8_HUMAN Decreases Expression [9]
Membrane-associated progesterone receptor component 1 (PGRMC1) OTBE6WAC PGRC1_HUMAN Decreases Expression [9]
Huntingtin-interacting protein 1 (HIP1) OT7AKCFQ HIP1_HUMAN Increases Expression [9]
Pyruvate dehydrogenase protein X component, mitochondrial (PDHX) OTG7O271 ODPX_HUMAN Decreases Expression [9]
RNA 3'-terminal phosphate cyclase (RTCA) OTSJRVTD RTCA_HUMAN Decreases Expression [9]
Interferon-related developmental regulator 1 (IFRD1) OT4SQMLQ IFRD1_HUMAN Decreases Expression [9]
RNA polymerase II elongation factor ELL2 (ELL2) OTZJRTFM ELL2_HUMAN Decreases Expression [9]
Butyrophilin subfamily 3 member A3 (BTN3A3) OTKMSJRA BT3A3_HUMAN Increases Expression [9]
Ribonuclease T2 (RNASET2) OTWY64L7 RNT2_HUMAN Increases Expression [9]
Pirin (PIR) OT8ALXHU PIR_HUMAN Decreases Expression [9]
Peroxisomal targeting signal 2 receptor (PEX7) OTM7VBRC PEX7_HUMAN Decreases Expression [9]
Fructose-1,6-bisphosphatase isozyme 2 (FBP2) OT9R1LF7 F16P2_HUMAN Decreases Expression [9]
Phospholipid phosphatase 3 (PLPP3) OTSSF7BK PLPP3_HUMAN Increases Expression [9]
Immunoglobulin superfamily containing leucine-rich repeat protein (ISLR) OTOLYLGI ISLR_HUMAN Increases Expression [9]
Homeobox protein cut-like 2 (CUX2) OTDJTQAJ CUX2_HUMAN Decreases Expression [9]
Testis-specific basic protein Y 2 (BPY2) OT2WQPNQ VCY2_HUMAN Decreases Expression [9]
Etoposide-induced protein 2.4 homolog (EI24) OTD4NOYS EI24_HUMAN Decreases Expression [9]
Proteasome subunit alpha type-7 (PSMA7) OTPHI6ST PSA7_HUMAN Decreases Expression [9]
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) OTAAS85T TIM23_HUMAN Decreases Expression [9]
Long-chain fatty acid transport protein 2 (SLC27A2) OT7JEG5F S27A2_HUMAN Decreases Expression [9]
NPC intracellular cholesterol transporter 1 (NPC1) OTRIPICX NPC1_HUMAN Decreases Expression [9]
Secretory carrier-associated membrane protein 1 (SCAMP1) OTFS4IKJ SCAM1_HUMAN Decreases Expression [9]
Dihydroxyacetone phosphate acyltransferase (GNPAT) OTF6LWPO GNPAT_HUMAN Decreases Expression [9]
Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B) OTWQQ08W LX15B_HUMAN Decreases Expression [9]
Inositol polyphosphate 4-phosphatase type II (INPP4B) OTLROA7G INP4B_HUMAN Decreases Expression [9]
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) OT8L6EGI BCAT2_HUMAN Decreases Expression [9]
High affinity copper uptake protein 1 (SLC31A1) OTXLRTUB COPT1_HUMAN Decreases Expression [9]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Decreases Expression [9]
Fatty acid-binding protein, brain (FABP7) OTRE2H4G FABP7_HUMAN Decreases Expression [9]
Cochlin (COCH) OTBEHD89 COCH_HUMAN Increases Expression [9]
Tetraspanin-6 (TSPAN6) OT8X0NWN TSN6_HUMAN Decreases Expression [9]
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) OTDV12IF NDUB3_HUMAN Decreases Expression [9]
Maleylacetoacetate isomerase (GSTZ1) OTQ43JCE MAAI_HUMAN Decreases Expression [9]
Synaptogyrin-1 (SYNGR1) OT0MBUK5 SNG1_HUMAN Decreases Expression [9]
Peroxisomal membrane protein PMP34 (SLC25A17) OT2TUHO8 PM34_HUMAN Decreases Expression [9]
Cleavage and polyadenylation specificity factor subunit 5 (NUDT21) OTZHKWAR CPSF5_HUMAN Decreases Expression [9]
Sushi domain-containing protein 5 (SUSD5) OTIMJGDH SUSD5_HUMAN Increases Expression [9]
Acyl-CoA (FADS1) OTUYOYHX FADS1_HUMAN Decreases Expression [9]
Lipid transferase CIDEA (CIDEA) OTDUTSOV CIDEA_HUMAN Decreases Expression [9]
Monocarboxylate transporter 2 (SLC16A7) OT7OI36B MOT2_HUMAN Decreases Expression [9]
Sushi repeat-containing protein SRPX2 (SRPX2) OT6A63TX SRPX2_HUMAN Decreases Expression [9]
Dual specificity protein phosphatase CDC14B (CDC14B) OTAESVOZ CC14B_HUMAN Increases Expression [9]
Histone H2B type 1-K (H2BC12) OTQ8V0KG H2B1K_HUMAN Decreases Expression [9]
Checkpoint protein HUS1 (HUS1) OTY1XON9 HUS1_HUMAN Decreases Expression [9]
Nibrin (NBN) OT73B5MD NBN_HUMAN Decreases Expression [9]
Slit homolog 3 protein (SLIT3) OTU8MKEU SLIT3_HUMAN Increases Expression [9]
Microfibrillar-associated protein 3-like (MFAP3L) OTNMHSAH MFA3L_HUMAN Decreases Expression [9]
Peroxisomal membrane protein 11A (PEX11A) OT8MJ9CJ PX11A_HUMAN Decreases Expression [9]
NADH dehydrogenase iron-sulfur protein 7, mitochondrial (NDUFS7) OTIRMB2O NDUS7_HUMAN Decreases Expression [9]
Large ribosomal subunit protein bL33m (MRPL33) OTA3YDH0 RM33_HUMAN Decreases Expression [9]
Mitochondrial-processing peptidase subunit beta (PMPCB) OTRMBHNM MPPB_HUMAN Decreases Expression [9]
NADH dehydrogenase iron-sulfur protein 3, mitochondrial (NDUFS3) OTX61TQQ NDUS3_HUMAN Decreases Expression [9]
Protein phosphatase 1B (PPM1B) OTZMH6V3 PPM1B_HUMAN Decreases Expression [9]
Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (PIK3C2G) OTW3LY1C P3C2G_HUMAN Decreases Expression [9]
Ribonuclease P protein subunit p40 (RPP40) OTRYY1AP RPP40_HUMAN Decreases Expression [9]
Lathosterol oxidase (SC5D) OT41KMW4 SC5D_HUMAN Decreases Expression [9]
Isocitrate dehydrogenase cytoplasmic (IDH1) OT4DLHC8 IDHC_HUMAN Decreases Expression [9]
Matrix metalloproteinase-23 (MMP23B) OT2OR6TS MMP23_HUMAN Increases Expression [9]
Carboxypeptidase D (CPD) OT2CS64Y CBPD_HUMAN Decreases Expression [9]
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX) OTIT4JL0 CLPX_HUMAN Decreases Expression [9]
Delta(14)-sterol reductase TM7SF2 (TM7SF2) OTILU5S7 ERG24_HUMAN Decreases Expression [9]
Mitochondrial import receptor subunit TOM70 (TOMM70) OT8QBYZ0 TOM70_HUMAN Decreases Expression [9]
Rho-related BTB domain-containing protein 3 (RHOBTB3) OT1BFKPH RHBT3_HUMAN Increases Expression [9]
NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) OTXL10N9 NDUA3_HUMAN Decreases Expression [9]
RasGAP-activating-like protein 1 (RASAL1) OTAHUNN7 RASL1_HUMAN Decreases Expression [9]
NADH dehydrogenase 1 subunit C2 (NDUFC2) OT9M119L NDUC2_HUMAN Decreases Expression [9]
CUGBP Elav-like family member 2 (CELF2) OTLJJ4VT CELF2_HUMAN Increases Expression [9]
