Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4KLPT)

Drug Name
Terfenadine Drug Info
Synonyms
Aldaban; Allerplus; Cyater; Hisfedin; Rapidal; Seldane; Teldane; Teldanex; Terdin; Terfedura; Terfemundin; Terfen; Terfenadina; Terfenadinum; Terfenidine; Terfex; Ternadin; Triludan; Aliud Brand of Terfenadine; Balkis Saft Spezial; Bial Brand of Terfenadine; Cantabria Brand of Terfenadine; Ct Arzneimittel Brand of Terfenadine; Dolorgiet Brand of Terfenadine; Heumann Brand of Terfenadine; Hoechst Brand of Terfenadine; Merck dura Brand of Terfenadine; Mundipharma Brand of Terfenadine; Ratiopharm Brand of Terfenadine; Sigma Tau Brand of Terfenadine; Stadapharm Brand of Terfenadine; Terfenadin AL; Terfenadin Heumann; Terfenadin Stada; Terfenadin von ct; Wolff Brand of Terfenadine; MDL 9918; RMI 9918; RMI9918; T 9652; Ct-Arzneimittel Brand of Terfenadine; MDL-9918; RMI-9918; Seldane (TN); Sigma-Tau Brand of Terfenadine; Teldane (TN); Terfenadin-ratiopharm; Terfenadina [INN-Spanish]; Terfenadinum [INN-Latin]; Triludan (TN); Terfenadine (JAN/USAN/INN); Terfenadine [USAN:BAN:INN:JAN]; Alpha-(4-[1,1-Dimethylethyl]phenyl)-4-[hydroxydiphenylmethyl]-1-piperidinebutanol; Alpha-(p-tert-Butylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperdinebutanol; Alpha-(4-(1,1-Dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol; Alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenyl-methyl)-1-piperidine butanol; 1-(4-tert-Butylphenyl)-4-(4-(alpha-hydroxybenzhydryl)piperidino)-butan-1-ol; 1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol; 1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butan-1-ol; 1-(p-tert-Butylphenyl)-4-(4'-(alpha-hydroxydiphenylmethyl)-1'-piperidyl)butanol; 1-[4-(1,1-dimethylethyl)phenyl]-4-{4-[hydroxy(diphenyl)methyl]piperidin-1-yl}butan-1-ol
Indication
Disease Entry ICD 11 Status REF
Allergy 4A80-4A85 Withdrawn from market [1]
Therapeutic Class
Antihistamines
Cross-matching ID
PubChem CID
5405
ChEBI ID
CHEBI:9453
CAS Number
CAS 50679-08-8
TTD Drug ID
DM4KLPT
VARIDT Drug ID
DR00755
INTEDE Drug ID
DR1558

