Details of the Drug Combination

General Information of Drug Combination (ID: DCP8Z0X)

• Drug Combination Name: Ethanol + Nicotine
• Indication: Alcohol Consumption; Status: Phase 1 [1]
• Component Drugs:
  Ethanol (DMDRQZU): Small molecular drug
  Nicotine (DMWX5CO): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Ethanol

Disease Entry	ICD 11	Status	REF
Chronic pain	MG30	Approved	[2]
Cystic tumor of the pancreas	N.A.	Approved	[3]
Cystitis	GC00	Approved	[2]

Ethanol Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
GABA(A) receptor alpha-1 (GABRA1)	TT1MPAY	GBRA1_HUMAN	Antagonist	[15]

Ethanol Interacts with 13 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[16]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[16]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[17]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Metabolism	[18]
Alcohol dehydrogenase class-V (ADH6)	DE017IC	ADH6_HUMAN	Metabolism	[19]
Aldo-keto reductase 1A1 (AKR1A1)	DED2FW3	AK1A1_HUMAN	Metabolism	[19]
Alcohol dehydrogenase class-I alpha (ADH1A)	DEE5M8O	ADH1A_HUMAN	Metabolism	[20]
Alcohol dehydrogenase class-I beta (ADH1B)	DEEN9RD	ADH1B_HUMAN	Metabolism	[20]
Alcohol dehydrogenase class-I gamma (ADH1C)	DEM1HNL	ADH1G_HUMAN	Metabolism	[20]
Alcohol dehydrogenase class-II (ADH4)	DEOCWU3	ADH4_HUMAN	Metabolism	[21]
Gastric alcohol dehydrogenase (ADH7)	DEZMAHX	ADH7_HUMAN	Metabolism	[19]
Alcohol dehydrogenase class-III (ADH5)	DEIOH6A	ADHX_HUMAN	Metabolism	[19]
Alcohol dehydrogenase (ADH)	DEG8NJD	A0A2I1XAT4_NEISI	Metabolism	[22]

Ethanol Interacts with 406 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
All-trans-retinol dehydrogenase ADH1B (ADH1B)	OTV3TB81	ADH1B_HUMAN	Increases Expression	[8]
Alcohol dehydrogenase 1C (ADH1C)	OTO1DV7F	ADH1G_HUMAN	Increases Expression	[23]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Phosphorylation	[24]
Serotransferrin (TF)	OT41PEMS	TRFE_HUMAN	Increases Expression	[11]
Proenkephalin-A (PENK)	OT8P3HMP	PENK_HUMAN	Decreases Expression	[25]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Increases Expression	[26]
Protein-glutamine gamma-glutamyltransferase 2 (TGM2)	OT6MFOWF	TGM2_HUMAN	Increases Expression	[27]
Cytochrome b-245 heavy chain (CYBB)	OTGSG868	CY24B_HUMAN	Increases Expression	[7]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Increases Expression	[28]
Neurogenic locus notch homolog protein 3 (NOTCH3)	OTMVVA7F	NOTC3_HUMAN	Increases Expression	[28]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Increases Expression	[8]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Secretion	[23]
Protein shisa-3 homolog (SHISA3)	OTE8TPCP	SHSA3_HUMAN	Increases Expression	[9]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)	OT7C68YV	BACH_HUMAN	Decreases Expression	[9]
Left-right determination factor 2 (LEFTY2)	OT3RX4QF	LFTY2_HUMAN	Increases Expression	[9]
TNF receptor-associated factor 5 (TRAF5)	OTSBTLO0	TRAF5_HUMAN	Increases Expression	[9]
Class E basic helix-loop-helix protein 40 (BHLHE40)	OTITX14U	BHE40_HUMAN	Increases Expression	[9]
Copper chaperone for superoxide dismutase (CCS)	OTXHT3QO	CCS_HUMAN	Increases Expression	[9]
Centrin-3 (CETN3)	OTG4PL7H	CETN3_HUMAN	Decreases Expression	[9]
Histone H2B type 1-K (H2BC12)	OTQ8V0KG	H2B1K_HUMAN	Decreases Expression	[9]
Forkhead box protein H1 (FOXH1)	OTEXJ9SL	FOXH1_HUMAN	Increases Expression	[9]
Left-right determination factor 1 (LEFTY1)	OT51HVC4	LFTY1_HUMAN	Increases Expression	[9]
Protein FAM13A (FAM13A)	OTZ6GN0Q	FA13A_HUMAN	Increases Expression	[9]
Lecithin retinol acyltransferase (LRAT)	OTB7CJKY	LRAT_HUMAN	Increases Expression	[9]
Heat shock 70 kDa protein 4L (HSPA4L)	OT181WZB	HS74L_HUMAN	Increases Expression	[9]
Thy-1 membrane glycoprotein (THY1)	OTVONVTB	THY1_HUMAN	Decreases Expression	[9]
Histone H2B type 1-J (H2BC11)	OTGM083T	H2B1J_HUMAN	Decreases Expression	[9]
Gamma-enolase (ENO2)	OTRODL0T	ENOG_HUMAN	Decreases Expression	[9]
Fructose-bisphosphate aldolase C (ALDOC)	OTEC13I5	ALDOC_HUMAN	Decreases Expression	[9]
Thymosin beta-15A (TMSB15A)	OTSBWCES	TB15A_HUMAN	Decreases Expression	[9]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Decreases Expression	[9]
Histone H1.2 (H1-2)	OT0AVI4M	H12_HUMAN	Decreases Expression	[9]
Heat shock 70 kDa protein 6 (HSPA6)	OTH4S7WB	HSP76_HUMAN	Increases Expression	[9]
Blood group Rh(CE) polypeptide (RHCE)	OTS18IZ5	RHCE_HUMAN	Decreases Expression	[9]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Increases Expression	[9]
5-hydroxytryptamine receptor 1D (HTR1D)	OTLS74AF	5HT1D_HUMAN	Increases Expression	[9]
Protein-lysine 6-oxidase (LOX)	OT1C2HIU	LYOX_HUMAN	Increases Expression	[9]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Decreases Expression	[9]
Replication factor C subunit 1 (RFC1)	OT3L5PK3	RFC1_HUMAN	Decreases Expression	[9]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A)	OTE2KVZV	SCNNA_HUMAN	Increases Expression	[9]
Steroidogenic acute regulatory protein, mitochondrial (STAR)	OTFEZ5AI	STAR_HUMAN	Decreases Expression	[9]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4)	OTOXNDI9	GBG4_HUMAN	Decreases Expression	[9]
Homeobox protein goosecoid (GSC)	OT4DH7PR	GSC_HUMAN	Increases Expression	[9]
Small nuclear ribonucleoprotein G (SNRPG)	OTWX4XK1	RUXG_HUMAN	Decreases Expression	[9]
Histone H2B type 1-C/E/F/G/I (H2BC10)	OTLQH0D6	H2B1C_HUMAN	Decreases Expression	[9]
Disabled homolog 2 (DAB2)	OTRMQTMZ	DAB2_HUMAN	Decreases Expression	[9]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Increases Expression	[9]
Mothers against decapentaplegic homolog 4 (SMAD4)	OTWQWCKG	SMAD4_HUMAN	Increases Expression	[9]
Protein patched homolog 1 (PTCH1)	OTMG07H5	PTC1_HUMAN	Increases Expression	[9]
Endogenous retrovirus group 3 member 1 Env polyprotein (ERV3-1)	OT4CW64T	ENR1_HUMAN	Increases Expression	[9]
Neuronatin (NNAT)	OTNRLO7G	NNAT_HUMAN	Decreases Expression	[9]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[9]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)	OTQYEXL2	F264_HUMAN	Increases Expression	[9]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)	OTN7XAUD	LRRF1_HUMAN	Decreases Expression	[9]
Leucine-rich repeat and calponin homology domain-containing protein 2 (LRCH2)	OTUEUEHY	LRCH2_HUMAN	Decreases Expression	[9]
Gliomedin (GLDN)	OTA8TQU9	GLDN_HUMAN	Increases Expression	[9]
Basic immunoglobulin-like variable motif-containing protein (BIVM)	OTQEJWSA	BIVM_HUMAN	Decreases Expression	[9]
Dedicator of cytokinesis protein 3 (DOCK3)	OTF3YS2W	DOCK3_HUMAN	Increases Expression	[9]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Increases Expression	[9]
Kinetochore protein Spc24 (SPC24)	OT1HVYV4	SPC24_HUMAN	Decreases Expression	[9]
Olfactory receptor 5P3 (OR5P3)	OTIXMOUN	OR5P3_HUMAN	Increases Expression	[9]
Arrestin domain-containing protein 3 (ARRDC3)	OTAKW7R9	ARRD3_HUMAN	Increases Expression	[9]
Dynein axonemal heavy chain 11 (DNAH11)	OT6IYFVV	DYH11_HUMAN	Increases Expression	[9]
Cysteine and tyrosine-rich protein 1 (CYYR1)	OTKNFPUY	CYYR1_HUMAN	Decreases Expression	[9]
Histone H2A type 1-H (H2AC12)	OTLXVB97	H2A1H_HUMAN	Decreases Expression	[9]
RNA-binding protein 14 (RBM14)	OTO9GMBD	RBM14_HUMAN	Increases Expression	[9]
Histone H2B type 1-M (H2BC14)	OTSDZZZY	H2B1M_HUMAN	Decreases Expression	[9]
Kelch-like protein 4 (KLHL4)	OTEFI623	KLHL4_HUMAN	Increases Expression	[9]
Class E basic helix-loop-helix protein 41 (BHLHE41)	OTY9GJ1Y	BHE41_HUMAN	Increases Expression	[9]
Egl nine homolog 1 (EGLN1)	OT5QODDK	EGLN1_HUMAN	Increases Expression	[9]
Centromere protein H (CENPH)	OTPOO9LK	CENPH_HUMAN	Decreases Expression	[9]
Thiol S-methyltransferase TMT1A (TMT1A)	OT4IAAZP	TMT1A_HUMAN	Decreases Expression	[9]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Increases Expression	[9]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2)	OTY2AP6T	PKHA2_HUMAN	Increases Expression	[9]