NAD kinase (NADK) OTYN9GX0 NADK_HUMAN Decreases Expression [9]
Mitochondrial pyruvate carrier 2 (MPC2) OT0GHXGG MPC2_HUMAN Decreases Expression [9]
Fatty acid CoA ligase Acsl3 (ACSL3) OT3MWER1 ACSL3_HUMAN Decreases Expression [9]
STAM-binding protein (STAMBP) OTOT2OXM STABP_HUMAN Decreases Expression [9]
GTP-binding protein Di-Ras3 (DIRAS3) OT3XHLQA DIRA3_HUMAN Decreases Expression [9]
Geranylgeranyl pyrophosphate synthase (GGPS1) OTVEHG28 GGPPS_HUMAN Decreases Expression [9]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Decreases Expression [9]
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) OT0I2B4J FBLN4_HUMAN Increases Expression [9]
Anterior gradient protein 2 homolog (AGR2) OTRRZT7W AGR2_HUMAN Decreases Expression [9]
Cytochrome b5 (CYB5A) OT6SN4RM CYB5_HUMAN Decreases Expression [9]
Complement C1r subcomponent (C1R) OTA0ZNIU C1R_HUMAN Increases Expression [9]
2'-5'-oligoadenylate synthase 1 (OAS1) OT8ZLOCY OAS1_HUMAN Decreases Expression [9]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Increases Expression [9]
Cystatin-C (CST3) OTNZ6AO4 CYTC_HUMAN Increases Expression [9]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Increases Expression [9]
Apolipoprotein C-I (APOC1) OTA58CED APOC1_HUMAN Decreases Expression [9]
Cystatin-B (CSTB) OT3U0JF8 CYTB_HUMAN Decreases Expression [9]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [9]
T-cell surface glycoprotein CD3 delta chain (CD3D) OTRBLP0R CD3D_HUMAN Increases Expression [9]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) OTW8JHU2 DPB1_HUMAN Increases Expression [9]
Histone H2A type 1-B/E (H2AC4) OTMFQ662 H2A1B_HUMAN Decreases Expression [9]
Plasma protease C1 inhibitor (SERPING1) OT6CVN45 IC1_HUMAN Increases Expression [9]
Propionyl-CoA carboxylase beta chain, mitochondrial (PCCB) OTXUN47K PCCB_HUMAN Decreases Expression [9]
HLA class II histocompatibility antigen, DQ beta 2 chain (HLA-DQB2) OTZYAIBF DQB2_HUMAN Increases Expression [9]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Increases Expression [9]
Tyrosine-protein kinase Lck (LCK) OT883FG9 LCK_HUMAN Increases Expression [9]
Eukaryotic translation initiation factor 4E (EIF4E) OTDAWNLA IF4E_HUMAN Decreases Expression [9]
Acyl-CoA-binding protein (DBI) OT884QY9 ACBP_HUMAN Decreases Expression [9]
Vitamin K-dependent protein S (PROS1) OTXQWNOI PROS_HUMAN Increases Expression [9]
Tyrosine-protein kinase Lyn (LYN) OTP686K2 LYN_HUMAN Increases Expression [9]
Fumarate hydratase, mitochondrial (FH) OTEQWU6Q FUMH_HUMAN Decreases Expression [9]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Decreases Expression [9]
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1) OTGEU8IK ODPA_HUMAN Decreases Expression [9]
Collagen alpha-2(IV) chain (COL4A2) OTJK1LKN CO4A2_HUMAN Increases Expression [9]
Receptor-type tyrosine-protein phosphatase C (PTPRC) OT6KOR77 PTPRC_HUMAN Increases Expression [9]
Keratin, type I cytoskeletal 16 (KRT16) OTGA0EQN K1C16_HUMAN Decreases Expression [9]
Alpha-2A adrenergic receptor (ADRA2A) OTZFGOTP ADA2A_HUMAN Increases Expression [9]
3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) OTVKRET0 THIK_HUMAN Decreases Expression [9]
Dihydrolipoyl dehydrogenase, mitochondrial (DLD) OT378CU9 DLDH_HUMAN Decreases Expression [9]
Histone H2A type 1 (H2AC11) OTN9P0BO H2A1_HUMAN Decreases Expression [9]
Myocardial zonula adherens protein (MYZAP) OTAZCNBT MYZAP_HUMAN Increases Expression [9]
RNA-binding protein RO60 (RO60) OTLGM5A8 RO60_HUMAN Decreases Expression [9]
COUP transcription factor 1 (NR2F1) OTGWZWYL COT1_HUMAN Increases Expression [9]
Cytochrome c oxidase subunit 5B, mitochondrial (COX5B) OTDP94F3 COX5B_HUMAN Decreases Expression [9]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Decreases Expression [9]
Laminin subunit gamma-1 (LAMC1) OTIG527N LAMC1_HUMAN Increases Expression [9]
Hepatic triacylglycerol lipase (LIPC) OTZY5SC9 LIPC_HUMAN Increases Expression [9]
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHB) OT2NHE5E ODPB_HUMAN Decreases Expression [9]
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (DBT) OT4KZ5R9 ODB2_HUMAN Decreases Expression [9]
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) OTA4P0FC ACADM_HUMAN Decreases Expression [9]
Cytochrome c oxidase subunit 6A1, mitochondrial (COX6A1) OT77MV8G CX6A1_HUMAN Decreases Expression [9]
Collagen alpha-2(VI) chain (COL6A2) OTQC6PPO CO6A2_HUMAN Increases Expression [9]
Collagen alpha-3(VI) chain (COL6A3) OTAS6R6I CO6A3_HUMAN Increases Expression [9]
Myosin light chain 4 (MYL4) OTURFCSE MYL4_HUMAN Decreases Expression [9]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Increases Expression [9]
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) OTQY6ZSF HEM1_HUMAN Decreases Expression [9]
Intercellular adhesion molecule 2 (ICAM2) OT3E070F ICAM2_HUMAN Increases Expression [9]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) OTPWI88U CEAM1_HUMAN Decreases Expression [9]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Increases Expression [9]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Decreases Expression [9]
Hematopoietic lineage cell-specific protein (HCLS1) OTX7WGYN HCLS1_HUMAN Increases Expression [9]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Decreases Expression [9]
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) OTVT146E CX7A2_HUMAN Decreases Expression [9]
Aldo-keto reductase family 1 member A1 (AKR1A1) OTZT9NOW AK1A1_HUMAN Decreases Expression [9]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Increases Expression [9]
Myoblast determination protein 1 (MYOD1) OTV2S79X MYOD1_HUMAN Decreases Expression [9]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Expression [9]
Solute carrier family 25 member 16 (SLC25A16) OTTTUL91 GDC_HUMAN Decreases Expression [9]
Histone H1.2 (H1-2) OT0AVI4M H12_HUMAN Decreases Expression [9]
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (PDE6A) OTPUTR2K PDE6A_HUMAN Decreases Expression [9]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Increases Expression [9]
