Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM802V7)

• Drug Name: Syringic Acid Drug Info
• Synonyms: SYRINGIC ACID; 530-57-4; 4-Hydroxy-3,5-dimethoxybenzoic acid; 3,5-Dimethoxy-4-hydroxybenzoic acid; Cedar acid; Gallic acid 3,5-dimethyl ether; Benzoic acid, 4-hydroxy-3,5-dimethoxy-; 3,5-Dimethoxy-4-hydroxybenzyl acid; UNII-E390O181H5; NSC 2129; EINECS 208-486-8; 4-Hydroxy-3,5-dimethoxy-benzoic acid; BRN 2115262; CHEMBL1414; AI3-24376; CHEBI:68329; JMSVCTWVEWCHDZ-UHFFFAOYSA-N; MFCD00002552; E390O181H5; Syringic acid, 97%; Syringlicacid; Syringicacid; PubChem2673; SpecPlus_000485; AC1L1VUN; Spectrum3_001866; Spectrum5_000963

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10742
  ChEBI ID: CHEBI:68329
  CAS Number: CAS 530-57-4
  TTD Drug ID: DM802V7

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase VI (CA-VI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[4]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[5]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[1]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[7]
SAR566658	DM6Q295	Solid tumour/cancer	2A00-2F9Z	Phase 2	[8]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[1]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[9]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[1]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting Carbonic anhydrase I (CA-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[4]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[11]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[11]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[12]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[11]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[1]
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[13]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[6]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[7]

Drug(s) Targeting Carbonic anhydrase XII (CA-XII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[4]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[14]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[1]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[6]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[7]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[1]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[1]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[10]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[6]

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[4]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[14]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[15]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[16]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[17]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[17]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[18]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[19]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[20]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]

Drug(s) Targeting Carbonic anhydrase XIV (CA-XIV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[21]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[9]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[1]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[6]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[7]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[1]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[9]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[1]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[10]

Drug(s) Targeting Carbonic anhydrase (CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[22]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[5]
Quinethazone	DMWCOSR	Hypertension	BA00-BA04	Approved	[23]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[1]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[6]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[7]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[24]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[1]
PMID30074415-Compound-21	DM3NPOU	N. A.	N. A.	Patented	[25]

Drug(s) Targeting Carbonic anhydrase IV (CA-IV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[4]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[26]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[11]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[1]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[6]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[7]
Sodium pyruvate	DMST6A3	Asthma	CA23	Phase 1/2	[27]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[24]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[1]

Drug(s) Targeting Carbonic anhydrase IX (CA-IX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[6]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[1]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[6]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[7]
INDISULAM	DM9SX6Y	Lymphoma	2A80-2A86	Phase 2	[28]
Girentuximab I-124	DMG3O2Z	Renal cell carcinoma	2C90	Phase 2	[29]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[30]
BAY 79-4620	DM14XQN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[31]
90Y-cG250	DMJR6TC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[32]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[1]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[33]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[35]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[40]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[41]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[47]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[48]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[49]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[50]
Ketoprofen	DMRKXPT	Bursitis		Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[59]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[60]
Fructose	DM43AN2	Vomiting	MD90	Approved	[33]
Ketoprofen	DMRKXPT	Bursitis		Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[62]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[63]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[64]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Haloperidol	DM96SE0	Delirium		Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[70]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]

Drug(s) Affected By Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[82]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[83]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[87]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[88]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[89]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[91]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[93]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[96]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[97]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[99]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[101]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[104]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[105]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[106]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[62]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[107]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[108]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[113]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[118]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[126]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[127]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[107]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[130]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[132]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[133]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[134]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[136]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[139]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[141]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[115]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[142]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[143]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[62]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[145]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[147]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[148]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[151]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[143]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[152]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[153]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[142]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[62]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[145]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[156]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[157]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[107]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[160]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[161]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[133]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[164]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[167]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[172]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[87]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[173]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[177]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[178]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[183]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[184]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[185]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[182]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[186]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[187]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[188]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[106]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[191]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[192]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[193]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[194]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[33]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[195]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[119]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[200]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[202]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[203]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[207]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[101]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[178]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[105]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[208]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[189]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[209]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[139]

Drug(s) Affected By FAS-associated death domain protein (FADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[210]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[190]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[212]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[213]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[214]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[216]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[217]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[219]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[226]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[227]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[229]
LY294002	DMY1AFS	Neuroblastoma	2D11.2	Phase 1	[222]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[230]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[233]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[234]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[236]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[237]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[238]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[191]
Selenium	DM25CGV	N. A.	N. A.	Approved	[76]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[243]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[245]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[247]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG3 (ATG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[248]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[249]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[250]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[224]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[82]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[249]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[252]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[1]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[1]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[1]
Carbonic anhydrase VI (CA-VI)	TTCFSPE	CAH6_HUMAN	Inhibitor	[1]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[1]
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[2]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[2]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Gene/Protein Processing	[3]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[2]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[2]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[2]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[3]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[3]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Gene/Protein Processing	[2]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Gene/Protein Processing	[2]

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