Protein BEX1 (BEX1)	OTBQIF0H	BEX1_HUMAN	Decreases Expression	[9]
Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)	OTR1XD9B	GPAT1_HUMAN	Decreases Expression	[9]
Muscleblind-like protein 3 (MBNL3)	OT2T2YOK	MBNL3_HUMAN	Increases Expression	[9]
Cell growth-regulating nucleolar protein (LYAR)	OTQNA67C	LYAR_HUMAN	Decreases Expression	[9]
PTB domain-containing engulfment adapter protein 1 (GULP1)	OT1WMVDH	GULP1_HUMAN	Decreases Expression	[9]
Claudin-16 (CLDN16)	OTTHAIKR	CLD16_HUMAN	Increases Expression	[9]
Insulin-induced gene 2 protein (INSIG2)	OTX4VY51	INSI2_HUMAN	Increases Expression	[9]
Protein patched homolog 2 (PTCH2)	OTOQ0K9V	PTC2_HUMAN	Decreases Expression	[9]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Affects Localization	[29]
Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3)	OTYOORME	NFAC3_HUMAN	Increases Expression	[29]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Phosphorylation	[30]
Mitogen-activated protein kinase 9 (MAPK9)	OTCEVJ9E	MK09_HUMAN	Increases Phosphorylation	[30]
Cytochrome P450 4F11 (CYP4F11)	OTHZ2GG2	CP4FB_HUMAN	Increases Expression	[30]
Synaptophysin (SYP)	OTFJKMO4	SYPH_HUMAN	Decreases Expression	[31]
Drebrin (DBN1)	OTZVKG8A	DREB_HUMAN	Decreases Expression	[31]
Ankyrin repeat domain-containing protein 33B (ANKRD33B)	OTTO39IV	AN33B_HUMAN	Increases Expression	[10]
Elongin BC and Polycomb repressive complex 2-associated protein (EPOP)	OTOYAP3V	EPOP_HUMAN	Increases Expression	[10]
Huntingtin-interacting protein 1 (HIP1)	OT7AKCFQ	HIP1_HUMAN	Increases Expression	[10]
Homeobox protein Meis2 (MEIS2)	OTG4ADLM	MEIS2_HUMAN	Decreases Expression	[10]
Calmegin (CLGN)	OTEWVFQV	CLGN_HUMAN	Increases Expression	[10]
Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)	OTP45YKX	P4HA2_HUMAN	Increases Expression	[10]
Calpain-5 (CAPN5)	OTQ8QM7K	CAN5_HUMAN	Increases Expression	[10]
Uncharacterized protein KIAA0513 (KIAA0513)	OT7AVTFB	K0513_HUMAN	Increases Expression	[10]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)	OTRNDZXB	HNRPQ_HUMAN	Decreases Expression	[10]
Syndecan-3 (SDC3)	OT1P0LJM	SDC3_HUMAN	Increases Expression	[10]
Low-density lipoprotein receptor-related protein 4 (LRP4)	OTO4M459	LRP4_HUMAN	Increases Expression	[10]
Filamin-B (FLNB)	OTPCOYL6	FLNB_HUMAN	Increases Expression	[10]
Src kinase-associated phosphoprotein 2 (SKAP2)	OTSF44KP	SKAP2_HUMAN	Decreases Expression	[10]
Microtubule cross-linking factor 2 (MTCL2)	OTYL5HK1	MTCL2_HUMAN	Increases Expression	[10]
Ras-related protein Rab-3D (RAB3D)	OTGKRR3C	RAB3D_HUMAN	Increases Expression	[10]
Phosphoglycerate kinase 1 (PGK1)	OT6V1ICH	PGK1_HUMAN	Decreases Expression	[10]
Plasma serine protease inhibitor (SERPINA5)	OTTZXPGD	IPSP_HUMAN	Increases Expression	[10]
Transcription factor AP-2-alpha (TFAP2A)	OTMYT3NK	AP2A_HUMAN	Increases Expression	[10]
Histone H1.0 (H1-0)	OTRLJK4Z	H10_HUMAN	Decreases Expression	[10]
Tumor necrosis factor receptor superfamily member 16 (NGFR)	OTPKSM49	TNR16_HUMAN	Increases Expression	[10]
Apelin receptor early endogenous ligand (APELA)	OTYY0P69	ELA_HUMAN	Decreases Expression	[10]
Protein Cripto (CRIPTO)	OT46DZXJ	TDGF1_HUMAN	Decreases Expression	[10]
Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)	OTSLZBVY	PTN3_HUMAN	Increases Expression	[10]
Large ribosomal subunit protein uL13 (RPL13A)	OTME3VXN	RL13A_HUMAN	Decreases Expression	[10]
OX-2 membrane glycoprotein (CD200)	OTQEQSRT	OX2G_HUMAN	Decreases Expression	[10]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9)	OTV9L89D	TNFL9_HUMAN	Decreases Expression	[10]
Chromobox protein homolog 5 (CBX5)	OT8VYY84	CBX5_HUMAN	Decreases Expression	[10]
Transcriptional regulator ATRX (ATRX)	OT77RSQW	ATRX_HUMAN	Decreases Expression	[10]
Nuclear autoantigenic sperm protein (NASP)	OTNE4THC	NASP_HUMAN	Decreases Expression	[10]
Emerin (EMD)	OTR8ZANE	EMD_HUMAN	Increases Expression	[10]
Serpin B9 (SERPINB9)	OTJ811IF	SPB9_HUMAN	Decreases Expression	[10]
Annexin A11 (ANXA11)	OT8SRY1C	ANX11_HUMAN	Increases Expression	[10]
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)	OT4O4NFS	ROA3_HUMAN	Decreases Expression	[10]
Mitogen-activated protein kinase 10 (MAPK10)	OTC46VX1	MK10_HUMAN	Decreases Expression	[10]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1)	OTK71JYU	TCP4_HUMAN	Decreases Expression	[10]
CD81 antigen (CD81)	OTQFXNAZ	CD81_HUMAN	Increases Expression	[10]
Triosephosphate isomerase (TPI1)	OT14KP4B	TPIS_HUMAN	Decreases Expression	[10]
Myelin proteolipid protein (PLP1)	OT8CM9CX	MYPR_HUMAN	Increases Expression	[10]
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)	OTYFTYFR	PP1B_HUMAN	Decreases Expression	[10]
Rho-related GTP-binding protein RhoB (RHOB)	OTHQFQF7	RHOB_HUMAN	Decreases Expression	[10]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[10]
Histone H3.1 (H3C1)	OTGBGOZW	H31_HUMAN	Decreases Expression	[10]
RNA-binding protein 3 (RBM3)	OTAJ7R31	RBM3_HUMAN	Decreases Expression	[10]
Heterogeneous nuclear ribonucleoprotein U (HNRNPU)	OTLQN1E2	HNRPU_HUMAN	Decreases Expression	[10]
Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4)	OTPV1D60	FKBP4_HUMAN	Increases Expression	[10]
Activin receptor type-1 (ACVR1)	OT4JATFE	ACVR1_HUMAN	Increases Expression	[10]
Protocadherin-1 (PCDH1)	OT7KDEL3	PCDH1_HUMAN	Increases Expression	[10]
Lysyl oxidase homolog 1 (LOXL1)	OTA0NEJU	LOXL1_HUMAN	Increases Expression	[10]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Decreases Expression	[10]
Serine/arginine-rich splicing factor 6 (SRSF6)	OTGLOSYE	SRSF6_HUMAN	Decreases Expression	[10]
Transcription initiation factor TFIID subunit 7 (TAF7)	OT43QHS3	TAF7_HUMAN	Decreases Expression	[10]
Dixin (DIXDC1)	OT87DXEG	DIXC1_HUMAN	Increases Expression	[10]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)	OT25JBA3	F263_HUMAN	Decreases Expression	[10]
Protogenin (PRTG)	OTDE8D9Z	PRTG_HUMAN	Decreases Expression	[10]
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB)	OT2Z03OB	GNPTA_HUMAN	Increases Expression	[10]
La-related protein 7 (LARP7)	OTLLOZTL	LARP7_HUMAN	Decreases Expression	[10]
Solute carrier family 35 member F1 (SLC35F1)	OTRXHR2P	S35F1_HUMAN	Increases Expression	[10]
EEIG family member 2 (EEIG2)	OTN8R8DQ	EEIG2_HUMAN	Increases Expression	[10]
Early estrogen-induced gene 1 protein (EEIG1)	OT2BMEAE	EEIG1_HUMAN	Increases Expression	[10]
Protein lin-9 homolog (LIN9)	OTLHW00C	LIN9_HUMAN	Decreases Expression	[10]
Complexin-2 (CPLX2)	OTU5QWFH	CPLX2_HUMAN	Decreases Expression	[10]
Oligodendrocyte transcription factor 3 (OLIG3)	OTU8XLAF	OLIG3_HUMAN	Decreases Expression	[10]
Monocarboxylate transporter 9 (SLC16A9)	OTVCLKQQ	MOT9_HUMAN	Increases Expression	[10]
L-xylulose reductase (DCXR)	OTYVXRXB	DCXR_HUMAN	Increases Expression	[10]
Choline transporter-like protein 2 (SLC44A2)	OT11T33C	CTL2_HUMAN	Increases Expression	[10]
E3 ubiquitin-protein ligase TRIM22 (TRIM22)	OTJBLG5R	TRI22_HUMAN	Increases Expression	[10]
Xaa-Arg dipeptidase (PM20D2)	OTD2Y7LU	P20D2_HUMAN	Increases Expression	[10]
Large neutral amino acids transporter small subunit 4 (SLC43A2)	OTMSOSOX	LAT4_HUMAN	Increases Expression	[10]
Refilin-B (RFLNB)	OTI7ZM75	RFLB_HUMAN	Increases Expression	[10]
Myc target protein 1 (MYCT1)	OTZ8A9L3	MYCT1_HUMAN	Decreases Expression	[10]
Insulin-like growth factor-binding protein-like 1 (IGFBPL1)	OTY4HVN8	IBPL1_HUMAN	Increases Expression	[10]
TBC1 domain family member 5 (TBC1D5)	OTNHLLAX	TBCD5_HUMAN	Increases Expression	[10]
Neogenin (NEO1)	OTGJ1997	NEO1_HUMAN	Increases Expression	[10]
Exostosin-like 1 (EXTL1)	OTMSNY9N	EXTL1_HUMAN	Increases Expression	[10]
Arylsulfatase G (ARSG)	OTT7TDW7	ARSG_HUMAN	Increases Expression	[10]
Protein LRATD2 (LRATD2)	OTEZBUUL	LRAT2_HUMAN	Increases Expression	[10]
Transmembrane protein 237 (TMEM237)	OTQEVL7L	TM237_HUMAN	Decreases Expression	[10]
