Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2FGRT)

Drug Name
Clavulanate Drug Info
Synonyms
Clavulansaeure; Clavulox; Acide clavulanique; Acido clavulanico; Acidum clavulanicum; CLAVULANIC ACID; Clavulansaeure [INN]; Clavulinic Acid; Sodium Clavulanate; Antibiotic MM 14151; MM 14151; Acide clavulanique [INN-French]; Acido clavulanico [INN-Spanish]; Acidum clavulanicum [INN-Latin]; BRL-14151; Clavulanic acid (INN); Clavulanic acid [BAN:INN]; Clavulox (TN); MM-14151; (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (Z)-(2R,5R)-3-(2-Hydroxyethyliden)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptan-2-carbonsaeure; (Z)-(2R,5R)-3-(2-Hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid; 3008-B; 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha,3Z,5alpha))
Indication
Disease Entry ICD 11 Status REF
Bacteremia 1A73 Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Staphylococcal pneumonia Approved [1]
Staphylococcus aureus infection Approved [1]
Streptococcal pneumonia Approved [1]
Urinary tract infection GC08 Approved [1]
Pneumonia due to Klebsiella pneumoniae CA40.03 Investigative [1]
Sinusitis CA0A.Z Investigative [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
5280980
ChEBI ID
CHEMBL777
CAS Number
CAS 58001-44-8
TTD Drug ID
DM2FGRT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Staphylococcus Beta-lactamase (Stap-coc blaZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tazobactam DM3XNUI Appendicitis DB10 Approved [6]
CAZ AVI DMPG4OM Serious infection 1H0Z Phase 3 [7]
Enmetazobactam DMZKTYJ Urinary tract infection GC08 Phase 3 [8]
Vaborbactam DMDCFXJ Urinary tract infection GC08 Phase 3 [9]
MK-7655 DMLMV0O Bacterial infection 1A00-1C4Z Phase 2 [10]
CXL DM3JFZ2 Methicillin-resistant staphylococci infection 1A00-1A09 Phase 2 [11]
RASV-Sp DM4VTX6 Streptococcus infection 1B53 Phase 1 [12]
ME-1071 DMEMQ5J Bacterial infection 1A00-1C4Z Phase 1 [13]
OP-0595 DMECVP9 Bacterial infection 1A00-1C4Z Phase 1 [14]
VNRX-5133 DMNZ6XH Bacterial infection 1A00-1C4Z Phase 1 [15]
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Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [16]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [16]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [19]
Fluoxetine DM3PD2C Bipolar depression Approved [16]
Fructose DM43AN2 Vomiting MD90 Approved [20]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [21]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [16]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [22]
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Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [27]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [5]
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Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [30]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [31]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [32]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [33]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [34]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [35]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [37]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [38]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [38]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [39]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [37]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [38]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [40]
Gefitinib DM15F0X Colon adenocarcinoma Approved [37]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [41]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [37]
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Drug(s) Affected By Antileukoproteinase (SLPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [5]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [5]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [5]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [5]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [43]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [44]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [5]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [46]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [45]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [5]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [47]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [48]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [49]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [50]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [51]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [52]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [5]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [53]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [54]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [5]
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Drug(s) Affected By Glutathione peroxidase 2 (GPX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [55]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [56]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [57]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [58]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [59]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [60]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [32]
Testosterone DM7HUNW Hot flushes GA30 Approved [61]
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Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [62]
Verapamil DMA7PEW Angina pectoris BA40 Approved [63]
Methysergide DM1EF73 Migraine 8A80 Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [40]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [57]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [66]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [67]
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Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [5]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [5]
Trihexyphenidyl DMB19L8 Dystonia 8A02 Approved [5]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [5]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [72]
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Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [73]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [57]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [74]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [75]
Testosterone DM7HUNW Hot flushes GA30 Approved [76]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [77]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [79]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [80]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
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Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [81]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [82]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [83]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [82]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [84]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [85]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Fluoxetine DM3PD2C Bipolar depression Approved [82]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [86]
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Drug(s) Affected By Organic solute transporter subunit alpha (SLC51A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [57]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [42]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [88]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [89]
Leflunomide DMR8ONJ Arthritis FA20 Approved [90]
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Drug(s) Affected By ATP-binding cassette sub-family G member 5 (ABCG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [91]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [87]
Leflunomide DMR8ONJ Arthritis FA20 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [39]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [92]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [87]
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Drug(s) Affected By 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [87]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [18]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [57]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [79]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Arsenic DMTL2Y1 N. A. N. A. Approved [93]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [94]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Staphylococcus Beta-lactamase (Stap-coc blaZ) TTHI19T BLAC_STAAU Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1) OTRI4UR1 CP8B1_HUMAN Gene/Protein Processing [4]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Gene/Protein Processing [4]
Antileukoproteinase (SLPI) OTUNFUU8 SLPI_HUMAN Gene/Protein Processing [5]
ATP-binding cassette sub-family G member 5 (ABCG5) OT1OMY93 ABCG5_HUMAN Gene/Protein Processing [4]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [4]
Glutathione peroxidase 2 (GPX2) OTXI2NTI GPX2_HUMAN Gene/Protein Processing [4]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Gene/Protein Processing [5]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Gene/Protein Processing [5]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Gene/Protein Processing [4]
Organic solute transporter subunit alpha (SLC51A) OTDJRZ0P OSTA_HUMAN Gene/Protein Processing [4]

References

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5 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
6 Selection of TNF-alpha binding affibody molecules using a beta-lactamase protein fragment complementation assay. N Biotechnol. 2009 Nov 30;26(5):251-9.
7 NXL104 irreversibly inhibits the -lactamase from Mycobacterium tuberculosis. Biochemistry. 2012 Jun 5;51(22):4551-7.
8 Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum--Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2020 May 21;64(6):e00180-20.
9 Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae. Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01443-17.
10 Discovery of MK-7655, a beta-lactamase inhibitor for combination with Primaxin . Bioorg Med Chem Lett. 2014 Feb 1;24(3):780-5.
11 Beta-Lactam Antibiotics Renaissance. Antibiotics. 2014, 3(2), 193-215.
12 WO patent application no. 2010,0456,20, Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae.
13 Multidrug-resistant Gram-negative bacterial infections: are you ready for the challenge. Curr Clin Pharmacol. 2014 Feb;9(1):27-38.
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15 Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo--lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2020 Mar 26;63(6):2789-2801.
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18 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
19 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
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22 Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells. J Steroid Biochem Mol Biol. 2003 May;85(1):1-8. doi: 10.1016/s0960-0760(03)00142-0.
23 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
24 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
25 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
26 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
27 Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol. 2006 Apr;126(4):732-9. doi: 10.1038/sj.jid.5700202.
28 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
29 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
30 Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. Arch Toxicol. 2018 Apr;92(4):1435-1451.
31 Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
32 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
33 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
34 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
35 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
36 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
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38 Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
39 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
40 Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4.
41 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
42 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
43 ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway. Toxicol Appl Pharmacol. 2019 Nov 15;383:114768. doi: 10.1016/j.taap.2019.114768. Epub 2019 Oct 19.
44 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
45 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
46 All-trans retinoic acid inhibits the cell proliferation but enhances the cell invasion through up-regulation of c-met in pancreatic cancer cells. Cancer Lett. 2005 Jun 28;224(2):303-10. doi: 10.1016/j.canlet.2004.10.016. Epub 2004 Dec 8.
47 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
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