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) OTSZF7D6 NDUV2_HUMAN Decreases Expression [9]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Increases Expression [9]
Tryptase beta-2 (TPSB2) OTN769MT TRYB2_HUMAN Increases Expression [9]
Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) OTP0961M COX5A_HUMAN Decreases Expression [9]
Collagen alpha-1(V) chain (COL5A1) OT24078H CO5A1_HUMAN Increases Expression [9]
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (AGA) OTNWT1WB ASPG_HUMAN Decreases Expression [9]
Cytoplasmic aconitate hydratase (ACO1) OT2VUR7L ACOHC_HUMAN Decreases Expression [9]
Biglycan (BGN) OT3AV6IF PGS1_HUMAN Increases Expression [9]
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (BCKDHB) OT8OSVYU ODBB_HUMAN Decreases Expression [9]
Tenascin-X (TNXB) OTVBWAV5 TENX_HUMAN Increases Expression [9]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Decreases Expression [9]
Galanin peptides (GAL) OTB3VPTO GALA_HUMAN Decreases Expression [9]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Increases Expression [9]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [9]
Glycine dehydrogenase (GLDC) OTVVDNW0 GCSP_HUMAN Decreases Expression [9]
Glycine cleavage system H protein, mitochondrial (GCSH) OTNC1OKA GCSH_HUMAN Decreases Expression [9]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Increases Expression [9]
Receptor-type tyrosine-protein phosphatase beta (PTPRB) OTCQPLGZ PTPRB_HUMAN Increases Expression [9]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) OT9N2WOF PTPRG_HUMAN Increases Expression [9]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4) OTMWFDAC AT2B4_HUMAN Increases Expression [9]
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) OTIN6G20 CPT2_HUMAN Decreases Expression [9]
Cytochrome c oxidase subunit 7B, mitochondrial (COX7B) OT67PIDP COX7B_HUMAN Decreases Expression [9]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Increases Expression [9]
Proteasome subunit alpha type-1 (PSMA1) OTNBVM2U PSA1_HUMAN Decreases Expression [9]
Proteasome subunit alpha type-3 (PSMA3) OT52M10V PSA3_HUMAN Decreases Expression [9]
Proteasome subunit alpha type-4 (PSMA4) OTAD2XXI PSA4_HUMAN Decreases Expression [9]
Protein S100-A4 (S100A4) OTLRGFSQ S10A4_HUMAN Increases Expression [9]
V-type proton ATPase 16 kDa proteolipid subunit c (ATP6V0C) OTKPL09B VATL_HUMAN Decreases Expression [9]
Calmodulin-like protein 3 (CALML3) OTM8DNQU CALL3_HUMAN Decreases Expression [9]
Proteasome subunit alpha type-5 (PSMA5) OT38E6Y1 PSA5_HUMAN Decreases Expression [9]
Proteasome subunit beta type-5 (PSMB5) OTOZXAS6 PSB5_HUMAN Decreases Expression [9]
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) OTTIZDFR NDUS1_HUMAN Decreases Expression [9]
Receptor-type tyrosine-protein phosphatase mu (PTPRM) OTCEL6PN PTPRM_HUMAN Increases Expression [9]
Flavin reductase (BLVRB) OTHCFN2C BLVRB_HUMAN Decreases Expression [9]
D-dopachrome decarboxylase (DDT) OTF5HTYL DOPD_HUMAN Decreases Expression [9]
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) OTRA8ZVE PPIF_HUMAN Decreases Expression [9]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Increases Expression [9]
CAMPATH-1 antigen (CD52) OT02LDQN CD52_HUMAN Increases Expression [9]
Peroxiredoxin-2 (PRDX2) OTLWCY9T PRDX2_HUMAN Decreases Expression [9]
Glycerol kinase (GK) OTK2YRA0 GLPK_HUMAN Decreases Expression [9]
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (MAN1A1) OT6LIGJP MA1A1_HUMAN Increases Expression [9]
Serine hydroxymethyltransferase, cytosolic (SHMT1) OTIINA3J GLYC_HUMAN Decreases Expression [9]
Thrombospondin-4 (THBS4) OTA1T9KK TSP4_HUMAN Increases Expression [9]
Metalloproteinase inhibitor 3 (TIMP3) OTDGQAD1 TIMP3_HUMAN Increases Expression [9]
Chitinase-3-like protein 1 (CHI3L1) OT2Z7VJH CH3L1_HUMAN Decreases Expression [9]
ATP synthase subunit gamma, mitochondrial (ATP5F1C) OTV5GZK5 ATPG_HUMAN Decreases Expression [9]
Transaldolase (TALDO1) OTDKV2S2 TALDO_HUMAN Decreases Expression [9]
Stress-70 protein, mitochondrial (HSPA9) OT4TMVS9 GRP75_HUMAN Decreases Expression [9]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [9]
Peroxisomal biogenesis factor 19 (PEX19) OTQIDE9Z PEX19_HUMAN Decreases Expression [9]
Chloride anion exchanger (SLC26A3) OTBNK2U2 S26A3_HUMAN Decreases Expression [9]
Malate dehydrogenase, cytoplasmic (MDH1) OTJEO4E8 MDHC_HUMAN Decreases Expression [9]
Melanocyte protein PMEL (PMEL) OTCDDHHM PMEL_HUMAN Decreases Expression [9]
Prostaglandin-H2 D-isomerase (PTGDS) OT71NN7C PTGDS_HUMAN Increases Expression [9]
Enoyl-CoA delta isomerase 1, mitochondrial (ECI1) OTRQTK84 ECI1_HUMAN Decreases Expression [9]
Biotinidase (BTD) OTJYTQ69 BTD_HUMAN Decreases Expression [9]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Decreases Expression [9]
Gamma-aminobutyric acid receptor subunit alpha-4 (GABRA4) OT5I7OI2 GBRA4_HUMAN Decreases Expression [9]
ATP synthase F(0) complex subunit C3, mitochondrial (ATP5MC3) OTX674BU AT5G3_HUMAN Decreases Expression [9]
Adhesion G protein-coupled receptor E5 (ADGRE5) OTTSB84Q AGRE5_HUMAN Increases Expression [9]
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) OT50L4XB ACADV_HUMAN Decreases Expression [9]
Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2) OTAKUO27 ACOT2_HUMAN Decreases Expression [9]
Fms-related tyrosine kinase 3 ligand (FLT3LG) OTU0YGC4 FLT3L_HUMAN Increases Expression [9]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4) OTOXNDI9 GBG4_HUMAN Decreases Expression [9]
Biotin--protein ligase (HLCS) OTPDUX30 BPL1_HUMAN Decreases Expression [9]
Ras association domain-containing protein 2 (RASSF2) OT2JHDO4 RASF2_HUMAN Increases Expression [9]
Ras-related protein Rab-27A (RAB27A) OT9SQRWY RB27A_HUMAN Decreases Expression [9]
Gastrotropin (FABP6) OTIRQWLW FABP6_HUMAN Decreases Expression [9]
B-cell receptor-associated protein 31 (BCAP31) OTKSACR4 BAP31_HUMAN Decreases Expression [9]