La-related protein 6 (LARP6)	OTUQ9QS9	LARP6_HUMAN	Increases Expression	[10]
Acidic leucine-rich nuclear phosphoprotein 32 family member E (ANP32E)	OTTWELUQ	AN32E_HUMAN	Decreases Expression	[10]
TNF receptor-associated factor 4 (TRAF4)	OTJLRVMC	TRAF4_HUMAN	Increases Expression	[10]
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1)	OTOOXC7B	HOIL1_HUMAN	Increases Expression	[10]
Transmembrane gamma-carboxyglutamic acid protein 4 (PRRG4)	OT2SZQI7	TMG4_HUMAN	Increases Expression	[10]
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMNAT2)	OT5JLP2H	NMNA2_HUMAN	Increases Expression	[10]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Increases Expression	[10]
Thiamine transporter 2 (SLC19A3)	OTOWP1CT	S19A3_HUMAN	Decreases Expression	[10]
Homeobox protein Hox-D1 (HOXD1)	OTN4V9ZF	HXD1_HUMAN	Decreases Expression	[10]
Protein mono-ADP-ribosyltransferase PARP12 (PARP12)	OTCQTYIO	PAR12_HUMAN	Increases Expression	[10]
Probable E3 ubiquitin-protein ligase IRF2BPL (IRF2BPL)	OTV8MNT1	I2BPL_HUMAN	Increases Expression	[10]
Nucleoporin-62 C-terminal-like protein (NUP62CL)	OTEN1HET	N62CL_HUMAN	Increases Expression	[10]
Ras association domain-containing protein 4 (RASSF4)	OT7YLOFH	RASF4_HUMAN	Increases Expression	[10]
Olfactomedin-like protein 3 (OLFML3)	OTDN45FN	OLFL3_HUMAN	Decreases Expression	[10]
Anoctamin-10 (ANO10)	OTG3BNOU	ANO10_HUMAN	Increases Expression	[10]
Dapper homolog 1 (DACT1)	OT19Z704	DACT1_HUMAN	Decreases Expression	[10]
Bcl-2-associated transcription factor 1 (BCLAF1)	OT7T8H6A	BCLF1_HUMAN	Decreases Expression	[10]
Transcription factor CP2-like protein 1 (TFCP2L1)	OT7QIJ0X	TF2L1_HUMAN	Increases Expression	[10]
Peroxisomal sarcosine oxidase (PIPOX)	OTWTCOTN	SOX_HUMAN	Decreases Expression	[10]
Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L)	OT3HG324	ASH2L_HUMAN	Increases Expression	[10]
Large neutral amino acids transporter small subunit 2 (SLC7A8)	OT8XXVO8	LAT2_HUMAN	Increases Expression	[10]
Bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)	OTB98CEY	BAZ2B_HUMAN	Decreases Expression	[10]
Inhibitor of growth protein 4 (ING4)	OT0VVG4V	ING4_HUMAN	Decreases Expression	[10]
LIM and calponin homology domains-containing protein 1 (LIMCH1)	OTYPC4XA	LIMC1_HUMAN	Decreases Expression	[10]
Lysosome-associated membrane glycoprotein 3 (LAMP3)	OTN0XL3W	LAMP3_HUMAN	Increases Expression	[10]
Carbohydrate sulfotransferase 2 (CHST2)	OTV11IZF	CHST2_HUMAN	Increases Expression	[10]
Steroidogenic factor 1 (NR5A1)	OTOULYR4	STF1_HUMAN	Decreases Expression	[32]
CCN family member 1 (CCN1)	OTKJBEMD	CCN1_HUMAN	Decreases Expression	[11]
Astrotactin-1 (ASTN1)	OT23FQIB	ASTN1_HUMAN	Increases Expression	[11]
Beta-1,4-glucuronyltransferase 1 (B4GAT1)	OT5NH9TD	B4GA1_HUMAN	Increases Expression	[11]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)	OT8V1J4M	GA45G_HUMAN	Decreases Expression	[11]
GTP-binding protein Di-Ras3 (DIRAS3)	OT3XHLQA	DIRA3_HUMAN	Increases Expression	[11]
Vitamin D-binding protein (GC)	OTWS63BY	VTDB_HUMAN	Decreases Expression	[11]
Coagulation factor XIII B chain (F13B)	OTIZXROK	F13B_HUMAN	Decreases Expression	[11]
Large ribosomal subunit protein P2 (RPLP2)	OT2YBK3W	RLA2_HUMAN	Increases Expression	[11]
Mast/stem cell growth factor receptor Kit (KIT)	OTHUY3VZ	KIT_HUMAN	Increases Expression	[11]
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MYL2)	OT78PC0C	MLRV_HUMAN	Decreases Expression	[11]
Natriuretic peptides B (NPPB)	OTSN2IPY	ANFB_HUMAN	Decreases Expression	[11]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Increases Expression	[11]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Decreases Expression	[11]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Decreases Expression	[11]
Sodium/myo-inositol cotransporter (SLC5A3)	OT6FY2KA	SC5A3_HUMAN	Increases Expression	[11]
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Increases Expression	[11]
Collagen alpha-1(XIV) chain (COL14A1)	OTLNJ13O	COEA1_HUMAN	Increases Expression	[11]
Ankyrin repeat domain-containing protein 1 (ANKRD1)	OTHJ7JV9	ANKR1_HUMAN	Decreases Expression	[11]
FRAS1-related extracellular matrix protein 2 (FREM2)	OTEK6BZR	FREM2_HUMAN	Increases Expression	[11]
OTU domain-containing protein 1 (OTUD1)	OTE6O5XB	OTUD1_HUMAN	Decreases Expression	[11]
Leiomodin-2 (LMOD2)	OTFXHQFL	LMOD2_HUMAN	Decreases Expression	[11]
Transmembrane protein 71 (TMEM71)	OTA7W26O	TMM71_HUMAN	Decreases Expression	[11]
Synaptotagmin-10 (SYT10)	OTVV19BW	SYT10_HUMAN	Increases Expression	[11]
Fc receptor-like A (FCRLA)	OT6MK4M1	FCRLA_HUMAN	Decreases Expression	[11]
Monocarboxylate transporter 14 (SLC16A14)	OTUGDEUV	MOT14_HUMAN	Increases Expression	[11]
Retrotransposon-derived protein PEG10 (PEG10)	OTWD2278	PEG10_HUMAN	Increases Expression	[11]
Dynein axonemal assembly factor 3 (DNAAF3)	OT3OHO0O	DAAF3_HUMAN	Decreases Expression	[11]
Arrestin domain-containing protein 4 (ARRDC4)	OTINJ0FX	ARRD4_HUMAN	Increases Expression	[11]
EMI domain-containing protein 1 (EMID1)	OTJ27FQ1	EMID1_HUMAN	Increases Expression	[11]
BTB/POZ domain-containing protein KCTD12 (KCTD12)	OTPYKT4Z	KCD12_HUMAN	Increases Expression	[11]
Chemokine-like protein TAFA-4 (TAFA4)	OT0RHMNG	TAFA4_HUMAN	Increases Expression	[11]
Hemicentin-1 (HMCN1)	OTLZAS0P	HMCN1_HUMAN	Increases Expression	[11]
SPARC-related modular calcium-binding protein 1 (SMOC1)	OTJG2JQY	SMOC1_HUMAN	Increases Expression	[11]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)	OT5V52LN	TNR12_HUMAN	Decreases Expression	[11]
Inward rectifier potassium channel 16 (KCNJ16)	OT174UPV	KCJ16_HUMAN	Decreases Expression	[11]
Kv channel-interacting protein 2 (KCNIP2)	OTY4BLOJ	KCIP2_HUMAN	Increases Expression	[11]
Ras-like protein family member 12 (RASL12)	OTNAK9X4	RASLC_HUMAN	Increases Expression	[11]
Potassium voltage-gated channel subfamily G member 1 (KCNG1)	OTZ9ZRG8	KCNG1_HUMAN	Increases Expression	[11]
Probable small intestine urate exporter (SLC17A4)	OTFOOYB9	S17A4_HUMAN	Decreases Expression	[11]
Myosin-4 (MYH4)	OT4657W4	MYH4_HUMAN	Decreases Expression	[11]
Scinderin (SCIN)	OT6U09OL	SCIN_HUMAN	Increases Expression	[11]
Dynamin-1-like protein (DNM1L)	OTXK1Q1G	DNM1L_HUMAN	Increases Expression	[33]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)	OTKOZRZP	PLOD2_HUMAN	Increases Expression	[34]
Myc box-dependent-interacting protein 1 (BIN1)	OTK8O0X8	BIN1_HUMAN	Increases Expression	[13]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Increases Expression	[35]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[36]
Histone-lysine N-methyltransferase SETD1A (SETD1A)	OTVVWRIC	SET1A_HUMAN	Decreases Expression	[36]
Phospholipid scramblase 1 (PLSCR1)	OTGY9B5T	PLS1_HUMAN	Affects Expression	[12]
Matrilin-3 (MATN3)	OTH9H74J	MATN3_HUMAN	Decreases Expression	[13]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[37]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)	OTDTF5BU	SUV91_HUMAN	Increases Expression	[36]
Forkhead box protein O3 (FOXO3)	OTHXQG4P	FOXO3_HUMAN	Increases Phosphorylation	[38]
5-hydroxymethyl-dUMP N-hydrolase (DNPH1)	OTEZVTI1	DNPH1_HUMAN	Decreases Expression	[39]
E3 ubiquitin-protein ligase parkin (PRKN)	OTJBN41W	PRKN_HUMAN	Decreases Expression	[40]
Dynamin-like 120 kDa protein, mitochondrial (OPA1)	OTJGNWPW	OPA1_HUMAN	Decreases Expression	[33]
Liprin-alpha-4 (PPFIA4)	OTWXG0DO	LIPA4_HUMAN	Decreases Expression	[13]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)	OTY9R6FZ	ERN1_HUMAN	Increases Expression	[41]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Expression	[37]
Cell cycle checkpoint protein RAD17 (RAD17)	OT1I93DT	RAD17_HUMAN	Decreases Expression	[13]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1)	OTERJ4VQ	SO2B1_HUMAN	Increases Expression	[37]
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)	OTW3GO4Y	ARK73_HUMAN	Decreases Expression	[13]
