Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9RD0C)

• Drug Name: GW7647 Drug Info
• Synonyms: GW-7647; GW 7647

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3392731
  ChEBI ID: CHEMBL21241
  CAS Number: CAS 265129-71-3
  TTD Drug ID: DM9RD0C

Molecule-Related Drug Atlas

Drug(s) Targeting Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lobeglitazone	DMHY3IP	Type-2 diabetes	5A11	Approved	[6]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[7]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[8]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[7]
Pemafibrate	DMD1VZL	Hyperlipidemia	5C80.Z	Approved	[9]
MURAGLITAZAR	DMG3NFZ	N. A.	N. A.	Phase 3	[10]
Ragaglitazar	DMFSHEM	Type-1 diabetes	5A10	Phase 3	[11]
CS-038	DM67P0F	Type-2 diabetes	5A11	Phase 3	[12]
TESAGLITAZAR	DMGRBN5	Type-1 diabetes	5A10	Phase 3	[13]
GFT-505	DM7ZOAE	Non-alcoholic steatohepatitis	DB92.1	Phase 3	[14]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[15]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[16]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[19]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[16]
Fructose	DM43AN2	Vomiting	MD90	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[16]

Drug(s) Affected By Long-chain fatty acid transport protein 2 (SLC27A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[37]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]

Drug(s) Affected By Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[29]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[29]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 4 (ACSL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[43]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[47]

Drug(s) Affected By Fatty acid CoA ligase Acsl3 (ACSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[50]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[51]

Drug(s) Affected By 3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]

Drug(s) Affected By Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]

Drug(s) Affected By Short-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[61]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[30]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[63]
CITCO	DM0N634	Discovery agent	N.A.	Investigative	[3]

Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]

Drug(s) Affected By Enoyl-CoA hydratase, mitochondrial (ECHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[53]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[69]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]

Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[76]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[38]
Bortezomib	DMNO38U	Leukemia		Approved	[77]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[30]

Drug(s) Affected By Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[47]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[63]

Drug(s) Affected By Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Haloperidol	DM96SE0	Delirium		Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[53]

Drug(s) Affected By Apolipoprotein C-IV (APOC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[85]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[86]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[87]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[89]
Farnesol	DMV2X1B	Discovery agent	N.A.	Investigative	[3]

Drug(s) Affected By Trifunctional enzyme subunit beta, mitochondrial (HADHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[81]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[81]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[53]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[47]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[90]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[91]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[92]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[93]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[92]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[92]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[92]

Drug(s) Affected By Peroxisomal bifunctional enzyme (EHHADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[97]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[94]

Drug(s) Affected By Protoheme IX farnesyltransferase, mitochondrial (COX10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[47]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[35]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[100]

Drug(s) Affected By Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[98]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[53]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[103]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[50]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[104]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[105]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[106]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[15]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[106]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[108]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[106]

Drug(s) Affected By Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[53]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[68]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[110]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[111]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[29]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[29]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]

Drug(s) Affected By Apolipoprotein A-V (APOA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[114]

Drug(s) Affected By Dehydrodolichyl diphosphate synthase complex subunit DHDDS (DHDDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[47]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[115]

Drug(s) Affected By Acyl-coenzyme A thioesterase 1 (ACOT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[116]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[63]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[117]

Drug(s) Affected By Peroxisomal succinyl-coenzyme A thioesterase (ACOT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[85]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[34]
CITCO	DM0N634	Discovery agent	N.A.	Investigative	[3]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[119]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[120]

Drug(s) Affected By Acetyl-coenzyme A thioesterase (ACOT12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[34]
OLEIC ACID	DM54O1Z	Discovery agent	N.A.	Investigative	[3]
Farnesol	DMV2X1B	Discovery agent	N.A.	Investigative	[3]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[22]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[121]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[124]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[121]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[122]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[126]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[126]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[60]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[34]
CITCO	DM0N634	Discovery agent	N.A.	Investigative	[3]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[132]

Drug(s) Affected By Enoyl- reductase, mitochondrial (MECR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[47]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[114]

Drug(s) Affected By Very long chain fatty acid elongase 1 (ELOVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[136]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[86]

Drug(s) Affected By Very long chain fatty acid elongase 5 (ELOVL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[137]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 5 (ACSL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[141]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[37]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]

Drug(s) Affected By E3 ubiquitin-protein ligase Midline-1 (MID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[143]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[144]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[147]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[29]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[149]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[150]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[151]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[152]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[153]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[154]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[155]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[156]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[157]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[155]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[159]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[160]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[161]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[50]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[165]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[57]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[168]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[79]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[76]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[84]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[87]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[170]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase kappa (PTPRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[172]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[173]

Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[168]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[29]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[29]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Phospholipase A1 member A (PLA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[177]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[76]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[141]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[177]
bilirubin	DMI0V4O	Discovery agent	N.A.	Investigative	[178]

Drug(s) Affected By Fatty acid 2-hydroxylase (FA2H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[85]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[180]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[131]

Drug(s) Affected By Sphingosine-1-phosphate transporter SPNS2 (SPNS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Sphingosine-1-phosphate	DMJCQKA	Acne vulgaris	ED80	Phase 1	[183]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[116]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[63]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[185]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[172]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[190]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[141]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[36]

Drug(s) Affected By Protein transport protein Sec16B (SEC16B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[192]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[34]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[117]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[114]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[194]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[63]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[195]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Peroxisome proliferator-activated receptor alpha (PPARA)	TTJ584C	PPARA_HUMAN	Agonist	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1)	OTX65INE	PLCA_HUMAN	Gene/Protein Processing	[3]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Gene/Protein Processing	[3]
3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)	OTVKRET0	THIK_HUMAN	Gene/Protein Processing	[3]
Acetyl-coenzyme A thioesterase (ACOT12)	OTN4RQK8	ACO12_HUMAN	Gene/Protein Processing	[3]
Acyl-coenzyme A thioesterase 1 (ACOT1)	OTXFL7WM	ACOT1_HUMAN	Gene/Protein Processing	[3]
Apolipoprotein A-V (APOA5)	OTEVKLVA	APOA5_HUMAN	Gene/Protein Processing	[3]
Apolipoprotein C-IV (APOC4)	OTE8ZUXY	APOC4_HUMAN	Gene/Protein Processing	[3]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[4]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Gene/Protein Processing	[3]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)	OTI862QH	CPT1A_HUMAN	Gene/Protein Processing	[5]

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