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Decreases Expression [9]
G-protein coupled receptor 143 (GPR143) OTWUA2AV GP143_HUMAN Decreases Expression [9]
6-phosphogluconate dehydrogenase, decarboxylating (PGD) OTVG296F 6PGD_HUMAN Decreases Expression [9]
Rho GDP-dissociation inhibitor 2 (ARHGDIB) OT9PD6CS GDIR2_HUMAN Increases Expression [9]
Protein FosB (FOSB) OTW6C05J FOSB_HUMAN Decreases Expression [9]
Succinate--CoA ligase subunit alpha, mitochondrial (SUCLG1) OTDCSPXH SUCA_HUMAN Decreases Expression [9]
Microfibril-associated glycoprotein 4 (MFAP4) OT5W64QY MFAP4_HUMAN Increases Expression [9]
ATP synthase subunit f, mitochondrial (ATP5MF) OTE4TBG9 ATPK_HUMAN Decreases Expression [9]
ATP synthase subunit ATP5MJ, mitochondrial (ATP5MJ) OT7B6C6M ATP68_HUMAN Decreases Expression [9]
Peroxisomal biogenesis factor 3 (PEX3) OTGZ7ME2 PEX3_HUMAN Decreases Expression [9]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7) OTV7VOV3 DHB7_HUMAN Decreases Expression [9]
Transmembrane protein 33 (TMEM33) OTRG1DOY TMM33_HUMAN Decreases Expression [9]
Ras-related protein Rab-38 (RAB38) OTU0NZU0 RAB38_HUMAN Decreases Expression [9]
T-cell leukemia translocation-altered gene protein (TCTA) OT0AH12O TCTA_HUMAN Decreases Expression [9]
Histone H2B type 1-D (H2BC5) OTXDTDHN H2B1D_HUMAN Decreases Expression [9]
AP-3 complex subunit sigma-2 (AP3S2) OTN8P9OE AP3S2_HUMAN Decreases Expression [9]
CD81 antigen (CD81) OTQFXNAZ CD81_HUMAN Increases Expression [9]
Signal peptidase complex subunit 3 (SPCS3) OTAPFSUQ SPCS3_HUMAN Decreases Expression [9]
Rho-related GTP-binding protein RhoE (RND3) OTXMXPIH RND3_HUMAN Decreases Expression [9]
Histone H2B type 1-C/E/F/G/I (H2BC10) OTLQH0D6 H2B1C_HUMAN Decreases Expression [9]
AP-2 complex subunit beta (AP2B1) OTL6LZJ4 AP2B1_HUMAN Increases Expression [9]
Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA) OT2CEYTT SHPS1_HUMAN Increases Expression [9]
UDP-galactose translocator (SLC35A2) OTQOTOWZ S35A2_HUMAN Decreases Expression [9]
Solute carrier family 35 member B1 (SLC35B1) OTJ1MRN2 S35B1_HUMAN Decreases Expression [9]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Decreases Expression [9]
Interleukin-13 receptor subunit alpha-1 (IL13RA1) OT59OYXP I13R1_HUMAN Decreases Expression [9]
Interferon-induced 35 kDa protein (IFI35) OTV9RZ53 IN35_HUMAN Increases Expression [9]
Brain acid soluble protein 1 (BASP1) OTF4VS5G BASP1_HUMAN Increases Expression [9]
Cytochrome P450 4F8 (CYP4F8) OT437NB2 CP4F8_HUMAN Decreases Expression [9]
Ankyrin-2 (ANK2) OTWB4R1Y ANK2_HUMAN Increases Expression [9]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Decreases Expression [9]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Decreases Expression [9]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) OTEUYEW6 ROR1_HUMAN Increases Expression [9]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1) OT62RL5P BDH_HUMAN Decreases Expression [9]
Desmocollin-2 (DSC2) OTODVH8K DSC2_HUMAN Decreases Expression [9]
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) OT7EVFBK M2OM_HUMAN Decreases Expression [9]
Aminoacylase-1 (ACY1) OT9WU7X3 ACY1_HUMAN Decreases Expression [9]
6-pyruvoyl tetrahydrobiopterin synthase (PTS) OTTYWQXR PTPS_HUMAN Decreases Expression [9]
Trefoil factor 2 (TFF2) OTRXB19X TFF2_HUMAN Decreases Expression [9]
1,4-alpha-glucan-branching enzyme (GBE1) OTK2N05B GLGB_HUMAN Decreases Expression [9]
Dynamin-1 (DNM1) OTI8X2WQ DYN1_HUMAN Increases Expression [9]
Caldesmon (CALD1) OTNJKJ6Q CALD1_HUMAN Increases Expression [9]
Collagen alpha-1(XIV) chain (COL14A1) OTLNJ13O COEA1_HUMAN Increases Expression [9]
Myocyte-specific enhancer factor 2C (MEF2C) OTZGF1Y5 MEF2C_HUMAN Increases Expression [9]
Early growth response protein 3 (EGR3) OTGPJIRA EGR3_HUMAN Decreases Expression [9]
Cytochrome P450 4F3 (CYP4F3) OTYNSQAM CP4F3_HUMAN Decreases Expression [9]
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) OTA0UNHM ECH1_HUMAN Decreases Expression [9]
G antigen 5 (GAGE5) OTFI6OVS GAGE5_HUMAN Decreases Expression [9]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Decreases Expression [9]
Lymphocyte cytosolic protein 2 (LCP2) OT57KE22 LCP2_HUMAN Increases Expression [9]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Decreases Expression [9]
DnaJ homolog subfamily C member 3 (DNAJC3) OT7ROIJF DNJC3_HUMAN Decreases Expression [9]
Src-like-adapter (SLA) OTV17DY2 SLAP1_HUMAN Increases Expression [9]
Frizzled-5 (FZD5) OTXFFY56 FZD5_HUMAN Decreases Expression [9]
Dystrophin-related protein 2 (DRP2) OTWR7WGU DRP2_HUMAN Decreases Expression [9]
Metaxin-1 (MTX1) OTLSDNZO MTX1_HUMAN Decreases Expression [9]
Lysosomal-associated transmembrane protein 5 (LAPTM5) OT2XI2JG LAPM5_HUMAN Increases Expression [9]
CD166 antigen (ALCAM) OTCO4LP7 CD166_HUMAN Decreases Expression [9]
Plakophilin-1 (PKP1) OT9HSQ8F PKP1_HUMAN Increases Expression [9]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Decreases Expression [9]
Protein Tob2 (TOB2) OTEEHL60 TOB2_HUMAN Increases Expression [9]
Transcription factor Dp-2 (TFDP2) OTKQFX5H TFDP2_HUMAN Decreases Expression [9]
Src substrate cortactin (CTTN) OTJRG4ES SRC8_HUMAN Decreases Expression [9]
EKC/KEOPS complex subunit LAGE3 (LAGE3) OTKBQHZI LAGE3_HUMAN Decreases Expression [9]
DNA replication complex GINS protein PSF1 (GINS1) OTVQZMMQ PSF1_HUMAN Decreases Expression [9]
Phosphatidate phosphatase LPIN1 (LPIN1) OTQ75KF2 LPIN1_HUMAN Decreases Expression [9]
Latent-transforming growth factor beta-binding protein 1 (LTBP1) OTR7Q75L LTBP1_HUMAN Increases Expression [9]
Metal cation symporter ZIP14 (SLC39A14) OTGR686L S39AE_HUMAN Increases Expression [9]
Rho guanine nucleotide exchange factor 6 (ARHGEF6) OTN1ABGL ARHG6_HUMAN Increases Expression [9]
Procollagen C-endopeptidase enhancer 1 (PCOLCE) OTJXOAN4 PCOC1_HUMAN Increases Expression [9]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) OTSMGKXQ EBP_HUMAN Decreases Expression [9]