6-phosphogluconolactonase (PGLS)	OTO6C0IQ	6PGL_HUMAN	Increases Expression	[13]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Expression	[36]
Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)	OTVT4YA1	ATG7_HUMAN	Increases Expression	[42]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Decreases Expression	[43]
Claudin-14 (CLDN14)	OTS7GKOI	CLD14_HUMAN	Increases Expression	[44]
Pro-opiomelanocortin (POMC)	OTV41F7T	COLI_HUMAN	Decreases Expression	[25]
Proenkephalin-B (PDYN)	OTEJ6430	PDYN_HUMAN	Decreases Expression	[25]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Increases Expression	[45]
Ferritin light chain (FTL)	OTYQA8A6	FRIL_HUMAN	Increases Expression	[46]
Ferritin heavy chain (FTH1)	OT6IFS0O	FRIH_HUMAN	Decreases Expression	[40]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Decreases Activity	[47]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Expression	[41]
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Increases Expression	[13]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Increases Expression	[44]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Increases Phosphorylation	[48]
ATP synthase subunit beta, mitochondrial (ATP5F1B)	OTLFZUQK	ATPB_HUMAN	Increases Expression	[13]
Alpha-enolase (ENO1)	OTB1KWJS	ENOA_HUMAN	Decreases Expression	[13]
Calpain-1 catalytic subunit (CAPN1)	OTK6OQZR	CAN1_HUMAN	Increases Expression	[49]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[50]
Interleukin-3 (IL3)	OT0CQ35N	IL3_HUMAN	Increases Expression	[51]
SPARC (SPARC)	OTPN90H0	SPRC_HUMAN	Increases Expression	[46]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[52]
Chorionic somatomammotropin hormone 1 (CSH1)	OT33HTRR	CSH1_HUMAN	Decreases Expression	[13]
Heat shock cognate 71 kDa protein (HSPA8)	OTJI2RCI	HSP7C_HUMAN	Increases Expression	[53]
Acetylcholine receptor subunit beta (CHRNB1)	OTTJXD24	ACHB_HUMAN	Decreases Expression	[13]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Increases Expression	[54]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Increases Secretion	[55]
Glial fibrillary acidic protein (GFAP)	OTQ01ZAS	GFAP_HUMAN	Increases Expression	[13]
POU domain, class 2, transcription factor 1 (POU2F1)	OTK7ELJ0	PO2F1_HUMAN	Decreases Expression	[39]
Ezrin (EZR)	OTHBPF1Z	EZRI_HUMAN	Increases Expression	[56]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[57]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[41]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Increases Expression	[51]
Spermidine synthase (SRM)	OT4N5MDP	SPEE_HUMAN	Decreases Expression	[13]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)	OTDS2EAR	TNR1B_HUMAN	Increases Expression	[51]
Alpha-(1,3)-fucosyltransferase 4 (FUT4)	OTIBXRTL	FUT4_HUMAN	Increases Expression	[58]
Sterol carrier protein 2 (SCP2)	OTPAFCPQ	SCP2_HUMAN	Decreases Expression	[13]
Galanin peptides (GAL)	OTB3VPTO	GALA_HUMAN	Increases Expression	[57]
Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)	OTBZKX4P	ROA2_HUMAN	Increases Expression	[13]
Protein S100-A4 (S100A4)	OTLRGFSQ	S10A4_HUMAN	Increases Expression	[46]
Beta-crystallin B3 (CRYBB3)	OTTGTQIQ	CRBB3_HUMAN	Decreases Expression	[39]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Expression	[39]
Endoplasmic reticulum resident protein 29 (ERP29)	OTNKANMH	ERP29_HUMAN	Increases Expression	[13]
Peroxiredoxin-6 (PRDX6)	OTS8KC8A	PRDX6_HUMAN	Decreases Expression	[13]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[59]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Increases Expression	[13]
Cadherin-5 (CDH5)	OTVX0E1Q	CADH5_HUMAN	Increases Uptake	[60]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[41]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[57]
Kappa-type opioid receptor (OPRK1)	OTXCZF4L	OPRK_HUMAN	Decreases Expression	[25]
Reduced folate transporter (SLC19A1)	OTWB0BTO	S19A1_HUMAN	Decreases Expression	[61]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Increases Expression	[57]
F-actin-capping protein subunit beta (CAPZB)	OTF1A4N0	CAPZB_HUMAN	Increases Expression	[13]
Amphiphysin (AMPH)	OTWPGWZX	AMPH_HUMAN	Decreases Expression	[13]
CCAAT/enhancer-binding protein alpha (CEBPA)	OTOM9OE4	CEBPA_HUMAN	Increases Expression	[62]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Decreases Expression	[63]
Eotaxin (CCL11)	OT3BIFPK	CCL11_HUMAN	Decreases Expression	[51]
Mismatch repair endonuclease PMS2 (PMS2)	OTNLWTMI	PMS2_HUMAN	Decreases Expression	[39]
GTP-binding protein RAD (RRAD)	OTW2O4GD	RAD_HUMAN	Decreases Expression	[39]
Sodium/calcium exchanger 3 (SLC8A3)	OTIVTE0G	NAC3_HUMAN	Increases Expression	[49]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Decreases Expression	[64]
Heterogeneous nuclear ribonucleoprotein K (HNRNPK)	OTNPRM8U	HNRPK_HUMAN	Increases Expression	[13]
Histone-lysine N-methyltransferase 2A (KMT2A)	OT9GLJI6	KMT2A_HUMAN	Decreases Expression	[36]
Peroxiredoxin-1 (PRDX1)	OTZ3BEC4	PRDX1_HUMAN	Increases Expression	[13]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)	OTPYQX3K	C1QBP_HUMAN	Decreases Expression	[13]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Decreases Expression	[65]
DNA polymerase epsilon catalytic subunit A (POLE)	OTFM3MMU	DPOE1_HUMAN	Decreases Expression	[13]
AP-1 complex subunit beta-1 (AP1B1)	OTY0K84R	AP1B1_HUMAN	Increases Expression	[13]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Decreases Phosphorylation	[66]
Stromal interaction molecule 1 (STIM1)	OT8CLQ1W	STIM1_HUMAN	Increases Expression	[67]
Pro-interleukin-16 (IL16)	OTZ2MO6B	IL16_HUMAN	Decreases Expression	[51]
Protein scribble homolog (SCRIB)	OTW4N3FV	SCRIB_HUMAN	Decreases Expression	[13]
Protein-tyrosine kinase 2-beta (PTK2B)	OTGAS0I8	FAK2_HUMAN	Increases Phosphorylation	[48]
Caprin-1 (CAPRIN1)	OTEJAMS3	CAPR1_HUMAN	Increases Expression	[12]
Phosphatidate phosphatase LPIN1 (LPIN1)	OTQ75KF2	LPIN1_HUMAN	Increases Expression	[62]
Glycine N-methyltransferase (GNMT)	OT0O2OQO	GNMT_HUMAN	Increases Expression	[44]
Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4)	OTTDCUAO	NFAC4_HUMAN	Increases Expression	[57]
Retinoblastoma-binding protein 5 (RBBP5)	OT12W2MK	RBBP5_HUMAN	Increases Expression	[36]
Calponin-3 (CNN3)	OTJTAXAP	CNN3_HUMAN	Decreases Expression	[13]
Myosin light chain kinase, smooth muscle (MYLK)	OT78QB4A	MYLK_HUMAN	Increases Expression	[65]
Frataxin, mitochondrial (FXN)	OTE9U09A	FRDA_HUMAN	Affects Expression	[68]
Occludin (OCLN)	OTSUTVWL	OCLN_HUMAN	Decreases Expression	[65]
Centrosomal protein of 55 kDa (CEP55)	OTGSG2PA	CEP55_HUMAN	Decreases Expression	[13]
F-box/WD repeat-containing protein 9 (FBXW9)	OTM2MFOF	FBXW9_HUMAN	Decreases Expression	[13]
Dual specificity phosphatase 29 (DUSP29)	OTJOJZHG	DUS29_HUMAN	Increases Expression	[13]
Coiled-coil domain-containing protein 70 (CCDC70)	OTQMZUYJ	CCD70_HUMAN	Decreases Expression	[13]
Inactive caspase-12 (CASP12)	OTY2W6FG	CASPC_HUMAN	Increases Activity	[41]
Hsp90 co-chaperone Cdc37-like 1 (CDC37L1)	OTGKTFAC	CD37L_HUMAN	Decreases Expression	[46]
Autophagy-related protein 9A (ATG9A)	OTAZWZH7	ATG9A_HUMAN	Decreases Expression	[13]
Mitofusin-1 (MFN1)	OTCBXQZF	MFN1_HUMAN	Decreases Expression	[33]
Stromal membrane-associated protein 1 (SMAP1)	OTQN3BVL	SMAP1_HUMAN	Increases Expression	[13]
Inactive histone-lysine N-methyltransferase 2E (KMT2E)	OTYOLNOG	KMT2E_HUMAN	Decreases Expression	[36]
Mixed lineage kinase domain-like protein (MLKL)	OTDSLC81	MLKL_HUMAN	Increases Phosphorylation	[69]
Histone-lysine N-methyltransferase 2C (KMT2C)	OTC59BCO	KMT2C_HUMAN	Decreases Expression	[36]
Coiled-coil alpha-helical rod protein 1 (CCHCR1)	OT22C116	CCHCR_HUMAN	Decreases Expression	[13]
Transcription factor IIIB 90 kDa subunit (BRF1)	OTQC6DMG	TF3B_HUMAN	Increases Expression	[70]
Calcium release-activated calcium channel protein 1 (ORAI1)	OT2VE9UU	CRCM1_HUMAN	Increases Expression	[67]