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histamine H1 receptor (H1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [12]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [13]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [14]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [15]
Cinnarizine DM7U5QJ Meniere disease AB31.0 Approved [16]
Diphenhydramine DMKQTBA Hyperemesis gravidarum Approved [14]
Doxepin DMPI98T Anxiety Approved [17]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [14]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [18]
Desloratadine DM56YN7 Allergic rhinitis CA08.0 Approved [19]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [20]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [21]
Methotrexate DM2TEOL Anterior urethra cancer Approved [3]
Folic Acid DMEMBJC Colorectal carcinoma Approved [22]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [3]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [3]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [23]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [3]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [24]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [25]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [33]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [27]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [63]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [64]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [65]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [66]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [67]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [67]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [68]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [69]
Capsaicin DMGMF6V Back pain ME84.Z Approved [70]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [71]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [35]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [36]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [37]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [34]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [38]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [39]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [40]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [41]
Propranolol DM79NTF Angina pectoris BA40 Approved [42]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [43]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [44]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [45]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [46]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [47]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [48]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [49]
Verapamil DMA7PEW Angina pectoris BA40 Approved [50]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [7]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [51]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [7]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [7]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [52]
Verapamil DMA7PEW Angina pectoris BA40 Approved [53]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [7]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [7]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [7]
Metronidazole DMTIVEN Abscess Approved [54]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [55]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [56]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [57]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [58]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [52]
Verapamil DMA7PEW Angina pectoris BA40 Approved [59]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [60]
Estrone DM5T6US Acne vulgaris ED80 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [9]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [72]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [73]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [74]
Cepharanthine DM9Y5JB N. A. N. A. Approved [75]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [76]
Clozapine DMFC71L Schizophrenia 6A20 Approved [77]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [78]
Trifluoperazine DMKBYWI Anxiety Approved [79]
Olanzapine DMPFN6Y Bipolar depression Approved [77]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [80]
Quinidine DMLPICK N. A. N. A. Approved [81]
Verapamil DMA7PEW Angina pectoris BA40 Approved [82]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [83]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [83]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [84]
Propranolol DM79NTF Angina pectoris BA40 Approved [85]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [86]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [87]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [83]
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Drug(s) Affected By Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [88]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [88]
Quinidine DMLPICK N. A. N. A. Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [91]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [92]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Mepivacaine DMH2NMY Analgesia MB40.8 Approved [91]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [94]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [94]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [95]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [10]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [10]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [96]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [95]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [10]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [97]
Gefitinib DM15F0X Colon adenocarcinoma Approved [95]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [98]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [95]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [99]
Gefitinib DM15F0X Colon adenocarcinoma Approved [100]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [101]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [102]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [103]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [104]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [106]
Selenium DM25CGV N. A. N. A. Approved [107]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [108]
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Drug(s) Affected By Parathyroid hormone (PTH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [109]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [110]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [111]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [112]
Arsenic DMTL2Y1 N. A. N. A. Approved [113]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [114]
Phosphate DMUXQG7 Constipation DD91.1 Approved [115]
Paricalcitol DMYBV3G Hyperparathyroidism 5A51 Approved [116]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [89]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [89]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [118]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [119]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [120]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [121]
Paclitaxel DMLB81S Breast carcinoma Approved [122]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [123]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [125]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [126]
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Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [127]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [128]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [129]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [130]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [131]
Prednisone DM2HG4X Acute asthma CA23 Approved [132]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [118]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [134]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [135]
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Drug(s) Affected By Interleukin-5 (IL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [136]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [129]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [130]
Prednisone DM2HG4X Acute asthma CA23 Approved [137]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [140]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [142]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [143]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [144]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [145]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [146]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [147]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [89]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Verapamil DMA7PEW Angina pectoris BA40 Approved [149]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [150]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [151]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [152]
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Drug(s) Affected By Metallothionein-1G (MT1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [155]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [156]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [157]
Leflunomide DMR8ONJ Arthritis FA20 Approved [158]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [159]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [160]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [161]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [162]
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Drug(s) Affected By Nucleoside diphosphate kinase A (NME1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [159]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [161]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [169]
Ethanol DMDRQZU Chronic pain MG30 Approved [170]
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Drug(s) Affected By Potassium voltage-gated channel subfamily A member 5 (KCNA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [171]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Pergolide mesylate DM5GKOV N. A. N. A. Approved [173]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [174]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [175]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [176]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [174]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [177]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [177]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [177]
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Drug(s) Affected By CD82 antigen (CD82)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [179]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [92]
Testosterone DM7HUNW Hot flushes GA30 Approved [180]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [180]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [181]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [182]
Bortezomib DMNO38U Leukemia Approved [183]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [184]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [185]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [186]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [187]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [124]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [152]
Gefitinib DM15F0X Colon adenocarcinoma Approved [188]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [189]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [190]
Selenium DM25CGV N. A. N. A. Approved [191]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [192]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [193]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [153]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [194]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [105]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [195]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [196]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [197]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [198]
Methotrexate DM2TEOL Anterior urethra cancer Approved [199]
Quercetin DM3NC4M Obesity 5B81 Approved [155]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [200]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [201]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [202]
Gefitinib DM15F0X Colon adenocarcinoma Approved [203]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [204]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Etretinate DM2CZFA Keratosis ED56 Approved [205]
Prednisone DM2HG4X Acute asthma CA23 Approved [206]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [207]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [208]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [209]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [210]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [211]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [121]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [212]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [213]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [214]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [215]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [216]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-2 (CASP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [150]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [218]
Methotrexate DM2TEOL Anterior urethra cancer Approved [219]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [220]
Quercetin DM3NC4M Obesity 5B81 Approved [221]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [222]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [223]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [92]
Leflunomide DMR8ONJ Arthritis FA20 Approved [158]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [224]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [225]
Gefitinib DM15F0X Colon adenocarcinoma Approved [100]
Prednisone DM2HG4X Acute asthma CA23 Approved [206]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [227]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [102]
Quercetin DM3NC4M Obesity 5B81 Approved [228]
Fluoxetine DM3PD2C Bipolar depression Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [224]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [232]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [150]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [233]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [234]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [235]
Meloxicam DM2AR7L Arthritis FA20 Approved [236]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [237]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-6 (CASP6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [184]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [239]
Methotrexate DM2TEOL Anterior urethra cancer Approved [240]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [241]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [242]
Quercetin DM3NC4M Obesity 5B81 Approved [155]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [243]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [245]
Methotrexate DM2TEOL Anterior urethra cancer Approved [219]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [246]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [247]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [248]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [249]
Testosterone DM7HUNW Hot flushes GA30 Approved [250]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [251]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [186]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [144]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [217]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [148]
Verapamil DMA7PEW Angina pectoris BA40 Approved [149]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [252]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [233]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [204]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [253]
Meloxicam DM2AR7L Arthritis FA20 Approved [254]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [255]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [256]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [257]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [178]
Gefitinib DM15F0X Colon adenocarcinoma Approved [258]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [259]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [235]
Selenium DM25CGV N. A. N. A. Approved [191]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [237]
Methotrexate DM2TEOL Anterior urethra cancer Approved [118]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [260]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [261]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [262]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [263]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [264]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [264]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [264]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [159]
Testosterone enanthate DMB6871 N. A. N. A. Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [161]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [89]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [266]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [267]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [268]
Meloxicam DM2AR7L Arthritis FA20 Approved [269]
Quercetin DM3NC4M Obesity 5B81 Approved [270]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [271]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [272]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [174]
Retigabine DMGNYIH Behcet disease 4A62 Approved [273]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2J2 (CYP2J2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [274]
Quercetin DM3NC4M Obesity 5B81 Approved [155]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [275]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [276]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [277]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [274]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [159]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [274]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [278]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [279]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Misshapen-like kinase 1 (MINK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [191]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [93]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [169]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [183]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [280]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [281]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [282]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [283]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [89]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histamine H1 receptor (H1R) TTTIBOJ HRH1_HUMAN Antagonist [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [4]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [5]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [6]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [7]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [8]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [8]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [9]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [10]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Gene/Protein Processing [11]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [8]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Gene/Protein Processing [11]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Gene/Protein Processing [11]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Gene/Protein Processing [11]
CD82 antigen (CD82) OTH8MC64 CD82_HUMAN Gene/Protein Processing [8]

References

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