Dixin (DIXDC1) OT87DXEG DIXC1_HUMAN Increases Expression [9]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL) OTK3EJFD NSDHL_HUMAN Decreases Expression [9]
Chitinase-3-like protein 2 (CHI3L2) OT26R3HQ CH3L2_HUMAN Decreases Expression [9]
Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) OTOSKSFH ETFD_HUMAN Decreases Expression [9]
Drebrin (DBN1) OTZVKG8A DREB_HUMAN Increases Expression [9]
Prostasin (PRSS8) OT5KLL35 PRSS8_HUMAN Decreases Expression [9]
Melanoma antigen recognized by T-cells 1 (MLANA) OT1N2S2K MAR1_HUMAN Decreases Expression [9]
Forkhead box protein D1 (FOXD1) OT80PRHS FOXD1_HUMAN Increases Expression [9]
Thiosulfate sulfurtransferase (TST) OTZ4F5LK THTR_HUMAN Decreases Expression [9]
Histone H2B type 2-E (H2BC21) OT0FDCUC H2B2E_HUMAN Decreases Expression [9]
Reticulon-1 (RTN1) OTCX1SMK RTN1_HUMAN Increases Expression [9]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) OTJDOL20 HCDH_HUMAN Decreases Expression [9]
Tumor protein D53 (TPD52L1) OTSA6U0I TPD53_HUMAN Decreases Expression [9]
Protein BEAN1 (BEAN1) OT0WLH27 BEAN1_HUMAN Decreases Expression [9]
ORM1-like protein 2 (ORMDL2) OT2N1MW0 ORML2_HUMAN Decreases Expression [9]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Decreases Expression [9]
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) OTW95XD4 DHB12_HUMAN Decreases Expression [9]
Endoribonuclease LACTB2 (LACTB2) OTU4IFBU LACB2_HUMAN Decreases Expression [9]
Transmembrane protein 41B (TMEM41B) OTW0B0KS TM41B_HUMAN Decreases Expression [9]
Protein odr-4 homolog (ODR4) OTGC56W3 ODR4_HUMAN Decreases Expression [9]
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1) OTGFK4MH NHRF3_HUMAN Decreases Expression [9]
Transmembrane protein 164 (TMEM164) OTSIZY2T TM164_HUMAN Decreases Expression [9]
Terminal nucleotidyltransferase 5C (TENT5C) OTOWVQ4O TET5C_HUMAN Decreases Expression [9]
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) OT3SZIWM KANK2_HUMAN Increases Expression [9]
Dehydrogenase/reductase SDR family member 7B (DHRS7B) OTO2YA2O DRS7B_HUMAN Decreases Expression [9]
Desumoylating isopeptidase 1 (DESI1) OTFNIW98 DESI1_HUMAN Decreases Expression [9]
DENN domain-containing protein 5A (DENND5A) OT0QNNY1 DEN5A_HUMAN Increases Expression [9]
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH) OTU2VHWR HIBCH_HUMAN Decreases Expression [9]
Caveolae-associated protein 1 (CAVIN1) OTFO915U CAVN1_HUMAN Increases Expression [9]
Lysophospholipid acyltransferase 5 (LPCAT3) OTWI96P4 MBOA5_HUMAN Decreases Expression [9]
Transmembrane protein 53 (TMEM53) OTSXTGQK TMM53_HUMAN Decreases Expression [9]
Progestin and adipoQ receptor family member 3 (PAQR3) OTTKJ9Y4 PAQR3_HUMAN Decreases Expression [9]
CREB-regulated transcription coactivator 3 (CRTC3) OTVIGVUW CRTC3_HUMAN Increases Expression [9]
Dehydrogenase/reductase SDR family member 11 (DHRS11) OTU3J0ZL DHR11_HUMAN Decreases Expression [9]
MICOS complex subunit MIC27 (APOOL) OTC1WT8O MIC27_HUMAN Decreases Expression [9]
Calcium/manganese antiporter SLC30A10 (SLC30A10) OTXM5JW4 ZNT10_HUMAN Decreases Expression [9]
Solute carrier organic anion transporter family member 4C1 (SLCO4C1) OTVILUUN SO4C1_HUMAN Decreases Expression [9]
Lysophospholipid acyltransferase 2 (MBOAT2) OTZI3BXD MBOA2_HUMAN Decreases Expression [9]
La-related protein 4 (LARP4) OTB10IJH LARP4_HUMAN Decreases Expression [9]
BEN domain-containing protein 5 (BEND5) OT6J6LY3 BEND5_HUMAN Increases Expression [9]
Fatty acid 2-hydroxylase (FA2H) OT8HA13U FA2H_HUMAN Decreases Expression [9]
Histone H2A type 3 (H2AC25) OTPO62JI H2A3_HUMAN Decreases Expression [9]
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (SLC46A3) OTEMDLPS S46A3_HUMAN Decreases Expression [9]
L-xylulose reductase (DCXR) OTYVXRXB DCXR_HUMAN Decreases Expression [9]
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) OTUX685J SPRE2_HUMAN Increases Expression [9]
Glutaredoxin-related protein 5, mitochondrial (GLRX5) OTE3L48D GLRX5_HUMAN Decreases Expression [9]
TBC1 domain family member 1 (TBC1D1) OTI9V7B0 TBCD1_HUMAN Increases Expression [9]
Acetoacetyl-CoA synthetase (AACS) OTGGPR6J AACS_HUMAN Decreases Expression [9]
Ribosomal oxygenase 2 (RIOX2) OT2YFPI2 RIOX2_HUMAN Decreases Expression [9]
Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCAT) OTH07FIW FABD_HUMAN Decreases Expression [9]
Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) OTVYQ7ZL ANKH1_HUMAN Decreases Expression [9]
Intraflagellar transport protein 20 homolog (IFT20) OTKJS2BZ IFT20_HUMAN Decreases Expression [9]
Adhesion G-protein coupled receptor G2 (ADGRG2) OTPAD5S1 AGRG2_HUMAN Decreases Expression [9]
Multiple coagulation factor deficiency protein 2 (MCFD2) OTM0XU0U MCFD2_HUMAN Decreases Expression [9]
Kelch domain-containing protein 4 (KLHDC4) OTJ4UL5S KLDC4_HUMAN Decreases Expression [9]
Transmembrane protein 254 (TMEM254) OTGDPU8S TM254_HUMAN Decreases Expression [9]
Retinol dehydrogenase 11 (RDH11) OTIND43N RDH11_HUMAN Decreases Expression [9]
Disks large homolog 5 (DLG5) OTU9Z17K DLG5_HUMAN Increases Expression [9]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 (ASAP3) OTQB4H1J ASAP3_HUMAN Increases Expression [9]
E3 ubiquitin-protein ligase RNF128 (RNF128) OTJO86CJ RN128_HUMAN Decreases Expression [9]
Sushi, nidogen and EGF-like domain-containing protein 1 (SNED1) OTBQVXY5 SNED1_HUMAN Increases Expression [9]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5) OTY829Z3 ABHD5_HUMAN Decreases Expression [9]
Cysteine protease ATG4A (ATG4A) OTDHXAPG ATG4A_HUMAN Decreases Expression [9]
Protein FAM3C (FAM3C) OTBR6U9G FAM3C_HUMAN Decreases Expression [9]
Synapsin-2 (SYN2) OTK0DEGH SYN2_HUMAN Decreases Expression [9]
Deoxyribonuclease-1-like 2 (DNASE1L2) OT56VFRL DNSL2_HUMAN Decreases Expression [9]
Peroxisomal membrane protein PEX13 (PEX13) OTXUAYEW PEX13_HUMAN Decreases Expression [9]
RNA-binding protein with multiple splicing (RBPMS) OT1RDKR9 RBPMS_HUMAN Increases Expression [9]