Kremen protein 1 (KREMEN1)	OTGJFSAC	KREM1_HUMAN	Decreases Expression	[13]
Nectin-4 (NECTIN4)	OTJSFW1L	NECT4_HUMAN	Decreases Expression	[44]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3)	OTZM6MHU	NLRP3_HUMAN	Increases Expression	[69]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Decreases Expression	[63]
Histone-lysine N-methyltransferase SETDB2 (SETDB2)	OTBVVP9Q	SETB2_HUMAN	Decreases Expression	[36]
Prefoldin subunit 5 (PFDN5)	OTTKPTUP	PFD5_HUMAN	Decreases Expression	[39]
tRNA-specific adenosine deaminase 1 (ADAT1)	OTCDIRF4	ADAT1_HUMAN	Decreases Expression	[46]
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)	OT50NR57	PINK1_HUMAN	Decreases Expression	[40]
Fanconi anemia group D2 protein (FANCD2)	OTVEB5LF	FACD2_HUMAN	Increases Expression	[71]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Increases Expression	[42]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Decreases Expression	[72]
Leucine-rich melanocyte differentiation-associated protein (LRMDA)	OTIPNKTU	LRMDA_HUMAN	Increases Expression	[44]
Histone-lysine N-methyltransferase SUV39H2 (SUV39H2)	OTU0F4LL	SUV92_HUMAN	Decreases Expression	[36]
Prokineticin-2 (PROK2)	OT70IFEZ	PROK2_HUMAN	Increases Expression	[12]
Glyoxalase domain-containing protein 4 (GLOD4)	OTBJKFXA	GLOD4_HUMAN	Decreases Expression	[13]
N-lysine methyltransferase KMT5A (KMT5A)	OTW2A5YY	KMT5A_HUMAN	Decreases Expression	[36]
StAR-related lipid transfer protein 7, mitochondrial (STARD7)	OTDUZ296	STAR7_HUMAN	Decreases Expression	[13]
Histone-lysine N-methyltransferase ASH1L (ASH1L)	OTUT5NLJ	ASH1L_HUMAN	Decreases Expression	[36]
N-lysine methyltransferase SMYD2 (SMYD2)	OTN8035R	SMYD2_HUMAN	Decreases Expression	[36]
Phospholipid scramblase 3 (PLSCR3)	OTJ6K2XJ	PLS3_HUMAN	Increases Expression	[13]
Interleukin-1 receptor-associated kinase 4 (IRAK4)	OT9JTJWC	IRAK4_HUMAN	Increases Expression	[73]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)	OT0DZGY4	E2AK3_HUMAN	Increases Expression	[41]
DNA (DNMT3B)	OTZ0JCNP	DNM3B_HUMAN	Affects Expression	[36]
Tripartite motif-containing protein 10 (TRIM10)	OTEO4UCZ	TRI10_HUMAN	Increases Expression	[13]
Apoptosis-associated speck-like protein containing a CARD (PYCARD)	OT67RON3	ASC_HUMAN	Increases Expression	[74]
Histone-lysine N-methyltransferase 2B (KMT2B)	OTMMAZQX	KMT2B_HUMAN	Decreases Expression	[36]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Increases Expression	[37]
Dystrobrevin alpha (DTNA)	OTVBIRH2	DTNA_HUMAN	Increases Expression	[13]
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)	OTL1D484	RIPK3_HUMAN	Increases Expression	[75]
DNA (DNMT3A)	OTEJP0GH	DNM3A_HUMAN	Affects Expression	[36]
Regenerating islet-derived protein 3-alpha (REG3A)	OT0BVQRB	REG3A_HUMAN	Increases ADR	[76]
Mu-type opioid receptor (OPRM1)	OT16AAT8	OPRM_HUMAN	Increases Response To Substance	[77]
2'-5'-oligoadenylate synthase 3 (OAS3)	OT6E5FYS	OAS3_HUMAN	Affects Response To Substance	[62]
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11)	OT7EVFBK	M2OM_HUMAN	Increases ADR	[76]
Neuronal cell adhesion molecule (NRCAM)	OT80HHQ2	NRCAM_HUMAN	Increases Response To Substance	[78]
GABA receptor subunit B1 (GABAB1)	OT8KS945	M9TEZ7_TETCI	Increases ADR	[76]
Serine protease 1 (PRSS1)	OTA425AX	TRY1_HUMAN	Increases ADR	[79]
D(2) dopamine receptor (DRD2)	OTBLXKEG	DRD2_HUMAN	Increases ADR	[76]
Eukaryotic translation initiation factor 4E (EIF4E)	OTDAWNLA	IF4E_HUMAN	Increases ADR	[76]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)	OTFBU4GD	P3C2A_HUMAN	Increases ADR	[76]
Small ribosomal subunit protein eS6z (RPS6A)	OTIG8G1R	RS61_ARATH	Increases ADR	[76]
Ankyrin-3 (ANK3)	OTJ3IRBP	ANK3_HUMAN	Affects Response To Substance	[80]
MORC family CW-type zinc finger protein 4 (MORC4)	OTJBEHNE	MORC4_HUMAN	Increases ADR	[79]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases ADR	[76]
Coiled-coil domain-containing protein 63 (CCDC63)	OTKDRXAE	CCD63_HUMAN	Affects Response To Substance	[62]
Low-density lipoprotein receptor-related protein 6 (LRP6)	OTM7PSUR	LRP6_HUMAN	Decreases Response To Substance	[81]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Affects Response To Substance	[82]
Cyclin-dependent kinase 20 (CDK20)	OTOLNN68	CDK20_HUMAN	Affects Response To Substance	[82]
Sex hormone-binding globulin (SHBG)	OTPWU5IW	SHBG_HUMAN	Increases ADR	[76]
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)	OTQF5ZAK	PTH1R_HUMAN	Increases ADR	[76]
Opioid growth factor receptor (OGFR)	OTROS6RJ	OGFR_HUMAN	Increases ADR	[76]
Period circadian protein homolog 2 (PER2)	OTU2B1DJ	PER2_HUMAN	Affects Response To Substance	[83]
T-box transcription factor TBX19 (TBX19)	OTXEMR2U	TBX19_HUMAN	Affects Response To Substance	[82]
Protein DEK (DEK)	OTYCJ5H6	DEK_HUMAN	Increases Secretion	[84]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Affects Response To Substance	[85]

Indication(s) of Nicotine

Disease Entry	ICD 11	Status	REF
Lung cancer	2C25.0	Approved	[4]
Nicotine dependence	6C4A.2	Approved	[5]
Pellagra	N.A.	Approved	[4]
Tobacco dependence	6C4A.2	Clinical trial	[6]

Nicotine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Nicotinic acetylcholine receptor (nAChR)	TTJSZTB	NOUNIPROTAC	Antagonist	[97]

Nicotine Interacts with 13 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[98]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[98]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[99]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Metabolism	[100]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Metabolism	[98]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[98]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Metabolism	[101]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[98]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[98]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Metabolism	[102]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[98]
Cytochrome P450 2A13 (CYP2A13)	DEXZA9U	CP2AD_HUMAN	Metabolism	[103]
Nicotinate dehydrogenase (nicA)	DE4AMLP	NICA_PSEPK	Metabolism	[104]

Nicotine Interacts with 290 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[105]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Increases Expression	[86]
Regulatory factor X-associated protein (RFXAP)	OTX46DKQ	RFXAP_HUMAN	Decreases Expression	[87]
Receptor-type tyrosine-protein phosphatase alpha (PTPRA)	OTZA82J1	PTPRA_HUMAN	Decreases Expression	[87]
Ras-related protein Rab-6A (RAB6A)	OTLS86J5	RAB6A_HUMAN	Decreases Expression	[87]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Decreases Expression	[87]
Rho guanine nucleotide exchange factor 7 (ARHGEF7)	OT9BPJCL	ARHG7_HUMAN	Decreases Expression	[87]
E3 ubiquitin-protein ligase RBBP6 (RBBP6)	OTTVG4HU	RBBP6_HUMAN	Decreases Expression	[87]
Histone-lysine N-methyltransferase 2C (KMT2C)	OTC59BCO	KMT2C_HUMAN	Decreases Expression	[87]
Fasciculation and elongation protein zeta-1 (FEZ1)	OTWCXPRE	FEZ1_HUMAN	Decreases Expression	[87]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)	OTT5JX1F	LITAF_HUMAN	Decreases Expression	[87]
Copper chaperone for superoxide dismutase (CCS)	OTXHT3QO	CCS_HUMAN	Increases Expression	[106]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Decreases Expression	[106]
Syntaxin-binding protein 3 (STXBP3)	OTTTYMAQ	STXB3_HUMAN	Increases Expression	[88]
Segment polarity protein dishevelled homolog DVL-2 (DVL2)	OTMNYNCM	DVL2_HUMAN	Decreases Expression	[88]
Chromodomain-helicase-DNA-binding protein 2 (CHD2)	OTRKL6YC	CHD2_HUMAN	Increases Expression	[88]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)	OT1Z1ZXE	OGT1_HUMAN	Increases Expression	[88]
Apoptosis regulatory protein Siva (SIVA1)	OTDT0XZK	SIVA_HUMAN	Decreases Expression	[88]
Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2)	OTR7WJES	DC1L2_HUMAN	Increases Expression	[88]