Histone H2B type 1-H (H2BC9) OTQ9XX72 H2B1H_HUMAN Decreases Expression [9]
Homogentisate 1,2-dioxygenase (HGD) OTTKLQOO HGD_HUMAN Decreases Expression [9]
Riboflavin kinase (RFK) OT77IYIS RIFK_HUMAN Decreases Expression [9]
Protein N-terminal asparagine amidohydrolase (NTAN1) OTJF0U48 NTAN1_HUMAN Decreases Expression [9]
Mitochondrial calcium uniporter regulator 1 (MCUR1) OTSL49SR MCUR1_HUMAN Decreases Expression [9]
Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) OTYKLW1K FKB10_HUMAN Increases Expression [9]
Solute carrier family 22 member 18 (SLC22A18) OT9C3KR4 S22AI_HUMAN Decreases Expression [9]
Isochorismatase domain-containing protein 1 (ISOC1) OTAO7Z87 ISOC1_HUMAN Decreases Expression [9]
BTB/POZ domain-containing protein KCTD12 (KCTD12) OTPYKT4Z KCD12_HUMAN Increases Expression [9]
Regulator of microtubule dynamics protein 1 (RMDN1) OTE1NB6U RMD1_HUMAN Decreases Expression [9]
Ubiquitin thioesterase OTUB2 (OTUB2) OTZUMPH2 OTUB2_HUMAN Decreases Expression [9]
Molybdenum cofactor sulfurase (MOCOS) OT0TL3Q5 MOCOS_HUMAN Decreases Expression [9]
DnaJ homolog subfamily A member 3, mitochondrial (DNAJA3) OT61924T DNJA3_HUMAN Decreases Expression [9]
Mediator of RNA polymerase II transcription subunit 8 (MED8) OTSIZ1I7 MED8_HUMAN Decreases Expression [9]
Long-chain-fatty-acid--CoA ligase ACSBG1 (ACSBG1) OTM040MW ACBG1_HUMAN Decreases Expression [9]
PRKC apoptosis WT1 regulator protein (PAWR) OTKY7W52 PAWR_HUMAN Decreases Expression [9]
Androgen-dependent TFPI-regulating protein (ADTRP) OTFI2BQX ADTRP_HUMAN Decreases Expression [9]
Fatty acyl-CoA reductase 2 (FAR2) OTRYY709 FACR2_HUMAN Decreases Expression [9]
Cytosolic non-specific dipeptidase (CNDP2) OTJR9436 CNDP2_HUMAN Decreases Expression [9]
bMERB domain-containing protein 1 (BMERB1) OT1IH086 MERB1_HUMAN Increases Expression [9]
Ganglioside-induced differentiation-associated protein 1-like 1 (GDAP1L1) OT9IEBRD GD1L1_HUMAN Decreases Expression [9]
Adhesion G protein-coupled receptor A2 (ADGRA2) OTBT4W36 AGRA2_HUMAN Increases Expression [9]
KH domain-containing RNA-binding protein QKI (QKI) OTTAUGLB QKI_HUMAN Increases Expression [9]
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCC1) OTLOHEQE MCCA_HUMAN Decreases Expression [9]
Mitochondrial tRNA methylthiotransferase CDK5RAP1 (CDK5RAP1) OTDEJXD0 CK5P1_HUMAN Decreases Expression [9]
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) OTZJFX5C PP16B_HUMAN Increases Expression [9]
c-Myc-binding protein (MYCBP) OT4IZR4R MYCBP_HUMAN Decreases Expression [9]
Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2) OT3VH359 ACOX2_HUMAN Decreases Expression [9]
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) OT8GTI1V VATO_HUMAN Decreases Expression [9]
Platelet-activating factor acetylhydrolase 2, cytoplasmic (PAFAH2) OTSHD5M5 PAFA2_HUMAN Decreases Expression [9]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Decreases Expression [9]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) OTC8G2MX C560_HUMAN Decreases Expression [9]
Calcineurin B homologous protein 1 (CHP1) OTHTXN1A CHP1_HUMAN Decreases Expression [9]
ATP-sensitive inward rectifier potassium channel 15 (KCNJ15) OTZT6EQB KCJ15_HUMAN Decreases Expression [9]
Dehydrogenase/reductase SDR family member 9 (DHRS9) OTB1WOZA DHRS9_HUMAN Decreases Expression [9]
Calsyntenin-3 (CLSTN3) OTPUFK4C CSTN3_HUMAN Decreases Expression [9]
Sugar transporter SWEET1 (SLC50A1) OTF1DT72 SWET1_HUMAN Decreases Expression [9]
Transmembrane protein 208 (TMEM208) OTMGH9OA TM208_HUMAN Decreases Expression [9]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1) OTU230MC ISCA1_HUMAN Decreases Expression [9]
GEL complex subunit OPTI (RAB5IF) OTNNWX7E RCAF1_HUMAN Decreases Expression [9]
Bublin coiled-coil protein (BBLN) OTUMVEWE BBLN_HUMAN Decreases Expression [9]
Enoyl- reductase, mitochondrial (MECR) OTJQ5XKQ MECR_HUMAN Decreases Expression [9]
Very long chain fatty acid elongase 1 (ELOVL1) OTIDTQ8R ELOV1_HUMAN Decreases Expression [9]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) OTZ092ZJ THIC_HUMAN Decreases Expression [9]
Sorbin and SH3 domain-containing protein 1 (SORBS1) OTWH8762 SRBS1_HUMAN Decreases Expression [9]
N-acetylneuraminate lyase (NPL) OTA7P0TO NPL_HUMAN Decreases Expression [9]
Peroxisomal trans-2-enoyl-CoA reductase (PECR) OT5MS8EM PECR_HUMAN Decreases Expression [9]
Alpha-(1,6)-fucosyltransferase (FUT8) OTJJCVG1 FUT8_HUMAN Increases Expression [9]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) OTM3B3OA TBL1R_HUMAN Increases Expression [9]
Metal cation symporter ZIP8 (SLC39A8) OT6C6MNV S39A8_HUMAN Decreases Expression [9]
Very long chain fatty acid elongase 4 (ELOVL4) OT2M9W26 ELOV4_HUMAN Decreases Expression [9]
Superkiller complex protein 8 (SKIC8) OTDSQYDN SKI8_HUMAN Decreases Expression [9]
Carbohydrate sulfotransferase 6 (CHST6) OTXD2IWK CHST6_HUMAN Increases Expression [9]
E3 ubiquitin-protein ligase RNF38 (RNF38) OTRLV4WZ RNF38_HUMAN Increases Expression [9]
Uncharacterized protein C1orf21 (C1ORF21) OTMD7O88 CA021_HUMAN Increases Expression [9]
Growth hormone-inducible transmembrane protein (GHITM) OTBPNIC0 GHITM_HUMAN Decreases Expression [9]
Ribokinase (RBKS) OTDG01Y9 RBSK_HUMAN Decreases Expression [9]
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase (ST6GALNAC4) OTJCJQI7 SIA7D_HUMAN Decreases Expression [9]
Serine hydrolase-like protein 2 (SERHL2) OTVM8TVT SEHL2_HUMAN Increases Expression [9]
Coiled-coil domain-containing protein 86 (CCDC86) OT5YQ0R0 CCD86_HUMAN Decreases Expression [9]
Reticulophagy regulator 1 (RETREG1) OTYOSLZX RETR1_HUMAN Decreases Expression [9]
Ceramide synthase 4 (CERS4) OTV5ENAX CERS4_HUMAN Decreases Expression [9]
GrpE protein homolog 1, mitochondrial (GRPEL1) OT8O00YJ GRPE1_HUMAN Decreases Expression [9]
Roquin-2 (RC3H2) OTZR3GF6 RC3H2_HUMAN Decreases Expression [9]
Ethanolamine kinase 1 (ETNK1) OTDKB4DQ EKI1_HUMAN Decreases Expression [9]