E3 ubiquitin-protein ligase parkin (PRKN)	OTJBN41W	PRKN_HUMAN	Decreases Expression	[88]
C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)	OT45AHMB	JIP4_HUMAN	Increases Expression	[88]
Serine protease 1 (PRSS1)	OTA425AX	TRY1_HUMAN	Decreases Expression	[88]
Laminin subunit beta-1 (LAMB1)	OT6J9LJR	LAMB1_HUMAN	Increases Expression	[88]
Myb-related protein B (MYBL2)	OTZ3JX8Q	MYBB_HUMAN	Decreases Expression	[88]
Complement component C7 (C7)	OTZ27VJN	CO7_HUMAN	Increases Expression	[88]
Nucleoprotein TPR (TPR)	OTUBBA4W	TPR_HUMAN	Increases Expression	[88]
Glucosidase 2 subunit beta (PRKCSH)	OTJCQYUU	GLU2B_HUMAN	Decreases Expression	[88]
Creatine kinase S-type, mitochondrial (CKMT2)	OT1KNPI1	KCRS_HUMAN	Decreases Expression	[88]
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)	OT8DXMS3	E2AK2_HUMAN	Increases Expression	[88]
Cellular retinoic acid-binding protein 2 (CRABP2)	OTY01V9G	RABP2_HUMAN	Decreases Expression	[88]
Stress-induced-phosphoprotein 1 (STIP1)	OT7TXLOX	STIP1_HUMAN	Decreases Expression	[88]
Cyclin-dependent kinases regulatory subunit 2 (CKS2)	OTPTMHIV	CKS2_HUMAN	Increases Expression	[88]
Patatin-like phospholipase domain-containing protein 4 (PNPLA4)	OT5CVDJM	PLPL4_HUMAN	Decreases Expression	[88]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)	OTTOMI8J	PK3CA_HUMAN	Increases Expression	[88]
Transcriptional regulator ATRX (ATRX)	OT77RSQW	ATRX_HUMAN	Increases Expression	[88]
Translation initiation factor IF-2, mitochondrial (MTIF2)	OTAIOZ0J	IF2M_HUMAN	Increases Expression	[88]
F-actin-capping protein subunit alpha-2 (CAPZA2)	OTHAO4V2	CAZA2_HUMAN	Increases Expression	[88]
RNA-binding protein 25 (RBM25)	OTVOUOAG	RBM25_HUMAN	Increases Expression	[88]
DNA ligase 4 (LIG4)	OT40DNXU	DNLI4_HUMAN	Increases Expression	[88]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 (GNG10)	OTLMZGBE	GBG10_HUMAN	Increases Expression	[88]
Serpin H1 (SERPINH1)	OTKGI7BS	SERPH_HUMAN	Decreases Expression	[88]
H(+)/Cl(-) exchange transporter 3 (CLCN3)	OTEEXNMU	CLCN3_HUMAN	Increases Expression	[88]
Protein FosB (FOSB)	OTW6C05J	FOSB_HUMAN	Increases Expression	[88]
Protein transport protein Sec61 subunit gamma (SEC61G)	OT7MJRXY	SC61G_HUMAN	Increases Expression	[88]
Myosin light polypeptide 6 (MYL6)	OT84YKPM	MYL6_HUMAN	Decreases Expression	[88]
CMP-sialic acid transporter (SLC35A1)	OTPWOOVA	S35A1_HUMAN	Increases Expression	[88]
Centromere-associated protein E (CENPE)	OTQ7AP04	CENPE_HUMAN	Increases Expression	[88]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A)	OTSK5GFC	P2R3A_HUMAN	Increases Expression	[88]
Phosphatidylinositol-glycan biosynthesis class F protein (PIGF)	OTJKE6VW	PIGF_HUMAN	Increases Expression	[88]
Son of sevenless homolog 1 (SOS1)	OTTCWXC3	SOS1_HUMAN	Increases Expression	[88]
Zinc finger protein Rlf (RLF)	OTCSPZVK	RLF_HUMAN	Increases Expression	[88]
Chromobox protein homolog 3 (CBX3)	OTOP9RLD	CBX3_HUMAN	Increases Expression	[88]
Origin recognition complex subunit 2 (ORC2)	OTLIYP8M	ORC2_HUMAN	Increases Expression	[88]
Zinc transporter ZIP6 (SLC39A6)	OTCYF466	S39A6_HUMAN	Increases Expression	[88]
Golgin subfamily A member 4 (GOLGA4)	OTCMEHNJ	GOGA4_HUMAN	Increases Expression	[88]
Serine incorporator 3 (SERINC3)	OTQ1LAJ1	SERC3_HUMAN	Increases Expression	[88]
Transformer-2 protein homolog alpha (TRA2A)	OT5NHOO3	TRA2A_HUMAN	Increases Expression	[88]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	OTGM06VJ	IDI1_HUMAN	Increases Expression	[88]
Thyroid receptor-interacting protein 11 (TRIP11)	OT4FJEAR	TRIPB_HUMAN	Increases Expression	[88]
Serine/threonine-protein kinase N2 (PKN2)	OTW0SOID	PKN2_HUMAN	Increases Expression	[88]
DNA damage-binding protein 1 (DDB1)	OTTR2L3Z	DDB1_HUMAN	Decreases Expression	[88]
NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5)	OTR848KZ	NDUA5_HUMAN	Increases Expression	[88]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)	OTN7XAUD	LRRF1_HUMAN	Increases Expression	[88]
Transmembrane protein 41B (TMEM41B)	OTW0B0KS	TM41B_HUMAN	Increases Expression	[88]
Heterochromatin protein 1-binding protein 3 (HP1BP3)	OTTJ5LX2	HP1B3_HUMAN	Increases Expression	[88]
Pre-mRNA-splicing factor 38B (PRPF38B)	OTQLH551	PR38B_HUMAN	Increases Expression	[88]
Serine/threonine-protein kinase TAO1 (TAOK1)	OTFFLV6Q	TAOK1_HUMAN	Increases Expression	[88]
Ninein (NIN)	OTVH3M4Z	NIN_HUMAN	Increases Expression	[88]
Tribbles homolog 2 (TRIB2)	OTHSX3MX	TRIB2_HUMAN	Increases Expression	[88]
DNA topoisomerase 2-binding protein 1 (TOPBP1)	OT6UPZPD	TOPB1_HUMAN	Increases Expression	[88]
PHD finger protein 3 (PHF3)	OTNOYLG9	PHF3_HUMAN	Increases Expression	[88]
Probable ATP-dependent RNA helicase DDX17 (DDX17)	OTXRMMBP	DDX17_HUMAN	Increases Expression	[88]
DNA repair protein RAD50 (RAD50)	OTYMU9G1	RAD50_HUMAN	Increases Expression	[88]
snRNA-activating protein complex subunit 3 (SNAPC3)	OTSGZZCJ	SNPC3_HUMAN	Increases Expression	[88]
PHD finger protein 21A (PHF21A)	OTU3FFG4	PF21A_HUMAN	Increases Expression	[88]
THO complex subunit 1 (THOC1)	OTVABJ4Z	THOC1_HUMAN	Increases Expression	[88]
Chloride channel CLIC-like protein 1 (CLCC1)	OTTXCXVT	CLCC1_HUMAN	Increases Expression	[88]
Protein SCAF11 (SCAF11)	OTX59D0X	SCAFB_HUMAN	Increases Expression	[88]
Mediator of RNA polymerase II transcription subunit 28 (MED28)	OTEDM1L5	MED28_HUMAN	Increases Expression	[88]
Arginine and glutamate-rich protein 1 (ARGLU1)	OTRVRZ4Z	ARGL1_HUMAN	Increases Expression	[88]
DDB1- and CUL4-associated factor 16 (DCAF16)	OT60PR7J	DCA16_HUMAN	Increases Expression	[88]
Polypyrimidine tract-binding protein 2 (PTBP2)	OTF4S7NE	PTBP2_HUMAN	Increases Expression	[88]
Splicing factor 3B subunit 6 (SF3B6)	OTPRKS6S	SF3B6_HUMAN	Increases Expression	[88]
Protein PRRC2C (PRRC2C)	OTBX3MXM	PRC2C_HUMAN	Increases Expression	[88]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[107]
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Increases Expression	[108]
Beta-1 adrenergic receptor (ADRB1)	OTQBWN4U	ADRB1_HUMAN	Increases Expression	[108]
Deoxyribonuclease-2-alpha (DNASE2)	OT6RC1BL	DNS2A_HUMAN	Decreases Expression	[89]
NF-kappa-B inhibitor epsilon (NFKBIE)	OTLAYEL9	IKBE_HUMAN	Decreases Expression	[89]
Serine/threonine-protein kinase 25 (STK25)	OT4YPNTF	STK25_HUMAN	Increases Expression	[89]
Krueppel-like factor 11 (KLF11)	OTKVQDJD	KLF11_HUMAN	Decreases Expression	[89]
C-C motif chemokine 16 (CCL16)	OTOOQI1F	CCL16_HUMAN	Decreases Expression	[89]
Death effector domain-containing protein (DEDD)	OTIL349E	DEDD_HUMAN	Decreases Expression	[89]
DNA fragmentation factor subunit beta (DFFB)	OTPBW5N5	DFFB_HUMAN	Decreases Expression	[89]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Decreases Expression	[89]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Increases Expression	[89]
CD59 glycoprotein (CD59)	OTSUMQDH	CD59_HUMAN	Increases Expression	[89]
POU domain, class 2, transcription factor 1 (POU2F1)	OTK7ELJ0	PO2F1_HUMAN	Increases Expression	[89]
Ezrin (EZR)	OTHBPF1Z	EZRI_HUMAN	Increases Expression	[89]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Decreases Expression	[89]
Transcription factor BTF3 (BTF3)	OT5ZZFJL	BTF3_HUMAN	Decreases Expression	[89]
E3 ubiquitin-protein ligase CBL (CBL)	OTTKELCU	CBL_HUMAN	Increases Expression	[89]
Nuclear transcription factor Y subunit beta (NFYB)	OTXSE7KW	NFYB_HUMAN	Decreases Expression	[89]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Decreases Expression	[89]
Hepatocyte growth factor-like protein (MST1)	OTOC4UNG	HGFL_HUMAN	Decreases Expression	[89]
Interleukin-3 receptor subunit alpha (IL3RA)	OTDC3Y8O	IL3RA_HUMAN	Decreases Expression	[89]
Embryonic growth/differentiation factor 1 (GDF1)	OTZ1VRBH	GDF1_HUMAN	Increases Expression	[89]
Proteasome subunit beta type-6 (PSMB6)	OT9VXPNW	PSB6_HUMAN	Decreases Expression	[89]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)	OTZEXEFH	KAP3_HUMAN	Increases Expression	[89]
Receptor-type tyrosine-protein kinase FLT3 (FLT3)	OTMSRYMK	FLT3_HUMAN	Decreases Expression	[89]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Increases Expression	[89]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[89]
Kappa-type opioid receptor (OPRK1)	OTXCZF4L	OPRK_HUMAN	Decreases Expression	[89]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Expression	[89]
Signal transducer and activator of transcription 2 (STAT2)	OTO9G2RZ	STAT2_HUMAN	Decreases Expression	[89]
Protein S100-A10 (S100A10)	OTI71243	S10AA_HUMAN	Decreases Expression	[89]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B)	OTNUPLUJ	CKS1_HUMAN	Decreases Expression	[89]
Large ribosomal subunit protein eL8 (RPL7A)	OT6E6UKF	RL7A_HUMAN	Decreases Expression	[89]
Small ribosomal subunit protein eS25 (RPS25)	OTKLWED2	RS25_HUMAN	Increases Expression	[89]
Transcription elongation factor SPT4 (SUPT4H1)	OTB3UCTB	SPT4H_HUMAN	Decreases Expression	[89]
Protein CBFA2T1 (RUNX1T1)	OT30DED5	MTG8_HUMAN	Decreases Expression	[89]
Regulator of G-protein signaling 1 (RGS1)	OTGXJYMG	RGS1_HUMAN	Increases Expression	[89]
Nucleoside diphosphate kinase 3 (NME3)	OT0CA0GF	NDK3_HUMAN	Decreases Expression	[89]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Decreases Expression	[89]
Helicase-like transcription factor (HLTF)	OTRX2OSF	HLTF_HUMAN	Decreases Expression	[89]
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2)	OTRHB9SR	NHRF2_HUMAN	Decreases Expression	[89]
Cocaine- and amphetamine-regulated transcript protein (CARTPT)	OTTE4V9S	CART_HUMAN	Decreases Expression	[89]
POU domain class 2-associating factor 1 (POU2AF1)	OTOO6WHL	OBF1_HUMAN	Decreases Expression	[89]
Anti-Muellerian hormone type-2 receptor (AMHR2)	OT95APPM	AMHR2_HUMAN	Decreases Expression	[89]
Serine/threonine-protein kinase LMTK1 (AATK)	OTVHAX5N	LMTK1_HUMAN	Increases Expression	[89]
MAP kinase-activating death domain protein (MADD)	OTUFYVGG	MADD_HUMAN	Decreases Expression	[89]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Decreases Expression	[89]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Increases Expression	[109]
Transcription factor JunB (JUNB)	OTG2JXV5	JUNB_HUMAN	Increases Expression	[109]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Decreases Expression	[109]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Decreases Expression	[109]
Signal transducer and activator of transcription 5B (STAT5B)	OTZVPEBT	STA5B_HUMAN	Increases Expression	[109]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Affects Expression	[110]
Metalloproteinase inhibitor 3 (TIMP3)	OTDGQAD1	TIMP3_HUMAN	Affects Expression	[110]
Metalloproteinase inhibitor 4 (TIMP4)	OT8A68SW	TIMP4_HUMAN	Affects Expression	[110]
Matrilysin (MMP7)	OTVT3SEJ	MMP7_HUMAN	Increases Expression	[111]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Decreases Expression	[111]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Increases Expression	[111]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Phosphorylation	[112]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Increases Expression	[112]
Steroidogenic acute regulatory protein, mitochondrial (STAR)	OTFEZ5AI	STAR_HUMAN	Decreases Expression	[113]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Increases Expression	[90]
Zinc finger protein SNAI1 (SNAI1)	OTDPYAMC	SNAI1_HUMAN	Increases Expression	[90]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Increases Expression	[90]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Increases Expression	[90]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Increases Expression	[114]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[114]
Ankyrin repeat and BTB/POZ domain-containing protein 3 (ABTB3)	OT3PLG38	ABTB3_HUMAN	Increases Expression	[91]
Envoplakin-like protein (EVPLL)	OT1BCQEW	EVPLL_HUMAN	Increases Expression	[91]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Increases Expression	[91]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)	OTGD8TID	FLRT2_HUMAN	Increases Expression	[91]
Ephrin-A2 (EFNA2)	OTEAUKRX	EFNA2_HUMAN	Increases Expression	[91]
Sushi repeat-containing protein SRPX2 (SRPX2)	OT6A63TX	SRPX2_HUMAN	Increases Expression	[91]
Kinesin-like protein KIF21B (KIF21B)	OTFXFIU3	KI21B_HUMAN	Increases Expression	[91]
Immunoglobulin superfamily member 3 (IGSF3)	OT6GWBAF	IGSF3_HUMAN	Increases Expression	[91]
Gamma-glutamylcyclotransferase (GGCT)	OTKAICP5	GGCT_HUMAN	Increases Splicing	[91]
Mediator of RNA polymerase II transcription subunit 24 (MED24)	OTU4SJQ1	MED24_HUMAN	Increases Expression	[91]
CCN family member 5 (CCN5)	OTADU8JJ	CCN5_HUMAN	Increases Expression	[91]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Increases Expression	[91]
Keratin, type II cytoskeletal 6B (KRT6B)	OTBXJYHY	K2C6B_HUMAN	Increases Expression	[91]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Increases Expression	[91]
Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)	OTTLGRGH	GNAI2_HUMAN	Increases Splicing	[91]
Coiled-coil domain-containing protein 159 (CCDC159)	OTFKSPMZ	CC159_HUMAN	Increases Expression	[91]
Ras-related C3 botulinum toxin substrate 2 (RAC2)	OTAOHFNH	RAC2_HUMAN	Increases Expression	[91]
Fumarylacetoacetase (FAH)	OTGZA1YR	FAAA_HUMAN	Increases Expression	[91]
Homeobox protein Hox-B9 (HOXB9)	OTMVHQOU	HXB9_HUMAN	Increases Expression	[91]
Keratin, type I cytoskeletal 15 (KRT15)	OTS6WLF7	K1C15_HUMAN	Increases Expression	[91]
Small proline-rich protein 2D (SPRR2D)	OT47THNK	SPR2D_HUMAN	Increases Expression	[91]
Protein S100-A2 (S100A2)	OTTGHJ1H	S10A2_HUMAN	Increases Expression	[91]
Caspase-14 (CASP14)	OTKY93H9	CASPE_HUMAN	Increases Expression	[91]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1)	OTB06ESI	ACSL1_HUMAN	Increases Splicing	[91]
Interferon alpha-inducible protein 27, mitochondrial (IFI27)	OTI2XGIT	IFI27_HUMAN	Increases Expression	[91]
Epithelial membrane protein 1 (EMP1)	OTSZHUHQ	EMP1_HUMAN	Increases Expression	[91]
ATP synthase subunit epsilon, mitochondrial (ATP5F1E)	OTMPLAIS	ATP5E_HUMAN	Increases Splicing	[91]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)	OTV7VOV3	DHB7_HUMAN	Increases Splicing	[91]
Ribose-phosphate pyrophosphokinase 1 (PRPS1)	OTN3A6CN	PRPS1_HUMAN	Increases Splicing	[91]
Rho-related GTP-binding protein RhoE (RND3)	OTXMXPIH	RND3_HUMAN	Increases Splicing	[91]
Small ribosomal subunit protein eS24 (RPS24)	OTSNKIL5	RS24_HUMAN	Increases Splicing	[91]
Keratin, type II cuticular Hb5 (KRT85)	OT67IP7F	KRT85_HUMAN	Increases Expression	[91]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Increases Expression	[91]
Paired box protein Pax-8 (PAX8)	OTRPD9MI	PAX8_HUMAN	Increases Expression	[91]
Cytochrome P450 4F3 (CYP4F3)	OTYNSQAM	CP4F3_HUMAN	Increases Expression	[91]
Melatonin-related receptor (GPR50)	OT0EJBM4	MTR1L_HUMAN	Increases Expression	[91]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)	OT1QHOS2	NF2L1_HUMAN	Increases Splicing	[91]
Protein Aster-B (GRAMD1B)	OTCG1GX2	ASTRB_HUMAN	Increases Expression	[91]
Interferon-induced protein 44-like (IFI44L)	OTXKORJP	IF44L_HUMAN	Increases Expression	[91]
SH3 domain-containing protein 19 (SH3D19)	OTVU3VS2	SH319_HUMAN	Increases Splicing	[91]
Late cornified envelope protein 1B (LCE1B)	OT7BLO6L	LCE1B_HUMAN	Increases Expression	[91]
Keratin, type II cytoskeletal 80 (KRT80)	OTAU54U3	K2C80_HUMAN	Increases Expression	[91]
TMF-regulated nuclear protein 1 (TRNP1)	OTYYV8LN	TRNP1_HUMAN	Increases Expression	[91]
Solute carrier family 25 member 48 (SLC25A48)	OTAMLAGE	S2548_HUMAN	Decreases Expression	[91]
Activity-regulated cytoskeleton-associated protein (ARC)	OTN2QQPG	ARC_HUMAN	Increases Expression	[91]
5'-deoxynucleotidase HDDC2 (HDDC2)	OTSO0JP4	HDDC2_HUMAN	Increases Expression	[91]
Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3)	OTYAKC55	LRAD3_HUMAN	Increases Splicing	[91]