Popeye domain-containing protein 2 (POPDC2) OTDAZSY5 POPD2_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase Sgk2 (SGK2) OTCTVSHF SGK2_HUMAN Decreases Expression [9]
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) OTQDHSMI MCCB_HUMAN Decreases Expression [9]
Stromal cell-derived factor 2-like protein 1 (SDF2L1) OTE7JIO2 SDF2L_HUMAN Decreases Expression [9]
Magnesium transporter MRS2 homolog, mitochondrial (MRS2) OTICD11V MRS2_HUMAN Decreases Expression [9]
Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (ALG13) OTOH9PMY ALG13_HUMAN Decreases Expression [9]
Lysophosphatidic acid phosphatase type 6 (ACP6) OTPW6HEK PPA6_HUMAN Decreases Expression [9]
Omega-amidase NIT2 (NIT2) OTC1RAH3 NIT2_HUMAN Decreases Expression [9]
Translation initiation factor eIF2B subunit gamma (EIF2B3) OTG6HE7D EI2BG_HUMAN Decreases Expression [9]
Peroxisomal membrane protein 2 (PXMP2) OTYHX5MI PXMP2_HUMAN Decreases Expression [9]
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3) OTAUR5TG PLCC_HUMAN Decreases Expression [9]
Glutaredoxin-2, mitochondrial (GLRX2) OT4LIRBC GLRX2_HUMAN Decreases Expression [9]
SAM domain-containing protein SAMSN-1 (SAMSN1) OT7N88T1 SAMN1_HUMAN Increases Expression [9]
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3) OTR4990X PLPL3_HUMAN Decreases Expression [9]
Ethylmalonyl-CoA decarboxylase (ECHDC1) OTMS00PY ECHD1_HUMAN Decreases Expression [9]
S-acyl fatty acid synthase thioesterase, medium chain (OLAH) OTZVRM40 SAST_HUMAN Decreases Expression [9]
Septin-11 (SEPTIN11) OTX2O0ZX SEP11_HUMAN Decreases Expression [9]
Large ribosomal subunit protein mL66 (MRPS18A) OTFCBPX2 RT18A_HUMAN Decreases Expression [9]
Anoctamin-10 (ANO10) OTG3BNOU ANO10_HUMAN Decreases Expression [9]
Dipeptidyl peptidase 3 (DPP3) OTUIVL1C DPP3_HUMAN Decreases Expression [9]
Very long chain fatty acid elongase 5 (ELOVL5) OT375W1Z ELOV5_HUMAN Decreases Expression [9]
2-Hydroxyacid oxidase 2 (HAO2) OTDWSQ0L HAOX2_HUMAN Decreases Expression [9]
Very-long-chain enoyl-CoA reductase (TECR) OT2NT4MV TECR_HUMAN Decreases Expression [9]
Alpha-hemoglobin-stabilizing protein (AHSP) OTTHBSUS AHSP_HUMAN Decreases Expression [9]
Adenosine deaminase 2 (ADA2) OTGCV24S ADA2_HUMAN Increases Expression [9]
Cysteine-rich PDZ-binding protein (CRIPT) OTA6M8M4 CRIPT_HUMAN Decreases Expression [9]
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) OTMO1ZYQ HCN3_HUMAN Decreases Expression [9]
7-dehydrocholesterol reductase (DHCR7) OTLILBUI DHCR7_HUMAN Decreases Expression [9]
Signal-transducing adaptor protein 2 (STAP2) OTEB1VVI STAP2_HUMAN Decreases Expression [9]
B-cell receptor-associated protein 29 (BCAP29) OTLUBG86 BAP29_HUMAN Decreases Expression [9]
Fasciculation and elongation protein zeta-2 (FEZ2) OTAFCKAX FEZ2_HUMAN Increases Expression [9]
Transgelin-3 (TAGLN3) OTJBP3VJ TAGL3_HUMAN Decreases Expression [9]
Motile sperm domain-containing protein 1 (MOSPD1) OT993HTH MSPD1_HUMAN Decreases Expression [9]
F-box/LRR-repeat protein 7 (FBXL7) OTNUK1DJ FBXL7_HUMAN Increases Expression [9]
F-box only protein 9 (FBXO9) OTW5P5JF FBX9_HUMAN Decreases Expression [9]
A-kinase anchor protein 11 (AKAP11) OT7E2FVD AKA11_HUMAN Increases Expression [9]
Phosphatidylcholine transfer protein (PCTP) OTM36JXE PPCT_HUMAN Decreases Expression [9]
Ergosterol biosynthetic protein 28 homolog (ERG28) OT2KAOBA ERG28_HUMAN Decreases Expression [9]
Isobutyryl-CoA dehydrogenase, mitochondrial (ACAD8) OT3JI5GB ACAD8_HUMAN Decreases Expression [9]
Cilia- and flagella-associated protein 45 (CFAP45) OT8I8ZHH CFA45_HUMAN Decreases Expression [9]
Transmembrane protease serine 11E (TMPRSS11E) OTO5U2TK TM11E_HUMAN Decreases Expression [9]
Malignant T-cell-amplified sequence 1 (MCTS1) OT7SAOJP MCTS1_HUMAN Decreases Expression [9]
Long-chain-fatty-acid--CoA ligase 5 (ACSL5) OT3L9XO3 ACSL5_HUMAN Decreases Expression [9]
Myocardin-related transcription factor B (MRTFB) OT9OXGS9 MRTFB_HUMAN Increases Expression [9]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Decreases Expression [9]
LIM and calponin homology domains-containing protein 1 (LIMCH1) OTYPC4XA LIMC1_HUMAN Increases Expression [9]
Inactive phospholipase C-like protein 2 (PLCL2) OTK5FDF6 PLCL2_HUMAN Increases Expression [9]
Tenascin-N (TNN) OTQK2AMX TENN_HUMAN Increases Expression [9]
TRAF3-interacting JNK-activating modulator (TRAF3IP3) OTNG0L8X T3JAM_HUMAN Increases Expression [9]
Small ribosomal subunit protein mS33 (MRPS33) OTM44AZ1 RT33_HUMAN Decreases Expression [9]
BTB/POZ domain-containing protein 3 (BTBD3) OTZ607YT BTBD3_HUMAN Increases Expression [9]
Protein MTO1 homolog, mitochondrial (MTO1) OT7HCZ1D MTO1_HUMAN Decreases Expression [9]
Transmembrane emp24 domain-containing protein 5 (TMED5) OT70W1J8 TMED5_HUMAN Decreases Expression [9]
Nucleolar protein 16 (NOP16) OT2829ZC NOP16_HUMAN Decreases Expression [9]
Small ribosomal subunit protein bS16m (MRPS16) OT3XXKDZ RT16_HUMAN Decreases Expression [9]
Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2) OTBU39Q1 PTH2_HUMAN Decreases Expression [9]
Protein dopey-2 (DOP1B) OTQTOWLQ DOP2_HUMAN Decreases Expression [9]
Sorting and assembly machinery component 50 homolog (SAMM50) OTRYFYIU SAM50_HUMAN Decreases Expression [9]
V-type proton ATPase subunit D (ATP6V1D) OT4JDG0W VATD_HUMAN Decreases Expression [9]
Hypoxia-inducible lipid droplet-associated protein (HILPDA) OTEID3ZM HLPDA_HUMAN Decreases Expression [9]
Mitochondrial import inner membrane translocase subunit Tim13 (TIMM13) OTYZQJD3 TIM13_HUMAN Decreases Expression [9]
DnaJ homolog subfamily C member 15 (DNAJC15) OTNDUKAA DJC15_HUMAN Decreases Expression [9]
Mitochondrial pyruvate carrier 1 (MPC1) OT6DYFUO MPC1_HUMAN Decreases Expression [9]
Sorting nexin-13 (SNX13) OTB7IB7X SNX13_HUMAN Decreases Expression [9]
Peroxisomal membrane protein PEX16 (PEX16) OTJQJ2TZ PEX16_HUMAN Decreases Expression [9]
Mitochondrial ornithine transporter 1 (SLC25A15) OTOA9232 ORNT1_HUMAN Decreases Expression [9]
LHFPL tetraspan subfamily member 6 protein (LHFPL6) OTY6LHJY LHPL6_HUMAN Increases Expression [9]
GTP-binding protein SAR1b (SAR1B) OT0JZOMY SAR1B_HUMAN Decreases Expression [9]
Mitochondrial carrier homolog 2 (MTCH2) OTV3E4GU MTCH2_HUMAN Decreases Expression [9]
Peroxisomal membrane protein 4 (PXMP4) OTNDYSHU PXMP4_HUMAN Decreases Expression [9]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Decreases Expression [9]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [15]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [16]
Creatine kinase M-type (CKM) OTME0KO7 KCRM_HUMAN Increases Expression [17]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Expression [18]
Glutathione peroxidase 2 (GPX2) OTXI2NTI GPX2_HUMAN Increases Expression [19]
Paired box protein Pax-6 (PAX6) OTOC9876 PAX6_HUMAN Increases Expression [10]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Decreases Expression [20]
Retinoic acid receptor responder protein 1 (RARRES1) OTETUPP5 TIG1_HUMAN Increases Expression [21]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Decreases Expression [10]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [22]
Mesoderm posterior protein 2 (MESP2) OT7H4LYA MESP2_HUMAN Decreases Expression [10]
Transcription factor 15 (TCF15) OTA6UCWC TCF15_HUMAN Decreases Expression [10]
Sonic hedgehog protein (SHH) OTOG2BXF SHH_HUMAN Increases Expression [23]
Oligodendrocyte transcription factor 3 (OLIG3) OTU8XLAF OLIG3_HUMAN Increases Expression [10]
Eyes absent homolog 1 (EYA1) OTHU807A EYA1_HUMAN Decreases Expression [10]
Neurogenin-2 (NEUROG2) OTAEMIGT NGN2_HUMAN Increases Expression [10]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [24]
Low density lipoprotein (LDLR) OTEZ79V2 E1B4S5_HUMAN Increases ADR [25]
Vigilin (HDLBP) OTKDEEYX VIGLN_HUMAN Increases ADR [25]
Aquaporin PIP1-2 (PIP1-2) OTN8LSSF PIP12_ARATH Increases ADR [25]
------------------------------------------------------------------------------------
⏷ Show the Full List of 571 DOT(s)
Indication(s) of Itraconazole
Disease Entry ICD 11 Status REF
Aspergillosis 1F20 Approved [5]
Blastomycosis 1F22 Approved [5]
Fungal infection 1F29-1F2F Approved [6]
Fusariosis N.A. Approved [5]
Histoplasmosis N.A. Approved [5]
Invasive candidiasis 1F23 Approved [5]
Mycoses 1F2Z Approved [5]
Candidemia 1F23.3Y Investigative [5]
Esophageal candidiasis N.A. Investigative [5]
Itraconazole Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Hedgehog signaling pathway (HS pathway) TT4LXBC NOUNIPROTAC Inhibitor [26]
Candida Cytochrome P450 51 (Candi ERG11) TTTSOUD CP51_CANAL Modulator [27]
------------------------------------------------------------------------------------
Itraconazole Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [28]
------------------------------------------------------------------------------------
Itraconazole Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [29]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [30]
------------------------------------------------------------------------------------
Itraconazole Interacts with 4 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Activity [31]
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Decreases Activity [32]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Expression [33]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [34]
------------------------------------------------------------------------------------

References

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3 Isotretinoin FDA Label
4 ClinicalTrials.gov (NCT04361422) Isotretinoin in Treatment of COVID-19. U.S. National Institutes of Health.
5 Itraconazole FDA Label
6 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076104.
7 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
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13 The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone. Clin Pharmacol Ther. 2004 May;75(5):464-75.
14 Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo. Br J Cancer. 2007 Jun 4;96(11):1675-83.
15 Apoptotic events induced by naturally occurring retinoids ATRA and 13-cis retinoic acid on human hepatoma cell lines Hep3B and HepG2. Cancer Lett. 2005 Nov 18;229(2):271-81. doi: 10.1016/j.canlet.2005.06.047. Epub 2005 Aug 30.
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20 Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin. J Invest Dermatol. 2005 Oct;125(4):673-84. doi: 10.1111/j.0022-202X.2005.23848.x.
21 13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes. J Invest Dermatol. 2006 Oct;126(10):2178-89. doi: 10.1038/sj.jid.5700289. Epub 2006 Mar 30.
22 Antagonism of cytotoxic chemotherapy in neuroblastoma cell lines by 13-cis-retinoic acid is mediated by the antiapoptotic Bcl-2 family proteins. Mol Cancer Ther. 2010 Dec;9(12):3164-74. doi: 10.1158/1535-7163.MCT-10-0078.
23 Pituitary specific retinoid-X receptor ligand interactions with thyroid hormone receptor signaling revealed by high throughput reporter and endogenous gene responses. Toxicol In Vitro. 2015 Oct;29(7):1609-18. doi: 10.1016/j.tiv.2015.06.018. Epub 2015 Jun 19.
24 A high-throughput screen for teratogens using human pluripotent stem cells. Toxicol Sci. 2014 Jan;137(1):76-90. doi: 10.1093/toxsci/kft239. Epub 2013 Oct 23.
25 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
26 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
27 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
28 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
29 Effects of itraconazole and tandospirone on the pharmacokinetics of perospirone. Ther Drug Monit. 2006 Feb;28(1):73-5.
30 Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes. Drug Metab Dispos. 2010 Jun;38(6):923-9.
31 Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
32 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
33 Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos. 2008 Feb;36(2):339-48.
34 Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.