Neuronal PAS domain-containing protein 3 (NPAS3)	OT8D1ILB	NPAS3_HUMAN	Decreases Expression	[91]
Prominin-2 (PROM2)	OTT8IVS7	PROM2_HUMAN	Increases Expression	[91]
Synaptopodin (SYNPO)	OTICDJAB	SYNPO_HUMAN	Increases Expression	[91]
Cilia- and flagella-associated protein 43 (CFAP43)	OT6R8UGG	CFA43_HUMAN	Decreases Expression	[91]
Protein FAM83F (FAM83F)	OTGGJRO7	FA83F_HUMAN	Increases Expression	[91]
Interferon-induced protein 44 (IFI44)	OTOKSZVA	IFI44_HUMAN	Increases Expression	[91]
Retinoic acid early transcript 1E (RAET1E)	OTLR3CEC	RAE1E_HUMAN	Increases Expression	[91]
Glucose-6-phosphate exchanger SLC37A2 (SLC37A2)	OTH77FBE	G6PT3_HUMAN	Increases Expression	[91]
Prospero homeobox protein 1 (PROX1)	OT68R6IO	PROX1_HUMAN	Increases Expression	[91]
Phosphatidate cytidylyltransferase 1 (CDS1)	OT2F591M	CDS1_HUMAN	Increases Splicing	[91]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1)	OT3062CA	SO2A1_HUMAN	Increases Expression	[91]
SH3 domain-containing kinase-binding protein 1 (SH3KBP1)	OTIUA60B	SH3K1_HUMAN	Increases Expression	[91]
Androgen-dependent TFPI-regulating protein (ADTRP)	OTFI2BQX	ADTRP_HUMAN	Increases Expression	[91]
Gasdermin-A (GSDMA)	OT912R2E	GSDMA_HUMAN	Increases Expression	[91]
SH3 and cysteine-rich domain-containing protein (STAC)	OTRVBSLR	STAC_HUMAN	Increases Expression	[91]
Cell growth regulator with EF hand domain protein 1 (CGREF1)	OTBZQX97	CGRE1_HUMAN	Increases Expression	[91]
Melanophilin (MLPH)	OT7ADCXL	MELPH_HUMAN	Increases Expression	[91]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Increases Expression	[91]
Tubulointerstitial nephritis antigen-like (TINAGL1)	OTZZO56M	TINAL_HUMAN	Increases Expression	[91]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)	OTH88TXU	ADA19_HUMAN	Increases Expression	[91]
Transmembrane protein 222 (TMEM222)	OTWFLPK2	TM222_HUMAN	Increases Splicing	[91]
Beta-defensin 129 (DEFB129)	OT1R2LZM	DB129_HUMAN	Decreases Expression	[91]
CXADR-like membrane protein (CLMP)	OTU7C3GQ	CLMP_HUMAN	Increases Expression	[91]
Protein S100-A14 (S100A14)	OTVFJJ91	S10AE_HUMAN	Increases Expression	[91]
SH2 domain-containing protein 2A (SH2D2A)	OTQSKW7U	SH22A_HUMAN	Increases Expression	[91]
Triggering receptor expressed on myeloid cells 1 (TREM1)	OTCVFEE6	TREM1_HUMAN	Increases Expression	[91]
Serine palmitoyltransferase 3 (SPTLC3)	OTZDX6PT	SPTC3_HUMAN	Increases Expression	[91]
G patch domain-containing protein 2 (GPATCH2)	OT09TY4W	GPTC2_HUMAN	Increases Splicing	[91]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Increases Expression	[91]
Protocadherin Fat 2 (FAT2)	OTRGT3E8	FAT2_HUMAN	Increases Expression	[91]
Myoferlin (MYOF)	OTRFC3IJ	MYOF_HUMAN	Increases Splicing	[91]
Coiled-coil domain-containing protein 167 (CCDC167)	OTUIAUE7	CC167_HUMAN	Increases Expression	[91]
Cysteine-rich C-terminal protein 1 (CRCT1)	OTPYME8V	CRCT1_HUMAN	Increases Expression	[91]
STEAP1 protein (STEAP1)	OTJMW5R9	STEA1_HUMAN	Increases Expression	[91]
Protein mono-ADP-ribosyltransferase PARP4 (PARP4)	OTXBK59G	PARP4_HUMAN	Increases Splicing	[91]
Hippocalcin-like protein 4 (HPCAL4)	OT793RNP	HPCL4_HUMAN	Increases Expression	[91]
Angiopoietin-4 (ANGPT4)	OT881M3K	ANGP4_HUMAN	Increases Expression	[91]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)	OTJQL0I3	HEY1_HUMAN	Increases Expression	[91]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Increases Expression	[91]
Steroidogenic factor 1 (NR5A1)	OTOULYR4	STF1_HUMAN	Decreases Expression	[115]
ETS domain-containing protein Elk-1 (ELK1)	OTH9MXD6	ELK1_HUMAN	Increases Phosphorylation	[116]
RNA binding protein fox-1 homolog 3 (RBFOX3)	OTL0F3D6	RFOX3_HUMAN	Increases Expression	[117]
Dynamin-1-like protein (DNM1L)	OTXK1Q1G	DNM1L_HUMAN	Increases Expression	[95]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Increases Expression	[118]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Decreases Expression	[119]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[120]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Increases Activity	[121]
Lutropin subunit beta (LHB)	OT5GBOVJ	LSHB_HUMAN	Increases Secretion	[122]
Osteocalcin (BGLAP)	OTK1YLWQ	OSTCN_HUMAN	Decreases Expression	[123]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Increases Expression	[120]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Increases Activity	[121]
High affinity nerve growth factor receptor (NTRK1)	OTJORQAU	NTRK1_HUMAN	Increases Expression	[124]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Decreases Expression	[125]
Neurofilament medium polypeptide (NEFM)	OT8VCBNF	NFM_HUMAN	Increases Expression	[117]
Involucrin (IVL)	OT4VPNGY	INVO_HUMAN	Decreases Expression	[125]
Heat shock protein HSP 90-alpha (HSP90AA1)	OTLG1WPK	HS90A_HUMAN	Increases Expression	[126]
Tumor necrosis factor receptor superfamily member 16 (NGFR)	OTPKSM49	TNR16_HUMAN	Increases Expression	[124]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Increases Expression	[120]
Integrin alpha-IIb (ITGA2B)	OT4Y17PY	ITA2B_HUMAN	Decreases Expression	[127]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Increases Phosphorylation	[128]
Elongation factor 2 (EEF2)	OTZ7SZ39	EF2_HUMAN	Increases Expression	[95]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Decreases Expression	[129]
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)	OT6EBDHM	DHB1_HUMAN	Decreases Expression	[129]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Expression	[130]
Endothelial transcription factor GATA-2 (GATA2)	OTBP2QQ2	GATA2_HUMAN	Increases Expression	[131]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[132]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Activity	[133]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Activity	[134]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[135]
Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3)	OTCZQY1U	ACHA3_HUMAN	Decreases Expression	[136]
Reduced folate transporter (SLC19A1)	OTWB0BTO	S19A1_HUMAN	Decreases Expression	[61]
Collagenase 3 (MMP13)	OTY8BZIE	MMP13_HUMAN	Increases Expression	[120]
Histone H2B type 1-D (H2BC5)	OTXDTDHN	H2B1D_HUMAN	Increases Expression	[137]
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A)	OTIIGGZ2	RS27A_HUMAN	Decreases Expression	[138]
Casein kinase II subunit alpha (CSNK2A1)	OT9T8WQM	CSK21_HUMAN	Increases Expression	[137]
Histone H3.1 (H3C1)	OTGBGOZW	H31_HUMAN	Increases Expression	[137]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Decreases Secretion	[139]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Expression	[140]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Decreases Expression	[141]
Histone RNA hairpin-binding protein (SLBP)	OTVYYQRT	SLBP_HUMAN	Decreases Expression	[137]
Neuronal acetylcholine receptor subunit alpha-6 (CHRNA6)	OTT6W86V	ACHA6_HUMAN	Decreases Expression	[136]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3)	OTZM6MHU	NLRP3_HUMAN	Increases Expression	[142]
Flavin-containing monooxygenase 3 (FMO3)	OT1G2EV3	FMO3_HUMAN	Increases Metabolism	[143]
Regulatory-associated protein of mTOR (RPTOR)	OT4TQZ9F	RPTOR_HUMAN	Affects Response To Substance	[82]
LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3)	OTA7IBLE	LYSM3_HUMAN	Affects Response To Substance	[82]
Tyrosine-protein kinase JAK2 (JAK2)	OTBIDOOR	JAK2_HUMAN	Increases Response To Substance	[144]
Pleckstrin homology domain-containing family G member 1 (PLEKHG1)	OTDVYW2F	PKHG1_HUMAN	Affects Response To Substance	[82]
Solute carrier family 22 member 2 (SLC22A2)	OTGFK1AL	S22A2_HUMAN	Affects Response To Substance	[145]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Increases ADR	[76]
Plastin-2 (LCP1)	OTK61F2A	PLSL_HUMAN	Affects Response To Substance	[82]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)	OTO8JQJA	PK3CB_HUMAN	Increases ADR	[76]

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